IL157875A0 - Pyrazole derivatives for treating hiv - Google Patents

Pyrazole derivatives for treating hiv

Info

Publication number
IL157875A0
IL157875A0 IL15787502A IL15787502A IL157875A0 IL 157875 A0 IL157875 A0 IL 157875A0 IL 15787502 A IL15787502 A IL 15787502A IL 15787502 A IL15787502 A IL 15787502A IL 157875 A0 IL157875 A0 IL 157875A0
Authority
IL
Israel
Prior art keywords
pyrazole derivatives
treating hiv
hiv
treating
pyrazole
Prior art date
Application number
IL15787502A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0108999A external-priority patent/GB0108999D0/en
Priority claimed from GB0127426A external-priority patent/GB0127426D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of IL157875A0 publication Critical patent/IL157875A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL15787502A 2001-04-10 2002-04-04 Pyrazole derivatives for treating hiv IL157875A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0108999A GB0108999D0 (en) 2001-04-10 2001-04-10 Pyrazole derivatives
GB0127426A GB0127426D0 (en) 2001-11-15 2001-11-15 Pyrazole derivatives
PCT/IB2002/001234 WO2002085860A1 (en) 2001-04-10 2002-04-04 Pyrazole derivatives for treating hiv

Publications (1)

Publication Number Publication Date
IL157875A0 true IL157875A0 (en) 2004-03-28

Family

ID=26245955

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15787502A IL157875A0 (en) 2001-04-10 2002-04-04 Pyrazole derivatives for treating hiv
IL157875A IL157875A (en) 2001-04-10 2003-09-11 Pyrazole derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating hiv

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL157875A IL157875A (en) 2001-04-10 2003-09-11 Pyrazole derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating hiv

Country Status (43)

Country Link
US (4) US7109228B2 (sh)
EP (2) EP1377556B1 (sh)
JP (1) JP3806090B2 (sh)
KR (1) KR100569324B1 (sh)
CN (1) CN100408564C (sh)
AR (2) AR037319A1 (sh)
AT (2) ATE358669T1 (sh)
AU (1) AU2002242926B2 (sh)
BG (1) BG66349B1 (sh)
BR (1) BRPI0208811B8 (sh)
CA (1) CA2443449C (sh)
CR (1) CR7069A (sh)
CY (2) CY1107626T1 (sh)
CZ (1) CZ305099B6 (sh)
DE (1) DE60219292T2 (sh)
DK (2) DK1377556T3 (sh)
DO (1) DOP2002000378A (sh)
EA (1) EA007184B1 (sh)
EE (1) EE05400B1 (sh)
ES (2) ES2385659T3 (sh)
GE (1) GEP20053619B (sh)
HK (1) HK1063781A1 (sh)
HR (1) HRP20030783B1 (sh)
HU (1) HU229025B1 (sh)
IL (2) IL157875A0 (sh)
IS (1) IS2734B (sh)
MA (1) MA27009A1 (sh)
ME (1) ME00558A (sh)
MX (1) MXPA03009380A (sh)
MY (1) MY146669A (sh)
NO (1) NO326518B1 (sh)
NZ (1) NZ529403A (sh)
OA (1) OA12501A (sh)
PA (1) PA8543601A1 (sh)
PE (1) PE20021056A1 (sh)
PL (3) PL216985B1 (sh)
PT (2) PT1762567E (sh)
RS (1) RS51166B (sh)
SI (2) SI1377556T1 (sh)
SK (1) SK287858B6 (sh)
TW (1) TWI333488B (sh)
UY (1) UY27248A1 (sh)
WO (1) WO2002085860A1 (sh)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1377556T3 (da) * 2001-04-10 2007-07-16 Pfizer Pyrazolderivater til behandling af HIV
US20050119246A1 (en) * 2001-12-28 2005-06-02 Bayer Pharmaceuticals Corporation 1H-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor
JP4228587B2 (ja) * 2002-05-22 2009-02-25 昭和電工株式会社 アミノメチル基含有ベンズアミド化合物の製造方法
GB0221477D0 (en) * 2002-09-16 2002-10-23 Pfizer Ltd Chemical compounds
US20040132793A1 (en) * 2002-09-16 2004-07-08 Pfizer Inc. Pyrazole derivatives
US6933312B2 (en) 2002-10-07 2005-08-23 Agouron Pharmaceuticals, Inc. Pyrazole derivatives
GB0223234D0 (en) * 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
GB0223232D0 (en) * 2002-10-07 2002-11-13 Pfizer Ltd Chemical compounds
TW200423930A (en) * 2003-02-18 2004-11-16 Hoffmann La Roche Non-nucleoside reverse transcriptase inhibitors
KR20050119652A (ko) 2003-03-24 2005-12-21 에프. 호프만-라 로슈 아게 역전사 효소 저해제로서의 벤질-피리다진온
US20070066591A1 (en) * 2003-05-14 2007-03-22 Xiangping Qian Compounds, compositions, and methods
US7220772B2 (en) 2003-09-05 2007-05-22 Pfizer, Inc. Pyrazole derivatives
US7102001B2 (en) * 2003-12-12 2006-09-05 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine
WO2005080320A1 (en) 2004-02-13 2005-09-01 Warner-Lambert Company Llc Androgen receptor modulators
EP1737813A1 (en) 2004-04-13 2007-01-03 Warner-Lambert Company LLC Androgen modulators
CA2562672C (en) 2004-04-22 2009-09-29 Warner-Lambert Company Llc 4-cyano-phenoxy derivatives as androgen modulators
AR048650A1 (es) * 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
BRPI0513020A (pt) 2004-07-08 2008-04-22 Warner Lambert Co moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação
JP2008536910A (ja) * 2005-04-20 2008-09-11 ファイザー・リミテッド プロゲステロン受容体アンタゴニストとしてのピラゾール誘導体
TW200724139A (en) 2005-05-05 2007-07-01 Warner Lambert Co Androgen modulators
AR057455A1 (es) * 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
CA2628844C (en) * 2005-11-08 2011-12-06 Pfizer Limited Pyrazole derivatives and their medical use
JP5269761B2 (ja) 2006-04-12 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション ピリジルアミドｔ型カルシウムチャンネルアンタゴニスト
DE602007013573D1 (de) 2006-08-16 2011-05-12 Hoffmann La Roche Nicht-nukleosidische reverse-transkriptase-hemmer
US20080096950A1 (en) * 2006-10-19 2008-04-24 Karl Richard Gibson Compounds Useful In Therapy
US9280685B2 (en) * 2006-12-08 2016-03-08 Johnnie R. Jackson System and method for portable medical records
WO2008135824A1 (en) * 2007-05-02 2008-11-13 Pfizer Limited Oxyalkylpyrazole compounds useful in therapy
CN101784529A (zh) 2007-06-22 2010-07-21 弗·哈夫曼-拉罗切有限公司 作为非核苷逆转录酶抑制剂的脲和氨基甲酸酯衍生物
BRPI0818244A2 (pt) 2007-10-24 2015-06-16 Merck Sharp & Dohme Composto, composição farmacêutica, uso de um composto, e, método para tratamento de um distúrbio ou doença
WO2009054983A1 (en) * 2007-10-24 2009-04-30 Merck & Co., Inc. Heterocycle amide t-type calcium channel antagonists
KR101610415B1 (ko) 2007-12-21 2016-04-07 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
HUE026849T2 (en) 2010-01-27 2016-08-29 Viiv Healthcare Company Corp Service Company Therapeutic combination containing dolutegravir, abacavir and lamivudine
US20110282250A1 (en) * 2010-04-13 2011-11-17 Fung Gregory W Methods and devices for treating atrial fibrillation
EP2625292B1 (en) 2010-10-07 2018-12-05 The General Hospital Corporation Biomarkers of cancer
EP2649053B1 (en) * 2010-12-06 2015-11-04 Glaxo Group Limited Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp-pla2
WO2013057593A1 (en) 2011-10-07 2013-04-25 Phivco Uk Limited Process for the preparation of lersivirine
WO2013050884A1 (en) 2011-10-07 2013-04-11 Phivco Uk Limited Process for the preparation of lersivirine
WO2013050873A1 (en) 2011-10-07 2013-04-11 Phivco Uk Limited Process for the preparation of lersivirine
EP2716632A1 (en) * 2012-10-05 2014-04-09 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
US9695127B2 (en) 2012-11-08 2017-07-04 University of Pittsburgh—of the Commonwealth System of Higher Education Compounds for treating HIV and methods for using the compounds
US10026064B2 (en) 2013-09-13 2018-07-17 Microsoft Technology Licensing, Llc Automatically recommending updates based on stored lifecycle information
US20160318933A1 (en) * 2013-10-23 2016-11-03 Sumitomo Dainippon Pharma Co., Ltd. Fused pyrazole derivative
WO2015171392A1 (en) * 2014-05-06 2015-11-12 E. I. Du Pont De Nemours And Company Fungicidal pyrazoles
WO2016066664A1 (en) * 2014-10-31 2016-05-06 F. Hoffmann-La Roche Ag New pyridinyloxy- and phenyloxy-pyrazolyl compounds
US9925190B2 (en) 2015-02-16 2018-03-27 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecules targeting HIV-1 Nef
JOP20180092A1 (ar) * 2017-10-13 2019-04-13 Gilead Sciences Inc مثبطات hiv بروتياز
CA3090652A1 (en) 2018-02-06 2019-08-15 The General Hospital Corporation Repeat rna as biomarkers of tumor immune response
KR102114389B1 (ko) * 2018-05-02 2020-05-25 이화여자대학교 산학협력단 신규 소듐채널 저해 화합물, 이의 제조방법, 및 이를 포함하는 소듐채널 관련 질환의 예방 또는 치료용 약학적 조성물
WO2020056564A1 (zh) * 2018-09-17 2020-03-26 南通纺织丝绸产业技术研究院 基于金属氢化物/钯化合物体系制备1,3-二羰基化合物的方法
JP2022504982A (ja) * 2018-10-18 2022-01-13 南京聖和薬業股▲ふん▼有限公司 ＴＧＦ－βＲ１阻害剤としての化合物及びその応用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303200A (en) * 1963-11-05 1967-02-07 American Home Prod Pyrazole-1-ethanol derivatives
US3963742A (en) * 1974-07-12 1976-06-15 American Cyanamid Company 1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as herbicidal agents
US4009277A (en) * 1975-01-17 1977-02-22 American Cyanamid Company 1,2-Dialkyl-3,4,5-trisubstituted pyrazolium salts as fungicidal agents
US4041046A (en) 1975-06-06 1977-08-09 American Cyanamid Company 1,2-Dialkyl-3,4,5-trisubstituted pyrazole compounds
US4000301A (en) 1975-11-14 1976-12-28 American Cyanamid Company Fungicidal use of 4-alkoxypyrazoles
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
JPH0565237A (ja) 1991-09-10 1993-03-19 Mitsubishi Heavy Ind Ltd メタノールを媒体としたエネルギ供給方法
FR2682379B1 (fr) * 1991-10-09 1994-02-11 Rhone Poulenc Agrochimie Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en) 1993-03-31 1994-10-13 Smithkline Beecham Corporation Chemical compounds
FR2707295A1 (fr) 1993-06-07 1995-01-13 Rhone Poulenc Agrochimie Fongicides pyrazoles substitués en position 3 par un hétérocycle.
EP0658547B1 (en) 1993-12-14 1998-03-11 Mitsubishi Chemical Corporation N-pyrazolyl carbamate derivative, agricultural/horticultural fungicide containing the same as active ingredient and production intermediate thereof
FR2722369B1 (fr) 1994-07-13 1998-07-10 Rhone Poulenc Agrochimie Compositions fongicides a base de derives 3-phenyl-pyrazoles pour le traitement du materiel vegetal de multiplication, nouveaux derives 3-phenyl-pyrazoles et leurs applications fongicides
ATE255564T1 (de) * 1994-09-26 2003-12-15 Shionogi & Co Imidazolderivat
TW343232B (en) * 1994-10-13 1998-10-21 Chisso Corp Difluorooxymethane derivative and liquid crystal composition
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
CA2876779A1 (en) * 2000-05-12 2001-11-22 Genzyme Corporation Modulators of tnf-.alpha. signaling
GB0016787D0 (en) 2000-07-07 2000-08-30 Pfizer Ltd Compounds useful in therapy
DK1377556T3 (da) * 2001-04-10 2007-07-16 Pfizer Pyrazolderivater til behandling af HIV

Also Published As

Publication number Publication date
NZ529403A (en) 2005-06-24
MA27009A1 (fr) 2004-12-20
BG66349B1 (bg) 2013-08-30
PE20021056A1 (es) 2002-12-03
HRP20030783A2 (en) 2005-08-31
DK1762567T3 (da) 2012-06-25
ATE556059T1 (de) 2012-05-15
CA2443449A1 (en) 2002-10-31
BR0208811A (pt) 2004-03-09
BRPI0208811B8 (pt) 2021-05-25
CZ305099B6 (cs) 2015-05-06
EE200300497A (et) 2004-02-16
ES2385659T3 (es) 2012-07-27
US20060020012A1 (en) 2006-01-26
KR100569324B1 (ko) 2006-04-07
US20090215712A1 (en) 2009-08-27
HK1063781A1 (en) 2005-01-14
EA200300943A1 (ru) 2004-08-26
AU2002242926B2 (en) 2007-10-11
PL217224B1 (pl) 2014-06-30
PT1377556E (pt) 2007-06-06
DK1377556T3 (da) 2007-07-16
JP3806090B2 (ja) 2006-08-09
DE60219292T2 (de) 2008-04-10
AR037319A1 (es) 2004-11-03
KR20040007496A (ko) 2004-01-24
US20030100554A1 (en) 2003-05-29
JP2004531535A (ja) 2004-10-14
IS2734B (is) 2011-04-15
EP1377556B1 (en) 2007-04-04
WO2002085860A1 (en) 2002-10-31
UY27248A1 (es) 2002-11-29
PT1762567E (pt) 2012-07-16
US7109228B2 (en) 2006-09-19
EA007184B1 (ru) 2006-08-25
PL396946A1 (pl) 2012-01-02
NO20034523L (no) 2003-12-09
IS6939A (is) 2003-09-04
RS51166B (sr) 2010-10-31
OA12501A (en) 2006-05-26
SK287858B6 (sk) 2012-01-04
HRP20030783B1 (en) 2011-11-30
CA2443449C (en) 2008-11-04
EP1762567A1 (en) 2007-03-14
CY1113515T1 (el) 2016-06-22
NO326518B1 (no) 2008-12-22
HUP0303735A2 (hu) 2004-03-01
DOP2002000378A (es) 2002-10-15
PL365026A1 (en) 2004-12-27
PL216985B1 (pl) 2014-06-30
SI1762567T1 (sl) 2012-08-31
NO20034523D0 (no) 2003-10-09
US20120029192A1 (en) 2012-02-02
CR7069A (es) 2007-12-17
PL398536A1 (pl) 2012-06-04
IL157875A (en) 2010-05-17
MXPA03009380A (es) 2004-04-21
SK12442003A3 (sk) 2004-12-01
BG108244A (bg) 2005-04-30
CY1107626T1 (el) 2013-04-18
EE05400B1 (et) 2011-04-15
HU229025B1 (en) 2013-07-29
CN1514828A (zh) 2004-07-21
DE60219292D1 (de) 2007-05-16
CN100408564C (zh) 2008-08-06
TWI333488B (en) 2010-11-21
US7435728B2 (en) 2008-10-14
MY146669A (en) 2012-09-14
EP1377556A1 (en) 2004-01-07
PL217629B1 (pl) 2014-08-29
AR076259A2 (es) 2011-06-01
PA8543601A1 (es) 2002-10-31
BRPI0208811B1 (pt) 2018-03-13
EP1762567B1 (en) 2012-05-02
GEP20053619B (en) 2005-09-26
HUP0303735A3 (en) 2004-07-28
US8063044B2 (en) 2011-11-22
YU77503A (sh) 2006-05-25
CZ20032676A3 (cs) 2004-11-10
ME00558A (en) 2011-12-20
ES2283532T3 (es) 2007-11-01
SI1377556T1 (sl) 2007-08-31
ATE358669T1 (de) 2007-04-15

Similar Documents

Publication Publication Date Title
IL157875A0 (en) Pyrazole derivatives for treating hiv
HK1146646A1 (en) Imidazole derivatives
IL160642A0 (en) Pyrrolidinone derivatives
IL160701A0 (en) 3-substituted-4-pyrimidone derivatives
ZA200309522B (en) Substituted cyclohexane-1-4diamine derivatives
MXPA03000059A (es) Derivados de pirazol.
HK1066218A1 (en) Qunazoline derivatives as antitumor agents
IL153787A0 (en) Imidazole derivatives
HK1145449A1 (en) Hiv inhibiting pyrimidines derivatives hiv
EP1390029A4 (en) PHENYLINDOLES FOR THE TREATMENT OF HIV INFECTION
IL159742A0 (en) Azole derivatives useful as insecticide
HUP0303449A3 (en) Substituted benzofuran-2-carboxamides derivatives
HUP0303186A3 (en) 4-aminobenzopyran derivatives
HUP0401949A3 (en) 4-imidazolin-2-one derivatives
AU4498201A (en) Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment ofpain
HUP0500026A3 (en) N-heteroarylnicotinamide derivatives
PL369674A1 (en) Pyrazole derivatives as psychopharmaceuticals
IL159064A0 (en) New phenylalkyloxy- phenyl derivatives
ZA200404807B (en) Imidazoquinoline derivatives.
MXPA03008394A (es) Derivados de biuretano.
HK1049999B (zh) 咪唑類衍生物
EP1364954A4 (en) Dicarba closo DODECARBORANDERIVATE
IL160369A0 (en) Process for preparing pyridyl-alkylsulfonyl pyrazole derivatives
EP1451178A4 (en) PROCESS FOR PREPARING BEAT D RIBOFURANOSE DERIVATIVES
GB0127426D0 (en) Pyrazole derivatives