AU2007287205B8 - Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses - Google Patents

Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses Download PDF

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Publication number
AU2007287205B8
AU2007287205B8 AU2007287205A AU2007287205A AU2007287205B8 AU 2007287205 B8 AU2007287205 B8 AU 2007287205B8 AU 2007287205 A AU2007287205 A AU 2007287205A AU 2007287205 A AU2007287205 A AU 2007287205A AU 2007287205 B8 AU2007287205 B8 AU 2007287205B8
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AU
Australia
Prior art keywords
conjugate
rgd
group
tumor
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007287205A
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English (en)
Other versions
AU2007287205B2 (en
AU2007287205A1 (en
Inventor
Alexander Brandis
Doron Eren
Karin Neimann
Efrat Rubinstein
Yoram Salomon
Avigdor Scherz
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Yeda Research and Development Co Ltd
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Yeda Research and Development Co Ltd
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Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of AU2007287205A1 publication Critical patent/AU2007287205A1/en
Publication of AU2007287205B2 publication Critical patent/AU2007287205B2/en
Application granted granted Critical
Publication of AU2007287205B8 publication Critical patent/AU2007287205B8/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2007287205A 2006-08-23 2007-08-23 Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses Ceased AU2007287205B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83940906P 2006-08-23 2006-08-23
US60/839,409 2006-08-23
PCT/IL2007/001055 WO2008023378A1 (en) 2006-08-23 2007-08-23 Conjugates of rgd peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses

Publications (3)

Publication Number Publication Date
AU2007287205A1 AU2007287205A1 (en) 2008-02-28
AU2007287205B2 AU2007287205B2 (en) 2013-04-18
AU2007287205B8 true AU2007287205B8 (en) 2013-08-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007287205A Ceased AU2007287205B8 (en) 2006-08-23 2007-08-23 Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses

Country Status (12)

Country Link
US (1) US20080138278A1 (https=)
EP (1) EP2061512B1 (https=)
JP (3) JP2010502574A (https=)
AU (1) AU2007287205B8 (https=)
CA (1) CA2661319C (https=)
DK (1) DK2061512T3 (https=)
ES (1) ES2763237T3 (https=)
HU (1) HUE047789T2 (https=)
IL (1) IL197195A (https=)
PT (1) PT2061512T (https=)
RU (1) RU2450018C2 (https=)
WO (1) WO2008023378A1 (https=)

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US8673270B2 (en) * 2008-10-23 2014-03-18 Steba Biotech S.A. RGD-containing peptidomimetics and uses thereof
US8263133B2 (en) * 2009-02-18 2012-09-11 The Regents Of The University Of California Multivalent clustering targeting strategy for drug carriers
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RU2632439C2 (ru) * 2011-08-23 2017-10-04 Йеда Рисерч Энд Дивелопмент Ко., Лтд. Фотосенсибилизаторы на основе (бактерио)хлорофилла для лечения глазных заболеваний и расстройств
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CN103665107B (zh) * 2012-09-05 2017-07-14 上海晟顺生物科技有限公司 同时具溶血栓、清除自由基和血栓靶向功能的新颖化合物及其制备方法和用途
US9749232B2 (en) 2012-09-20 2017-08-29 Masimo Corporation Intelligent medical network edge router
RU2548675C9 (ru) * 2013-05-29 2015-11-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) Аминоамиды в ряду бактериохлорофилла a, обладающие фотодинамической активностью, и способ их получения
JP6263716B2 (ja) * 2013-07-31 2018-01-24 国立大学法人 筑波大学 悪性腫瘍のｐｅｔ診断用トレーサー
US10832818B2 (en) 2013-10-11 2020-11-10 Masimo Corporation Alarm notification system
US9522925B2 (en) * 2014-11-09 2016-12-20 Hong Kong Baptist University Selective cancer tracking eradicator and the uses thereof
AU2016300208B2 (en) * 2015-07-29 2019-08-08 Novartis Ag Combined use of anti PD-1 and anti M-CSF antibodies in the treatment of cancer
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Also Published As

Publication number Publication date
JP2017039700A (ja) 2017-02-23
JP2013231039A (ja) 2013-11-14
EP2061512A1 (en) 2009-05-27
CA2661319C (en) 2015-12-01
HUE047789T2 (hu) 2020-05-28
ES2763237T3 (es) 2020-05-27
AU2007287205B2 (en) 2013-04-18
JP2010502574A (ja) 2010-01-28
WO2008023378A1 (en) 2008-02-28
WO2008023378A9 (en) 2008-04-10
DK2061512T3 (da) 2020-01-20
RU2450018C2 (ru) 2012-05-10
EP2061512B1 (en) 2019-10-02
CA2661319A1 (en) 2008-02-28
AU2007287205A1 (en) 2008-02-28
US20080138278A1 (en) 2008-06-12
RU2009110226A (ru) 2010-09-27
JP6177013B2 (ja) 2017-08-09
IL197195A (en) 2015-10-29
IL197195A0 (en) 2009-12-24
PT2061512T (pt) 2020-01-14

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FGA Letters patent sealed or granted (standard patent)
TH Corrigenda

Free format text: IN VOL 27 , NO 15 , PAGE(S) 2067 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME YEDA RESEARCH & DEVELOPMENT CO. LTD, APPLICATION NO. 2007287205, UNDER INID (71) CORRECT THE APPLICANT NAME TO YEDA RESEARCH AND DEVELOPMENT CO. LTD

MK14 Patent ceased section 143(a) (annual fees not paid) or expired