AU2018288883B2 - Methods and intermediates for the preparation of bile acid derivatives - Google Patents

Methods and intermediates for the preparation of bile acid derivatives Download PDF

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Publication number
AU2018288883B2
AU2018288883B2 AU2018288883A AU2018288883A AU2018288883B2 AU 2018288883 B2 AU2018288883 B2 AU 2018288883B2 AU 2018288883 A AU2018288883 A AU 2018288883A AU 2018288883 A AU2018288883 A AU 2018288883A AU 2018288883 B2 AU2018288883 B2 AU 2018288883B2
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compound
formula
chr
reacting
disease
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AU2018288883A1 (en
Inventor
Gabriel Galvin
Antimo GIOIELLO
Thomas HENSEL
Myoung Goo Kim
Bartjan KONING
Fred Ronald LEUSINK
Ronald D. Lewis
Roberto Pellicciari
Matthew Yanik
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Intercept Pharmaceuticals Inc
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Intercept Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AU2018288883A 2017-06-23 2018-06-22 Methods and intermediates for the preparation of bile acid derivatives Active AU2018288883B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762523937P 2017-06-23 2017-06-23
US62/523,937 2017-06-23
PCT/US2018/039148 WO2018237350A1 (en) 2017-06-23 2018-06-22 METHODS AND INTERMEDIATES FOR PREPARING BILARY ACID DERIVATIVES

Publications (2)

Publication Number Publication Date
AU2018288883A1 AU2018288883A1 (en) 2020-01-16
AU2018288883B2 true AU2018288883B2 (en) 2022-06-02

Family

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AU2018288883A Active AU2018288883B2 (en) 2017-06-23 2018-06-22 Methods and intermediates for the preparation of bile acid derivatives

Country Status (10)

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US (2) US11066437B2 (enExample)
EP (1) EP3642217A4 (enExample)
JP (1) JP7224307B2 (enExample)
KR (2) KR102831293B1 (enExample)
CN (1) CN110945006A (enExample)
AU (1) AU2018288883B2 (enExample)
BR (1) BR112019027458A2 (enExample)
CA (1) CA3067219A1 (enExample)
IL (2) IL271343B2 (enExample)
WO (1) WO2018237350A1 (enExample)

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WO2013036835A1 (en) 2011-09-08 2013-03-14 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
RS67266B1 (sr) 2013-03-13 2025-10-31 Sage Therapeutics Inc Neuroaktivni steroidi i postupci za njihovu upotrebu
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
SMT202100476T1 (it) 2015-07-06 2021-09-14 Sage Therapeutics Inc Ossisteroli e metodi di uso degli stessi
JP6882996B2 (ja) 2015-07-06 2021-06-02 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびそれらの使用の方法
BR112018000129B1 (pt) 2015-07-06 2024-01-09 Sage Therapeutics, Inc Compostos oxiesteróis, seus usos e composição farmacêutica
TN2018000106A1 (en) * 2015-10-07 2019-10-04 Intercept Pharmaceuticals Inc Farnesoid x receptor modulators
SI3436022T1 (sl) 2016-04-01 2022-08-31 Sage Therapeutics, Inc. Oksisteroli in postopki za uporabo le-teh
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
ES2884071T3 (es) 2016-07-07 2021-12-10 Sage Therapeutics Inc 24-hidroxiesteroles sustituidos en 11 para el tratamiento de afecciones relacionadas con NMDA
MX392270B (es) 2016-09-30 2025-03-24 Sage Therapeutics Inc Oxisteroles sustituidos en c7 y metodos de uso de los mismos.
CN110267966B (zh) 2016-10-18 2022-07-08 萨奇治疗股份有限公司 氧甾醇及其使用方法
EP4105223B1 (en) 2016-10-18 2025-04-30 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
WO2021155167A1 (en) * 2020-01-31 2021-08-05 The Johns Hopkins University Bile acid-gcpii inhibitor conjugates to treat inflammatory diseases
PH12022552277A1 (en) 2020-02-28 2024-03-04 Kallyope Inc Gpr40 agonists
US12215127B2 (en) 2020-04-17 2025-02-04 Cornell University Compositions and methods for profiling of gut microbiota-associated bile salt hydrolase (BSH) activity
CA3178994A1 (en) 2020-05-19 2021-11-25 Iyassu Sebhat Ampk activators
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN112795615A (zh) * 2021-02-03 2021-05-14 湖南醇康医药科技有限公司 一种诱变菌种以及微生物发酵制备熊去氧胆酸的方法
WO2023288123A1 (en) * 2021-07-16 2023-01-19 Interecept Pharmaceuticals, Inc. Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid
CN114045239B (zh) * 2021-11-08 2023-09-29 浙江树人学院（浙江树人大学） 具有二甲基乙酰胺降解能力的泛养副球菌ybh-7及应用
AU2023257308A1 (en) * 2022-04-21 2024-10-10 Intercept Pharmaceuticals, Inc. Uses of farnesoid x receptor agonists
WO2024163640A2 (en) * 2023-02-01 2024-08-08 Intercept Pharmaceuticals, Inc. Methods and intermediates for the preparation of bile acid derivatives

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US3277121A (en) 1964-05-04 1966-10-04 Canada Packers Ltd Conversion of delta11-steroids to 11-oxygenated steroids
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Also Published As

Publication number Publication date
IL271343B1 (en) 2023-08-01
BR112019027458A2 (pt) 2020-07-07
CA3067219A1 (en) 2018-12-27
KR20250109791A (ko) 2025-07-17
WO2018237350A1 (en) 2018-12-27
JP7224307B2 (ja) 2023-02-17
AU2018288883A1 (en) 2020-01-16
US11066437B2 (en) 2021-07-20
IL271343B2 (en) 2023-12-01
EP3642217A1 (en) 2020-04-29
US20220127302A1 (en) 2022-04-28
IL271343A (en) 2020-01-30
KR20200020877A (ko) 2020-02-26
KR102831293B1 (ko) 2025-07-08
US20180371009A1 (en) 2018-12-27
JP2020525426A (ja) 2020-08-27
IL304455A (en) 2023-09-01
EP3642217A4 (en) 2021-06-16
CN110945006A (zh) 2020-03-31

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