IL197195A - Peptide conjugates containing rgd sequence or rgd peptidomycetic and porphyrin or (bacterio) chlorophyll photosensitizers and their use - Google Patents

Peptide conjugates containing rgd sequence or rgd peptidomycetic and porphyrin or (bacterio) chlorophyll photosensitizers and their use

Info

Publication number
IL197195A
IL197195A IL197195A IL19719509A IL197195A IL 197195 A IL197195 A IL 197195A IL 197195 A IL197195 A IL 197195A IL 19719509 A IL19719509 A IL 19719509A IL 197195 A IL197195 A IL 197195A
Authority
IL
Israel
Prior art keywords
rgd
bacterio
photosensitizers
peptidomimetics
chlorophyll
Prior art date
Application number
IL197195A
Other languages
English (en)
Hebrew (he)
Other versions
IL197195A0 (en
Inventor
Doron Eren
Yoram Salomon
Alexander Brandis
Avigdor Scherz
Efrat Rubinstein
Karin Neimann
Original Assignee
Yeda Res & Dev
Doron Eren
Yoram Salomon
Alexander Brandis
Avigdor Scherz
Efrat Rubinstein
Karin Neimann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Doron Eren, Yoram Salomon, Alexander Brandis, Avigdor Scherz, Efrat Rubinstein, Karin Neimann filed Critical Yeda Res & Dev
Publication of IL197195A0 publication Critical patent/IL197195A0/en
Publication of IL197195A publication Critical patent/IL197195A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL197195A 2006-08-23 2009-02-23 Peptide conjugates containing rgd sequence or rgd peptidomycetic and porphyrin or (bacterio) chlorophyll photosensitizers and their use IL197195A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83940906P 2006-08-23 2006-08-23
PCT/IL2007/001055 WO2008023378A1 (en) 2006-08-23 2007-08-23 Conjugates of rgd peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses

Publications (2)

Publication Number Publication Date
IL197195A0 IL197195A0 (en) 2009-12-24
IL197195A true IL197195A (en) 2015-10-29

Family

ID=38896083

Family Applications (1)

Application Number Title Priority Date Filing Date
IL197195A IL197195A (en) 2006-08-23 2009-02-23 Peptide conjugates containing rgd sequence or rgd peptidomycetic and porphyrin or (bacterio) chlorophyll photosensitizers and their use

Country Status (12)

Country Link
US (1) US20080138278A1 (https=)
EP (1) EP2061512B1 (https=)
JP (3) JP2010502574A (https=)
AU (1) AU2007287205B8 (https=)
CA (1) CA2661319C (https=)
DK (1) DK2061512T3 (https=)
ES (1) ES2763237T3 (https=)
HU (1) HUE047789T2 (https=)
IL (1) IL197195A (https=)
PT (1) PT2061512T (https=)
RU (1) RU2450018C2 (https=)
WO (1) WO2008023378A1 (https=)

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CN117045787A (zh) * 2023-09-27 2023-11-14 中国人民解放军陆军军医大学第二附属医院 一种自组装型纳米光敏剂及制备方法和应用

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AU2009219682B2 (en) 2008-02-27 2015-06-18 Yeda Research & Development Co. Ltd RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
LT5567B (lt) 2008-08-06 2009-04-27 Vilniaus Universitetas Maisto ir su maistu susietų paviršių nukenksminimo būdas
US8673270B2 (en) * 2008-10-23 2014-03-18 Steba Biotech S.A. RGD-containing peptidomimetics and uses thereof
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
US9153112B1 (en) 2009-12-21 2015-10-06 Masimo Corporation Modular patient monitor
PL219569B1 (pl) 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie
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RU2632439C2 (ru) * 2011-08-23 2017-10-04 Йеда Рисерч Энд Дивелопмент Ко., Лтд. Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств
JP6104920B2 (ja) 2011-10-13 2017-03-29 マシモ・コーポレイション 医療用監視ハブ
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JP6263716B2 (ja) * 2013-07-31 2018-01-24 国立大学法人 筑波大学 悪性腫瘍のｐｅｔ診断用トレーサー
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Also Published As

Publication number Publication date
JP2017039700A (ja) 2017-02-23
JP2013231039A (ja) 2013-11-14
EP2061512A1 (en) 2009-05-27
CA2661319C (en) 2015-12-01
HUE047789T2 (hu) 2020-05-28
ES2763237T3 (es) 2020-05-27
AU2007287205B2 (en) 2013-04-18
AU2007287205B8 (en) 2013-08-15
JP2010502574A (ja) 2010-01-28
WO2008023378A1 (en) 2008-02-28
WO2008023378A9 (en) 2008-04-10
DK2061512T3 (da) 2020-01-20
RU2450018C2 (ru) 2012-05-10
EP2061512B1 (en) 2019-10-02
CA2661319A1 (en) 2008-02-28
AU2007287205A1 (en) 2008-02-28
US20080138278A1 (en) 2008-06-12
RU2009110226A (ru) 2010-09-27
JP6177013B2 (ja) 2017-08-09
IL197195A0 (en) 2009-12-24
PT2061512T (pt) 2020-01-14

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