IL150329A0 - 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity - Google Patents
2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activityInfo
- Publication number
- IL150329A0 IL150329A0 IL15032900A IL15032900A IL150329A0 IL 150329 A0 IL150329 A0 IL 150329A0 IL 15032900 A IL15032900 A IL 15032900A IL 15032900 A IL15032900 A IL 15032900A IL 150329 A0 IL150329 A0 IL 150329A0
- Authority
- IL
- Israel
- Prior art keywords
- acetamides
- indol
- oxo
- antitumor activity
- colon
- Prior art date
Links
- AWMLDBKLOPNOAR-UHFFFAOYSA-N 2-(1h-indol-3-yl)-2-oxoacetamide Chemical class C1=CC=C2C(C(=O)C(=O)N)=CNC2=C1 AWMLDBKLOPNOAR-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 208000037841 lung tumor Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI002693A IT1315267B1 (it) | 1999-12-23 | 1999-12-23 | Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale |
| PCT/EP2000/013068 WO2001047916A1 (en) | 1999-12-23 | 2000-12-21 | 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL150329A0 true IL150329A0 (en) | 2002-12-01 |
Family
ID=11384182
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15032900A IL150329A0 (en) | 1999-12-23 | 2000-12-21 | 2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity |
| IL150329A IL150329A (en) | 1999-12-23 | 2002-06-19 | H1) - 2 - Indole – 3 – Eyal) - 2 - Oxo - acetamides with antisertic activity |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL150329A IL150329A (en) | 1999-12-23 | 2002-06-19 | H1) - 2 - Indole – 3 – Eyal) - 2 - Oxo - acetamides with antisertic activity |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6753342B2 (cs) |
| EP (1) | EP1244652B1 (cs) |
| JP (1) | JP2003519140A (cs) |
| KR (1) | KR100795533B1 (cs) |
| CN (1) | CN1250542C (cs) |
| AT (1) | ATE302772T1 (cs) |
| AU (1) | AU776332B2 (cs) |
| BR (1) | BR0016553A (cs) |
| CA (1) | CA2395205A1 (cs) |
| CZ (1) | CZ20022170A3 (cs) |
| DE (1) | DE60022227T2 (cs) |
| EA (1) | EA004925B1 (cs) |
| ES (1) | ES2246918T3 (cs) |
| HU (1) | HUP0203524A3 (cs) |
| IL (2) | IL150329A0 (cs) |
| IT (1) | IT1315267B1 (cs) |
| MX (1) | MXPA02006217A (cs) |
| NO (1) | NO323312B1 (cs) |
| NZ (1) | NZ519689A (cs) |
| PL (1) | PL356541A1 (cs) |
| SK (1) | SK285682B6 (cs) |
| TR (1) | TR200201613T2 (cs) |
| WO (1) | WO2001047916A1 (cs) |
| ZA (1) | ZA200204964B (cs) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1076657T1 (en) | 1998-04-28 | 2004-12-31 | Elbion Ag | New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same |
| IT1318641B1 (it) * | 2000-07-25 | 2003-08-27 | Novuspharma Spa | Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale. |
| DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
| WO2004005277A1 (en) * | 2002-07-09 | 2004-01-15 | Fasgen, Inc. | Novel compunds, pharmaceutical compositions containing same, and methods of use for same |
| SG146624A1 (en) | 2003-09-11 | 2008-10-30 | Kemia Inc | Cytokine inhibitors |
| ES2345662T3 (es) * | 2004-03-11 | 2010-09-29 | Actelion Pharmaceuticals Ltd. | Derivados de acido indol-1-il-acetico. |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| IN2014KN02423A (cs) | 2006-04-07 | 2015-05-01 | Vertex Pharma | |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| NZ596024A (en) * | 2006-08-07 | 2013-07-26 | Ironwood Pharmaceuticals Inc | Indole compounds |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CN105130948A (zh) | 2010-04-22 | 2015-12-09 | 弗特克斯药品有限公司 | 制备环烷基甲酰胺基-吲哚化合物的方法 |
| AR084433A1 (es) | 2010-12-22 | 2013-05-15 | Ironwood Pharmaceuticals Inc | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
| WO2012135027A2 (en) * | 2011-03-25 | 2012-10-04 | The Research Foundation Of State University Of New York | Thiolactone antibiotics |
| WO2014014841A1 (en) | 2012-07-16 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| EP3424534B1 (en) | 2014-04-15 | 2021-06-02 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
| CN115785079B (zh) * | 2022-11-28 | 2024-02-13 | 沈阳药科大学 | 4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK13598A3 (en) * | 1995-08-02 | 1998-06-03 | Univ Newcastle Ventures Ltd | Benzimidazole compounds |
| CO4970714A1 (es) * | 1997-09-05 | 2000-11-07 | Boehringer Mannheim Gmbh | Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales |
| DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| SI1076657T1 (en) * | 1998-04-28 | 2004-12-31 | Elbion Ag | New hydroxyindoles, their use as phosphodiesterase 4 inhibitors and method for producing same |
-
1999
- 1999-12-23 IT IT1999MI002693A patent/IT1315267B1/it active
-
2000
- 2000-12-21 BR BR0016553-0A patent/BR0016553A/pt not_active Application Discontinuation
- 2000-12-21 MX MXPA02006217A patent/MXPA02006217A/es active IP Right Grant
- 2000-12-21 PL PL00356541A patent/PL356541A1/xx not_active IP Right Cessation
- 2000-12-21 EP EP00985225A patent/EP1244652B1/en not_active Expired - Lifetime
- 2000-12-21 CA CA002395205A patent/CA2395205A1/en not_active Abandoned
- 2000-12-21 JP JP2001549386A patent/JP2003519140A/ja active Pending
- 2000-12-21 AT AT00985225T patent/ATE302772T1/de not_active IP Right Cessation
- 2000-12-21 DE DE60022227T patent/DE60022227T2/de not_active Expired - Fee Related
- 2000-12-21 AU AU21704/01A patent/AU776332B2/en not_active Ceased
- 2000-12-21 EA EA200200558A patent/EA004925B1/ru not_active IP Right Cessation
- 2000-12-21 NZ NZ519689A patent/NZ519689A/en unknown
- 2000-12-21 CZ CZ20022170A patent/CZ20022170A3/cs unknown
- 2000-12-21 CN CNB00817492XA patent/CN1250542C/zh not_active Expired - Fee Related
- 2000-12-21 WO PCT/EP2000/013068 patent/WO2001047916A1/en not_active Ceased
- 2000-12-21 KR KR1020027007960A patent/KR100795533B1/ko not_active Expired - Fee Related
- 2000-12-21 IL IL15032900A patent/IL150329A0/xx active IP Right Grant
- 2000-12-21 ES ES00985225T patent/ES2246918T3/es not_active Expired - Lifetime
- 2000-12-21 US US10/149,406 patent/US6753342B2/en not_active Expired - Fee Related
- 2000-12-21 TR TR2002/01613T patent/TR200201613T2/xx unknown
- 2000-12-21 HU HU0203524A patent/HUP0203524A3/hu unknown
- 2000-12-21 SK SK896-2002A patent/SK285682B6/sk not_active IP Right Cessation
-
2002
- 2002-06-19 IL IL150329A patent/IL150329A/en not_active IP Right Cessation
- 2002-06-20 ZA ZA200204964A patent/ZA200204964B/en unknown
- 2002-06-20 NO NO20022976A patent/NO323312B1/no not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |