IL229540B - Method of detecting and characterising analytes coupled to a membrane - Google Patents
Method of detecting and characterising analytes coupled to a membraneInfo
- Publication number
- IL229540B IL229540B IL229540A IL22954013A IL229540B IL 229540 B IL229540 B IL 229540B IL 229540 A IL229540 A IL 229540A IL 22954013 A IL22954013 A IL 22954013A IL 229540 B IL229540 B IL 229540B
- Authority
- IL
- Israel
- Prior art keywords
- discovering
- membrane
- characterizing materials
- materials conjugated
- conjugated
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490860P | 2011-05-27 | 2011-05-27 | |
| US201261599246P | 2012-02-15 | 2012-02-15 | |
| PCT/GB2012/051191 WO2012164270A1 (en) | 2011-05-27 | 2012-05-25 | Coupling method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL229540A0 IL229540A0 (en) | 2014-01-30 |
| IL229540B true IL229540B (en) | 2019-07-31 |
Family
ID=46210300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL229540A IL229540B (en) | 2011-05-27 | 2013-11-21 | Method of detecting and characterising analytes coupled to a membrane |
Country Status (11)
| Country | Link |
|---|---|
| US (9) | US10246741B2 (enExample) |
| EP (4) | EP2715343B1 (enExample) |
| JP (2) | JP6480183B2 (enExample) |
| KR (1) | KR101963918B1 (enExample) |
| CN (1) | CN103733063B (enExample) |
| AU (1) | AU2012264497B2 (enExample) |
| BR (1) | BR112013030529B1 (enExample) |
| CA (1) | CA2837306C (enExample) |
| IL (1) | IL229540B (enExample) |
| SG (1) | SG10201604316WA (enExample) |
| WO (1) | WO2012164270A1 (enExample) |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| KR101939420B1 (ko) | 2011-02-11 | 2019-01-16 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 세공 |
| AU2012264497B2 (en) | 2011-05-27 | 2017-06-15 | Oxford Nanopore Technologies Limited | Coupling method |
| JP6298404B2 (ja) | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
| WO2013041878A1 (en) | 2011-09-23 | 2013-03-28 | Oxford Nanopore Technologies Limited | Analysis of a polymer comprising polymer units |
| JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| EP2798083B1 (en) | 2011-12-29 | 2017-08-09 | Oxford Nanopore Technologies Limited | Method for characterising a polynucelotide by using a xpd helicase |
| KR102086182B1 (ko) | 2011-12-29 | 2020-03-06 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 효소 방법 |
| AU2013220156B2 (en) | 2012-02-15 | 2018-08-09 | Oxford Nanopore Technologies Limited | Aptamer method |
| EP3736339B1 (en) | 2012-02-16 | 2022-07-27 | Oxford Nanopore Technologies plc | Analysis of measurements of a polymer |
| CN112646019B (zh) | 2012-04-10 | 2022-08-16 | 牛津纳米孔科技公开有限公司 | 突变胞溶素孔 |
| US9797009B2 (en) | 2012-07-19 | 2017-10-24 | Oxford Nanopore Technologies Limited | Enzyme construct |
| EP2875154B1 (en) | 2012-07-19 | 2017-08-23 | Oxford Nanopore Technologies Limited | SSB method for characterising a nucleic acid |
| AU2013291763B2 (en) | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| EP2895618B1 (en) | 2012-09-14 | 2017-07-26 | Oxford Nanopore Technologies Limited | Sample preparation method |
| US9995728B2 (en) | 2012-11-06 | 2018-06-12 | Oxford Nanopore Technologies Ltd. | Quadruplex method |
| US9670526B2 (en) | 2012-11-09 | 2017-06-06 | Stratos Genomics, Inc. | Concentrating a target molecule for sensing by a nanopore |
| GB201222928D0 (en) | 2012-12-19 | 2013-01-30 | Oxford Nanopore Tech Ltd | Analysis of a polynucleotide |
| EP2953524B1 (en) | 2013-02-06 | 2018-08-01 | Freenome Holdings Inc. | Systems and methods for early disease detection and real-time disease monitoring |
| AU2014218911B2 (en) * | 2013-02-20 | 2018-07-12 | Eve Biomedical, Inc. | Methods and compositions for nanostructure-based nucleic acid sequencing |
| AU2014224432B2 (en) | 2013-03-08 | 2019-10-24 | Oxford Nanopore Technologies Limited | Enzyme stalling method |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| DK3351645T3 (da) * | 2013-05-24 | 2020-09-21 | Illumina Cambridge Ltd | Pyrofosforolytisk sekventering ved anvendelse af nanoporer |
| GB201316849D0 (en) * | 2013-09-23 | 2013-11-06 | Isis Innovation | Method |
| CA2927726A1 (en) | 2013-10-18 | 2015-04-23 | Oxford Nanopore Technologies Limited | Modified helicases for use in nucleic acid sequencing |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| EP3097210B2 (en) | 2014-01-22 | 2022-04-20 | Oxford Nanopore Technologies Limited | Method for attaching one or more polynucleotide binding proteins to a target polynucleotide |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| EP3126515B1 (en) | 2014-04-04 | 2018-08-29 | Oxford Nanopore Technologies Limited | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| JP6378924B2 (ja) * | 2014-04-23 | 2018-08-22 | 株式会社日立ハイテクノロジーズ | 核酸分析装置および核酸分析方法 |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| EP3137490B1 (en) | 2014-05-02 | 2021-01-27 | Oxford Nanopore Technologies Limited | Mutant pores |
| EP3683318A1 (en) * | 2014-06-03 | 2020-07-22 | Illumina, Inc. | Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores |
| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| CN115851894B (zh) | 2014-10-16 | 2025-06-27 | 牛津楠路珀尔科技股份有限公司 | 聚合物的分析 |
| GB201418469D0 (en) * | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
| CN107109489B (zh) | 2014-10-17 | 2021-11-30 | 牛津纳米孔技术公司 | 纳米孔rna表征方法 |
| ES2774802T3 (es) | 2014-10-31 | 2020-07-22 | Genia Tech Inc | Variantes de hemolisina alfa con características alteradas |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| EP3283887B1 (en) | 2015-04-14 | 2021-07-21 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| EP3303627B1 (en) | 2015-06-03 | 2024-12-11 | Illumina, Inc. | Systems and methods for sequencing polynucleotides using tethers anchored to polymerases adjacent to nanopores |
| JP6498314B2 (ja) | 2015-11-24 | 2019-04-10 | 株式会社日立ハイテクノロジーズ | 生体試料分析装置および生体試料分析方法 |
| AU2016369071B2 (en) | 2015-12-08 | 2022-05-19 | Katholieke Universiteit Leuven Ku Leuven Research & Development | Modified nanopores, compositions comprising the same, and uses thereof |
| EP3403079A4 (en) * | 2016-01-14 | 2019-09-04 | Roswell Biotechnologies, Inc | MOLECULAR SENSORS AND ASSOCIATED METHODS |
| CN109071212A (zh) * | 2016-01-28 | 2018-12-21 | 罗斯韦尔生物技术股份有限公司 | 使用大规模分子电子传感器阵列测量分析物的方法和装置 |
| KR102222192B1 (ko) | 2016-03-02 | 2021-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 기공 |
| JP7364333B2 (ja) | 2016-04-06 | 2023-10-18 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 変異体ポア |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| WO2017203268A1 (en) | 2016-05-25 | 2017-11-30 | Oxford Nanopore Technologies Limited | Method |
| JP6695450B2 (ja) | 2016-06-27 | 2020-05-20 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 二重層形成のための浸透性不均衡法 |
| US10577653B2 (en) * | 2016-06-27 | 2020-03-03 | Roche Sequencing Solutions, Inc. | Counteracting osmotic imbalance in a sequencing cell |
| GB201620450D0 (en) * | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
| JP6734210B2 (ja) * | 2017-02-20 | 2020-08-05 | 日本電信電話株式会社 | 脂質二分子膜基板、及びその製造方法 |
| EP4026916B1 (en) * | 2017-04-19 | 2023-10-18 | Electronic Biosciences Inc. | Nanopore/nanowell electrode enabled exonuclease sequencing |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| CN117106037B (zh) | 2017-06-30 | 2025-07-25 | 弗拉芒区生物技术研究所 | 新颖蛋白孔 |
| GB2569630B (en) | 2017-12-21 | 2022-10-12 | Sharp Life Science Eu Ltd | Droplet Interfaces in Electro-wetting Devices |
| GB2569977A (en) | 2018-01-05 | 2019-07-10 | Oxford Nanopore Tech Ltd | Method |
| GB201801768D0 (en) | 2018-02-02 | 2018-03-21 | Oxford Nanopore Tech Ltd | Synthesis method |
| EP3749608B1 (en) * | 2018-02-09 | 2025-04-09 | Ohio State Innovation Foundation | Bacteriophage-derived nanopore sensors |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| GB201808558D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| CN112203767B (zh) | 2018-05-24 | 2023-04-11 | 牛津纳米孔科技公司 | 电润湿装置中的液滴界面 |
| GB201808556D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB201808554D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| CN113227772B (zh) * | 2018-07-23 | 2024-11-01 | 纽约市哥伦比亚大学信托人 | 用于生物标志物检测的单分子电子多重纳米孔免疫测定 |
| US12398421B2 (en) | 2018-12-07 | 2025-08-26 | Bgi Shenzhen | Nanopore sequencing method |
| WO2020216885A1 (en) * | 2019-04-25 | 2020-10-29 | F. Hoffmann-La Roche Ag | Systems and methods for inserting a nanopore in a membrane using osmotic imbalance |
| GB201907246D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201907244D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201907243D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Sensing interactions between molecular entities and nanapores |
| WO2021036995A1 (en) * | 2019-08-23 | 2021-03-04 | Nanjing University | Direct microrna sequencing using enzyme assisted sequencing |
| GB201913997D0 (en) | 2019-09-27 | 2019-11-13 | Oxford Nanopore Tech Ltd | Method |
| GB201917060D0 (en) | 2019-11-22 | 2020-01-08 | Oxford Nanopore Tech Ltd | Method |
| CN118011004A (zh) | 2019-12-02 | 2024-05-10 | 牛津纳米孔科技公开有限公司 | 使用纳米孔表征靶多肽的方法 |
| GB201917742D0 (en) * | 2019-12-04 | 2020-01-15 | Oxford Nanopore Tech Ltd | Method |
| GB202004944D0 (en) | 2020-04-03 | 2020-05-20 | King S College London | Method |
| EP4168583A2 (en) | 2020-06-18 | 2023-04-26 | Oxford Nanopore Technologies plc | Method of characterising a polynucleotide moving through a nanopore |
| CN115698331A (zh) | 2020-06-18 | 2023-02-03 | 牛津纳米孔科技公开有限公司 | 使用检测器选择性地表征多核苷酸的方法 |
| GB202009349D0 (en) | 2020-06-18 | 2020-08-05 | Oxford Nanopore Tech Ltd | Method |
| GB202015993D0 (en) | 2020-10-08 | 2020-11-25 | Oxford Nanopore Tech Ltd | Method |
| US11248265B1 (en) | 2020-11-19 | 2022-02-15 | Clear Labs, Inc | Systems and processes for distinguishing pathogenic and non-pathogenic sequences from specimens |
| JP7421513B2 (ja) * | 2021-03-19 | 2024-01-24 | 株式会社東芝 | ケミカルセンサ装置及びその製造方法 |
| EP4314812A1 (en) | 2021-03-31 | 2024-02-07 | Illumina, Inc. | Scalable circuit for molecular detection |
| GB202107192D0 (en) | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| CN117337333A (zh) | 2021-05-19 | 2024-01-02 | 牛津纳米孔科技公开有限公司 | 用于补体链测序的方法 |
| GB202107354D0 (en) | 2021-05-24 | 2021-07-07 | Oxford Nanopore Tech Ltd | Method |
| CN113329110A (zh) | 2021-05-26 | 2021-08-31 | 武汉华星光电半导体显示技术有限公司 | 一种显示设备 |
| CN113588988B (zh) * | 2021-06-21 | 2023-05-26 | 东南大学 | 二维平面异质结构的蛋白质拉伸测序平台及其制备方法 |
| CN113789257A (zh) * | 2021-07-05 | 2021-12-14 | 厦门赛特奥斯生物技术有限公司 | 一种基于三代测序技术的微生物检测系统 |
| GB202118908D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202118906D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| CN113999291B (zh) * | 2021-12-28 | 2022-04-15 | 北京齐碳科技有限公司 | 嵌入接头、锚定分子、分子膜、装置、方法及应用 |
| WO2023187001A1 (en) * | 2022-03-31 | 2023-10-05 | Illumina Cambridge Limited | Devices including osmotically balanced barriers, and methods of making and using the same |
| GB202204919D0 (en) | 2022-04-04 | 2022-05-18 | Oxford Nanopore Tech Plc | Method |
| WO2023222657A1 (en) | 2022-05-17 | 2023-11-23 | Oxford Nanopore Technologies Plc | Method and adaptors |
| GB202207267D0 (en) | 2022-05-18 | 2022-06-29 | Oxford Nanopore Tech Plc | Calibration and profiling of a nanopore array device |
| CN117587110A (zh) * | 2022-08-16 | 2024-02-23 | 北京齐碳科技有限公司 | 富集方法、表征分析物的方法及其装置 |
| GB202215442D0 (en) | 2022-10-19 | 2022-11-30 | Oxford Nanopore Tech Plc | Analysis of a polymer |
| GB202216162D0 (en) | 2022-10-31 | 2022-12-14 | Oxford Nanopore Tech Plc | Method |
| EP4636094A1 (en) | 2022-12-16 | 2025-10-22 | BGI Shenzhen | Nanopore sequencing method and kit |
| CN120344850A (zh) * | 2022-12-28 | 2025-07-18 | 深圳华大生命科学研究院 | 纳米孔传感器及其在测序中的应用 |
| GB202301095D0 (en) | 2023-01-25 | 2023-03-08 | Oxford Nanopore Tech Plc | Calibration of a nanopore array device |
| GB202304324D0 (en) | 2023-03-24 | 2023-05-10 | Oxford Nanopore Tech Plc | Method and kits |
| US20240366124A1 (en) * | 2023-05-04 | 2024-11-07 | Analog Devices International Unlimited Company | Sensor assembly |
| GB202307494D0 (en) | 2023-05-18 | 2023-07-05 | Oxford Nanopore Tech Ltd | Nanopore sequencing and preparation modular instrument |
| GB202307486D0 (en) | 2023-05-18 | 2023-07-05 | Oxford Nanopore Tech Plc | Method |
| WO2024243214A2 (en) * | 2023-05-22 | 2024-11-28 | The Curators Of The University Of Missouri | A nanopore-based nucleic acid conformation reader for small molecule (e.g. neurotransmitters and hormones) biosensing and therapeutical compound screening |
| GB202317028D0 (en) | 2023-11-06 | 2023-12-20 | Oxford Nanopore Tech Ltd | Method |
| GB202407055D0 (en) | 2024-05-17 | 2024-07-03 | Oxford Nanopore Tech Plc | Enhanced polynucleotide sequencing |
| GB202407044D0 (en) | 2024-05-17 | 2024-07-03 | Oxford Nanopore Tech Plc | Polymer analysis using transformer neural network |
| GB202407228D0 (en) | 2024-05-21 | 2024-07-03 | Oxford Nanopore Tech Plc | Method |
| GB202407247D0 (en) | 2024-05-21 | 2024-07-03 | Oxford Nanopore Tech Plc | Method |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69030811T2 (de) | 1989-01-27 | 1997-10-02 | Au Membrane & Biotech Res Inst | Rezeptormembranen und selektive steuerung des ionenflusses durch ionophoren |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| US5712126A (en) | 1995-08-01 | 1998-01-27 | Yale University | Analysis of gene expression by display of 3-end restriction fragments of CDNA |
| AUPN980796A0 (en) | 1996-05-13 | 1996-06-06 | Australian Membrane And Biotechnology Research Institute | Improved reservoir components |
| US6267872B1 (en) | 1998-11-06 | 2001-07-31 | The Regents Of The University Of California | Miniature support for thin films containing single channels or nanopores and methods for using same |
| US7527787B2 (en) | 2005-10-19 | 2009-05-05 | Ibc Pharmaceuticals, Inc. | Multivalent immunoglobulin-based bioactive assemblies |
| JP2003502166A (ja) | 1999-06-22 | 2003-01-21 | プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 固体状態の次元的特徴の制御 |
| US6916488B1 (en) | 1999-11-05 | 2005-07-12 | Biocure, Inc. | Amphiphilic polymeric vesicles |
| WO2001088025A1 (en) | 2000-05-16 | 2001-11-22 | Biocure, Inc. | Membranes formed from amphiphilic copolymers |
| US20020197618A1 (en) | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
| US6849404B2 (en) | 2001-05-07 | 2005-02-01 | Bioneer Corporation | Polymerase chain reaction of DNA of which base sequence is completely unidentified |
| US7253434B2 (en) | 2002-10-29 | 2007-08-07 | President And Fellows Of Harvard College | Suspended carbon nanotube field effect transistor |
| WO2005124888A1 (en) | 2004-06-08 | 2005-12-29 | President And Fellows Of Harvard College | Suspended carbon nanotube field effect transistor |
| GB0505971D0 (en) | 2005-03-23 | 2005-04-27 | Isis Innovation | Delivery of molecules to a lipid bilayer |
| CN101203740B (zh) | 2005-04-06 | 2011-03-23 | 哈佛大学校长及研究员协会 | 用碳纳米管控制的分子鉴定 |
| ATE458824T1 (de) | 2005-10-28 | 2010-03-15 | Max Planck Gesellschaft | Zellfreie in-vitro-transkription und translation von membranproteinen in gebundene planare lipidschichten |
| GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
| US8003319B2 (en) | 2007-02-02 | 2011-08-23 | International Business Machines Corporation | Systems and methods for controlling position of charged polymer inside nanopore |
| NZ579083A (en) | 2007-02-20 | 2012-07-27 | Oxford Nanopore Tech Ltd | Lipid bilayer sensor system |
| AU2008236694B2 (en) | 2007-04-04 | 2014-01-23 | The Regents Of The University Of California | Compositions, devices, systems, and methods for using a nanopore |
| EP2158476B8 (en) | 2007-05-08 | 2019-10-09 | Trustees of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
| WO2009035647A1 (en) | 2007-09-12 | 2009-03-19 | President And Fellows Of Harvard College | High-resolution molecular graphene sensor comprising an aperture in the graphene layer |
| WO2009046282A1 (en) * | 2007-10-03 | 2009-04-09 | University Of Delaware Et Al. | Intelligent powered mobility for infants and special needs children |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| US8628940B2 (en) | 2008-09-24 | 2014-01-14 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
| WO2009151788A2 (en) | 2008-04-22 | 2009-12-17 | The Washington University | Universal anchor peptide for nanoparticles |
| JP2012500620A (ja) * | 2008-04-24 | 2012-01-12 | ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク | Ｄｎａ分子組織化のための幾何学的パターンおよび脂質二重層、ならびにその使用 |
| US20110229877A1 (en) | 2008-07-07 | 2011-09-22 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| US9447152B2 (en) | 2008-07-07 | 2016-09-20 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| US8784623B2 (en) | 2008-07-17 | 2014-07-22 | Koninklijke Philips N.V. | Nanopore device and a method for nucleic acid analysis |
| EP3029467B1 (en) | 2008-09-22 | 2020-01-08 | University of Washington | Msp nanopores and related methods |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| JP5843614B2 (ja) * | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
| CA2750874A1 (en) | 2009-01-30 | 2010-08-05 | Oxford Nanopore Technologies Limited | Hybridization linkers |
| GB0901588D0 (en) | 2009-02-02 | 2009-03-11 | Itis Holdings Plc | Apparatus and methods for providing journey information |
| US8986928B2 (en) * | 2009-04-10 | 2015-03-24 | Pacific Biosciences Of California, Inc. | Nanopore sequencing devices and methods |
| JP5781502B2 (ja) | 2009-04-20 | 2015-09-24 | オックスフォード ナノポール テクノロジーズ リミテッド | 脂質二重層センサアレイ |
| BR112012013074B1 (pt) | 2009-12-01 | 2018-09-18 | Oxford Nanopore Technologies Limited | instrumento de análise e módulo para realizar análise bioquímica, e, método para operar um instrumento de análise para realizar análise bioquímica |
| CA2790672C (en) | 2010-02-23 | 2018-05-29 | University Of Washington | Artificial mycolic acid membranes |
| WO2012005857A1 (en) | 2010-06-08 | 2012-01-12 | President And Fellows Of Harvard College | Nanopore device with graphene supported artificial lipid membrane |
| WO2012033524A2 (en) | 2010-09-07 | 2012-03-15 | The Regents Of The University Of California | Control of dna movement in a nanopore at one nucleotide precision by a processive enzyme |
| AU2011338841B2 (en) | 2010-11-12 | 2017-02-16 | Gen9, Inc. | Methods and devices for nucleic acids synthesis |
| KR101939420B1 (ko) | 2011-02-11 | 2019-01-16 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 세공 |
| AU2012264497B2 (en) | 2011-05-27 | 2017-06-15 | Oxford Nanopore Technologies Limited | Coupling method |
| JP6298404B2 (ja) | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
| WO2013041878A1 (en) | 2011-09-23 | 2013-03-28 | Oxford Nanopore Technologies Limited | Analysis of a polymer comprising polymer units |
| JP6226869B2 (ja) | 2011-10-21 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | 酵素法 |
| GB201120910D0 (en) | 2011-12-06 | 2012-01-18 | Cambridge Entpr Ltd | Nanopore functionality control |
| EP2798083B1 (en) | 2011-12-29 | 2017-08-09 | Oxford Nanopore Technologies Limited | Method for characterising a polynucelotide by using a xpd helicase |
| KR102086182B1 (ko) | 2011-12-29 | 2020-03-06 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 효소 방법 |
| WO2013119784A1 (en) | 2012-02-08 | 2013-08-15 | Brown University | Methods of sequencing nucleic acids using nanopores and active kinetic proofreading |
| CN112646019B (zh) | 2012-04-10 | 2022-08-16 | 牛津纳米孔科技公开有限公司 | 突变胞溶素孔 |
| US9797009B2 (en) | 2012-07-19 | 2017-10-24 | Oxford Nanopore Technologies Limited | Enzyme construct |
| EP2875154B1 (en) | 2012-07-19 | 2017-08-23 | Oxford Nanopore Technologies Limited | SSB method for characterising a nucleic acid |
| AU2013291763B2 (en) | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| US9823235B2 (en) | 2012-10-26 | 2017-11-21 | Oxford Nanopre Technologies Ltd. | Droplet interfaces |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| US9670526B2 (en) | 2012-11-09 | 2017-06-06 | Stratos Genomics, Inc. | Concentrating a target molecule for sensing by a nanopore |
| AU2014218911B2 (en) | 2013-02-20 | 2018-07-12 | Eve Biomedical, Inc. | Methods and compositions for nanostructure-based nucleic acid sequencing |
| AU2014224432B2 (en) | 2013-03-08 | 2019-10-24 | Oxford Nanopore Technologies Limited | Enzyme stalling method |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| JP6253251B2 (ja) | 2013-05-08 | 2017-12-27 | 株式会社ジェイシティ | コンテンツ提供サーバ、コンテンツ提供方法、及びコンテンツ提供サーバ用プログラム |
| GB201406151D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CA2927726A1 (en) | 2013-10-18 | 2015-04-23 | Oxford Nanopore Technologies Limited | Modified helicases for use in nucleic acid sequencing |
| CA2926138A1 (en) | 2013-10-23 | 2015-04-30 | Genia Technologies, Inc. | High speed molecular sensing with nanopores |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| WO2015138405A2 (en) | 2014-03-10 | 2015-09-17 | The Board Of Trustees Of The University Of Illinois | Detection and quantification of methylation in dna |
| EP3126515B1 (en) | 2014-04-04 | 2018-08-29 | Oxford Nanopore Technologies Limited | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
| GB201417712D0 (en) | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| US9925679B2 (en) | 2014-05-19 | 2018-03-27 | I+D+M Creative, Llc | Devices and methods for assisting with slicing items |
| US10400014B2 (en) | 2014-09-01 | 2019-09-03 | Oxford Nanopore Technologies Ltd. | Mutant CsgG pores |
| GB201418469D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
| WO2017203268A1 (en) | 2016-05-25 | 2017-11-30 | Oxford Nanopore Technologies Limited | Method |
| US11441118B2 (en) | 2017-11-02 | 2022-09-13 | The Board Of Trustees Of The University Of Illinois | Nucleic acid and other compositions and methods for the modulation of cell membranes |
| GB201801768D0 (en) | 2018-02-02 | 2018-03-21 | Oxford Nanopore Tech Ltd | Synthesis method |
| GB201917742D0 (en) | 2019-12-04 | 2020-01-15 | Oxford Nanopore Tech Ltd | Method |
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