IL159087A0 - Bridged bicyclic compounds and pharmaceutical compositions containing the same - Google Patents

Bridged bicyclic compounds and pharmaceutical compositions containing the same

Info

Publication number
IL159087A0
IL159087A0 IL15908702A IL15908702A IL159087A0 IL 159087 A0 IL159087 A0 IL 159087A0 IL 15908702 A IL15908702 A IL 15908702A IL 15908702 A IL15908702 A IL 15908702A IL 159087 A0 IL159087 A0 IL 159087A0
Authority
IL
Israel
Prior art keywords
bridged bicyclic
compounds
same
pharmaceutical compositions
compositions containing
Prior art date
Application number
IL15908702A
Other languages
English (en)
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of IL159087A0 publication Critical patent/IL159087A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL15908702A 2001-07-11 2002-07-11 Bridged bicyclic compounds and pharmaceutical compositions containing the same IL159087A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30461501P 2001-07-11 2001-07-11
US32271401P 2001-09-17 2001-09-17
PCT/US2002/022027 WO2003006490A1 (en) 2001-07-11 2002-07-11 Bridged bicyclic serine protease inhibitors

Publications (1)

Publication Number Publication Date
IL159087A0 true IL159087A0 (en) 2004-05-12

Family

ID=26974129

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15908702A IL159087A0 (en) 2001-07-11 2002-07-11 Bridged bicyclic compounds and pharmaceutical compositions containing the same
IL159087A IL159087A (en) 2001-07-11 2003-11-27 Bridged bicycles and pharmaceutical preparations containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159087A IL159087A (en) 2001-07-11 2003-11-27 Bridged bicycles and pharmaceutical preparations containing them

Country Status (15)

Country Link
US (1) US6909000B2 (de)
EP (1) EP1404704B9 (de)
JP (1) JP4455056B2 (de)
KR (1) KR100926244B1 (de)
CN (1) CN100402549C (de)
AT (1) ATE349463T1 (de)
CA (1) CA2449504A1 (de)
DE (1) DE60217114T2 (de)
ES (1) ES2279879T3 (de)
HK (1) HK1065322A1 (de)
IL (2) IL159087A0 (de)
MX (1) MXPA04000293A (de)
NO (1) NO20040127L (de)
NZ (1) NZ530000A (de)
WO (1) WO2003006490A1 (de)

Families Citing this family (83)

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PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
ATE539744T1 (de) * 2001-10-24 2012-01-15 Vertex Pharma Hemmer von serin-protease, insbesondere von hepatitis-c-virus-ns3-ns4a-protease, mit einem kondensierten ringsystem
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CA2536570A1 (en) * 2003-08-26 2005-03-10 Schering Corporation Novel peptidomimetic ns3-serine protease inhibitors of hepatitis c virus
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US20050119189A1 (en) * 2003-09-18 2005-06-02 Cottrell Kevin M. Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
EP1692157B1 (de) * 2003-10-10 2013-04-17 Vertex Pharmaceuticals Incorporated Inhibitoren von serinproteasen, insbesondere hcv-ns3-ns4a-protease
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EP1944042A1 (de) 2003-10-27 2008-07-16 Vertex Pharmceuticals Incorporated Kombinationen für die HCV-Behandlung
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EP2399916B1 (de) * 2004-03-12 2014-12-10 Vertex Pharmaceuticals Incorporated Verfahren und Zwischenprodukte zur Herstellung von Asparaginacetal-Caspase-Inhibitoren
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US7964624B1 (en) 2005-08-26 2011-06-21 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases
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Also Published As

Publication number Publication date
DE60217114T2 (de) 2007-10-25
KR20040018445A (ko) 2004-03-03
IL159087A (en) 2009-08-03
ES2279879T3 (es) 2007-09-01
CN100402549C (zh) 2008-07-16
JP2005522409A (ja) 2005-07-28
NZ530000A (en) 2007-03-30
CA2449504A1 (en) 2003-01-23
US6909000B2 (en) 2005-06-21
WO2003006490A1 (en) 2003-01-23
CN1525979A (zh) 2004-09-01
KR100926244B1 (ko) 2009-11-12
NO20040127L (no) 2004-03-11
DE60217114D1 (de) 2007-02-08
EP1404704A1 (de) 2004-04-07
US20030119752A1 (en) 2003-06-26
JP4455056B2 (ja) 2010-04-21
EP1404704B1 (de) 2006-12-27
HK1065322A1 (en) 2005-02-18
MXPA04000293A (es) 2004-05-04
EP1404704B9 (de) 2008-02-20
ATE349463T1 (de) 2007-01-15

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