IL155281A0 - Methods for determining protein and peptide terminal sequences - Google Patents

Methods for determining protein and peptide terminal sequences

Info

Publication number
IL155281A0
IL155281A0 IL15528101A IL15528101A IL155281A0 IL 155281 A0 IL155281 A0 IL 155281A0 IL 15528101 A IL15528101 A IL 15528101A IL 15528101 A IL15528101 A IL 15528101A IL 155281 A0 IL155281 A0 IL 155281A0
Authority
IL
Israel
Prior art keywords
methods
molecules
mass
useful
terminal sequences
Prior art date
Application number
IL15528101A
Other languages
English (en)
Original Assignee
Target Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Target Discovery Inc filed Critical Target Discovery Inc
Publication of IL155281A0 publication Critical patent/IL155281A0/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Peptides Or Proteins (AREA)
IL15528101A 2000-10-19 2001-10-19 Methods for determining protein and peptide terminal sequences IL155281A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24216500P 2000-10-19 2000-10-19
US24239800P 2000-10-19 2000-10-19
PCT/US2001/049491 WO2002061661A2 (fr) 2000-10-19 2001-10-19 Procedes servant a determiner des sequences terminales de proteines et de peptides

Publications (1)

Publication Number Publication Date
IL155281A0 true IL155281A0 (en) 2003-11-23

Family

ID=26934884

Family Applications (5)

Application Number Title Priority Date Filing Date
IL15551801A IL155518A0 (en) 2000-10-19 2001-10-19 Mass defect labeling for the determination of oligomer sequences
IL15528101A IL155281A0 (en) 2000-10-19 2001-10-19 Methods for determining protein and peptide terminal sequences
IL155281A IL155281A (en) 2000-10-19 2003-04-08 Methods for determining protein and peptide terminal sequences
IL155518A IL155518A (en) 2000-10-19 2003-04-18 Mass defect labeling for the determination of oligomer sequences
IL180304A IL180304A (en) 2000-10-19 2006-12-25 Mass defect labeling for the determination of oligomer sequences

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL15551801A IL155518A0 (en) 2000-10-19 2001-10-19 Mass defect labeling for the determination of oligomer sequences

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL155281A IL155281A (en) 2000-10-19 2003-04-08 Methods for determining protein and peptide terminal sequences
IL155518A IL155518A (en) 2000-10-19 2003-04-18 Mass defect labeling for the determination of oligomer sequences
IL180304A IL180304A (en) 2000-10-19 2006-12-25 Mass defect labeling for the determination of oligomer sequences

Country Status (13)

Country Link
US (4) US6962818B2 (fr)
EP (3) EP1430436A2 (fr)
JP (3) JP4259869B2 (fr)
AT (1) ATE552348T1 (fr)
AU (2) AU2002246744B2 (fr)
CA (2) CA2425798A1 (fr)
DK (1) DK1358458T3 (fr)
ES (1) ES2385335T3 (fr)
IL (5) IL155518A0 (fr)
IS (1) IS6781A (fr)
NO (1) NO20033632D0 (fr)
PT (1) PT1358458E (fr)
WO (2) WO2002061661A2 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6716636B1 (en) 1999-04-20 2004-04-06 Target Discovery, Inc. Methods for sequencing proteins
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
CA2370539C (fr) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology Systeme et procede de notation de polymeres
US6824981B2 (en) * 2000-08-11 2004-11-30 Agilix Corporation Ultra-sensitive detection systems using alterable peptide tags
ES2385335T3 (es) * 2000-10-19 2012-07-23 Target Discovery, Inc. Marcaje de defecto de masa para la determinación de secuencias de oligómeros
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
EP1451588A4 (fr) * 2001-11-06 2005-03-09 Agilix Corp Systemes de detection codes sensibles
ITMI20020396A1 (it) * 2002-02-27 2003-08-27 Gian Luigi Gianfranceschi Procedimento per la determinazione automatica della composizione e/o della sequenza di un polimero
EP1590648A4 (fr) * 2002-05-20 2007-04-18 Massachusetts Inst Technology Nouvelle technique de determination de sequence par irm
US20040172200A1 (en) * 2002-11-22 2004-09-02 Kearney Paul Edward Constellation mapping and uses thereof
JP3817523B2 (ja) * 2003-02-14 2006-09-06 株式会社日立製作所 質量分析データ解析システム
JP4532874B2 (ja) * 2003-10-07 2010-08-25 キヤノン株式会社 質量分析可能な原子群を構成単位とする鎖状構造を有する分子に対して付加情報を付与して、情報記録コードとして利用する方法
US7105806B2 (en) * 2003-11-26 2006-09-12 Applera Corporation Method and apparatus for de-convoluting a convoluted spectrum
GB0329554D0 (en) * 2003-12-22 2004-01-28 Micromass Ltd Mass spectrometer
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
JP4393270B2 (ja) * 2004-05-21 2010-01-06 株式会社日立ハイテクノロジーズ 質量分析装置および異性体分析方法
WO2006050130A2 (fr) * 2004-10-29 2006-05-11 Target Discovery, Inc. Analyse de glycanes utilisant le glucose deutere
CA2596117A1 (fr) * 2005-02-03 2006-08-10 Perkinelmer Las, Inc. Systemes de detection ultrasensible utilisant des signaux multidimensionnels
EP1894224A4 (fr) * 2005-05-27 2011-08-03 Ionwerks Inc Spectrometre de masse a temps de vol a mobilite ionique multifaisceau presentant des extraction ionique bipolaire et detection de zwitterions
JP5111399B2 (ja) * 2006-02-07 2013-01-09 アプライド バイオシステムズ （カナダ） リミテッド 質量分析のための化学ノイズの低減
JP5777269B2 (ja) * 2006-02-13 2015-09-09 フリューダイム カナダ インコーポレイテッド 元素分析によって実施される遺伝子発現アッセイ
WO2007095378A2 (fr) * 2006-02-15 2007-08-23 University Of Virginia Patent Foundation Marquage de masse pour l'analyse quantitative de biomolécules au moyen de phénylisocyanate étiqueté 13c
US7838303B2 (en) * 2006-07-27 2010-11-23 Agilent Technologies, Inc. Peptide derivatization method to increase fragmentation information from MS/MS spectra
DE102006035577A1 (de) * 2006-07-27 2008-01-31 Eberhard-Karls-Universität Tübingen Universitätsklinikum Röntgendichtes Konjugat
US7800057B2 (en) * 2007-06-01 2010-09-21 Perkinelmer Health Sciences, Inc. Atmospheric pressure ion source performance enhancement
US8536520B2 (en) 2007-08-06 2013-09-17 Iroa Technologies Llc Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US7820964B2 (en) * 2007-08-06 2010-10-26 Metabolic Analyses, Inc Method for generation and use of stable isotope patterns in mass spectral data
US7820963B2 (en) 2007-08-06 2010-10-26 Metabolic Alayses, Inc. Method for generation and use of isotopic patterns in mass spectral data of simple organisms
US8969251B2 (en) 2007-10-02 2015-03-03 Methabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
US20090095899A1 (en) * 2007-10-16 2009-04-16 Whitehouse Craig M Atmospheric pressure ion source performance enhancement
CN102203292B (zh) * 2008-10-29 2014-06-25 南克森制药公司 通过质谱分析法测序核酸分子
WO2011010964A1 (fr) 2009-07-22 2011-01-27 Agency For Science, Technology And Research Différentiation d’aminoacides isobariques et autres espèces
US8153961B2 (en) * 2009-08-31 2012-04-10 Thermo Finnigan Llc Methods for acquisition and deductive analysis of mixed fragment peptide mass spectra
PL390797A1 (pl) 2010-03-22 2011-09-26 Instytut Chemii Bioorganicznej Polskiej Akademii Nauk Biblioteka kombinatoryczna, sposób otrzymywania biblioteki kombinatorycznej, sposób identyfikacji sekwencji, sposób sekwencjonowania elementów kombinatorycznych bibliotek oligonukleotydów i/lub analogów oligonukleotydów, zastosowanie łącznika do tworzenia bibliotek kombinatorycznych oraz zestaw do identyfikacji sekwencji
NZ604013A (en) * 2010-06-16 2014-10-31 Abbott Lab Comparison of protein samples
US9046525B2 (en) * 2010-07-30 2015-06-02 California Institute Of Technology Method of determining the oligomeric state of a protein complex
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
EP2689250A1 (fr) 2011-03-23 2014-01-29 AbbVie Inc. Procédés et systèmes pour l'analyse d'échantillons protéiques
WO2012137804A1 (fr) * 2011-04-04 2012-10-11 株式会社Ｊｃｌバイオアッセイ Procédé pour la détermination de séquence oligonucléotidique
WO2013098609A1 (fr) * 2011-12-30 2013-07-04 Dh Technologies Development Pte. Ltd. Systèmes et procédés pour séquençage de peptides par spectrométrie de masse
EP3050074B1 (fr) * 2013-09-23 2020-08-26 Micromass UK Limited Évaluation de pointe pour les spectromètres de masse
JP2015121500A (ja) * 2013-12-25 2015-07-02 株式会社島津製作所 質量分析方法及び質量分析装置
EP3170006A1 (fr) 2014-07-18 2017-05-24 Thermo Finnigan LLC Procédés de spectrométrie de masse de mélanges de protéines de polypeptides au moyen de réaction de transfert de protons
EP3193352A1 (fr) 2016-01-14 2017-07-19 Thermo Finnigan LLC Procédés de caractérisation basée sur la spectrométrie de masse de molécules biologiques
EP3193174B1 (fr) 2016-01-14 2018-11-07 Thermo Finnigan LLC Procédés d'analyse spectrale descendante de masse multiplexé de mélanges de protéines ou de polypeptides
CN111164422B (zh) * 2017-08-07 2023-05-02 新加坡科技研究局 从液相色谱-质谱(lc-ms)数据中快速分析和鉴定脂质
US20190172553A1 (en) * 2017-11-08 2019-06-06 Koninklijke Philips N.V. Using k-mers for rapid quality control of sequencing data without alignment
WO2019232520A1 (fr) * 2018-06-01 2019-12-05 Cerno Bioscience Llc Analyse par spectre de masse de grosses molécules
JP2021534408A (ja) 2018-08-17 2021-12-09 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｄｅ ｎｏｖｏタンパク質シークエンシングのための方法
KR102648650B1 (ko) * 2018-10-25 2024-03-15 주식회사 엘지화학 고분자 말단기 분석 방법
CN113552204B (zh) * 2020-04-02 2024-06-21 株式会社岛津制作所 质谱分析方法和质谱系统
JP7249980B2 (ja) 2020-10-26 2023-03-31 日本電子株式会社 マススペクトル処理装置及び方法
CN112505328B (zh) * 2020-11-02 2024-02-13 武汉金开瑞生物工程有限公司 一种同位素标记试剂盒和标记方法

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4830010A (en) * 1986-04-04 1989-05-16 Marshall Barry J Methods for the diagnosis of gastrointestinal disorders
US4842701A (en) * 1987-04-06 1989-06-27 Battelle Memorial Institute Combined electrophoretic-separation and electrospray method and system
US4994155A (en) * 1988-12-09 1991-02-19 Learonal, Inc. High speed tin, lead or tin/lead alloy electroplating
US5174962A (en) * 1988-06-20 1992-12-29 Genomyx, Inc. Apparatus for determining DNA sequences by mass spectrometry
US4994165A (en) 1989-02-16 1991-02-19 Cornell Research Foundation, Inc. Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry
CA1340966C (fr) * 1989-05-19 2000-04-18 Thomas R. Covey Procede d'analyse des proteines
US5100778A (en) 1989-10-03 1992-03-31 Monsanto Company Oligosaccharide sequencing
EP0639227A1 (fr) * 1991-05-07 1995-02-22 Oxford Glycosciences (Uk) Limited Sequen age d'oligosaccharides
WO1992021138A1 (fr) * 1991-05-21 1992-11-26 Analytica Of Brandford, Inc. Procede et appareil permettant d'ameliorer l'ionisation par electrovaporisation d'especes de solutes
CA2132012C (fr) 1992-03-25 2003-04-22 John W. Shell Comprime ou capsule pour administration par voie orale et liberation lente, a base de derive de substitution alkylique de cellulose
EP0846950A3 (fr) * 1992-07-24 1999-08-25 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Peptides utiles comme standards internes pour le microséquençage et procédé pour les utiliser
US5470753A (en) * 1992-09-03 1995-11-28 Selectide Corporation Peptide sequencing using mass spectrometry
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US6194144B1 (en) * 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
WO1994016101A2 (fr) 1993-01-07 1994-07-21 Koester Hubert Sequençage d'adn par spectrometrie de masse
GB9310467D0 (en) 1993-05-20 1993-07-07 Oxford Glycosystems Ltd Glycoconjugates
US5386832A (en) * 1993-06-11 1995-02-07 New England Deaconess Hospital Liver function breath test using aromatic amino acids
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
DE4415480C2 (de) * 1994-05-02 1999-09-02 Bruker Daltonik Gmbh Vorrichtung und Verfahren zur massenspektrometrischen Untersuchung von Substanzgemischen durch Kopplung kapillarelektrophoretischer Separation (CE) mit Elektrospray-Ionisierung (ESI)
JP3415682B2 (ja) * 1994-08-10 2003-06-09 株式会社日立製作所 キャピラリー電気泳動・質量分析計
US5856082A (en) * 1994-08-31 1999-01-05 University Of British Columbia Devices and methods for characterizing proteins and peptides
US5766891A (en) * 1994-12-19 1998-06-16 Sloan-Kettering Institute For Cancer Research Method for molecular cloning and polynucleotide synthesis using vaccinia DNA topoisomerase
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US5625184A (en) * 1995-05-19 1997-04-29 Perseptive Biosystems, Inc. Time-of-flight mass spectrometry analysis of biomolecules
US5827659A (en) * 1995-05-19 1998-10-27 Perseptive Biosystems, Inc. Methods and apparatus for sequencing polymers using mass spectrometry
US5700642A (en) 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
US6004770A (en) * 1995-06-07 1999-12-21 Arizona State University Board Of Regents Sample presentation apparatus for mass spectrometry
US5872010A (en) * 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US5722642A (en) * 1996-02-16 1998-03-03 Bradshaw; Terry L. Standing privacy fence with a deployable bench
US5800784A (en) 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
CN100434531C (zh) 1997-01-15 2008-11-19 X齐里昂有限两合公司 与质量标记连接的杂交探针
US5953653A (en) 1997-01-28 1999-09-14 Mediaone Group, Inc. Method and system for preventing mobile roaming fraud
GB9710582D0 (en) 1997-05-22 1997-07-16 Oxford Glycosciences Uk Ltd A method for de novo peptide sequence determination
WO1999014375A2 (fr) 1997-09-19 1999-03-25 Genetrace Systems, Inc. Recherche de type de genes par spectrometrie de masse avec marqueurs de sequences repetees d'adn polymorphes
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6379971B1 (en) 1998-02-24 2002-04-30 Target Discovery, Inc. Methods for sequencing proteins
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
US5995989A (en) * 1998-04-24 1999-11-30 Eg&G Instruments, Inc. Method and apparatus for compression and filtering of data associated with spectrometry
US6359111B1 (en) * 1998-05-28 2002-03-19 Neorx Corporation Opioid receptor targeting
ATE536422T1 (de) 1998-08-25 2011-12-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
US6277644B1 (en) * 1999-03-22 2001-08-21 Beckman Coulter, Inc. Method for compositional tag sequencing
US6677114B1 (en) 1999-04-20 2004-01-13 Target Discovery, Inc. Polypeptide fingerprinting methods and bioinformatics database system
EP2293056A3 (fr) 1999-04-20 2011-06-29 Target Discovery, Inc. Procédé d'analyse d'une voie métabolique
US6391649B1 (en) * 1999-05-04 2002-05-21 The Rockefeller University Method for the comparative quantitative analysis of proteins and other biological material by isotopic labeling and mass spectroscopy
US6699846B2 (en) 2000-03-17 2004-03-02 Corixa Corporation Mono- and disaccharides for the treatment of nitric oxide related disorders
ES2385335T3 (es) 2000-10-19 2012-07-23 Target Discovery, Inc. Marcaje de defecto de masa para la determinación de secuencias de oligómeros
JP2004521616A (ja) 2000-10-30 2004-07-22 カロバイオス， インコーポレイテッド 競合的選択による親和性成熟
US6875668B2 (en) 2000-11-03 2005-04-05 Advanced Micro Devices, Inc. Notched gate structure fabrication
US6727361B2 (en) * 2000-11-07 2004-04-27 Symyx Technologies, Inc. Phosphino substituted pyridine amine ligands
CA2429633A1 (fr) 2000-11-16 2002-05-30 Ciphergen Biosystems, Inc. Procede d'analyse de spectres de masse
EP1353617A2 (fr) 2001-01-18 2003-10-22 The Regents Of The University Of California Instrument chirurgical et methode de traitement du glaucome peu invasifs
WO2002062436A2 (fr) 2001-02-06 2002-08-15 Electronic Arts Inc. Integration de donnees en temps reel dans une application de jeu
US7265378B2 (en) 2002-07-10 2007-09-04 E. I. Du Pont De Nemours And Company Electronic devices made with electron transport and/or anti-quenching layers
JP2005533102A (ja) 2002-07-12 2005-11-04 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 微小器官によって生物学的プロセスを誘発する方法と装置
JP4116351B2 (ja) 2002-07-16 2008-07-09 ジヤトコ株式会社 車両の制御装置
GB0216571D0 (en) 2002-07-17 2002-08-28 Celltech R&D Ltd Chemical compounds
US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
JP2005241161A (ja) 2004-02-27 2005-09-08 Fujita Corp 変流量変更時の消費エネルギー算出方法および省エネルギー診断方法

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PT1358458E (pt) 2012-05-24
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NO20033632D0 (no) 2003-08-15
ES2385335T3 (es) 2012-07-23
EP1430436A2 (fr) 2004-06-23
AU2002246744B2 (en) 2008-04-10
WO2002066952A2 (fr) 2002-08-29
DK1358458T3 (da) 2012-06-18
US20060073485A1 (en) 2006-04-06
US20040209251A1 (en) 2004-10-21
IL155281A (en) 2012-05-31
AU2002253825B8 (en) 2007-03-22
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EP1358458B1 (fr) 2012-04-04
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JP4467589B2 (ja) 2010-05-26
US8352193B2 (en) 2013-01-08
US20070154900A1 (en) 2007-07-05
US20020172961A1 (en) 2002-11-21
CA2426580C (fr) 2011-09-13
JP2004519665A (ja) 2004-07-02
IS6781A (is) 2003-04-11
WO2002061661A2 (fr) 2002-08-08
US6962818B2 (en) 2005-11-08
AU2002253825B2 (en) 2007-03-15
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US7316931B2 (en) 2008-01-08
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