IL153654A0 - Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture - Google Patents

Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Info

Publication number
IL153654A0
IL153654A0 IL15365401A IL15365401A IL153654A0 IL 153654 A0 IL153654 A0 IL 153654A0 IL 15365401 A IL15365401 A IL 15365401A IL 15365401 A IL15365401 A IL 15365401A IL 153654 A0 IL153654 A0 IL 153654A0
Authority
IL
Israel
Prior art keywords
manufacture
processes
controlled
cross
pharmaceutical formulations
Prior art date
Application number
IL15365401A
Other languages
English (en)
Inventor
Vincent Lenaerts
Francois Chouinard
Roland Herwig Friedrich Beck
Elsie Van Bogaert
Reiner Hopcke
Cyril Desevaux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24427807&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL153654(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of IL153654A0 publication Critical patent/IL153654A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B33/00—Preparation of derivatives of amylose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL15365401A 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture IL153654A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/606,399 US6607748B1 (en) 2000-06-29 2000-06-29 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
PCT/US2001/020319 WO2002002084A1 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Publications (1)

Publication Number Publication Date
IL153654A0 true IL153654A0 (en) 2003-07-06

Family

ID=24427807

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15365401A IL153654A0 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
IL153654A IL153654A (en) 2000-06-29 2002-12-25 Cross-starch containing a high concentration of amylose for use in pharmaceuticals for delayed release and processes for its production

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL153654A IL153654A (en) 2000-06-29 2002-12-25 Cross-starch containing a high concentration of amylose for use in pharmaceuticals for delayed release and processes for its production

Country Status (27)

Country Link
US (2) US6607748B1 (es)
EP (1) EP1305009B1 (es)
JP (1) JP5025066B2 (es)
KR (1) KR100840393B1 (es)
CN (1) CN100352509C (es)
AR (1) AR029549A1 (es)
AT (1) ATE328585T1 (es)
AU (2) AU2001271481B2 (es)
BR (1) BRPI0112140B8 (es)
CA (1) CA2414349C (es)
CZ (1) CZ300152B6 (es)
DE (1) DE60120413T2 (es)
DK (1) DK1305009T3 (es)
ES (1) ES2272499T3 (es)
HK (1) HK1059574A1 (es)
HU (1) HUP0301302A2 (es)
IL (2) IL153654A0 (es)
MX (1) MXPA03000035A (es)
MY (1) MY128308A (es)
NO (1) NO20026254L (es)
NZ (1) NZ523644A (es)
PL (1) PL202177B1 (es)
PT (1) PT1305009E (es)
RU (1) RU2274443C2 (es)
SI (1) SI1305009T1 (es)
TW (1) TWI289460B (es)
WO (1) WO2002002084A1 (es)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
EP1162890B1 (en) * 1998-10-30 2005-10-12 RJ Innovation A method of preventing parturient hypocalcemia in animals and compositions used therein
US6607748B1 (en) * 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
FR2822471B1 (fr) * 2001-03-26 2003-06-13 Roquette Freres Procede de cuisson/sechage d'amidons riches en amylose
WO2003037301A2 (en) * 2001-10-29 2003-05-08 King Pharmaceuticals Research And Development, Inc Oral dosage forms for improving the bioavailability of therapeutic agents
US7815936B2 (en) * 2001-10-30 2010-10-19 Evonik Degussa Gmbh Use of granular materials based on pyrogenically produced silicon dioxide in pharmaceutical compositions
US7887838B2 (en) * 2002-01-18 2011-02-15 Banner Pharmacaps, Inc. Non-gelatin film and method and apparatus for producing same
US6949256B2 (en) * 2002-01-18 2005-09-27 Banner Pharmacaps, Inc. Non-gelatin capsule shell formulation
US8128957B1 (en) 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
WO2003080031A1 (en) * 2002-03-22 2003-10-02 Cilag Ag Sustained release formulation of tramadol
US20030191029A1 (en) * 2002-03-28 2003-10-09 Elementis Specialties, Inc. Aqueous-based oil well drilling fluids containing high amylose starch polymers
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
AR045972A1 (es) * 2002-10-25 2005-11-23 Labopharm Inc Formulaciones de tramadol de liberacion sostenida con eficacia de 24 horas
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
MY142195A (en) * 2002-10-25 2010-10-15 Labopharm Inc Controlled-release compositions
DE60322091D1 (de) * 2002-10-25 2008-08-21 Labopharm Inc Zubereitungen mit kontrollierter freisetzung
US6846497B2 (en) 2003-01-30 2005-01-25 National Starch And Chemical Investment Holding Corporation Rapidly expanding starches with altered crystalline structure
JP4602326B2 (ja) * 2003-04-14 2010-12-22 エフ エム シー コーポレーション 低粘度カラゲニンを含む均一な熱可逆性ゲル及びそれから製造される製品
US20050013847A1 (en) * 2003-04-14 2005-01-20 Fmc Corporation Delivery systems of homogeneous, thermoreversible alginate films
US20050048185A1 (en) * 2003-04-14 2005-03-03 Fmc Corporation Delivery systems of homogeneous, thermoreversible low viscosity polymannan gum films
US7816341B2 (en) * 2003-04-14 2010-10-19 Fmc Corporation Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom
US20050019294A1 (en) * 2003-04-14 2005-01-27 Fmc Corporation Homogeneous, thermoreversible alginate films and soft capsules made therefrom
US20050019295A1 (en) * 2003-04-14 2005-01-27 Fmc Corporation Homogeneous, thermoreversible low viscosity polymannan gum films and soft capsules made therefrom
US20050008677A1 (en) * 2003-04-14 2005-01-13 Fmc Corporation Delivery system of homogeneous, thermoreversible gel film containing kappa-2 carrageenan
EP1479381A1 (en) * 2003-05-19 2004-11-24 Euro-Celtique S.A. Pharmaceutical dosage form comprising a solid solution
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
EP1737454A4 (en) * 2004-04-22 2007-08-08 Mor Research Applic Ltd METHOD OF MANAGING FOOD RECOVERY
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
CA2491665A1 (fr) * 2004-12-24 2006-06-24 Louis Cartilier Formulation de comprime pour liberation soutenue de principe actif
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20060188631A1 (en) * 2005-02-18 2006-08-24 Kyungsoo Woo Pregelatinized chemically modified resistant starch products and uses thereof
CA2616204C (en) * 2005-09-09 2015-12-01 Labopharm Inc. Sustained drug release composition
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
CN100437113C (zh) * 2006-04-11 2008-11-26 汪运山 一种检测血液中非那西丁与醋氨酚浓度比值的试剂盒
WO2009018169A1 (en) * 2007-07-27 2009-02-05 Auspex Pharmaceuticals, Inc. Substituted cyclohexanols
RU2445320C2 (ru) * 2007-08-31 2012-03-20 Сирал Бельгия Нв Способ получения набухающего в холодной воде сшитого фосфатом желатинизированного крахмала
CA2678092C (en) * 2007-10-16 2013-07-30 Labopharm Inc. Bilayer composition for the sustained release of acetaminophen and tramadol
GB0722484D0 (en) * 2007-11-15 2007-12-27 Ucl Business Plc Solid compositions
AU2008338207A1 (en) * 2007-12-17 2009-06-25 Labopharm (Barbados) Limited Misuse preventative, controlled release formulation
PT2234607E (pt) * 2007-12-28 2011-09-30 Acraf Formulação de libertação lenta com base numa associação de glicogénio e alginato
TWI454288B (zh) 2008-01-25 2014-10-01 Gruenenthal Chemie 藥物劑型
EP2252271B1 (en) * 2008-02-19 2012-05-23 McNeil-PPC, Inc. Dip coated compositions containing a starch having a high amylose content
PT2273983T (pt) 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
WO2010028489A1 (en) 2008-09-15 2010-03-18 Labopharm Inc. Starch-based microparticles for the release of agents disposed therein
ES2425762T3 (es) * 2008-10-27 2013-10-17 Roquette Freres Polímero insoluble en agua: revestimientos de película a base de derivados de almidón modificado para la liberación dirigida al colon
CA2746888C (en) 2008-12-16 2015-05-12 Labopharm (Barbados) Limited Misuse preventative, controlled release formulation
KR101713810B1 (ko) 2009-01-23 2017-03-09 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 제어 방출형 약학적 제제 또는 식품 제제 및 이의 제조 방법
CN102573805A (zh) 2009-07-22 2012-07-11 格吕伦塔尔有限公司 热熔挤出的控制释放剂型
ES2560210T3 (es) 2009-07-22 2016-02-17 Grünenthal GmbH Forma de dosificación resistente a la manipulación para opiádes sensibles a la oxidación
CA2775890C (en) * 2009-09-30 2016-06-21 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse
CN102821757B (zh) 2010-02-03 2016-01-20 格吕伦塔尔有限公司 通过挤出机制备粉末状药物组合物
KR20120129945A (ko) 2010-02-07 2012-11-28 클레어파르마 인더스트리즈 리미티드. 병아리콩 조성물 및 이의 용도
EP2386297A1 (en) * 2010-04-28 2011-11-16 Roquette Frères Indigestible polymer: starch acetate -based film coatings for colon targeting
AR082189A1 (es) 2010-07-06 2012-11-21 Gruenenthal Gmbh Formas de dosificacion gastrorretentivas, procedimiento
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
TWI516286B (zh) 2010-09-02 2016-01-11 歌林達股份有限公司 含陰離子聚合物之抗破碎劑型
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
CN103857386A (zh) 2011-07-29 2014-06-11 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
LT2736495T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
WO2013025572A1 (en) * 2011-08-12 2013-02-21 Rutgers, The State University Of New Jersey An interpolymer network delivery system
JP6117249B2 (ja) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
CA2868142A1 (en) 2012-04-18 2013-10-24 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
GB201207907D0 (en) 2012-05-04 2012-06-20 E Therapeutics Plc Treatment of depression
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
MX366159B (es) 2012-11-30 2019-07-01 Acura Pharmaceuticals Inc Liberacion autorregulada de ingrediente farmaceutico activo.
CN103070845B (zh) * 2013-01-14 2014-10-22 北京爱特康科贸有限责任公司 一种淀粉空心胶囊及其制备方法
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
CN105682643B (zh) 2013-07-12 2019-12-13 格吕伦塔尔有限公司 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
CA2943728C (en) 2014-03-26 2020-03-24 Sun Pharma Advanced Research Company Ltd. Abuse deterrent immediate release biphasic matrix solid dosage form
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
GB201413832D0 (en) * 2014-08-05 2014-09-17 Tate & Lyle Ingredients Starch compositions useful for thickening aqueous liquids
WO2015187631A1 (en) 2014-06-02 2015-12-10 Tethis, Inc. Modified biopolymers and methods of producing and using the same
CN107889459A (zh) 2015-04-24 2018-04-06 格吕伦塔尔有限公司 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
US11103581B2 (en) 2015-08-31 2021-08-31 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient
EP3346991A1 (en) 2015-09-10 2018-07-18 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
WO2017091463A1 (en) 2015-11-23 2017-06-01 Tethis, Inc. Coated particles and methods of making and using the same
CN106337030A (zh) * 2016-08-24 2017-01-18 宁波枫叶杰科生物技术有限公司 一种治理重金属污染盐碱地的微生物制品及其制造方法
JP6216088B1 (ja) * 2017-04-21 2017-10-18 森永製菓株式会社 口腔徐放用組成物及びその製造方法
GB2567493B (en) * 2017-10-13 2019-12-18 Altus Formulation Inc Starch-based release modifying excipients and pharmaceutical compositions derived therefrom
CN113121709B (zh) * 2019-12-30 2022-08-26 仙乐健康科技股份有限公司 一种变性淀粉的制备方法及应用
CN112098408B (zh) * 2020-09-14 2022-12-09 湖北亿纬动力有限公司 一种羧甲基纤维素钠溶解效果的检测方法及应用
CN117530929B (zh) * 2024-01-10 2024-03-29 东华大学 一种减肥胶囊

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2938901A (en) 1954-08-06 1960-05-31 Corn Products Co Surgical dusting powder and process therefor
US2987445A (en) 1958-10-10 1961-06-06 Rohm & Haas Drug composition
US3087860A (en) 1958-12-19 1963-04-30 Abbott Lab Method of prolonging release of drug from a precompressed solid carrier
US3034911A (en) 1959-03-25 1962-05-15 Nat Starch Chem Corp Tablet disintegrants
US3453368A (en) 1966-01-13 1969-07-01 Hoffmann La Roche Smaller high potency compressed tablets of ascorbic acid
US3490742A (en) 1966-01-14 1970-01-20 Staley Mfg Co A E Compressed tablets
US3622677A (en) 1969-07-07 1971-11-23 Staley Mfg Co A E Compressed tablets containing compacted starch as binder-disintegrant ingredient
US4072535A (en) 1970-12-28 1978-02-07 A. E. Staley Manufacturing Company Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules
US3904601A (en) * 1972-12-21 1975-09-09 Nat Starch Chem Corp Hydroxypropylated, inhibited high amylose retort starches
US4026986A (en) 1975-05-22 1977-05-31 The Dow Chemical Company Capsule shell
GB1576475A (en) * 1977-01-19 1980-10-08 Unilever Ltd Absorbent cross-linked starch materials
US4308251A (en) 1980-01-11 1981-12-29 Boots Pharmaceuticals, Inc. Controlled release formulations of orally-active medicaments
US4369308A (en) 1981-07-24 1983-01-18 National Starch And Chemical Corporation Low swelling starches as tablet disintegrants
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4551177A (en) 1984-04-23 1985-11-05 National Starch And Chemical Corporation Compressible starches as binders for tablets or capsules
US4904476A (en) 1986-03-04 1990-02-27 American Home Products Corporation Formulations providing three distinct releases
IT1200178B (it) 1986-07-23 1989-01-05 Alfa Farmaceutici Spa Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica
GB8812490D0 (en) 1988-05-26 1988-06-29 Agricultural & Food Res Delayed release formulations
CA2041774C (en) 1990-11-27 1994-04-19 Mircea A. Mateescu Use of cross-linked amylose as a matrix for the slow release of biologically active compounds
CA2032385A1 (en) 1990-12-17 1992-06-18 Chung Wai-Chiu Enzymatically debranched starches as tablet excipients
HU221591B (hu) 1992-07-24 2002-11-28 Labopharm Inc. Keresztkötéses polihidroxil-származék enzimatikusan szabályozott hatóanyag-kibocsátáshoz
US5616343A (en) 1993-03-25 1997-04-01 Labopharm, Inc. Cross-linked amylose as a binder/disintegrant in tablets
US5830884A (en) 1995-01-18 1998-11-03 National Starch And Chemical Investment Holding Corporation Pharmaceutical products containing thermally-inhibited starches
JP3949746B2 (ja) * 1996-02-28 2007-07-25 日澱化學株式会社 硝子繊維集束剤用化工澱粉
US5879707A (en) 1996-10-30 1999-03-09 Universite De Montreal Substituted amylose as a matrix for sustained drug release
US5807575A (en) 1997-02-14 1998-09-15 Rougier Inc. Manufacture of cross-linked amylose useful as a excipient for control release of active compounds
US6284273B1 (en) * 1998-02-24 2001-09-04 Vincent Lenaerts Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds
US6607748B1 (en) * 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Also Published As

Publication number Publication date
CZ300152B6 (cs) 2009-02-25
KR100840393B1 (ko) 2008-06-23
WO2002002084A8 (en) 2002-04-04
CA2414349C (en) 2008-09-16
AU7148101A (en) 2002-01-14
AU2001271481B2 (en) 2005-05-26
SI1305009T1 (sl) 2007-08-31
BR0112140B1 (pt) 2013-04-30
IL153654A (en) 2008-12-29
HK1059574A1 (en) 2004-07-09
EP1305009B1 (en) 2006-06-07
JP5025066B2 (ja) 2012-09-12
ES2272499T3 (es) 2007-05-01
WO2002002084A1 (en) 2002-01-10
MY128308A (en) 2007-01-31
CZ20024269A3 (cs) 2003-06-18
TWI289460B (en) 2007-11-11
RU2274443C2 (ru) 2006-04-20
ATE328585T1 (de) 2006-06-15
NZ523644A (en) 2005-10-28
PT1305009E (pt) 2006-10-31
PL365634A1 (en) 2005-01-10
US6607748B1 (en) 2003-08-19
HUP0301302A2 (en) 2003-08-28
PL202177B1 (pl) 2009-06-30
BR0112140A (pt) 2003-10-07
CN1449279A (zh) 2003-10-15
DE60120413T2 (de) 2007-06-14
CN100352509C (zh) 2007-12-05
CA2414349A1 (en) 2002-01-10
NO20026254L (no) 2003-02-27
AR029549A1 (es) 2003-07-02
JP2004501957A (ja) 2004-01-22
KR20030031504A (ko) 2003-04-21
NO20026254D0 (no) 2002-12-27
BRPI0112140B8 (pt) 2021-05-25
EP1305009A4 (en) 2004-11-17
DK1305009T3 (da) 2006-12-27
EP1305009A1 (en) 2003-05-02
US20040013726A1 (en) 2004-01-22
DE60120413D1 (de) 2006-07-20
MXPA03000035A (es) 2005-09-21

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