ZA201103125B - Methods for indentifying immunobinders of cell-surface antigens - Google Patents

Methods for indentifying immunobinders of cell-surface antigens

Info

Publication number
ZA201103125B
ZA201103125B ZA2011/03125A ZA201103125A ZA201103125B ZA 201103125 B ZA201103125 B ZA 201103125B ZA 2011/03125 A ZA2011/03125 A ZA 2011/03125A ZA 201103125 A ZA201103125 A ZA 201103125A ZA 201103125 B ZA201103125 B ZA 201103125B
Authority
ZA
South Africa
Prior art keywords
immunobinders
indentifying
cell
methods
surface antigens
Prior art date
Application number
ZA2011/03125A
Inventor
Valerie Hulmann-Cottier
David Urech
Original Assignee
Esbatech Alcon Biomed Res Unit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CH2009/000222 external-priority patent/WO2009155726A2/en
Priority claimed from PCT/CH2010/000044 external-priority patent/WO2010096941A1/en
Application filed by Esbatech Alcon Biomed Res Unit filed Critical Esbatech Alcon Biomed Res Unit
Publication of ZA201103125B publication Critical patent/ZA201103125B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/5052—Cells of the immune system involving B-cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ZA2011/03125A 2009-02-24 2011-04-28 Methods for indentifying immunobinders of cell-surface antigens ZA201103125B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15510509P 2009-02-24 2009-02-24
US15504109P 2009-02-24 2009-02-24
CH8322009 2009-06-02
PCT/CH2009/000222 WO2009155726A2 (en) 2008-06-25 2009-06-25 Humanization of rabbit antibodies using a universal antibody framework
PCT/CH2010/000044 WO2010096941A1 (en) 2009-02-24 2010-02-22 Methods for identifying immunobinders of cell-surface antigens

Publications (1)

Publication Number Publication Date
ZA201103125B true ZA201103125B (en) 2012-08-29

Family

ID=48917567

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2011/03125A ZA201103125B (en) 2009-02-24 2011-04-28 Methods for indentifying immunobinders of cell-surface antigens

Country Status (12)

Country Link
JP (3) JP6161655B2 (en)
KR (4) KR101689791B1 (en)
CN (1) CN105116138A (en)
BR (1) BRPI1005398A2 (en)
CL (1) CL2011001453A1 (en)
ES (1) ES2618181T3 (en)
IL (4) IL226956A (en)
MX (1) MX352922B (en)
PH (1) PH12014502468B1 (en)
RU (2) RU2577965C2 (en)
SG (3) SG10201408247SA (en)
ZA (1) ZA201103125B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110016462B (en) * 2019-02-20 2020-04-24 优睿赛思(武汉)生物科技有限公司 Method for efficiently separating single antigen-specific B lymphocytes from spleen cells

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63253098A (en) * 1987-04-10 1988-10-20 Ube Ind Ltd Monoclonal antibody against human antibody, its production and use thereof
IL91948A (en) * 1988-10-26 1994-05-30 Immunomedics Removal of immunoreactive components from a sample
US5417972A (en) * 1993-08-02 1995-05-23 The Board Of Trustees Of The Leland Stanford Junior University Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
KR0119909B1 (en) * 1993-10-05 1997-10-20 김은영 Immunology measurement using flow cytometer
KR100654645B1 (en) * 1995-04-27 2007-04-04 아브게닉스, 인크. Human Antibodies from Immunized Genomous
JP2000516452A (en) * 1996-07-16 2000-12-12 プリュックテュン，アンドレアス Immunoglobulin superfamily domains and fragments with increased solubility
DK2332989T3 (en) * 2002-05-22 2015-05-11 Esbatech Alcon Biomed Res Unit IMMUNGLOBULIN FRAMEWORKS PROVIDING IMPROVED STABILITY IN THE INTRACELLULAR ENVIRONMENT AND PROCEDURES FOR IDENTIFICATION THEREOF
CN1396182A (en) * 2002-07-31 2003-02-12 陕西超英生物医学研究开发有限公司 Human monoclonal antibody of human endophloeodal growth factor receptor 2 protein and its preparing process
CA2492524A1 (en) 2002-08-15 2004-02-26 Epitomics, Inc. Humanized rabbit antibodies
WO2004044584A1 (en) * 2002-11-13 2004-05-27 Micromet Ag Method for identifying antigen specific b cells
JP4336812B2 (en) * 2003-03-07 2009-09-30 博夫 岩田 Analytical method for rapid identification of surface antigens expressed in cells
EP1623229A2 (en) * 2003-05-15 2006-02-08 Cytos Biotechnology AG Selection of b cells with specificity of interest: method of preparation and use
JP2007520991A (en) * 2003-08-07 2007-08-02 エピトミクス インコーポレーティッド Method for humanizing rabbit monoclonal antibody
EP1910513B1 (en) * 2005-07-01 2016-08-10 John Schrader Methods of isolating antibody secreting cells from blood samples of immunized animals and generating monoclonal antibodies from said antibody secreting cells.
US20070134249A1 (en) * 2005-12-08 2007-06-14 Genitope Corporation Combination therapy and antibody panels
AU2006334029B2 (en) * 2005-12-28 2013-01-31 Osaka University An antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved
US7582298B2 (en) * 2006-06-02 2009-09-01 Regeneron Pharmaceuticals, Inc. High affinity antibodies to human IL-6 receptor
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor

Also Published As

Publication number Publication date
IL237985B (en) 2018-12-31
BRPI1005398A2 (en) 2019-03-26
ES2618181T3 (en) 2017-06-21
RU2017135831A3 (en) 2019-04-09
KR102059866B1 (en) 2019-12-27
JP6604989B2 (en) 2019-11-13
KR101689791B1 (en) 2016-12-26
JP2017192384A (en) 2017-10-26
RU2017135831A (en) 2019-04-09
SG10201708233VA (en) 2017-11-29
MX352922B (en) 2017-12-14
JP6161655B2 (en) 2017-07-12
IL263158A (en) 2018-12-31
SG10201408247SA (en) 2015-02-27
KR20160022397A (en) 2016-02-29
PH12014502468A1 (en) 2016-01-18
IL226956A0 (en) 2013-07-31
CN105116138A (en) 2015-12-02
IL226955A0 (en) 2013-07-31
KR20160150642A (en) 2016-12-30
IL226955A (en) 2015-04-30
KR101817279B1 (en) 2018-01-10
JP2018196395A (en) 2018-12-13
JP2015146825A (en) 2015-08-20
KR20190020202A (en) 2019-02-27
RU2011124039A (en) 2012-12-20
KR20180005752A (en) 2018-01-16
RU2577965C2 (en) 2016-03-20
SG2014014864A (en) 2014-09-26
IL263158B (en) 2019-10-31
CL2011001453A1 (en) 2012-02-24
IL226956A (en) 2015-04-30
PH12014502468B1 (en) 2016-01-18

Similar Documents

Publication Publication Date Title
ZA201204459B (en) Formulations of antibody
IL212738A0 (en) Methods for identifying immunobinders of cell-surface antigens
EP2473531A4 (en) Anti-gitr antibodies
IL214996A0 (en) Anti-bcma antibodies
GB0920127D0 (en) Antibodies
GB0909906D0 (en) Antibodies
ZA201104545B (en) Anti-siglec-15 antibody
EP2427496A4 (en) Anti-vegf-d antibodies
EP2717857A4 (en) Method for the synthesis of porphyrin-phospholipid conjugates
GB0920324D0 (en) Antibodies
IL217066A0 (en) Anti notch-1 antibodies
GB0905972D0 (en) Antibodies against IL-17BR
SI3251823T1 (en) Apparatus for napkin manufacture
GB2473934B (en) Anti-VEEV antibody
EP2499256A4 (en) Anti-c-mpl antibodies
PL2453805T3 (en) Device for producing anastomoses
IL263158B (en) Methods for identifying immunobinders of cell-surface antigens
EP2424892A4 (en) Dc-stamp antibodies
AP3595A (en) Novel gp41 antigens
GB0908945D0 (en) Antibodies
GB0911712D0 (en) Antibody
TH114196B (en) Methods for producing coral powders