CA3073442C - Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton - Google Patents
Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton Download PDFInfo
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- CA3073442C CA3073442C CA3073442A CA3073442A CA3073442C CA 3073442 C CA3073442 C CA 3073442C CA 3073442 A CA3073442 A CA 3073442A CA 3073442 A CA3073442 A CA 3073442A CA 3073442 C CA3073442 C CA 3073442C
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- 229940052907 telazol Drugs 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- UIERETOOQGIECD-ONEGZZNKSA-N tiglic acid Chemical compound C\C=C(/C)C(O)=O UIERETOOQGIECD-ONEGZZNKSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- KQTIIICEAUMSDG-UHFFFAOYSA-N tricarballylic acid Chemical compound OC(=O)CC(C(O)=O)CC(O)=O KQTIIICEAUMSDG-UHFFFAOYSA-N 0.000 description 1
- 210000000836 trigeminal nuclei Anatomy 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
- 229940032196 zolmitriptan 2.5 mg oral tablet Drugs 0.000 description 1
- 229940112955 zolmitriptan nasal spray Drugs 0.000 description 1
- 229940003675 zomig Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
L'invention concerne des compositions, des dispositifs et des méthodes utilisant des concentrations thérapeutiques d'un triptan pour le traitement de la migraine. L'invention concerne également des méthodes et des appareils pour l'administration du zolmitriptan permettant d'obtenir un Tmax en un délai aussi rapide que 2 minutes et en moins de 30 minutes chez la majorité des sujets.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA3223555A CA3223555A1 (fr) | 2017-08-23 | 2017-08-23 | Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2017/048258 WO2019040063A1 (fr) | 2017-08-23 | 2017-08-23 | Procédé d'obtention rapide de concentrations thérapeutiques de zolmitriptan pour le traitement de migraines et de céphalées de horton |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3223555A Division CA3223555A1 (fr) | 2017-08-23 | 2017-08-23 | Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton |
Publications (2)
Publication Number | Publication Date |
---|---|
CA3073442A1 CA3073442A1 (fr) | 2019-02-28 |
CA3073442C true CA3073442C (fr) | 2024-02-06 |
Family
ID=59829462
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3223555A Pending CA3223555A1 (fr) | 2017-08-23 | 2017-08-23 | Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton |
CA3073442A Active CA3073442C (fr) | 2017-08-23 | 2017-08-23 | Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3223555A Pending CA3223555A1 (fr) | 2017-08-23 | 2017-08-23 | Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP3672570A1 (fr) |
JP (2) | JP7219384B2 (fr) |
KR (2) | KR20210155817A (fr) |
CN (1) | CN111050749A (fr) |
AU (1) | AU2017428907B2 (fr) |
CA (2) | CA3223555A1 (fr) |
IL (1) | IL272776B2 (fr) |
WO (1) | WO2019040063A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017143345A1 (fr) | 2016-02-19 | 2017-08-24 | Zp Opco, Inc. | Procédé pour obtenir rapidement des concentrations thérapeutiques de triptans pour le traitement de migraines |
US11660264B2 (en) | 2017-08-23 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
US11660265B2 (en) | 2018-06-28 | 2023-05-30 | Emergex USA Corporation | Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches |
EP3980111A1 (fr) * | 2019-06-06 | 2022-04-13 | Kindeva Drug Delivery L.P. | Support de microréseau destiné à un applicateur de microréseau |
CA3145203A1 (fr) * | 2019-06-28 | 2020-12-30 | Passport Technologies, Inc. | Systeme de distribution de micro-porosites de triptan |
CN114699510B (zh) * | 2021-12-29 | 2024-07-16 | 浙江湃肽生物有限公司 | 一种司美格鲁肽微针阵列及其制备方法 |
CN115887903A (zh) * | 2022-12-15 | 2023-04-04 | 太平洋康泰科学仪器(济南)有限公司 | 微针贴片给药组件及给药方法 |
Family Cites Families (27)
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US5080646A (en) | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
US5169382A (en) | 1988-10-03 | 1992-12-08 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
US5147296A (en) | 1988-10-03 | 1992-09-15 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
CA2253549C (fr) | 1996-06-18 | 2005-10-25 | Alza Corporation | Dispositif d'amelioration d'apport ou d'echantillonnage d'agents transdermiques |
US5743960A (en) | 1996-07-26 | 1998-04-28 | Bio-Dot, Inc. | Precision metered solenoid valve dispenser |
US5916524A (en) | 1997-07-23 | 1999-06-29 | Bio-Dot, Inc. | Dispensing apparatus having improved dynamic range |
US5741554A (en) | 1996-07-26 | 1998-04-21 | Bio Dot, Inc. | Method of dispensing a liquid reagent |
US5738728A (en) | 1996-07-26 | 1998-04-14 | Bio Dot, Inc. | Precision metered aerosol dispensing apparatus |
AU739616B2 (en) | 1997-12-11 | 2001-10-18 | Alza Corporation | Device for enhancing transdermal agent flux |
KR100561892B1 (ko) | 1997-12-11 | 2006-03-16 | 알자 코포레이션 | 경피성 작용제 유동률을 증진시키기 위한 장치 |
CN1206004C (zh) | 1997-12-11 | 2005-06-15 | 阿尔扎有限公司 | 增强透皮物剂流量的装置 |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
WO2001041863A1 (fr) | 1999-12-10 | 2001-06-14 | Alza Corporation | Dispositif et procede d'amelioration de percage de peau par micro-protuberances |
PL360998A1 (en) | 2000-10-13 | 2004-09-20 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
JP4104975B2 (ja) | 2000-10-13 | 2008-06-18 | アルザ・コーポレーシヨン | 衝撃適用装置用の微小突起部材保持器 |
MXPA03003301A (es) | 2000-10-13 | 2004-12-13 | Johnson & Johnson | Aplicador de un conjunto de microsalientes mediante impacto. |
US7419481B2 (en) | 2000-10-13 | 2008-09-02 | Alza Corporation | Apparatus and method for piercing skin with microprotrusions |
CA2427381A1 (fr) | 2000-10-26 | 2002-11-28 | Alza Corporation | Dispositifs d'administration de medicament transdermique avec des microprotrusions enrobees |
US6855372B2 (en) | 2001-03-16 | 2005-02-15 | Alza Corporation | Method and apparatus for coating skin piercing microprojections |
IL158480A0 (en) | 2001-04-20 | 2004-05-12 | Alza Corp | Microprojection array having a beneficial agent containing coating |
US7097631B2 (en) | 2003-10-31 | 2006-08-29 | Alza Corporation | Self-actuating applicator for microprojection array |
EP1744683B1 (fr) | 2004-05-13 | 2016-03-16 | Alza Corporation | Appareil et procédé pour la délivrance transdermique d'agents à base d'hormone parathyroïde |
WO2007106597A2 (fr) | 2006-03-15 | 2007-09-20 | Alza Corporation | Appareil et procede d'administration transdermique d'agents hormonaux parathyroidiens destines a traiter ou prevenir l'osteopenie |
WO2008115586A1 (fr) * | 2007-03-21 | 2008-09-25 | Alza Corporation | Appareil et procédé d'administration transdermique d'un agoniste de triptane |
JP6121734B2 (ja) * | 2012-02-09 | 2017-04-26 | 久光製薬株式会社 | マイクロニードル用ゾルミトリプタン含有コーティング組成物及びマイクロニードルデバイス |
EP3027263A1 (fr) | 2013-07-30 | 2016-06-08 | ZP Opco, Inc. | Applicateur extra-plat de tampon de micro-aiguilles |
WO2017143345A1 (fr) * | 2016-02-19 | 2017-08-24 | Zp Opco, Inc. | Procédé pour obtenir rapidement des concentrations thérapeutiques de triptans pour le traitement de migraines |
-
2017
- 2017-08-23 KR KR1020217040858A patent/KR20210155817A/ko active IP Right Grant
- 2017-08-23 KR KR1020207005263A patent/KR102340393B1/ko active IP Right Grant
- 2017-08-23 EP EP17764703.9A patent/EP3672570A1/fr active Pending
- 2017-08-23 JP JP2020532539A patent/JP7219384B2/ja active Active
- 2017-08-23 CN CN201780094159.6A patent/CN111050749A/zh active Pending
- 2017-08-23 WO PCT/US2017/048258 patent/WO2019040063A1/fr unknown
- 2017-08-23 CA CA3223555A patent/CA3223555A1/fr active Pending
- 2017-08-23 CA CA3073442A patent/CA3073442C/fr active Active
- 2017-08-23 AU AU2017428907A patent/AU2017428907B2/en not_active Expired - Fee Related
- 2017-08-23 IL IL272776A patent/IL272776B2/en unknown
-
2023
- 2023-01-05 JP JP2023000670A patent/JP2023033378A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3223555A1 (fr) | 2019-02-28 |
WO2019040063A1 (fr) | 2019-02-28 |
JP2023033378A (ja) | 2023-03-10 |
CA3073442A1 (fr) | 2019-02-28 |
AU2017428907B2 (en) | 2021-12-16 |
KR20210155817A (ko) | 2021-12-23 |
CN111050749A (zh) | 2020-04-21 |
KR102340393B1 (ko) | 2021-12-17 |
JP2021500397A (ja) | 2021-01-07 |
KR20200032170A (ko) | 2020-03-25 |
AU2017428907A1 (en) | 2020-03-05 |
IL272776B1 (en) | 2024-02-01 |
IL272776A (en) | 2020-04-30 |
JP7219384B2 (ja) | 2023-02-08 |
EP3672570A1 (fr) | 2020-07-01 |
IL272776B2 (en) | 2024-06-01 |
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