IL226956A - Methods for identifying training binds that bind specifically to a desired antigen - Google Patents
Methods for identifying training binds that bind specifically to a desired antigenInfo
- Publication number
- IL226956A IL226956A IL226956A IL22695613A IL226956A IL 226956 A IL226956 A IL 226956A IL 226956 A IL226956 A IL 226956A IL 22695613 A IL22695613 A IL 22695613A IL 226956 A IL226956 A IL 226956A
- Authority
- IL
- Israel
- Prior art keywords
- immunobinder
- antigen
- interest
- identifying
- methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5052—Cells of the immune system involving B-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15504109P | 2009-02-24 | 2009-02-24 | |
US15510509P | 2009-02-24 | 2009-02-24 | |
CH8322009 | 2009-06-02 | ||
PCT/CH2009/000222 WO2009155726A2 (en) | 2008-06-25 | 2009-06-25 | Humanization of rabbit antibodies using a universal antibody framework |
PCT/CH2010/000044 WO2010096941A1 (en) | 2009-02-24 | 2010-02-22 | Methods for identifying immunobinders of cell-surface antigens |
Publications (2)
Publication Number | Publication Date |
---|---|
IL226956A0 IL226956A0 (en) | 2013-07-31 |
IL226956A true IL226956A (en) | 2015-04-30 |
Family
ID=48917567
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL226955A IL226955A (en) | 2009-02-24 | 2013-06-13 | Methods for identifying b-cell clones that bind specifically to a desired antigen, a method of training binding and training binders produced by these methods |
IL226956A IL226956A (en) | 2009-02-24 | 2013-06-13 | Methods for identifying training binds that bind specifically to a desired antigen |
IL237985A IL237985B (en) | 2009-02-24 | 2015-03-26 | A humanized immunolinker capable of binding to a desired antigen |
IL26315818A IL263158B (en) | 2009-02-24 | 2018-11-20 | Methods for the detection of immunobinding antigens on the surface of cells |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL226955A IL226955A (en) | 2009-02-24 | 2013-06-13 | Methods for identifying b-cell clones that bind specifically to a desired antigen, a method of training binding and training binders produced by these methods |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL237985A IL237985B (en) | 2009-02-24 | 2015-03-26 | A humanized immunolinker capable of binding to a desired antigen |
IL26315818A IL263158B (en) | 2009-02-24 | 2018-11-20 | Methods for the detection of immunobinding antigens on the surface of cells |
Country Status (12)
Country | Link |
---|---|
JP (3) | JP6161655B2 (ja) |
KR (4) | KR101817279B1 (ja) |
CN (1) | CN105116138A (ja) |
BR (1) | BRPI1005398A2 (ja) |
CL (1) | CL2011001453A1 (ja) |
ES (1) | ES2618181T3 (ja) |
IL (4) | IL226955A (ja) |
MX (1) | MX352922B (ja) |
PH (1) | PH12014502468A1 (ja) |
RU (2) | RU2577965C2 (ja) |
SG (3) | SG2014014864A (ja) |
ZA (1) | ZA201103125B (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110016462B (zh) * | 2019-02-20 | 2020-04-24 | 优睿赛思(武汉)生物科技有限公司 | 从脾脏细胞中高效分离单个抗原特异性b淋巴细胞的方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63253098A (ja) * | 1987-04-10 | 1988-10-20 | Ube Ind Ltd | ヒト抗体に対するモノクロ−ナル抗体、その製法及び用途 |
IL91948A (en) * | 1988-10-26 | 1994-05-30 | Immunomedics | Removal of immunoreactive components from a sample |
US5417972A (en) * | 1993-08-02 | 1995-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM |
KR0119909B1 (ko) * | 1993-10-05 | 1997-10-20 | 김은영 | 플로우 사이토미터를 이용한 고상형 면역 측정방법 |
EP1978033A3 (en) * | 1995-04-27 | 2008-12-24 | Amgen Fremont Inc. | Human antibodies derived from immunized xenomice |
JP2000516452A (ja) * | 1996-07-16 | 2000-12-12 | プリュックテュン,アンドレアス | 可溶性が増大した免疫グロブリンスーパーファミリードメインおよびフラグメント |
CN103739706B (zh) * | 2002-05-22 | 2015-11-18 | 艾斯巴技术-诺华有限责任公司 | 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法 |
CN1396182A (zh) * | 2002-07-31 | 2003-02-12 | 陕西超英生物医学研究开发有限公司 | 人内皮生长因子受体2蛋白全人单克隆抗体及其制备方法 |
WO2004016740A2 (en) * | 2002-08-15 | 2004-02-26 | Epitomics, Inc. | Humanized rabbit antibodies |
WO2004044584A1 (en) * | 2002-11-13 | 2004-05-27 | Micromet Ag | Method for identifying antigen specific b cells |
JP4336812B2 (ja) * | 2003-03-07 | 2009-09-30 | 博夫 岩田 | 細胞に発現する表面抗原を迅速に同定するための分析方法 |
WO2004102198A2 (en) * | 2003-05-15 | 2004-11-25 | Cytos Biotechnology Ag | Selection of b cells with specificity of interest: method of preparation and use |
WO2005016950A1 (en) * | 2003-08-07 | 2005-02-24 | Epitomics, Inc. | Methods for humanizing rabbit monoclonal antibodies |
WO2007003041A1 (en) * | 2005-07-01 | 2007-01-11 | John Schrader | Methods of isolating cells and generating monoclonal antibodies |
US20070134249A1 (en) | 2005-12-08 | 2007-06-14 | Genitope Corporation | Combination therapy and antibody panels |
CN101389656A (zh) * | 2005-12-28 | 2009-03-18 | 阿斯比奥制药株式会社 | 抗骨膜素的抗体和含有该抗体的用于预防或治疗骨膜素相关疾病的药物组合物 |
DK2374818T3 (da) * | 2006-06-02 | 2013-01-21 | Regeneron Pharma | Højaffinitetsantistoffer mod human IL-6-receptor |
WO2008004834A1 (en) * | 2006-07-06 | 2008-01-10 | Isu Abxis Co., Ltd | Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor |
-
2010
- 2010-02-22 KR KR1020167035683A patent/KR101817279B1/ko active IP Right Grant
- 2010-02-22 SG SG2014014864A patent/SG2014014864A/en unknown
- 2010-02-22 KR KR1020197005221A patent/KR102059866B1/ko active IP Right Grant
- 2010-02-22 KR KR1020167003693A patent/KR101689791B1/ko active IP Right Grant
- 2010-02-22 CN CN201510261116.5A patent/CN105116138A/zh active Pending
- 2010-02-22 ES ES10705086.6T patent/ES2618181T3/es active Active
- 2010-02-22 RU RU2011124039/10A patent/RU2577965C2/ru active
- 2010-02-22 SG SG10201708233VA patent/SG10201708233VA/en unknown
- 2010-02-22 BR BRPI1005398-0A patent/BRPI1005398A2/pt not_active Application Discontinuation
- 2010-02-22 SG SG10201408247SA patent/SG10201408247SA/en unknown
- 2010-02-22 MX MX2015017453A patent/MX352922B/es unknown
- 2010-02-22 KR KR1020187000320A patent/KR20180005752A/ko active Application Filing
-
2011
- 2011-04-28 ZA ZA2011/03125A patent/ZA201103125B/en unknown
- 2011-06-15 CL CL2011001453A patent/CL2011001453A1/es unknown
-
2013
- 2013-06-13 IL IL226955A patent/IL226955A/en active IP Right Grant
- 2013-06-13 IL IL226956A patent/IL226956A/en active IP Right Grant
-
2014
- 2014-11-05 PH PH12014502468A patent/PH12014502468A1/en unknown
-
2015
- 2015-03-26 IL IL237985A patent/IL237985B/en active IP Right Grant
- 2015-05-19 JP JP2015101581A patent/JP6161655B2/ja active Active
-
2017
- 2017-04-28 JP JP2017090650A patent/JP6604989B2/ja not_active Expired - Fee Related
- 2017-10-09 RU RU2017135831A patent/RU2017135831A/ru not_active Application Discontinuation
-
2018
- 2018-09-14 JP JP2018172287A patent/JP2018196395A/ja active Pending
- 2018-11-20 IL IL26315818A patent/IL263158B/en active IP Right Grant
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |