JP2010502574A - Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用 - Google Patents

Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用 Download PDF

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Publication number
JP2010502574A
JP2010502574A JP2009525172A JP2009525172A JP2010502574A JP 2010502574 A JP2010502574 A JP 2010502574A JP 2009525172 A JP2009525172 A JP 2009525172A JP 2009525172 A JP2009525172 A JP 2009525172A JP 2010502574 A JP2010502574 A JP 2010502574A
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conjugate
rgd
photosensitizer
bacteriochlorophyll
group
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Pending
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Japanese (ja)
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JP2010502574A5 (https=
Inventor
シェルツ、アビグドル
サロモン、ヨラム
ルビンシュタイン、エフラット
ブランディス、アレクサンダー
エレン、ドロン
ナイマン、カリン
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Yeda Research and Development Co Ltd
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Yeda Research and Development Co Ltd
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Publication of JP2010502574A publication Critical patent/JP2010502574A/ja
Publication of JP2010502574A5 publication Critical patent/JP2010502574A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2009525172A 2006-08-23 2007-08-23 Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用 Pending JP2010502574A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83940906P 2006-08-23 2006-08-23
PCT/IL2007/001055 WO2008023378A1 (en) 2006-08-23 2007-08-23 Conjugates of rgd peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses

Related Child Applications (1)

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JP2013118542A Division JP6177013B2 (ja) 2006-08-23 2013-06-05 Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用

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JP2010502574A true JP2010502574A (ja) 2010-01-28
JP2010502574A5 JP2010502574A5 (https=) 2010-10-07

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JP2009525172A Pending JP2010502574A (ja) 2006-08-23 2007-08-23 Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用
JP2013118542A Expired - Fee Related JP6177013B2 (ja) 2006-08-23 2013-06-05 Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用
JP2016144093A Pending JP2017039700A (ja) 2006-08-23 2016-07-22 Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用

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JP2013118542A Expired - Fee Related JP6177013B2 (ja) 2006-08-23 2013-06-05 Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用
JP2016144093A Pending JP2017039700A (ja) 2006-08-23 2016-07-22 Ｒｇｄペプチドとポルフィリン又は（バクテリオ）クロロフィル光合成剤とのコンジュゲート及びその使用

Country Status (12)

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US (1) US20080138278A1 (https=)
EP (1) EP2061512B1 (https=)
JP (3) JP2010502574A (https=)
AU (1) AU2007287205B8 (https=)
CA (1) CA2661319C (https=)
DK (1) DK2061512T3 (https=)
ES (1) ES2763237T3 (https=)
HU (1) HUE047789T2 (https=)
IL (1) IL197195A (https=)
PT (1) PT2061512T (https=)
RU (1) RU2450018C2 (https=)
WO (1) WO2008023378A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015030671A (ja) * 2013-07-31 2015-02-16 国立大学法人 筑波大学 悪性腫瘍のｐｅｔ診断用トレーサー
JP2019510807A (ja) * 2016-04-10 2019-04-18 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド バクテリオクロロフィル誘導体を含む、がんの治療のための併用療法
WO2025105486A1 (ja) * 2023-11-17 2025-05-22 第一三共株式会社 抗体－光感受性物質コンジュゲート

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AU2009219682B2 (en) 2008-02-27 2015-06-18 Yeda Research & Development Co. Ltd RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors
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US8673270B2 (en) * 2008-10-23 2014-03-18 Steba Biotech S.A. RGD-containing peptidomimetics and uses thereof
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015030671A (ja) * 2013-07-31 2015-02-16 国立大学法人 筑波大学 悪性腫瘍のｐｅｔ診断用トレーサー
JP2019510807A (ja) * 2016-04-10 2019-04-18 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド バクテリオクロロフィル誘導体を含む、がんの治療のための併用療法
JP2022031823A (ja) * 2016-04-10 2022-02-22 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド バクテリオクロロフィル誘導体を含む、がんの治療のための併用療法
WO2025105486A1 (ja) * 2023-11-17 2025-05-22 第一三共株式会社 抗体－光感受性物質コンジュゲート

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JP2017039700A (ja) 2017-02-23
JP2013231039A (ja) 2013-11-14
EP2061512A1 (en) 2009-05-27
CA2661319C (en) 2015-12-01
HUE047789T2 (hu) 2020-05-28
ES2763237T3 (es) 2020-05-27
AU2007287205B2 (en) 2013-04-18
AU2007287205B8 (en) 2013-08-15
WO2008023378A1 (en) 2008-02-28
WO2008023378A9 (en) 2008-04-10
DK2061512T3 (da) 2020-01-20
RU2450018C2 (ru) 2012-05-10
EP2061512B1 (en) 2019-10-02
CA2661319A1 (en) 2008-02-28
AU2007287205A1 (en) 2008-02-28
US20080138278A1 (en) 2008-06-12
RU2009110226A (ru) 2010-09-27
JP6177013B2 (ja) 2017-08-09
IL197195A (en) 2015-10-29
IL197195A0 (en) 2009-12-24
PT2061512T (pt) 2020-01-14

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