IL236183A0 - Engineered three-dimensional connective tissue structures and methods for their preparation - Google Patents

Engineered three-dimensional connective tissue structures and methods for their preparation

Info

Publication number
IL236183A0
IL236183A0 IL236183A IL23618314A IL236183A0 IL 236183 A0 IL236183 A0 IL 236183A0 IL 236183 A IL236183 A IL 236183A IL 23618314 A IL23618314 A IL 23618314A IL 236183 A0 IL236183 A0 IL 236183A0
Authority
IL
Israel
Prior art keywords
engineered
making
methods
same
connective tissue
Prior art date
Application number
IL236183A
Other languages
English (en)
Hebrew (he)
Original Assignee
Organovo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organovo Inc filed Critical Organovo Inc
Publication of IL236183A0 publication Critical patent/IL236183A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
IL236183A 2012-06-19 2014-12-11 Engineered three-dimensional connective tissue structures and methods for their preparation IL236183A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261661768P 2012-06-19 2012-06-19
US13/801,780 US20140099709A1 (en) 2012-06-19 2013-03-13 Engineered three-dimensional connective tissue constructs and methods of making the same
PCT/US2013/046519 WO2013192290A1 (en) 2012-06-19 2013-06-19 Engineered three-dimensional connective tissue constructs and methods of making the same

Publications (1)

Publication Number Publication Date
IL236183A0 true IL236183A0 (en) 2015-01-29

Family

ID=49769324

Family Applications (1)

Application Number Title Priority Date Filing Date
IL236183A IL236183A0 (en) 2012-06-19 2014-12-11 Engineered three-dimensional connective tissue structures and methods for their preparation

Country Status (13)

Country Link
US (2) US20140099709A1 (esLanguage)
EP (1) EP2861270A4 (esLanguage)
JP (1) JP2015523142A (esLanguage)
KR (1) KR20150020702A (esLanguage)
CN (1) CN104717987A (esLanguage)
AU (2) AU2013277275B2 (esLanguage)
BR (1) BR112014032074A2 (esLanguage)
HK (1) HK1210439A1 (esLanguage)
IL (1) IL236183A0 (esLanguage)
IN (1) IN2015DN00017A (esLanguage)
RU (1) RU2015100977A (esLanguage)
SG (1) SG11201408405WA (esLanguage)
WO (1) WO2013192290A1 (esLanguage)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241905B2 (en) 2004-02-24 2012-08-14 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
AU2009271223B2 (en) 2008-06-24 2013-05-16 The Curators Of The University Of Missouri Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
AU2011318437B2 (en) 2010-10-21 2015-02-26 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue
JP6163104B2 (ja) 2010-11-15 2017-07-12 アクセラレイテッド・バイオサイエンシズ・コーポレーション ヒト・トロホブラスト幹細胞からの神経幹細胞の生成
DK2756073T3 (da) 2011-09-12 2021-03-22 Organovo Inc Manipuleret væv til in vitro-forskningsanvendelser, anordninger deraf og fremgangsmåder til fremstilling deraf
US9499779B2 (en) 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US9186380B2 (en) 2012-11-15 2015-11-17 Allosource Minced cartilage systems and methods
CN113604423B (zh) 2012-11-30 2025-06-03 艾克塞利瑞提德生物技术公司 通过调节mir-124分化干细胞的方法
KR102215401B1 (ko) 2013-02-22 2021-02-10 알로소스 연골 모자이크 조성물 및 방법
WO2014151939A1 (en) 2013-03-15 2014-09-25 Allosource Perforated osteochondral allograft compositions
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
EP3028042B1 (en) 2013-07-31 2021-06-30 Organovo, Inc. Automated devices, systems, and methods for the fabrication of tissue
EP3126490B1 (en) * 2014-04-04 2020-09-30 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
EP3149156B1 (en) 2014-05-28 2021-02-17 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
KR101690872B1 (ko) 2014-08-19 2016-12-29 이화여자대학교 산학협력단 편도 유래 중간엽 줄기세포로부터 인슐린 분비 세포의 분화 방법
CA2962778C (en) 2014-10-06 2023-05-16 Organovo, Inc. Engineered renal tissues, arrays thereof, and methods of making the same
EP3207123A1 (en) 2014-10-17 2017-08-23 Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
US20160122723A1 (en) 2014-11-05 2016-05-05 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
US10538725B1 (en) 2014-11-14 2020-01-21 Autodesk, Inc. Multi-dimensional bioprinting system
JP6836990B2 (ja) 2014-11-26 2021-03-03 アクセラレイテッド・バイオサイエンシズ・コーポレーション 誘導肝細胞およびそれらの使用
KR102311639B1 (ko) * 2015-03-26 2021-10-12 주식회사 티앤알바이오팹 심근조직 재생용 3차원 구조체의 제조방법
KR20160115204A (ko) * 2015-03-26 2016-10-06 포항공과대학교 산학협력단 3차원 프린팅용 조성물, 이의 제조방법, 및 이를 사용한 3차원 구조체의 제조방법
WO2017008035A1 (en) * 2015-07-08 2017-01-12 The Trustees Of The University Of Pennesylvania Decellularized organ-derived tissue engineering scaffolds
EP3320925B1 (en) 2015-07-10 2024-02-28 FUJIFILM Corporation Cell structure and method for producing cell structure
KR102078602B1 (ko) 2015-07-23 2020-02-19 한국화학연구원 지방세포와 마크로파지의 3차원 공동 배양 방법
NZ776411A (en) 2015-10-09 2023-09-29 Deka Products Lp Fluid pumping and bioreactor system
WO2017083402A1 (en) 2015-11-09 2017-05-18 Organovo, Inc. Improved methods for tissue fabrication
WO2017123722A1 (en) 2016-01-12 2017-07-20 Cleveland State University 3d-printed miniature biological constructs
ES2929758T3 (es) 2016-05-05 2022-12-01 Childrens Hospital Med Ct Métodos para la fabricación in vitro de tejido del fondo gástrico y composiciones relacionadas con el mismo
US11254901B2 (en) 2016-07-12 2022-02-22 Deka Products Limited Partnership System and method for printing tissue
WO2018013727A1 (en) 2016-07-12 2018-01-18 Deka Products Limited Partnership System and method for applying force to a device
US11850324B2 (en) 2016-10-12 2023-12-26 Advanced Biomatrix, Inc. Three-dimensional (3-D) printing inks made from natural extracellular matrix molecules
SG11201903697WA (en) 2016-11-04 2019-05-30 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
CN110087772B (zh) 2016-11-17 2022-07-19 克利夫兰州立大学 用于微阵列3d生物打印的芯片平台
KR102807995B1 (ko) 2016-12-05 2025-05-16 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
US12297416B2 (en) 2017-07-12 2025-05-13 Deka Products Limited Partneship System and method for transferring tissue
US10570362B2 (en) 2017-07-12 2020-02-25 Deka Products Limited Partnership System and method for transferring tissue
WO2019074793A1 (en) 2017-10-10 2019-04-18 Children's Hospital Medical Center OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME
US11262349B2 (en) 2017-10-11 2022-03-01 Cleveland State University Multiplexed immune cell assays on a micropillar/microwell chip platform
AU2018352842A1 (en) * 2017-10-20 2020-05-07 Indiana University Research And Technology Corporation Scaffold-free 3D bioprinting of porcine cells
WO2019126626A1 (en) 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
JP7105898B2 (ja) * 2018-01-31 2022-07-25 ロキット ヘルスケア インク． 真皮再生シート用バイオインク組成物、これを用いたオーダーメード型真皮再生シートの製造方法、および該製造方法を用いて製造されたオーダーメード型真皮再生シート
CN108409917B (zh) * 2018-03-07 2021-03-30 广州锐澄医疗技术有限公司 一种羊膜固定器的制备方法
CO2018004340A1 (es) * 2018-04-24 2018-07-19 Univ Del Valle Implante para la regeneración de tejidos
AU2019311783A1 (en) 2018-07-26 2021-02-04 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
JP2021535753A (ja) 2018-09-12 2021-12-23 チルドレンズ ホスピタル メディカル センター 造血幹細胞およびその派生体の生成のためのオルガノイド組成物
EP3911734A4 (en) * 2019-01-16 2022-11-09 University of Utah Research Foundation USING MESENCHYMATOUS STEM CELL SHEETS TO PREVENT UTERINE SCARS
KR20220016809A (ko) 2019-03-29 2022-02-10 코오롱 티슈진 인크. 추간판 퇴행의 치료
WO2020243613A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
CA3141814A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US11718823B2 (en) * 2020-02-03 2023-08-08 Purdue Research Foundation Methods and materials for rapid preparation of 3D spheroids/organoids
WO2021247907A1 (en) * 2020-06-03 2021-12-09 Northeastern University Biodegradable implant for sustained trans-nasal delivery of therapeutic agents to the brain
CN113941029B (zh) * 2020-07-17 2022-11-18 四川大学华西医院 一种3d打印神经导管及其应用
CN112251352B (zh) * 2020-09-29 2022-06-07 中国肉类食品综合研究中心 一种3d生物组织专用培养装置和块状培育肉的制备方法
CA3206143A1 (en) 2021-02-26 2022-09-01 Wei Hsu Skeletal stem cell isolation and uses thereof
CN113403268B (zh) * 2021-08-20 2022-01-07 北京大学第三医院（北京大学第三临床医学院） 一种含干细胞外泌体的生物墨水及其制造方法
WO2023159107A1 (en) 2022-02-18 2023-08-24 The Forsyth Institute Markers for skeletal stem cell and uses thereof
KR102670562B1 (ko) * 2022-10-13 2024-05-29 바오밥헬스케어 주식회사 3차원 바이오프린팅 기술을 이용한 생선근육 형태 모사 근육을 포함하는 배양생선의 제조방법 및 이에 의해 제조된 배양생선
WO2024091824A1 (en) 2022-10-26 2024-05-02 Ada Forsyth Institute, Inc. Differentiation and reprogramming of chondrocyte
EP4375362A1 (en) 2022-11-28 2024-05-29 Universität Zürich A rotating tissue culture insert for the position inside a rotatable roller bottle partially filled with a liquid for the cultivation of cells

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6998264B2 (en) * 2002-11-19 2006-02-14 Huntington Medical Research Institutes Replication of biological tissue
US20040197375A1 (en) * 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
US20090142307A1 (en) * 2004-07-09 2009-06-04 Athanasiou Kyriacos A Shape-Based Approach for Scaffoldless Tissue Engineering
CA2609145C (en) * 2005-05-24 2018-10-30 The Regents Of The University Of California Microscale micropatterned engineered in vitro tissue
AU2009271223B2 (en) * 2008-06-24 2013-05-16 The Curators Of The University Of Missouri Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same
WO2010060080A1 (en) * 2008-11-24 2010-05-27 Immunotrex Corporation Three dimensional tissue generation
HUP0900819A2 (en) * 2009-05-05 2011-01-28 Pecsi Tudomanyegyetem Lung tissue culture
US9592255B2 (en) * 2010-07-01 2017-03-14 The Regents Of The University Of Michigan Scaffold-free three dimensional nerve fibroblast constructs
AU2011318437B2 (en) * 2010-10-21 2015-02-26 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue
HUE029316T2 (en) * 2010-11-04 2017-03-28 Univ Of Pecs Lung tissue model
US10072257B2 (en) * 2012-02-29 2018-09-11 Massachusetts Institute Of Technology Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types
EP3126490B1 (en) * 2014-04-04 2020-09-30 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Also Published As

Publication number Publication date
WO2013192290A1 (en) 2013-12-27
US20140099709A1 (en) 2014-04-10
EP2861270A1 (en) 2015-04-22
RU2015100977A (ru) 2016-08-10
IN2015DN00017A (esLanguage) 2015-05-22
AU2013277275B2 (en) 2016-10-13
CA2876659A1 (en) 2013-12-27
CN104717987A (zh) 2015-06-17
US20190062707A1 (en) 2019-02-28
BR112014032074A2 (pt) 2017-06-27
KR20150020702A (ko) 2015-02-26
EP2861270A4 (en) 2016-01-20
JP2015523142A (ja) 2015-08-13
HK1210439A1 (en) 2016-04-22
AU2013277275A1 (en) 2015-01-29
SG11201408405WA (en) 2015-01-29
AU2017200162A1 (en) 2017-02-02

Similar Documents

Publication Publication Date Title
IL236183A0 (en) Engineered three-dimensional connective tissue structures and methods for their preparation
GB201223276D0 (en) Antibodies and methods of producing same
HUE042637T2 (hu) Laminátumok és azok elõállítására szolgáló módszerek
EP3038659A4 (en) Engineered anti-dll3 conjugates and methods of use
IL241055A (en) Transgenic liver tissue, their arrays and methods of preparation
AP2014008172A0 (en) Nanocomposite and method of making the same
EP3049030A4 (en) Intrabody osteotomy implant and methods of use
EP2892577A4 (en) METHOD OF TISSUE GENERATION
IL234108A0 (en) Preparations of factor viii and methods for their preparation and use
SG11201404580QA (en) Nanostructured materials and methods of making the same
SG11201404488UA (en) Nanostructured materials and methods of making the same
EP3008242A4 (en) Soft and strong engineered tissue
EP3089707A4 (en) Tissue grafts and methods of making and using the same
IL238329A0 (en) Preparations that include peracetic acid and methods for their preparation and use
SG11201405941QA (en) Article and method of making the same
GB2510538B (en) Connector and method of making the same
EP2806811A4 (en) VERTEBRAL CONSTRUCTION
EP3068396A4 (en) Rapidly disintegrating formulations and methods of use
EP3060060A4 (en) Tissue engineered devices and methods for making same
GB201211903D0 (en) Artificial eyes and manufacture thereof
ZA201502531B (en) Fabric and method of making the same
ZA201405644B (en) Weatherised minerals and methods of making and using same
EP2838543A4 (en) IMMUNOSTIMULANT COMPOSITIONS AND METHODS OF MAKING
ZA201406909B (en) Modified agave food and method of making same
GB201416065D0 (en) Catalysts and methods of making and using catalysts