IL271343B2 - Methods and intermediates for the preparation of bile acid derivatives - Google Patents

Methods and intermediates for the preparation of bile acid derivatives

Info

Publication number
IL271343B2
IL271343B2 IL271343A IL27134319A IL271343B2 IL 271343 B2 IL271343 B2 IL 271343B2 IL 271343 A IL271343 A IL 271343A IL 27134319 A IL27134319 A IL 27134319A IL 271343 B2 IL271343 B2 IL 271343B2
Authority
IL
Israel
Prior art keywords
compound
formula
reacting
disease
pct
Prior art date
Application number
IL271343A
Other languages
English (en)
Hebrew (he)
Other versions
IL271343B1 (en
IL271343A (en
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Publication of IL271343A publication Critical patent/IL271343A/en
Publication of IL271343B1 publication Critical patent/IL271343B1/en
Publication of IL271343B2 publication Critical patent/IL271343B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
IL271343A 2017-06-23 2018-06-22 Methods and intermediates for the preparation of bile acid derivatives IL271343B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762523937P 2017-06-23 2017-06-23
PCT/US2018/039148 WO2018237350A1 (en) 2017-06-23 2018-06-22 METHODS AND INTERMEDIATES FOR PREPARING BILARY ACID DERIVATIVES

Publications (3)

Publication Number Publication Date
IL271343A IL271343A (en) 2020-01-30
IL271343B1 IL271343B1 (en) 2023-08-01
IL271343B2 true IL271343B2 (en) 2023-12-01

Family

ID=64691408

Family Applications (2)

Application Number Title Priority Date Filing Date
IL271343A IL271343B2 (en) 2017-06-23 2018-06-22 Methods and intermediates for the preparation of bile acid derivatives
IL304455A IL304455A (en) 2017-06-23 2023-07-13 Methods and intermediates for the preparation of bile acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL304455A IL304455A (en) 2017-06-23 2023-07-13 Methods and intermediates for the preparation of bile acid derivatives

Country Status (10)

Country Link
US (2) US11066437B2 (enExample)
EP (1) EP3642217A4 (enExample)
JP (1) JP7224307B2 (enExample)
KR (2) KR102831293B1 (enExample)
CN (1) CN110945006A (enExample)
AU (1) AU2018288883B2 (enExample)
BR (1) BR112019027458A2 (enExample)
CA (1) CA3067219A1 (enExample)
IL (2) IL271343B2 (enExample)
WO (1) WO2018237350A1 (enExample)

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WO2013036835A1 (en) 2011-09-08 2013-03-14 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
RS67266B1 (sr) 2013-03-13 2025-10-31 Sage Therapeutics Inc Neuroaktivni steroidi i postupci za njihovu upotrebu
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
SMT202100476T1 (it) 2015-07-06 2021-09-14 Sage Therapeutics Inc Ossisteroli e metodi di uso degli stessi
JP6882996B2 (ja) 2015-07-06 2021-06-02 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびそれらの使用の方法
BR112018000129B1 (pt) 2015-07-06 2024-01-09 Sage Therapeutics, Inc Compostos oxiesteróis, seus usos e composição farmacêutica
TN2018000106A1 (en) * 2015-10-07 2019-10-04 Intercept Pharmaceuticals Inc Farnesoid x receptor modulators
SI3436022T1 (sl) 2016-04-01 2022-08-31 Sage Therapeutics, Inc. Oksisteroli in postopki za uporabo le-teh
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
ES2884071T3 (es) 2016-07-07 2021-12-10 Sage Therapeutics Inc 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA
MX392270B (es) 2016-09-30 2025-03-24 Sage Therapeutics Inc Oxisteroles sustituidos en c7 y metodos de uso de los mismos.
CN110267966B (zh) 2016-10-18 2022-07-08 萨奇治疗股份有限公司 氧甾醇及其使用方法
EP4105223B1 (en) 2016-10-18 2025-04-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
WO2021155167A1 (en) * 2020-01-31 2021-08-05 The Johns Hopkins University Bile acid-gcpii inhibitor conjugates to treat inflammatory diseases
PH12022552277A1 (en) 2020-02-28 2024-03-04 Kallyope Inc Gpr40 agonists
US12215127B2 (en) 2020-04-17 2025-02-04 Cornell University Compositions and methods for profiling of gut microbiota-associated bile salt hydrolase (BSH) activity
CA3178994A1 (en) 2020-05-19 2021-11-25 Iyassu Sebhat Ampk activators
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN112795615A (zh) * 2021-02-03 2021-05-14 湖南醇康医药科技有限公司 一种诱变菌种以及微生物发酵制备熊去氧胆酸的方法
WO2023288123A1 (en) * 2021-07-16 2023-01-19 Interecept Pharmaceuticals, Inc. Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid
CN114045239B (zh) * 2021-11-08 2023-09-29 浙江树人学院（浙江树人大学） 具有二甲基乙酰胺降解能力的泛养副球菌ybh-7及应用
AU2023257308A1 (en) * 2022-04-21 2024-10-10 Intercept Pharmaceuticals, Inc. Uses of farnesoid x receptor agonists
WO2024163640A2 (en) * 2023-02-01 2024-08-08 Intercept Pharmaceuticals, Inc. Methods and intermediates for the preparation of bile acid derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2554882A (en) * 1943-02-04 1951-05-29 Reichstein Tadeus 3-hydroxy-11-ketoetiocholanic acid and its esters
US3277121A (en) * 1964-05-04 1966-10-04 Canada Packers Ltd Conversion of delta11-steroids to 11-oxygenated steroids
DE3040634A1 (de) * 1980-10-29 1982-05-27 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von 3 (alpha) -hydroxy-5- (beta) -pregnan-11,20-dion
WO2014184271A1 (en) * 2013-05-14 2014-11-20 Tes Pharma Srl. 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators

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US2403683A (en) * 1942-04-25 1946-07-09 Relchstein Tadeus Compounds of the cyclopentanopolyhydrophenanthrene series and process of making same
DE10113257C1 (de) 2001-03-19 2002-11-14 Inst Mikrotechnik Mainz Gmbh Elektrophoresevorrichtung und ihre Verwendung
US20080318870A1 (en) 2007-06-19 2008-12-25 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
CA2966885A1 (en) 2014-11-06 2016-05-12 Enanta Pharmaceuticals, Inc. Bile acid analogs an fxr/tgr5 agonists and methods of use thereof
WO2016086115A1 (en) 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Tetrazole derivatives of bile acids as fxr/tgr5 agonists and methods of use thereof
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
HK1244708A1 (zh) 2014-11-26 2018-08-17 英安塔制药有限公司 作爲fxr/tgr5激动剂的胆汁酸类似物及其使用方法
RU2017130466A (ru) 2015-02-11 2019-03-12 Энанта Фармасьютикалс, Инк. Аналоги желчной кислоты в качестве агонистов fxr/tgr5 и способы их применения
NZ735126A (en) 2015-03-31 2022-10-28 Enanta Pharm Inc Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
BR112018002499A2 (pt) 2015-08-07 2018-09-18 Intercept Pharmaceuticals Inc método de preparação de um composto da fórmula (a) ou um seu sal, solvato ou conjugado de aminoácido farmaceuticamente aceitável, composto produzido pelo método e composição farmacêutica
TN2018000106A1 (en) 2015-10-07 2019-10-04 Intercept Pharmaceuticals Inc Farnesoid x receptor modulators
CN107973834A (zh) 2016-10-22 2018-05-01 合帕吉恩治疗公司 作为fxr/tgr5调节剂的胆酸衍生物
US10597391B2 (en) 2016-10-26 2020-03-24 Enanta Pharmaceuticals, Inc. Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2554882A (en) * 1943-02-04 1951-05-29 Reichstein Tadeus 3-hydroxy-11-ketoetiocholanic acid and its esters
US3277121A (en) * 1964-05-04 1966-10-04 Canada Packers Ltd Conversion of delta11-steroids to 11-oxygenated steroids
DE3040634A1 (de) * 1980-10-29 1982-05-27 Hoechst Ag, 6000 Frankfurt Verfahren zur herstellung von 3 (alpha) -hydroxy-5- (beta) -pregnan-11,20-dion
WO2014184271A1 (en) * 2013-05-14 2014-11-20 Tes Pharma Srl. 11-hydroxyl-derivatives of bile acids and amino acid conjugates thereof as farnesoid x receptor modulators

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LARDON A, REIEHSTEIN T., UBER GALLENSAUREN UND VERWANDTE STOFFE. 35. MITTEILUNG1). 3ALPHA?ACETOXY?NOR?, BISNOR?UND?ATIO?CHOLEN?(9)?SAURE?METHYLESTER, 1 January 1945 (1945-01-01) *
OTT GH, REICHSTEIN T. UBER, GALLENSAUREN UND VERWANDTE STOFFE. 27. MITTEILUNG. ALPHA?OXYDE DER BEIDEN 3?OXY?UND DER 3?KETO?CHOLEN?(11)?SAURE, 15 October 1943 (1943-10-15) *
SARETT LH., PARTIAL SYNTHESIS OF PREGNENE-4-TRIOL-17 (?), 20 (?), 21-DIONE-3, 11 AND PREGNENE-4-DIOL-17 (?), 21-TRIONE-3, 11, 20 MONOACETATE, 31 March 1946 (1946-03-31) *

Also Published As

Publication number Publication date
IL271343B1 (en) 2023-08-01
BR112019027458A2 (pt) 2020-07-07
CA3067219A1 (en) 2018-12-27
KR20250109791A (ko) 2025-07-17
WO2018237350A1 (en) 2018-12-27
JP7224307B2 (ja) 2023-02-17
AU2018288883A1 (en) 2020-01-16
US11066437B2 (en) 2021-07-20
AU2018288883B2 (en) 2022-06-02
EP3642217A1 (en) 2020-04-29
US20220127302A1 (en) 2022-04-28
IL271343A (en) 2020-01-30
KR20200020877A (ko) 2020-02-26
KR102831293B1 (ko) 2025-07-08
US20180371009A1 (en) 2018-12-27
JP2020525426A (ja) 2020-08-27
IL304455A (en) 2023-09-01
EP3642217A4 (en) 2021-06-16
CN110945006A (zh) 2020-03-31

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