IL263158B - שיטות לזיהוי קושרים אימוניים של אנטיגנים על פני השטח של תאים - Google Patents
שיטות לזיהוי קושרים אימוניים של אנטיגנים על פני השטח של תאיםInfo
- Publication number
- IL263158B IL263158B IL26315818A IL26315818A IL263158B IL 263158 B IL263158 B IL 263158B IL 26315818 A IL26315818 A IL 26315818A IL 26315818 A IL26315818 A IL 26315818A IL 263158 B IL263158 B IL 263158B
- Authority
- IL
- Israel
- Prior art keywords
- cell
- methods
- surface antigens
- immunobinders
- identifying
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5052—Cells of the immune system involving B-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15504109P | 2009-02-24 | 2009-02-24 | |
| US15510509P | 2009-02-24 | 2009-02-24 | |
| CH8322009 | 2009-06-02 | ||
| PCT/CH2009/000222 WO2009155726A2 (en) | 2008-06-25 | 2009-06-25 | Humanization of rabbit antibodies using a universal antibody framework |
| PCT/CH2010/000044 WO2010096941A1 (en) | 2009-02-24 | 2010-02-22 | Methods for identifying immunobinders of cell-surface antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL263158A IL263158A (he) | 2018-12-31 |
| IL263158B true IL263158B (he) | 2019-10-31 |
Family
ID=48917567
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL226956A IL226956A (he) | 2009-02-24 | 2013-06-13 | שיטות לזיהוי קושרים אימוני הנקשר באופן ספציפי לאנטיגן מבוקש |
| IL226955A IL226955A (he) | 2009-02-24 | 2013-06-13 | שיטות לזיהוי שיבוט תאי b הנקשר באופן ספציפי לאנטיגן מבוקש, שיטת יצור קושר אימוני וקושרי אימוניים המיוצרים ע" י שיטות אלו |
| IL237985A IL237985B (he) | 2009-02-24 | 2015-03-26 | קושר אימוני מואנש המסוגל להיקשר לאנטיגן רצוי |
| IL26315818A IL263158B (he) | 2009-02-24 | 2018-11-20 | שיטות לזיהוי קושרים אימוניים של אנטיגנים על פני השטח של תאים |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL226956A IL226956A (he) | 2009-02-24 | 2013-06-13 | שיטות לזיהוי קושרים אימוני הנקשר באופן ספציפי לאנטיגן מבוקש |
| IL226955A IL226955A (he) | 2009-02-24 | 2013-06-13 | שיטות לזיהוי שיבוט תאי b הנקשר באופן ספציפי לאנטיגן מבוקש, שיטת יצור קושר אימוני וקושרי אימוניים המיוצרים ע" י שיטות אלו |
| IL237985A IL237985B (he) | 2009-02-24 | 2015-03-26 | קושר אימוני מואנש המסוגל להיקשר לאנטיגן רצוי |
Country Status (12)
| Country | Link |
|---|---|
| JP (3) | JP6161655B2 (he) |
| KR (4) | KR20180005752A (he) |
| CN (1) | CN105116138A (he) |
| BR (1) | BRPI1005398A2 (he) |
| CL (1) | CL2011001453A1 (he) |
| ES (1) | ES2618181T3 (he) |
| IL (4) | IL226956A (he) |
| MX (1) | MX352922B (he) |
| PH (1) | PH12014502468B1 (he) |
| RU (2) | RU2577965C2 (he) |
| SG (3) | SG2014014864A (he) |
| ZA (1) | ZA201103125B (he) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110016462B (zh) * | 2019-02-20 | 2020-04-24 | 优睿赛思(武汉)生物科技有限公司 | 从脾脏细胞中高效分离单个抗原特异性b淋巴细胞的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63253098A (ja) * | 1987-04-10 | 1988-10-20 | Ube Ind Ltd | ヒト抗体に対するモノクロ−ナル抗体、その製法及び用途 |
| IL91948A (he) | 1988-10-26 | 1994-05-30 | Immunomedics | סילוק של מרכיבים אימונוריאקטיביים מדגימה |
| US5417972A (en) * | 1993-08-02 | 1995-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM |
| KR0119909B1 (ko) * | 1993-10-05 | 1997-10-20 | 김은영 | 플로우 사이토미터를 이용한 고상형 면역 측정방법 |
| EP0822830B1 (en) * | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| CA2267620A1 (en) * | 1996-07-16 | 1998-01-22 | Andreas Pluckthun | Immunoglobulin superfamily domains and fragments with increased solubility |
| EP2314622B1 (en) * | 2002-05-22 | 2017-10-18 | ESBATech, an Alcon Biomedical Research Unit LLC | Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same |
| CN1396182A (zh) * | 2002-07-31 | 2003-02-12 | 陕西超英生物医学研究开发有限公司 | 人内皮生长因子受体2蛋白全人单克隆抗体及其制备方法 |
| JP2005535341A (ja) | 2002-08-15 | 2005-11-24 | エピトミスク インコーポレーティッド | ヒト化ウサギ抗体 |
| CA2505924A1 (en) * | 2002-11-13 | 2004-05-27 | Micromet Ag | Method for identifying antigen specific b cells |
| JP4336812B2 (ja) * | 2003-03-07 | 2009-09-30 | 博夫 岩田 | 細胞に発現する表面抗原を迅速に同定するための分析方法 |
| EP1623229A2 (en) * | 2003-05-15 | 2006-02-08 | Cytos Biotechnology AG | Selection of b cells with specificity of interest: method of preparation and use |
| AU2003259718A1 (en) | 2003-08-07 | 2005-03-07 | Epitomics, Inc. | Methods for humanizing rabbit monoclonal antibodies |
| EP1910513B1 (en) * | 2005-07-01 | 2016-08-10 | John Schrader | Methods of isolating antibody secreting cells from blood samples of immunized animals and generating monoclonal antibodies from said antibody secreting cells. |
| US20070134249A1 (en) * | 2005-12-08 | 2007-06-14 | Genitope Corporation | Combination therapy and antibody panels |
| EP1978034B2 (en) * | 2005-12-28 | 2018-05-16 | Osaka University | Anti-periostin antibody and pharmaceutical composition containing the same for preventing or treating periostin-related disease |
| ES2398076T3 (es) * | 2006-06-02 | 2013-03-13 | Regeneron Pharmaceuticals, Inc. | Anticuerpos de alta afinidad contra el receptor de IL-6 humano |
| WO2008004834A1 (en) * | 2006-07-06 | 2008-01-10 | Isu Abxis Co., Ltd | Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor |
-
2010
- 2010-02-22 CN CN201510261116.5A patent/CN105116138A/zh active Pending
- 2010-02-22 SG SG2014014864A patent/SG2014014864A/en unknown
- 2010-02-22 SG SG10201408247SA patent/SG10201408247SA/en unknown
- 2010-02-22 SG SG10201708233VA patent/SG10201708233VA/en unknown
- 2010-02-22 KR KR1020187000320A patent/KR20180005752A/ko not_active Ceased
- 2010-02-22 BR BRPI1005398-0A patent/BRPI1005398A2/pt not_active Application Discontinuation
- 2010-02-22 ES ES10705086.6T patent/ES2618181T3/es active Active
- 2010-02-22 KR KR1020167003693A patent/KR101689791B1/ko active Active
- 2010-02-22 MX MX2015017453A patent/MX352922B/es unknown
- 2010-02-22 RU RU2011124039/10A patent/RU2577965C2/ru active
- 2010-02-22 KR KR1020197005221A patent/KR102059866B1/ko not_active Expired - Fee Related
- 2010-02-22 KR KR1020167035683A patent/KR101817279B1/ko active Active
-
2011
- 2011-04-28 ZA ZA2011/03125A patent/ZA201103125B/en unknown
- 2011-06-15 CL CL2011001453A patent/CL2011001453A1/es unknown
-
2013
- 2013-06-13 IL IL226956A patent/IL226956A/he active IP Right Grant
- 2013-06-13 IL IL226955A patent/IL226955A/he active IP Right Grant
-
2014
- 2014-11-05 PH PH12014502468A patent/PH12014502468B1/en unknown
-
2015
- 2015-03-26 IL IL237985A patent/IL237985B/he active IP Right Grant
- 2015-05-19 JP JP2015101581A patent/JP6161655B2/ja active Active
-
2017
- 2017-04-28 JP JP2017090650A patent/JP6604989B2/ja not_active Expired - Fee Related
- 2017-10-09 RU RU2017135831A patent/RU2017135831A/ru not_active Application Discontinuation
-
2018
- 2018-09-14 JP JP2018172287A patent/JP2018196395A/ja active Pending
- 2018-11-20 IL IL26315818A patent/IL263158B/he active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |