IL264819A - - Google Patents

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Publication number
IL264819A
IL264819A IL26481919A IL26481919A IL264819A IL 264819 A IL264819 A IL 264819A IL 26481919 A IL26481919 A IL 26481919A IL 26481919 A IL26481919 A IL 26481919A IL 264819 A IL264819 A IL 264819A
Authority
IL
Israel
Application number
IL26481919A
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English (en)
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IL264819B2 (en
IL264819B1 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59762045&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL264819(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of IL264819A publication Critical patent/IL264819A/en
Publication of IL264819B1 publication Critical patent/IL264819B1/en
Publication of IL264819B2 publication Critical patent/IL264819B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL264819A 2016-08-15 2017-08-14 Methods to determine the serotype and heterogeneity of a viral particle and to improve the stability of an raav particle, and aav capsid protein variants and compositions comprising same IL264819B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662375314P 2016-08-15 2016-08-15
PCT/US2017/046814 WO2018035059A1 (en) 2016-08-15 2017-08-14 Methods for detecting aav

Publications (3)

Publication Number Publication Date
IL264819A true IL264819A (enExample) 2019-04-30
IL264819B1 IL264819B1 (en) 2024-06-01
IL264819B2 IL264819B2 (en) 2024-10-01

Family

ID=59762045

Family Applications (3)

Application Number Title Priority Date Filing Date
IL264819A IL264819B2 (en) 2016-08-15 2017-08-14 Methods to determine the serotype and heterogeneity of a viral particle and to improve the stability of an raav particle, and aav capsid protein variants and compositions comprising same
IL312792A IL312792B2 (en) 2016-08-15 2017-08-14 Methods to determine the serotype and heterogeneity of a viral particle and to improve the stability of an raav particle, and aav capsid protein variants and compositions comprising same
IL323969A IL323969A (en) 2016-08-15 2025-10-15 Methods to determine the serotype and heterogeneity of a viral particle and to improve the stability of an raav particle, and aav capsid protein variants and compositions comprising same

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL312792A IL312792B2 (en) 2016-08-15 2017-08-14 Methods to determine the serotype and heterogeneity of a viral particle and to improve the stability of an raav particle, and aav capsid protein variants and compositions comprising same
IL323969A IL323969A (en) 2016-08-15 2025-10-15 Methods to determine the serotype and heterogeneity of a viral particle and to improve the stability of an raav particle, and aav capsid protein variants and compositions comprising same

Country Status (22)

Country Link
US (5) US11698377B2 (enExample)
EP (2) EP3851449A1 (enExample)
JP (3) JP7021191B2 (enExample)
KR (5) KR102922101B1 (enExample)
CN (2) CN118688363A (enExample)
AU (2) AU2017312951B2 (enExample)
CA (1) CA3033856A1 (enExample)
CL (2) CL2019000392A1 (enExample)
CR (1) CR20190127A (enExample)
CY (1) CY1124364T1 (enExample)
DK (1) DK3497207T3 (enExample)
ES (1) ES2863674T3 (enExample)
HU (1) HUE053747T2 (enExample)
IL (3) IL264819B2 (enExample)
MA (1) MA55748A (enExample)
MX (2) MX2019001938A (enExample)
PH (1) PH12019500316A1 (enExample)
SG (2) SG10201913002QA (enExample)
TN (1) TN2019000047A1 (enExample)
TW (2) TW202309068A (enExample)
WO (1) WO2018035059A1 (enExample)
ZA (2) ZA201900945B (enExample)

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JOP20190200A1 (ar) 2017-02-28 2019-08-27 Univ Pennsylvania تركيبات نافعة في معالجة ضمور العضل النخاعي
EP3768695A4 (en) * 2018-02-27 2022-04-06 The Trustees of the University of Pennsylvania NOVEL ADENO-ASSOCIATED VIRUS (AAV) VECTORS, AAV VECTORS WITH REDUCED CAPSIID DEAMIDATION AND USES THEREOF
IL276859B2 (en) * 2018-02-27 2025-12-01 Univ Pennsylvania Novel adeno-associated virus (aav) vectors, aav vectors having reduced capsid deamidation and uses therefor
EP3762500A1 (en) * 2018-03-06 2021-01-13 Voyager Therapeutics, Inc. Insect cell manufactured partial self-complementary aav genomes
US11391707B2 (en) * 2018-07-27 2022-07-19 Waters Technologies Corporation Liquid chromatography/mass spectrometry methods for the analysis of polar molecules
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WO2021155137A1 (en) 2020-01-29 2021-08-05 Genzyme Corporation Modified adeno-associated viral capsid proteins for ocular gene therapy and methods of use thereof
CN111517359B (zh) * 2020-04-23 2021-08-20 江南大学 一种手性硫化铜超粒子的合成方法
RU2748540C1 (ru) * 2021-02-08 2021-05-26 Автономная некоммерческая образовательная организация высшего образования "Сколковский институт науки и технологий" Способ детектирования вируса SARS-CoV-2 методом масс-спектрометрии
US20220268783A1 (en) * 2021-02-19 2022-08-25 Waters Technologies Corporation Methods for peptide mapping of adeno-associated virus (aav) proteins
WO2022224965A1 (ja) * 2021-04-20 2022-10-27 株式会社ユニバーサル・バイオサンプリング 検体保持カード及びそれを用いた検体の検査方法
JP2024525686A (ja) * 2021-07-12 2024-07-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ａａｖカプシド比を決定するための液体クロマトグラフィーアッセイ
CA3225360A1 (en) * 2021-07-12 2023-01-19 Victoria COTHAM Online native mass spectrometry methods for assaying viral particles
CN113552349B (zh) * 2021-07-30 2022-07-19 上海勉亦生物科技有限公司 Aav蛋白外壳的检测方法
EP4462114A4 (en) * 2022-01-06 2025-04-16 FUJIFILM Corporation Method and kit for identifying sugar-bound amino acid site in protein
US20250110119A1 (en) * 2023-03-03 2025-04-03 Sartorius Bioanalytical Instruments, Inc. Methods for quantitating viral capsids
WO2024263520A1 (en) * 2023-06-19 2024-12-26 Regeneron Pharmaceuticals, Inc. Host cell protein analysis for adeno-associated virus (aav)-based gene therapy
AU2024378556A1 (en) * 2023-11-08 2026-05-21 Oxford Biomedica (Us) Llc Deamidation depleted adeno-associated virus product

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Also Published As

Publication number Publication date
US20250138024A1 (en) 2025-05-01
JP2024023460A (ja) 2024-02-21
AU2017312951B2 (en) 2024-02-08
ES2863674T3 (es) 2021-10-11
CL2019000392A1 (es) 2019-05-10
JP2019533803A (ja) 2019-11-21
EP3497207A1 (en) 2019-06-19
US12298313B1 (en) 2025-05-13
US20250027951A1 (en) 2025-01-23
EP3851449A1 (en) 2021-07-21
US11698377B2 (en) 2023-07-11
CN118688363A (zh) 2024-09-24
KR20230078834A (ko) 2023-06-02
KR102425289B1 (ko) 2022-07-27
KR20220107327A (ko) 2022-08-02
AU2017312951A1 (en) 2019-04-04
RU2019107207A3 (enExample) 2021-04-29
US20240044910A1 (en) 2024-02-08
EP3497207B1 (en) 2021-01-06
CN110168080A (zh) 2019-08-23
IL264819B2 (en) 2024-10-01
NZ791263A (en) 2025-11-28
IL312792B2 (en) 2026-03-01
NZ791267A (en) 2025-11-28
MX2023009081A (es) 2023-08-08
TWI781953B (zh) 2022-11-01
ZA202101002B (en) 2024-07-31
AU2024200349B2 (en) 2026-05-14
TN2019000047A1 (en) 2020-07-15
JP2022064980A (ja) 2022-04-26
JP7021191B2 (ja) 2022-02-16
CY1124364T1 (el) 2022-07-22
TW202309068A (zh) 2023-03-01
AU2024200349A1 (en) 2024-02-08
BR112019002934A2 (pt) 2019-05-14
IL264819B1 (en) 2024-06-01
KR102538037B1 (ko) 2023-05-30
ZA201900945B (en) 2021-06-30
TW201825898A (zh) 2018-07-16
SG10201913002QA (en) 2020-03-30
US20250147042A1 (en) 2025-05-08
RU2019107207A (ru) 2020-09-15
KR20190039253A (ko) 2019-04-10
MX2019001938A (es) 2019-07-04
CN110168080B (zh) 2024-05-31
SG11201901221YA (en) 2019-03-28
PH12019500316A1 (en) 2019-08-05
IL312792B1 (en) 2025-11-01
WO2018035059A1 (en) 2018-02-22
WO2018035059A9 (en) 2019-03-14
NZ751711A (en) 2025-11-28
CL2019002912A1 (es) 2020-03-06
DK3497207T3 (da) 2021-03-22
KR20260036296A (ko) 2026-03-16
US20210041451A1 (en) 2021-02-11
IL323969A (en) 2025-12-01
IL312792A (en) 2024-07-01
CA3033856A1 (en) 2018-02-22
CR20190127A (es) 2019-06-25
HUE053747T2 (hu) 2021-07-28
KR102738219B1 (ko) 2024-12-05
US12123880B2 (en) 2024-10-22
KR102922101B1 (ko) 2026-02-03
MA55748A (fr) 2022-03-02
KR20240172773A (ko) 2024-12-10

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