IL272776B1 - A method for rapidly obtaining therapeutic concentrations of zolmitriptan for the treatment of migraines and cluster headaches - Google Patents
A method for rapidly obtaining therapeutic concentrations of zolmitriptan for the treatment of migraines and cluster headachesInfo
- Publication number
- IL272776B1 IL272776B1 IL272776A IL27277620A IL272776B1 IL 272776 B1 IL272776 B1 IL 272776B1 IL 272776 A IL272776 A IL 272776A IL 27277620 A IL27277620 A IL 27277620A IL 272776 B1 IL272776 B1 IL 272776B1
- Authority
- IL
- Israel
- Prior art keywords
- microns
- microprojections
- patch
- zolmitriptan
- group
- Prior art date
Links
- UTAZCRNOSWWEFR-ZDUSSCGKSA-N zolmitriptan Chemical compound C=1[C]2C(CCN(C)C)=CN=C2C=CC=1C[C@H]1COC(=O)N1 UTAZCRNOSWWEFR-ZDUSSCGKSA-N 0.000 title claims 41
- 229960001360 zolmitriptan Drugs 0.000 title claims 41
- 238000000034 method Methods 0.000 title claims 10
- 208000006561 Cluster Headache Diseases 0.000 title claims 4
- 208000019695 Migraine disease Diseases 0.000 title claims 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000008199 coating composition Substances 0.000 claims 34
- 239000007787 solid Substances 0.000 claims 21
- 239000007788 liquid Substances 0.000 claims 19
- 238000001035 drying Methods 0.000 claims 15
- 239000011248 coating agent Substances 0.000 claims 14
- 238000000576 coating method Methods 0.000 claims 14
- 238000009472 formulation Methods 0.000 claims 10
- 238000002493 microarray Methods 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000000758 substrate Substances 0.000 claims 10
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 9
- 210000003491 skin Anatomy 0.000 claims 9
- 235000002906 tartaric acid Nutrition 0.000 claims 9
- 239000011975 tartaric acid Substances 0.000 claims 9
- 230000035515 penetration Effects 0.000 claims 8
- 238000010521 absorption reaction Methods 0.000 claims 5
- 208000002193 Pain Diseases 0.000 claims 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 4
- 230000004907 flux Effects 0.000 claims 4
- 210000000434 stratum corneum Anatomy 0.000 claims 4
- 239000010936 titanium Substances 0.000 claims 4
- 239000005414 inactive ingredient Substances 0.000 claims 3
- 210000002381 plasma Anatomy 0.000 claims 3
- 230000036470 plasma concentration Effects 0.000 claims 3
- 229910052719 titanium Inorganic materials 0.000 claims 3
- 206010033546 Pallor Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 238000005452 bending Methods 0.000 claims 2
- 208000018912 cluster headache syndrome Diseases 0.000 claims 2
- 210000004207 dermis Anatomy 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000037368 penetrate the skin Effects 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 206010015150 Erythema Diseases 0.000 claims 1
- 206010016825 Flushing Diseases 0.000 claims 1
- 206010027603 Migraine headaches Diseases 0.000 claims 1
- 208000001431 Psychomotor Agitation Diseases 0.000 claims 1
- 206010038743 Restlessness Diseases 0.000 claims 1
- 208000036071 Rhinorrhea Diseases 0.000 claims 1
- 206010039101 Rhinorrhoea Diseases 0.000 claims 1
- 229910001069 Ti alloy Inorganic materials 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 201000004356 excessive tearing Diseases 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 210000001061 forehead Anatomy 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910001000 nickel titanium Inorganic materials 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 201000003004 ptosis Diseases 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
- 229910001256 stainless steel alloy Inorganic materials 0.000 claims 1
- 230000035900 sweating Effects 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2017/048258 WO2019040063A1 (fr) | 2017-08-23 | 2017-08-23 | Procédé d'obtention rapide de concentrations thérapeutiques de zolmitriptan pour le traitement de migraines et de céphalées de horton |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL272776A IL272776A (en) | 2020-04-30 |
| IL272776B1 true IL272776B1 (en) | 2024-02-01 |
| IL272776B2 IL272776B2 (en) | 2024-06-01 |
Family
ID=59829462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL272776A IL272776B2 (en) | 2017-08-23 | 2017-08-23 | A method for rapidly obtaining therapeutic concentrations of zolmitriptan for the treatment of migraines and cluster headaches |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP3672570A1 (fr) |
| JP (2) | JP7219384B2 (fr) |
| KR (2) | KR20210155817A (fr) |
| CN (1) | CN111050749A (fr) |
| AU (1) | AU2017428907B2 (fr) |
| CA (2) | CA3223555A1 (fr) |
| IL (1) | IL272776B2 (fr) |
| WO (1) | WO2019040063A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3416618A1 (fr) | 2016-02-19 | 2018-12-26 | ZP Opco, Inc. | Procédé pour obtenir rapidement des concentrations thérapeutiques de triptans pour le traitement de migraines |
| US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
| US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
| WO2020245667A1 (fr) * | 2019-06-06 | 2020-12-10 | Kindeva Drug Delivery L.P. | Support de microréseau destiné à un applicateur de microréseau |
| US11638809B2 (en) * | 2019-06-28 | 2023-05-02 | Passport Technologies, Inc. | Triptan microporation delivery system |
| CN114699510A (zh) * | 2021-12-29 | 2022-07-05 | 浙江湃肽生物有限公司 | 一种司美格鲁肽微针阵列及其制备方法 |
| CN115887903A (zh) * | 2022-12-15 | 2023-04-04 | 太平洋康泰科学仪器（济南）有限公司 | 微针贴片给药组件及给药方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013177376A (ja) * | 2012-02-09 | 2013-09-09 | Hisamitsu Pharmaceut Co Inc | マイクロニードル用ゾルミトリプタン含有コーティング組成物及びマイクロニードルデバイス |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5080646A (en) | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US5147296A (en) | 1988-10-03 | 1992-09-15 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US5169382A (en) | 1988-10-03 | 1992-12-08 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| CA2253549C (fr) | 1996-06-18 | 2005-10-25 | Alza Corporation | Dispositif d'amelioration d'apport ou d'echantillonnage d'agents transdermiques |
| US5741554A (en) | 1996-07-26 | 1998-04-21 | Bio Dot, Inc. | Method of dispensing a liquid reagent |
| US5738728A (en) | 1996-07-26 | 1998-04-14 | Bio Dot, Inc. | Precision metered aerosol dispensing apparatus |
| US5743960A (en) | 1996-07-26 | 1998-04-28 | Bio-Dot, Inc. | Precision metered solenoid valve dispenser |
| US5916524A (en) | 1997-07-23 | 1999-06-29 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
| DE69831268T2 (de) | 1997-12-11 | 2006-03-09 | Alza Corp., Palo Alto | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
| AU739616B2 (en) | 1997-12-11 | 2001-10-18 | Alza Corporation | Device for enhancing transdermal agent flux |
| DK1037687T3 (da) | 1997-12-11 | 2009-01-26 | Alza Corp | Anordning til at forbedre et middels transdermale strömning |
| US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
| DE60024312T2 (de) | 1999-12-10 | 2006-08-17 | Alza Corp., Mountain View | Transdermale Wirkstoffabgabe von makromolekularen Wirkstoffen und Vorrichtung hierfür |
| BR0114634A (pt) | 2000-10-13 | 2004-01-27 | Alza Corp | Aplicador por impacto de disposição de microlâmina |
| RU2278623C2 (ru) | 2000-10-13 | 2006-06-27 | Алза Корпорейшн | Держатель микровыступающего элемента для силового аппликатора |
| BR0114629A (pt) | 2000-10-13 | 2004-01-20 | Alza Corp | Aparelho e método para a perfuração da pele com microprojeções |
| US7419481B2 (en) | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
| BR0114909A (pt) | 2000-10-26 | 2004-02-03 | Alza Corp | Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas |
| US6855372B2 (en) | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
| CA2444883A1 (fr) | 2001-04-20 | 2002-10-31 | Alza Corporation | Reseau de micro-projections avec revetement contenant un principe benefique |
| ATE539687T1 (de) | 2003-10-31 | 2012-01-15 | Alza Corp | Selbstbetätigter applikator für eine mikroprojektionsanordnung |
| EP1744683B1 (fr) | 2004-05-13 | 2016-03-16 | Alza Corporation | Appareil et procédé pour la délivrance transdermique d'agents à base d'hormone parathyroïde |
| CA2680690A1 (fr) | 2006-03-15 | 2007-09-20 | Alza Corporation | Appareil et procede d'administration transdermique d'agents hormonaux parathyroidiens destines a traiter ou prevenir l'osteopenie |
| WO2008115586A1 (fr) * | 2007-03-21 | 2008-09-25 | Alza Corporation | Appareil et procédé d'administration transdermique d'un agoniste de triptane |
| WO2015017561A1 (fr) | 2013-07-30 | 2015-02-05 | Zosano Pharma, Inc. | Applicateur extra-plat de tampon de micro-aiguilles |
| EP3416618A1 (fr) * | 2016-02-19 | 2018-12-26 | ZP Opco, Inc. | Procédé pour obtenir rapidement des concentrations thérapeutiques de triptans pour le traitement de migraines |
-
2017
- 2017-08-23 CA CA3223555A patent/CA3223555A1/fr active Pending
- 2017-08-23 AU AU2017428907A patent/AU2017428907B2/en not_active Expired - Fee Related
- 2017-08-23 CN CN201780094159.6A patent/CN111050749A/zh active Pending
- 2017-08-23 KR KR1020217040858A patent/KR20210155817A/ko active IP Right Grant
- 2017-08-23 CA CA3073442A patent/CA3073442C/fr active Active
- 2017-08-23 KR KR1020207005263A patent/KR102340393B1/ko active IP Right Grant
- 2017-08-23 WO PCT/US2017/048258 patent/WO2019040063A1/fr unknown
- 2017-08-23 EP EP17764703.9A patent/EP3672570A1/fr active Pending
- 2017-08-23 JP JP2020532539A patent/JP7219384B2/ja active Active
- 2017-08-23 IL IL272776A patent/IL272776B2/en unknown
-
2023
- 2023-01-05 JP JP2023000670A patent/JP2023033378A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013177376A (ja) * | 2012-02-09 | 2013-09-09 | Hisamitsu Pharmaceut Co Inc | マイクロニードル用ゾルミトリプタン含有コーティング組成物及びマイクロニードルデバイス |
Non-Patent Citations (1)
| Title |
|---|
| KELLERMAN DONALD J ET AL,, RAPID SYSTEMIC DELIVERY OF ZOLMITRIPTAN USING AN ADHESIVE DERMALLY APPLIED MICROARRAY, 25 July 2017 (2017-07-25) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3223555A1 (fr) | 2019-02-28 |
| KR20200032170A (ko) | 2020-03-25 |
| JP2023033378A (ja) | 2023-03-10 |
| JP2021500397A (ja) | 2021-01-07 |
| KR20210155817A (ko) | 2021-12-23 |
| CA3073442A1 (fr) | 2019-02-28 |
| EP3672570A1 (fr) | 2020-07-01 |
| KR102340393B1 (ko) | 2021-12-17 |
| AU2017428907A1 (en) | 2020-03-05 |
| JP7219384B2 (ja) | 2023-02-08 |
| CA3073442C (fr) | 2024-02-06 |
| CN111050749A (zh) | 2020-04-21 |
| IL272776A (en) | 2020-04-30 |
| AU2017428907B2 (en) | 2021-12-16 |
| WO2019040063A1 (fr) | 2019-02-28 |
| IL272776B2 (en) | 2024-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL272776B1 (en) | A method for rapidly obtaining therapeutic concentrations of zolmitriptan for the treatment of migraines and cluster headaches | |
| RU2282468C2 (ru) | Устройство для трансдермальной доставки лекарственных средств, имеющее микровыступы с покрытием | |
| TW200539907A (en) | Delivery of polymer conjugates of therapeutic peptides and proteins via coated microprojections | |
| AU2003299958A1 (en) | Active agent delivery device having composite members | |
| US20040062813A1 (en) | Transdermal drug delivery devices having coated microprotrusions | |
| WO2007116959A1 (fr) | Appareil à micro-aiguilles et appareil d'administration transdermique à micro-aiguilles | |
| JPH0442025B2 (fr) | ||
| US11660264B2 (en) | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches | |
| KR20060120156A (ko) | 담배의 이용빈도를 감소시키기 위한 방법 및 장치 | |
| JP2013075165A (ja) | マイクロニードル迅速溶解法 | |
| US20130304002A1 (en) | Sheet and liquid combination systems for dermal drug delivery | |
| Pawar et al. | Recent advancements in transdermal drug delivery system | |
| Bhowmik et al. | Recent trends in challenges and opportunities in transdermal drug delivery system | |
| CA2275769A1 (fr) | Emplatre extremement souple a effet dermique ou transdermique et son procede de production | |
| WO2008115586A1 (fr) | Appareil et procédé d'administration transdermique d'un agoniste de triptane | |
| CN112999199A (zh) | 酮咯酸氨丁三醇凝胶贴膏的制备及应用 | |
| Deulkar et al. | A review on transdermal drug delivery system | |
| US20230255881A1 (en) | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches | |
| WO2024053625A1 (fr) | Système d'application locale | |
| KR20190127235A (ko) | 미용액의 전달성이 향상된 니들 패치 | |
| MXPA06004719A (en) | Method and apparatus for reducing the incidence of tobacco use |