IL190489A0 - [4-(benzo[b] thiophen-2-yl) pyrimidin-2yl]-amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases - Google Patents

[4-(benzo[b] thiophen-2-yl) pyrimidin-2yl]-amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases

Info

Publication number
IL190489A0
IL190489A0 IL190489A IL19048908A IL190489A0 IL 190489 A0 IL190489 A0 IL 190489A0 IL 190489 A IL190489 A IL 190489A IL 19048908 A IL19048908 A IL 19048908A IL 190489 A0 IL190489 A0 IL 190489A0
Authority
IL
Israel
Prior art keywords
ikk
thiophen
pyrimidin
benzo
cancer
Prior art date
Application number
IL190489A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL190489A0 publication Critical patent/IL190489A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL190489A 2005-11-18 2008-03-27 [4-(benzo[b] thiophen-2-yl) pyrimidin-2yl]-amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases IL190489A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73809705P 2005-11-18 2005-11-18
PCT/US2006/060911 WO2007092095A2 (en) 2005-11-18 2006-11-15 [4-(benzo [b] thi0phen-2-yl) pyrimidin-2yl] -amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases.

Publications (1)

Publication Number Publication Date
IL190489A0 true IL190489A0 (en) 2008-11-03

Family

ID=38345605

Family Applications (1)

Application Number Title Priority Date Filing Date
IL190489A IL190489A0 (en) 2005-11-18 2008-03-27 [4-(benzo[b] thiophen-2-yl) pyrimidin-2yl]-amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases

Country Status (27)

Country Link
US (1) US7547691B2 (en.when)
EP (1) EP1989200B1 (en.when)
JP (1) JP2009516697A (en.when)
KR (1) KR100990771B1 (en.when)
CN (1) CN101309918B (en.when)
AR (1) AR057911A1 (en.when)
AT (1) ATE437873T1 (en.when)
AU (1) AU2006337626B2 (en.when)
BR (1) BRPI0618245A2 (en.when)
CA (1) CA2629336A1 (en.when)
CR (1) CR9947A (en.when)
DE (1) DE602006008187D1 (en.when)
DK (1) DK1989200T3 (en.when)
EA (1) EA014426B1 (en.when)
EC (1) ECSP088456A (en.when)
ES (1) ES2329085T3 (en.when)
IL (1) IL190489A0 (en.when)
MA (1) MA30053B1 (en.when)
NO (1) NO20082594L (en.when)
PE (1) PE20070833A1 (en.when)
PL (1) PL1989200T3 (en.when)
PT (1) PT1989200E (en.when)
SI (1) SI1989200T1 (en.when)
TN (1) TNSN08227A1 (en.when)
TW (1) TW200800201A (en.when)
WO (1) WO2007092095A2 (en.when)
ZA (1) ZA200803940B (en.when)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2007752B1 (en) 2006-03-31 2010-08-18 Janssen Pharmaceutica NV Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor
WO2008011560A2 (en) * 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
BRPI0721045A2 (pt) * 2006-12-21 2014-07-29 Lilly Co Eli Compostos de aminopirimidina de imidazolidinonila para o tratamento do câncer
JP2010513553A (ja) * 2006-12-21 2010-04-30 イーライ リリー アンド カンパニー 癌治療用イミダゾリジノニルアミノピリミジン化合物
JP5248600B2 (ja) 2007-05-16 2013-07-31 イーライ リリー アンド カンパニー トリアゾリルアミノピリミジン化合物
CN101679396B (zh) 2007-05-16 2012-06-06 伊莱利利公司 三唑基氨基嘧啶化合物
TWI481603B (zh) 2008-06-30 2015-04-21 Janssen Pharmaceutica Nv 用於製備經取代之嘧啶衍生物之化合物
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
KR101123178B1 (ko) * 2009-04-09 2012-06-13 (주)에스메디 2-아릴벤조싸이오펜 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
EP2467137A1 (en) 2009-08-19 2012-06-27 Ambit Biosciences Corporation Biaryl compounds and methods of use thereof
CN102858764B (zh) 2010-04-27 2014-08-20 和记黄埔医药（上海）有限公司 嘧啶基吲哚化合物
WO2013058824A1 (en) 2011-04-07 2013-04-25 Cornell University Monomers capable of dimerizing in an aqueous solution, and methods of using same
US9245773B2 (en) 2011-09-02 2016-01-26 Taiwan Semiconductor Manufacturing Company, Ltd. Semiconductor device packaging methods and structures thereof
CN103159742B (zh) * 2011-12-16 2015-08-12 北京韩美药品有限公司 5-氯嘧啶类化合物及其作为egfr酪氨酸激酶抑制剂的应用
US10189825B2 (en) 2012-02-08 2019-01-29 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
CN105085434B (zh) * 2014-05-09 2018-02-09 上海特化医药科技有限公司 硫乙拉嗪或其中间体的制备方法
US9796699B2 (en) 2015-11-03 2017-10-24 Janssen Pharmaceutica Nv Substituted 2-[3-(1-methyl-piperidin-4-yl)-propylamino]-pyrimidine-5-carboxylic acids and amides and methods of making the same
IL264446B2 (en) 2016-07-29 2024-09-01 Pgi Drug Discovery Llc Compounds and compositions and uses thereof
SG11201900687VA (en) 2016-07-29 2019-02-27 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
US11358959B2 (en) * 2017-01-26 2022-06-14 Araxes Pharma Llc Benzothiophene and benzothiazole compounds and methods of use thereof
US11274093B2 (en) 2017-01-26 2022-03-15 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
EP3573971A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
EP3630747A1 (en) 2017-05-25 2020-04-08 Araxes Pharma LLC Quinazoline derivatives as modulators of mutant kras, hras or nras
AU2018271990A1 (en) 2017-05-25 2019-12-12 Araxes Pharma Llc Covalent inhibitors of KRAS
EP3661929B1 (en) 2017-08-02 2021-07-14 Sunovion Pharmaceuticals Inc. Isochroman compounds and uses thereof
CA3107168A1 (en) 2018-08-01 2020-02-06 Araxes Pharma Llc Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
US11136304B2 (en) 2019-03-14 2021-10-05 Sunovion Pharmaceuticals Inc. Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989011279A1 (en) * 1988-05-16 1989-11-30 Georgia State University Foundation, Inc. Nucleic acid interacting unfused heteropolycyclic compounds
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
ES2397362T3 (es) * 2004-12-17 2013-03-06 Amgen Inc. Compuestos de aminopirimidina como inhibidores de PLK

Also Published As

Publication number Publication date
DK1989200T3 (da) 2009-11-09
US7547691B2 (en) 2009-06-16
NO20082594L (no) 2008-06-10
ECSP088456A (es) 2008-06-30
KR100990771B1 (ko) 2010-10-29
WO2007092095A2 (en) 2007-08-16
JP2009516697A (ja) 2009-04-23
DE602006008187D1 (de) 2009-09-10
TW200800201A (en) 2008-01-01
PL1989200T3 (pl) 2009-12-31
WO2007092095A3 (en) 2007-11-08
ZA200803940B (en) 2009-09-30
TNSN08227A1 (en) 2009-10-30
ATE437873T1 (de) 2009-08-15
PE20070833A1 (es) 2007-08-27
AU2006337626B2 (en) 2012-03-22
BRPI0618245A2 (pt) 2011-08-23
PT1989200E (pt) 2009-10-12
CR9947A (es) 2008-11-28
ES2329085T3 (es) 2009-11-20
EP1989200B1 (en) 2009-07-29
AU2006337626A8 (en) 2008-06-19
AU2006337626A1 (en) 2007-08-16
CA2629336A1 (en) 2007-08-16
MA30053B1 (fr) 2008-12-01
US20080306082A1 (en) 2008-12-11
EP1989200A2 (en) 2008-11-12
KR20080059451A (ko) 2008-06-27
CN101309918B (zh) 2010-12-29
CN101309918A (zh) 2008-11-19
EA200801362A1 (ru) 2009-02-27
SI1989200T1 (sl) 2009-12-31
EA014426B1 (ru) 2010-12-30
AR057911A1 (es) 2007-12-26

Similar Documents

Publication Publication Date Title
IL190489A0 (en) [4-(benzo[b] thiophen-2-yl) pyrimidin-2yl]-amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases
PL3456707T3 (pl) Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych
IL183188A0 (en) Pyrrolidyl derivatives of heteroaromatic compounds as phosphodiesterase inhibitors
IL193230A (en) Use of benzoxoborol derivatives in the preparation of drugs for the treatment of inflammatory diseases
ZA201008875B (en) Thiophene or thiazole derivatives and their use as pi3k inhibitors
IL194425A0 (en) N-oxides of heterocyclic substituted bisarylureas for treating kinase-mediated diseases
MX2009006706A (es) Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos.
IL176554A0 (en) Thiophene derivatives as chk 1 inhibitors
ZA201000075B (en) Purin derivatives for use in the treatment of fab-related diseases
ZA200707896B (en) Benzazole derivatives, compositions, and methods of use as B-secretase inhibitors
ZA200801888B (en) Derivatives of 4-piperazin-1-1-YL-4-benzo [B] thiophene suitable for the treatment of CNS disorders
AU2006343359A8 (en) Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
IL201537A0 (en) Heteroaryl substituted pyarzole derivatives useful for treating hyper- proliferative disorders and diseases associated with angiogenesis
IL184934A0 (en) 4-oxoquinazoline-3-yl-benzamide derivatives for the treatment of cytokine diseases
ZA200710605B (en) New 2-azetidinone derivatives for the treatment of hyperlipidaemic diseases
ZA200809024B (en) 2-Pyridone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial
IL212716A0 (en) Thieno [3,2-c] pyridine derivatives as kinase inhibitors for use in the treatment of cancer
PL2049127T3 (pl) N-metanokarbapochodne do leczenia chorób serca
IL197504A0 (en) ISOSERINE DERIVATIVES AS INHIBITORS OF COAGULATION FACTOR IXa
IL179210A0 (en) Heterocyclic derivatives for treatment of hyperlipidemia and related diseases
PT1828151E (pt) Derivados de malonamida como inibidores de gama-secretase para o tratamento da doença de alzheimer
IL189928A0 (en) Thiophene derivatives for the treatment of diabetes
HK1123805A (en) [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-amine derivatives as ikk-beta inhibitors for the treatment of cancer and inflammatory diseases
IL194261A0 (en) S-alkylisothiouronium derivatives for the treatment of inflammatory diseases
PL3733642T3 (pl) Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych