MX2020006042A - Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas. - Google Patents

Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas.

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Publication number
MX2020006042A
MX2020006042A MX2020006042A MX2020006042A MX2020006042A MX 2020006042 A MX2020006042 A MX 2020006042A MX 2020006042 A MX2020006042 A MX 2020006042A MX 2020006042 A MX2020006042 A MX 2020006042A MX 2020006042 A MX2020006042 A MX 2020006042A
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Mexico
Prior art keywords
colon cancer
mtor inhibitor
methods
combination therapy
inhibitor combination
Prior art date
Application number
MX2020006042A
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English (en)
Inventor
Neil P Desai
Original Assignee
Abraxis Bioscience Llc
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Publication date
Application filed by Abraxis Bioscience Llc filed Critical Abraxis Bioscience Llc
Publication of MX2020006042A publication Critical patent/MX2020006042A/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
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    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
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    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Abstract

La presente solicitud proporciona métodos para tratar un cáncer de colon (tal como el cáncer de colon avanzado y/o metastásico) en un individuo, que comprenden administrar al individuo: a) una cantidad efectiva de una composición que comprende nanopartículas que comprenden un inhibidor de Mtor (tal como un fármaco tipo limus, tal como sirolimus o un derivado del mismo) y una albúmina, b) una cantidad efectiva de anticuerpo anti-VEGF (tal como bevacizumab), y c) un régimen de FOLFOX terapéuticamente efectivo (tal como FOLFOX4 o un FOLFOX6 modificado).
MX2020006042A 2017-12-19 2018-12-18 Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas. MX2020006042A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762607798P 2017-12-19 2017-12-19
PCT/US2018/066309 WO2019126223A1 (en) 2017-12-19 2018-12-18 Methods of treating colon cancer using nanoparticle mtor inhibitor combination therapy

Publications (1)

Publication Number Publication Date
MX2020006042A true MX2020006042A (es) 2020-10-20

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MX2020006042A MX2020006042A (es) 2017-12-19 2018-12-18 Metodos de tratamiento de cancer de colon usando terapia combinada de inhibidor del objetivo mamifero de la rapamicina (mtor) en nanoparticulas.

Country Status (13)

Country Link
US (2) US20190184031A1 (es)
EP (1) EP3727368A4 (es)
JP (1) JP2021506839A (es)
KR (1) KR20200101396A (es)
CN (1) CN111683657A (es)
AU (1) AU2018388579A1 (es)
BR (1) BR112020012060A2 (es)
CA (1) CA3084994A1 (es)
EA (1) EA202091514A1 (es)
IL (1) IL275261A (es)
MX (1) MX2020006042A (es)
SG (1) SG11202005613SA (es)
WO (1) WO2019126223A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2117520T (lt) 2006-12-14 2018-12-10 Abraxis Bioscience, Llc Krūties vėžio terapija hormonų receptoriaus statuso pagrindu su nanodalelėmis, apimančiomis taksaną
RS59322B1 (sr) 2011-12-14 2019-10-31 Abraxis Bioscience Llc Upotreba polimernih ekscipijenata za liofilizaciju ili zamrzavanje partikula
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
KR20230165356A (ko) 2015-06-29 2023-12-05 아브락시스 바이오사이언스, 엘엘씨 상피양 세포 종양을 치료하는 방법
CA3094453A1 (en) 2018-03-20 2019-09-26 Abraxis Bioscience, Llc Methods of treating central nervous system disorders via administration of nanoparticles of an mtor inhibitor and an albumin
AU2020375810A1 (en) 2019-10-28 2022-05-12 Abraxis Bioscience, Llc Pharmaceutical compositions of albumin and rapamycin
TW202123935A (zh) * 2019-11-11 2021-07-01 美商亞伯辛生物科學有限責任公司 用於奈米粒子組合物之生物標記
JP2023500391A (ja) * 2019-11-11 2023-01-05 アブラクシス バイオサイエンス， エルエルシー ナノ粒子組成物のためのバイオマーカー
WO2022031630A1 (en) * 2020-08-03 2022-02-10 Oncocyte Corporation Classifying tumors and predicting responsiveness
CN113925975A (zh) * 2021-08-31 2022-01-14 杭州师范大学 p53及UTX信使RNA纳米粒的制备方法及该信使RNA的应用
WO2023150194A2 (en) * 2022-02-02 2023-08-10 Oncocyte Corporation Classifying tumors and predicting responsiveness
CN114702552A (zh) * 2022-03-11 2022-07-05 苏州思萃免疫技术研究所有限公司 mTORC2抑制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2481409T3 (en) * 2007-03-07 2018-08-06 Abraxis Bioscience Llc Nanoparticle comprising rapamycin and albumin as anticancer agent
DE102011100122A1 (de) * 2011-04-26 2012-10-31 Eurocor Gmbh Katheterballon beschichtet mit Rapamycin und Schellack
AU2016287508B2 (en) * 2015-06-29 2021-10-14 Abraxis Bioscience, Llc Methods of treating solid tumors using nanoparticle MTOR inhibitor combination therapy

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CA3084994A1 (en) 2019-06-27
KR20200101396A (ko) 2020-08-27
JP2021506839A (ja) 2021-02-22
EA202091514A1 (ru) 2020-09-15
WO2019126223A1 (en) 2019-06-27
SG11202005613SA (en) 2020-07-29
CN111683657A (zh) 2020-09-18
AU2018388579A1 (en) 2020-07-09
US20190184031A1 (en) 2019-06-20
BR112020012060A2 (pt) 2020-11-24
US20240009323A1 (en) 2024-01-11
EP3727368A4 (en) 2021-10-20
EP3727368A1 (en) 2020-10-28
IL275261A (en) 2020-07-30

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