IL156462A0 - Pyridazinone aldose reductase inhibitors - Google Patents

Pyridazinone aldose reductase inhibitors

Info

Publication number
IL156462A0
IL156462A0 IL15646202A IL15646202A IL156462A0 IL 156462 A0 IL156462 A0 IL 156462A0 IL 15646202 A IL15646202 A IL 15646202A IL 15646202 A IL15646202 A IL 15646202A IL 156462 A0 IL156462 A0 IL 156462A0
Authority
IL
Israel
Prior art keywords
reductase inhibitors
aldose reductase
pyridazinone aldose
pyridazinone
inhibitors
Prior art date
Application number
IL15646202A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of IL156462A0 publication Critical patent/IL156462A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL15646202A 2001-03-30 2002-01-31 Pyridazinone aldose reductase inhibitors IL156462A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28005101P 2001-03-30 2001-03-30
PCT/IB2002/000320 WO2002079198A1 (fr) 2001-03-30 2002-01-31 Inhibiteurs pyridazinone d'aldose réductase

Publications (1)

Publication Number Publication Date
IL156462A0 true IL156462A0 (en) 2004-01-04

Family

ID=23071435

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15646202A IL156462A0 (en) 2001-03-30 2002-01-31 Pyridazinone aldose reductase inhibitors

Country Status (44)

Country Link
US (2) US6579879B2 (fr)
EP (3) EP1491540B1 (fr)
JP (1) JP2004528319A (fr)
KR (1) KR100586138B1 (fr)
CN (1) CN1215067C (fr)
AP (1) AP2002002461A0 (fr)
AR (1) AR035798A1 (fr)
AT (3) ATE286049T1 (fr)
AU (1) AU2002226634B2 (fr)
BG (1) BG108179A (fr)
BR (1) BR0208571A (fr)
CA (1) CA2442476A1 (fr)
CZ (1) CZ20032563A3 (fr)
DE (3) DE60216823T2 (fr)
DK (2) DK1373259T3 (fr)
EA (1) EA006023B1 (fr)
EC (1) ECSP034671A (fr)
EE (1) EE200300470A (fr)
ES (2) ES2231681T3 (fr)
GE (1) GEP20053675B (fr)
HK (1) HK1061678A1 (fr)
HR (1) HRP20030752A2 (fr)
HU (1) HUP0303644A3 (fr)
IL (1) IL156462A0 (fr)
IS (3) IS2205B (fr)
MA (1) MA27003A1 (fr)
MX (1) MXPA03008850A (fr)
MY (1) MY134304A (fr)
NO (1) NO20034345D0 (fr)
NZ (1) NZ528406A (fr)
OA (1) OA12453A (fr)
PA (1) PA8541801A1 (fr)
PE (1) PE20030007A1 (fr)
PL (1) PL365294A1 (fr)
PT (2) PT1491540E (fr)
SI (1) SI1373259T1 (fr)
SK (1) SK11852003A3 (fr)
TN (1) TNSN02037A1 (fr)
TW (1) TWI245762B (fr)
UA (1) UA73236C2 (fr)
UY (1) UY27237A1 (fr)
WO (1) WO2002079198A1 (fr)
YU (1) YU71403A (fr)
ZA (1) ZA200304671B (fr)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ-氨基丁酸及其衍生物
ES2240657T3 (es) * 2001-02-28 2005-10-16 Pfizer Products Inc. Compuestos de sulfonilpiridazinona utiles como inhibidores de aldosa reductasa.
EE200300470A (et) * 2001-03-30 2004-02-16 Pfizer Products Inc. Aldoosreduktaasi püridasinooninhibiitorid
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
IL162594A0 (en) * 2002-01-09 2005-11-20 Pfizer Prod Inc Process and intermediates for pyridazinone antidiabetic agents
US7419981B2 (en) * 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US20040092522A1 (en) * 2002-08-15 2004-05-13 Field Mark John Synergistic combinations
US6872833B2 (en) * 2003-04-14 2005-03-29 Hoffmann-La Roche Inc. Adenosine receptor ligands
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
DE602005025755D1 (de) 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
WO2006028565A2 (fr) * 2004-06-30 2006-03-16 Whitehead Institute For Biomedical Research Procedes pour analyse de site haut rendement au niveau du genome
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
KR20080114688A (ko) * 2006-01-13 2008-12-31 와이어쓰 5-히드록시트립타민 수용체에 대한 리간드로서의 술포닐 치환된 1h-인돌
PT2248812E (pt) 2006-06-27 2014-03-12 Takeda Pharmaceutical Compostos cíclicos fundidos como moduladores do receptor gpr40
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
JP5815552B2 (ja) 2009-12-08 2015-11-17 ケース ウェスタン リザーブ ユニバーシティCase Westernreserve University 眼疾患を治療する化合物および方法
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
CA2848877A1 (fr) * 2011-09-15 2013-03-21 Taipei Medical University Utilisation d'indolyl et d'hydroxamates d'indolinyl pour le traitement d'une defaillance cardiaque ou d'une lesion neuronale
US9339542B2 (en) * 2013-04-16 2016-05-17 John L Couvaras Hypertension reducing composition
SG11201507496UA (en) 2013-04-17 2015-11-27 Pfizer N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN103739547B (zh) * 2014-01-03 2015-09-02 沈阳药科大学 2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
EP3283074A4 (fr) * 2015-04-14 2018-12-05 Case Western Reserve University Compositions et procédés de modulation de l'activité de la déshydrogénase à chaîne courte
WO2017168174A1 (fr) 2016-04-02 2017-10-05 N4 Pharma Uk Limited Nouvelles formes pharmaceutiques du sildénafil
EP4316603A3 (fr) 2016-06-21 2024-04-17 The Trustees of Columbia University in the City of New York Composés de 4-oxo-3,4-dihydrothiéno[3,4-d!pyridazine utilisés comme inhibiteurs de l'aldose réductase et leurs procédés d'utilisation
WO2018002673A1 (fr) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Nouvelles formulations d'antagonistes du récepteur de l'angiotensine ii
WO2018058109A1 (fr) * 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions et méthodes pour le traitement de troubles métaboliques
JP2020502070A (ja) 2016-11-30 2020-01-23 ケース ウエスタン リザーブ ユニバーシティ 15−pgdh阻害剤とコルチコステロイドおよび/またはtnf阻害剤との組み合わせならびにその使用
JP2020514323A (ja) 2017-02-06 2020-05-21 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物と方法
EP4417260A2 (fr) 2017-07-28 2024-08-21 Applied Therapeutics, Inc. Compositions et procédés pour traiter la galactosémie
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
AU2020268368A1 (en) 2019-05-07 2022-01-06 Ucl Business Ltd Treatment and detection of inherited neuropathies and associated disorders
MX2021014441A (es) 2019-05-31 2022-01-06 Ikena Oncology Inc Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
CA3142351A1 (fr) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations
WO2022120353A1 (fr) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Inhibiteurs de tead et leurs utilisations

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE47592B1 (en) 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4939140A (en) 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
US4996204A (en) 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
FR2647676A1 (fr) 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
EP0516860A4 (en) * 1990-11-30 1993-12-01 Tsumura & Co. Chromone derivative and aldose reductase inhibitor containing the same as active ingredient
AU658887B2 (en) 1991-03-28 1995-05-04 Pfizer Inc. Pyridazinone acetic acids as aldose reductase inhibitors
US5834466A (en) 1994-12-22 1998-11-10 The Regents Of The University Of California Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia
TWI238064B (en) 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
SK3902000A3 (en) * 1997-09-24 2000-12-11 Orion Corp Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors
FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
EE200300470A (et) * 2001-03-30 2004-02-16 Pfizer Products Inc. Aldoosreduktaasi püridasinooninhibiitorid
HUP0303920A3 (en) * 2001-04-30 2004-07-28 Pfizer Prod Inc Pharmaceutical compositions containing combinations of aldose reductase inhibitor pyridazinons and cyclooxygenase 2 inhibitors
IL162594A0 (en) * 2002-01-09 2005-11-20 Pfizer Prod Inc Process and intermediates for pyridazinone antidiabetic agents

Also Published As

Publication number Publication date
DE60217930D1 (de) 2007-03-15
AP2002002461A0 (en) 2002-06-30
YU71403A (sh) 2006-05-25
EP1373259B1 (fr) 2004-12-29
IS2205B (is) 2007-02-15
EA006023B1 (ru) 2005-08-25
HUP0303644A2 (hu) 2004-03-01
EE200300470A (et) 2004-02-16
DK1491540T3 (da) 2007-03-26
ZA200304671B (en) 2004-06-25
BR0208571A (pt) 2004-03-23
PE20030007A1 (es) 2003-01-28
DK1373259T3 (da) 2005-03-29
US20020143017A1 (en) 2002-10-03
AR035798A1 (es) 2004-07-14
NZ528406A (en) 2004-03-26
CA2442476A1 (fr) 2002-10-10
NO20034345L (no) 2003-09-29
PT1491540E (pt) 2007-01-31
MA27003A1 (fr) 2004-12-20
AU2002226634B2 (en) 2007-01-25
DE60216823T2 (de) 2007-10-04
PA8541801A1 (es) 2002-10-28
TWI245762B (en) 2005-12-21
OA12453A (en) 2006-05-24
EA200300673A1 (ru) 2003-12-25
WO2002079198A1 (fr) 2002-10-10
EP1491540A1 (fr) 2004-12-29
ATE348100T1 (de) 2007-01-15
UY27237A1 (es) 2002-12-31
DE60202452T2 (de) 2006-02-09
CN1215067C (zh) 2005-08-17
SI1373259T1 (en) 2005-04-30
ATE286049T1 (de) 2005-01-15
HUP0303644A3 (en) 2008-06-30
US6849629B2 (en) 2005-02-01
DE60202452D1 (de) 2005-02-03
HRP20030752A2 (en) 2005-06-30
EP1491540B1 (fr) 2006-12-13
CZ20032563A3 (cs) 2004-05-12
DE60202452C5 (de) 2006-11-23
IS8250A (is) 2006-01-23
IS6845A (is) 2003-06-16
SK11852003A3 (sk) 2004-07-07
CN1500087A (zh) 2004-05-26
NO20034345D0 (no) 2003-09-29
DE60216823D1 (de) 2007-01-25
MXPA03008850A (es) 2003-12-04
UA73236C2 (en) 2005-06-15
ECSP034671A (es) 2003-08-29
MY134304A (en) 2007-12-31
EP1491541B1 (fr) 2007-01-24
IS8251A (is) 2006-01-23
EP1491541A1 (fr) 2004-12-29
DE60217930T2 (de) 2007-10-18
BG108179A (en) 2004-09-30
HK1061678A1 (en) 2004-09-30
EP1373259A1 (fr) 2004-01-02
ES2274369T3 (es) 2007-05-16
US20030162784A1 (en) 2003-08-28
KR20030088484A (ko) 2003-11-19
PL365294A1 (en) 2004-12-27
US6579879B2 (en) 2003-06-17
PT1373259E (pt) 2005-03-31
TNSN02037A1 (fr) 2005-12-23
KR100586138B1 (ko) 2006-06-07
GEP20053675B (en) 2005-11-25
ATE352551T1 (de) 2007-02-15
JP2004528319A (ja) 2004-09-16
ES2231681T3 (es) 2005-05-16

Similar Documents

Publication Publication Date Title
IL156462A0 (en) Pyridazinone aldose reductase inhibitors
AU2002250394A1 (en) Rho-kinase inhibitors
AU2002245709A1 (en) Rho-kinase inhibitors
AU2002357117A8 (en) Simplified eukaryotic nitrate reductase
PL363391A1 (en) Phthalayinone-piperidino-derivatives as pde4 inhibitors
GB2406009B (en) Amplifier
AU4217201A (en) Tri-aryl-substituted-ethane pde4 inhibitors
IL158099A0 (en) Amplifier
EP1570847A4 (fr) Inhibiteurs de phosphodiesterase 10a
AU2002303712A1 (en) Novel telomerase inhibitors and uses therefor
AU2003244080A1 (en) Phosphodiesterase inhibitor
GB0101784D0 (en) Amplifier
EP1352911A4 (fr) Inhibiteurs de l'enzyme de conversion de l'angiotensine
GB0109278D0 (en) Enzyme inhibitors
GB0001565D0 (en) Dihydrofolate reductase inhibitors
GB2381977B (en) Amplifiers
GB0110854D0 (en) Amplifier
GB0120882D0 (en) Amplifier
GB0116458D0 (en) Amplifier
GB0104691D0 (en) Enzyme inhibitor
GB0109145D0 (en) Enzyme inhibitors
GB0101537D0 (en) Enzyme inhibitors
GB0102018D0 (en) Enzyme inhibitors
GB0102194D0 (en) Enzyme inhibitors
GB0106564D0 (en) Enzyme inhibitors