BR0112140A - Comprimido de liberação controlada, processo para a fabricação, em um meio aquoso, de um excipiente de liberação controlada e amido reticulado de elevado teor de amilose - Google Patents

Comprimido de liberação controlada, processo para a fabricação, em um meio aquoso, de um excipiente de liberação controlada e amido reticulado de elevado teor de amilose

Info

Publication number
BR0112140A
BR0112140A BR0112140-5A BR0112140A BR0112140A BR 0112140 A BR0112140 A BR 0112140A BR 0112140 A BR0112140 A BR 0112140A BR 0112140 A BR0112140 A BR 0112140A
Authority
BR
Brazil
Prior art keywords
controlled release
high amylose
excipient
amylose starch
starch
Prior art date
Application number
BR0112140-5A
Other languages
English (en)
Other versions
BR0112140B1 (pt
BRPI0112140B8 (pt
Inventor
Vincent Lenaerts
Roland Herwig Friedrich Beck
Elsie Van Bogaret
Francois Chouinard
Reiner Hopcke
Cyril Desevaux
Original Assignee
Vincent Lenaerts
Roland Herwig Friedrich Beck
Elsie Van Bogaret
Francois Chouinard
Reiner Hopcke
Cyril Desevaux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24427807&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0112140(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vincent Lenaerts, Roland Herwig Friedrich Beck, Elsie Van Bogaret, Francois Chouinard, Reiner Hopcke, Cyril Desevaux filed Critical Vincent Lenaerts
Publication of BR0112140A publication Critical patent/BR0112140A/pt
Publication of BR0112140B1 publication Critical patent/BR0112140B1/pt
Publication of BRPI0112140B8 publication Critical patent/BRPI0112140B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B33/00—Preparation of derivatives of amylose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPRIMIDO DE LIBERAçãO CONTROLADA, PROCESSO PARA A FABRICAçãO, EM UM MEIO AQUOSO, DE UM EXCIPIENTE DE LIBERAçãO CONTROLADA E AMIDO RETICULADO DE ELEVADO TEOR DE AMILOSE". A presente invenção refere-se a uma forma nova de um amido de elevado teor de amilose reticulado e processo para sua fabricação. Este amido de elevado teor de amilose reticulado é utilizável como um excipiente em uma formulação farmacêutica de liberação controlada quando comprimido com um agente(s) farmacêutico(s) em um comprimido. Este amido de elevado teor de amilose reticulado é preparado por (a) reticulação e modificação química de amido de elevado teor de amilose, (b) gelatinização, e (c) secagem para obter um pó de referido excipiente de liberação controlada. Em uma forma de realização preferida, este amido de elevado teor de amilose reticulado é preparado nas seguintes etapas: (1) reticulação granular e adicionalmente modificação química (por exemplo hidroxipropilação) de amido de elevado teor de amilose, (2) gelatinização térmica de amido da etapa (1), e (3) secagem do amido da etapa (2) para dar um pó capaz de ser usado como um excipiente de liberação controlada.
BRPI0112140A 2000-06-29 2001-06-26 comprimido de liberação controlada, processo para a fabricação, em um meio aquoso, de um excipiente de liberação controlada e amido reticulado de elevado teor de amilose. BRPI0112140B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/606,399 US6607748B1 (en) 2000-06-29 2000-06-29 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
PCT/US2001/020319 WO2002002084A1 (en) 2000-06-29 2001-06-26 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Publications (3)

Publication Number Publication Date
BR0112140A true BR0112140A (pt) 2003-10-07
BR0112140B1 BR0112140B1 (pt) 2013-04-30
BRPI0112140B8 BRPI0112140B8 (pt) 2021-05-25

Family

ID=24427807

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0112140A BRPI0112140B8 (pt) 2000-06-29 2001-06-26 comprimido de liberação controlada, processo para a fabricação, em um meio aquoso, de um excipiente de liberação controlada e amido reticulado de elevado teor de amilose.

Country Status (27)

Country Link
US (2) US6607748B1 (pt)
EP (1) EP1305009B1 (pt)
JP (1) JP5025066B2 (pt)
KR (1) KR100840393B1 (pt)
CN (1) CN100352509C (pt)
AR (1) AR029549A1 (pt)
AT (1) ATE328585T1 (pt)
AU (2) AU2001271481B2 (pt)
BR (1) BRPI0112140B8 (pt)
CA (1) CA2414349C (pt)
CZ (1) CZ300152B6 (pt)
DE (1) DE60120413T2 (pt)
DK (1) DK1305009T3 (pt)
ES (1) ES2272499T3 (pt)
HK (1) HK1059574A1 (pt)
HU (1) HUP0301302A2 (pt)
IL (2) IL153654A0 (pt)
MX (1) MXPA03000035A (pt)
MY (1) MY128308A (pt)
NO (1) NO20026254L (pt)
NZ (1) NZ523644A (pt)
PL (1) PL202177B1 (pt)
PT (1) PT1305009E (pt)
RU (1) RU2274443C2 (pt)
SI (1) SI1305009T1 (pt)
TW (1) TWI289460B (pt)
WO (1) WO2002002084A1 (pt)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL109460A (en) 1993-05-10 1998-03-10 Euro Celtique Sa Controlled release formulation comprising tramadol
NZ514896A (en) * 1998-10-30 2003-11-28 Rj Innovation A method of preventing parturient hypocalcemia in animals and compositions used therein
US6607748B1 (en) * 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture
FR2822471B1 (fr) * 2001-03-26 2003-06-13 Roquette Freres Procede de cuisson/sechage d'amidons riches en amylose
WO2003037301A2 (en) * 2001-10-29 2003-05-08 King Pharmaceuticals Research And Development, Inc Oral dosage forms for improving the bioavailability of therapeutic agents
US7815936B2 (en) * 2001-10-30 2010-10-19 Evonik Degussa Gmbh Use of granular materials based on pyrogenically produced silicon dioxide in pharmaceutical compositions
US6949256B2 (en) * 2002-01-18 2005-09-27 Banner Pharmacaps, Inc. Non-gelatin capsule shell formulation
US7887838B2 (en) * 2002-01-18 2011-02-15 Banner Pharmacaps, Inc. Non-gelatin film and method and apparatus for producing same
US8128957B1 (en) 2002-02-21 2012-03-06 Valeant International (Barbados) Srl Modified release compositions of at least one form of tramadol
KR20050009983A (ko) * 2002-03-22 2005-01-26 시락 아게 트라마돌의 서방성 제제
US20030191029A1 (en) * 2002-03-28 2003-10-09 Elementis Specialties, Inc. Aqueous-based oil well drilling fluids containing high amylose starch polymers
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
MY142195A (en) * 2002-10-25 2010-10-15 Labopharm Inc Controlled-release compositions
US8487002B2 (en) * 2002-10-25 2013-07-16 Paladin Labs Inc. Controlled-release compositions
AR045972A1 (es) * 2002-10-25 2005-11-23 Labopharm Inc Formulaciones de tramadol de liberacion sostenida con eficacia de 24 horas
TWI319713B (en) * 2002-10-25 2010-01-21 Sustained-release tramadol formulations with 24-hour efficacy
ATE400819T1 (de) * 2002-10-25 2008-07-15 Labopharm Inc Zubereitungen mit kontrollierter freisetzung
US6846497B2 (en) 2003-01-30 2005-01-25 National Starch And Chemical Investment Holding Corporation Rapidly expanding starches with altered crystalline structure
US20050048185A1 (en) * 2003-04-14 2005-03-03 Fmc Corporation Delivery systems of homogeneous, thermoreversible low viscosity polymannan gum films
US20050019294A1 (en) * 2003-04-14 2005-01-27 Fmc Corporation Homogeneous, thermoreversible alginate films and soft capsules made therefrom
US20050019295A1 (en) * 2003-04-14 2005-01-27 Fmc Corporation Homogeneous, thermoreversible low viscosity polymannan gum films and soft capsules made therefrom
US7816341B2 (en) * 2003-04-14 2010-10-19 Fmc Corporation Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom
US20050013847A1 (en) * 2003-04-14 2005-01-20 Fmc Corporation Delivery systems of homogeneous, thermoreversible alginate films
US20050008677A1 (en) * 2003-04-14 2005-01-13 Fmc Corporation Delivery system of homogeneous, thermoreversible gel film containing kappa-2 carrageenan
BRPI0409342A (pt) * 2003-04-14 2006-04-25 Fmc Corp pelìcula de gel termorreversìvel homogênea, cápsulas moles, processos para fabricar as pelìculas de gel e para fabricar cápsulas moles contendo as pelìculas de gel, e, forma sólida
EP1479381A1 (en) * 2003-05-19 2004-11-24 Euro-Celtique S.A. Pharmaceutical dosage form comprising a solid solution
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
US20060172006A1 (en) * 2003-10-10 2006-08-03 Vincent Lenaerts Sustained-release tramadol formulations with 24-hour clinical efficacy
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
BRPI0506807A (pt) * 2004-04-22 2007-05-29 Mor Research Applic Ltd método de gerenciamento de consumo de alimento e composição farmacológica
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
CA2491665A1 (fr) * 2004-12-24 2006-06-24 Louis Cartilier Formulation de comprime pour liberation soutenue de principe actif
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
US20060188631A1 (en) * 2005-02-18 2006-08-24 Kyungsoo Woo Pregelatinized chemically modified resistant starch products and uses thereof
JP5269595B2 (ja) * 2005-09-09 2013-08-21 アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー １日１回投与用トラゾドン組成物
US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
CN100437113C (zh) * 2006-04-11 2008-11-26 汪运山 一种检测血液中非那西丁与醋氨酚浓度比值的试剂盒
US20090028873A1 (en) * 2007-07-27 2009-01-29 Auspex Pharmaceuticals, Inc. Substituted cyclohexanols
RU2445320C2 (ru) * 2007-08-31 2012-03-20 Сирал Бельгия Нв Способ получения набухающего в холодной воде сшитого фосфатом желатинизированного крахмала
ES2541809T3 (es) * 2007-10-16 2015-07-24 Paladin Labs Inc. Composición bicapa para la liberación sostenida de acetaminofeno y tramadol
GB0722484D0 (en) * 2007-11-15 2007-12-27 Ucl Business Plc Solid compositions
EP2219612A4 (en) 2007-12-17 2013-10-30 Paladin Labs Inc CONTROLLED RELEASE FORMULATION AVOIDING IMPROPER USES
KR101561571B1 (ko) * 2007-12-28 2015-10-19 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 글리코겐과 알긴산염의 회합을 기초로 한 서방형 제제
BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
CN101945649A (zh) * 2008-02-19 2011-01-12 麦克内尔-Ppc股份有限公司 包含具有高直链淀粉含量的淀粉的浸涂组合物
KR101690094B1 (ko) 2008-05-09 2016-12-27 그뤼넨탈 게엠베하 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법
US20100003322A1 (en) * 2008-07-03 2010-01-07 Lai Felix S Enteric coated hydrophobic matrix formulation
WO2010028489A1 (en) 2008-09-15 2010-03-18 Labopharm Inc. Starch-based microparticles for the release of agents disposed therein
EP2179727B1 (en) * 2008-10-27 2013-05-29 Roquette Freres Water insoluble polymer: modified starch derivative-based film coatings for colon targeting
EP2367541B1 (en) * 2008-12-16 2014-07-16 Paladin Labs Inc. Misuse preventative, controlled release formulation
EA026651B1 (ru) 2009-01-23 2017-05-31 Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. Фармацевтический или пищевой состав с контролируемым высвобождением и способ его получения
PE20121067A1 (es) 2009-07-22 2012-09-05 Gruenenthal Chemie Forma de dosificacion de liberacion controlada extruida por fusion en caliente
WO2011009604A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Oxidation-stabilized tamper-resistant dosage form
AU2010300641B2 (en) * 2009-09-30 2016-03-17 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse
ES2606227T3 (es) 2010-02-03 2017-03-23 Grünenthal GmbH Preparación de una composición farmacéutica en polvo mediante una extrusora
MX2012009119A (es) 2010-02-07 2012-11-21 Clearfarma Ind Ltd Preparacion de garbanzos y usos de ella.
EP2386297A1 (en) * 2010-04-28 2011-11-16 Roquette Frères Indigestible polymer: starch acetate -based film coatings for colon targeting
BR112013000190A2 (pt) * 2010-07-06 2017-11-07 Gruenenthal Gmbh formas de dosagem de retenção gástrica compreendendo um análogo de gaba e um opioide
CA2808541C (en) 2010-09-02 2019-01-08 Gruenenthal Gmbh Tamper resistant dosage form comprising an anionic polymer
WO2012028319A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
AR087360A1 (es) 2011-07-29 2014-03-19 Gruenenthal Gmbh Tableta a prueba de manipulacion que proporciona liberacion de farmaco inmediato
KR20140053158A (ko) 2011-07-29 2014-05-07 그뤼넨탈 게엠베하 즉시 약물 방출을 제공하는 탬퍼-저항성 정제
US9511147B2 (en) * 2011-08-12 2016-12-06 Rutgers, The State University Of New Jersey Interpolymer network delivery system
CA2864949A1 (en) 2012-02-28 2013-09-06 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
JP6282261B2 (ja) 2012-04-18 2018-02-21 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 不正使用防止および過量放出防止医薬剤形
GB201207907D0 (en) 2012-05-04 2012-06-20 E Therapeutics Plc Treatment of depression
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP5922851B2 (ja) 2012-11-30 2016-05-24 アキュラ・ファーマシューティカルズ・インコーポレーテッド 活性医薬成分の自己制御放出
CN103070845B (zh) * 2013-01-14 2014-10-22 北京爱特康科贸有限责任公司 一种淀粉空心胶囊及其制备方法
EP3003279A1 (en) 2013-05-29 2016-04-13 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
CA2913209A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper resistant dosage form with bimodal release profile
AU2014289187B2 (en) 2013-07-12 2019-07-11 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
MX371372B (es) 2013-11-26 2020-01-28 Gruenenthal Gmbh Preparacion de una composicion farmaceutica en polvo por medio de criomolienda.
US9616029B2 (en) 2014-03-26 2017-04-11 Sun Pharma Advanced Research Company Ltd. Abuse deterrent immediate release coated reservoir solid dosage form
CA2947786A1 (en) 2014-05-12 2015-11-19 Grunenthal Gmbh Tamper resistant immediate release capsule formulation comprising tapentadol
WO2015181059A1 (en) 2014-05-26 2015-12-03 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
GB201413832D0 (en) * 2014-08-05 2014-09-17 Tate & Lyle Ingredients Starch compositions useful for thickening aqueous liquids
KR20170016386A (ko) 2014-06-02 2017-02-13 테티스, 아이엔씨. 개질된 생체중합체, 및 이의 제조 및 사용 방법
JP2018517676A (ja) 2015-04-24 2018-07-05 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 即時放出および溶媒抽出に対する耐性を有する改変防止製剤
WO2017040607A1 (en) 2015-08-31 2017-03-09 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient
WO2017042325A1 (en) 2015-09-10 2017-03-16 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
EP3380577A4 (en) 2015-11-23 2019-04-17 Tethis, Inc. COATED PARTICLES AND METHODS OF PRODUCTION AND USE
CN106337030A (zh) * 2016-08-24 2017-01-18 宁波枫叶杰科生物技术有限公司 一种治理重金属污染盐碱地的微生物制品及其制造方法
JP6216088B1 (ja) * 2017-04-21 2017-10-18 森永製菓株式会社 口腔徐放用組成物及びその製造方法
GB2567493B (en) 2017-10-13 2019-12-18 Altus Formulation Inc Starch-based release modifying excipients and pharmaceutical compositions derived therefrom
CN113121709B (zh) * 2019-12-30 2022-08-26 仙乐健康科技股份有限公司 一种变性淀粉的制备方法及应用
CN112098408B (zh) * 2020-09-14 2022-12-09 湖北亿纬动力有限公司 一种羧甲基纤维素钠溶解效果的检测方法及应用
CN117530929B (zh) * 2024-01-10 2024-03-29 东华大学 一种减肥胶囊

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2938901A (en) 1954-08-06 1960-05-31 Corn Products Co Surgical dusting powder and process therefor
US2987445A (en) 1958-10-10 1961-06-06 Rohm & Haas Drug composition
US3087860A (en) 1958-12-19 1963-04-30 Abbott Lab Method of prolonging release of drug from a precompressed solid carrier
US3034911A (en) 1959-03-25 1962-05-15 Nat Starch Chem Corp Tablet disintegrants
US3453368A (en) 1966-01-13 1969-07-01 Hoffmann La Roche Smaller high potency compressed tablets of ascorbic acid
US3490742A (en) 1966-01-14 1970-01-20 Staley Mfg Co A E Compressed tablets
US3622677A (en) 1969-07-07 1971-11-23 Staley Mfg Co A E Compressed tablets containing compacted starch as binder-disintegrant ingredient
US4072535A (en) 1970-12-28 1978-02-07 A. E. Staley Manufacturing Company Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules
US3904601A (en) * 1972-12-21 1975-09-09 Nat Starch Chem Corp Hydroxypropylated, inhibited high amylose retort starches
US4026986A (en) 1975-05-22 1977-05-31 The Dow Chemical Company Capsule shell
GB1576475A (en) * 1977-01-19 1980-10-08 Unilever Ltd Absorbent cross-linked starch materials
US4308251A (en) 1980-01-11 1981-12-29 Boots Pharmaceuticals, Inc. Controlled release formulations of orally-active medicaments
US4369308A (en) 1981-07-24 1983-01-18 National Starch And Chemical Corporation Low swelling starches as tablet disintegrants
US4818542A (en) 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4551177A (en) 1984-04-23 1985-11-05 National Starch And Chemical Corporation Compressible starches as binders for tablets or capsules
US4904476A (en) 1986-03-04 1990-02-27 American Home Products Corporation Formulations providing three distinct releases
IT1200178B (it) 1986-07-23 1989-01-05 Alfa Farmaceutici Spa Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica
GB8812490D0 (en) 1988-05-26 1988-06-29 Agricultural & Food Res Delayed release formulations
CA2041774C (en) 1990-11-27 1994-04-19 Mircea A. Mateescu Use of cross-linked amylose as a matrix for the slow release of biologically active compounds
CA2032385A1 (en) 1990-12-17 1992-06-18 Chung Wai-Chiu Enzymatically debranched starches as tablet excipients
KR100304997B1 (ko) 1992-07-24 2002-04-24 드니랑글로아 효소에의해제어되는약물방출을위한가교결합된폴리하이드록실물질을포함하는정제
US5616343A (en) 1993-03-25 1997-04-01 Labopharm, Inc. Cross-linked amylose as a binder/disintegrant in tablets
US5830884A (en) 1995-01-18 1998-11-03 National Starch And Chemical Investment Holding Corporation Pharmaceutical products containing thermally-inhibited starches
JP3949746B2 (ja) * 1996-02-28 2007-07-25 日澱化學株式会社 硝子繊維集束剤用化工澱粉
US5879707A (en) 1996-10-30 1999-03-09 Universite De Montreal Substituted amylose as a matrix for sustained drug release
US5807575A (en) 1997-02-14 1998-09-15 Rougier Inc. Manufacture of cross-linked amylose useful as a excipient for control release of active compounds
US6284273B1 (en) * 1998-02-24 2001-09-04 Vincent Lenaerts Cross-linked high amylose starch resistant to amylase as a matrix for the slow release of biologically active compounds
US6607748B1 (en) * 2000-06-29 2003-08-19 Vincent Lenaerts Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture

Also Published As

Publication number Publication date
ATE328585T1 (de) 2006-06-15
CZ20024269A3 (cs) 2003-06-18
CN100352509C (zh) 2007-12-05
KR20030031504A (ko) 2003-04-21
BR0112140B1 (pt) 2013-04-30
CZ300152B6 (cs) 2009-02-25
AU2001271481B2 (en) 2005-05-26
PL365634A1 (en) 2005-01-10
DE60120413T2 (de) 2007-06-14
DE60120413D1 (de) 2006-07-20
EP1305009A4 (en) 2004-11-17
NZ523644A (en) 2005-10-28
PT1305009E (pt) 2006-10-31
JP2004501957A (ja) 2004-01-22
MY128308A (en) 2007-01-31
US6607748B1 (en) 2003-08-19
WO2002002084A8 (en) 2002-04-04
IL153654A (en) 2008-12-29
SI1305009T1 (sl) 2007-08-31
CA2414349A1 (en) 2002-01-10
TWI289460B (en) 2007-11-11
RU2274443C2 (ru) 2006-04-20
BRPI0112140B8 (pt) 2021-05-25
IL153654A0 (en) 2003-07-06
WO2002002084A1 (en) 2002-01-10
CA2414349C (en) 2008-09-16
HUP0301302A2 (en) 2003-08-28
NO20026254L (no) 2003-02-27
EP1305009B1 (en) 2006-06-07
CN1449279A (zh) 2003-10-15
MXPA03000035A (es) 2005-09-21
PL202177B1 (pl) 2009-06-30
US20040013726A1 (en) 2004-01-22
ES2272499T3 (es) 2007-05-01
JP5025066B2 (ja) 2012-09-12
NO20026254D0 (no) 2002-12-27
HK1059574A1 (en) 2004-07-09
EP1305009A1 (en) 2003-05-02
AU7148101A (en) 2002-01-14
KR100840393B1 (ko) 2008-06-23
AR029549A1 (es) 2003-07-02
DK1305009T3 (da) 2006-12-27

Similar Documents

Publication Publication Date Title
BR0112140A (pt) Comprimido de liberação controlada, processo para a fabricação, em um meio aquoso, de um excipiente de liberação controlada e amido reticulado de elevado teor de amilose
NO20004208L (no) Fornettet stivelse med høyt amyloseinnhold og med funksjonelle grupper som en matriks for frigivning av farmasøytiske midler
HUP9800465A2 (hu) Polimerszál prepreg, eljárás előállítására, valamint ennek alkalmazása
ATE212040T1 (de) Herstellung von vernetzter amylose als hilfstoff zur kontrollierten freisetzung von wirkstoffen
BR9916235A (pt) Processo para a produção de um derivado de polissacarìdeo superabsorvente, derivado de polissacarìdeo superabsorvente, e, artigo absorvente
DK1163274T3 (da) Fremgangsmåde til tværbinding af hyaluronsyre til polymerer
BR0113663A (pt) Composições de pelìcula de pectina
SE0200539D0 (sv) Granulation process and starch granulate
DK0933079T3 (da) Fritflydende, direkte sammenpresselig stivelse som bindemiddel, sprængmiddel og fyldstof til sammenpresningstabletter og hårde gelatinekapsler
BR0310012A (pt) Processo para a preparação de um polìmero formador de hidrogel, polìmero formador de hidrogel, usos do mesmo e de um ácido acrìlico, e, artigo de higiene com um corpo de absorção
Juneja et al. Development of Corn Starch‐Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets
NO953767L (no) Tverrbundet amylose som et binde-/opplösende middel i tabletter
ATE230002T1 (de) Agglomerate zur herstellung eines wässrigen bindemittelsystems
DE69007869D1 (de) Leimung mit Gellangummi.
BRPI0520618A2 (pt) material de embrulho de artigo de fumar com melhores propriedades de queima espontánea
Ardhaoui et al. Exploring Interactions and Properties of the Sodium Carboxymethyl Cellulose–Chitosan Biopolymer Complex
Karimi et al. Tunable Thermo‐and pH‐Responsive Hydrogels and MWCNTs/Hydrogel Containing 2‐Aminobenzamide Units in Their Crosslink Chains
DE59914377D1 (de) Retardtablette hergestellt aus linearen wasserunlöslichen polysacchariden
AR022118A1 (es) Composiciones de hidroxipropil celulosa y polimero anionico y su uso como revestimientos de peliculas farmaceuticas
DE60044414D1 (de) Gel-pulver zusammensetzung
AU2002365956A1 (en) Granulated composition based on starchy substance and non-food and non-pharmaceutical use thereof
JP2003530458A5 (pt)
Hailegebriel et al. Preparation and Evaluation of Dual Modified Godare (Colocasia esculenta) Starch as a Sustained Release Excipient in Tablet Formulations
HUP9903838A2 (hu) Szuperabszorbens anyagot tartalmazó hordozó,eljárás előállítására és alkalmazása
BRPI0417985A (pt) uso de água para controlar o tamanho de partìculas, e, processo para a produção de partìculas para uso em uma composição farmacêutica

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/04/2013, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/06/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B15V Prolongation of time limit allowed
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 22A ANUIDADE.

B21H Decision of lapse of a patent or of a certificate of addition of invention cancelled [chapter 21.8 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 21.6 NA RPI NO 2728 DE 18/04/2023 POR TER SIDO INDEVIDA.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 26/06/2021