IL149995A0 - Depsipeptides and pharmaceutical compositions containing the same - Google Patents

Depsipeptides and pharmaceutical compositions containing the same

Info

Publication number
IL149995A0
IL149995A0 IL14999500A IL14999500A IL149995A0 IL 149995 A0 IL149995 A0 IL 149995A0 IL 14999500 A IL14999500 A IL 14999500A IL 14999500 A IL14999500 A IL 14999500A IL 149995 A0 IL149995 A0 IL 149995A0
Authority
IL
Israel
Prior art keywords
depsipeptides
same
pharmaceutical compositions
compositions containing
grant
Prior art date
Application number
IL14999500A
Other languages
English (en)
Original Assignee
Xcyte Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26865325&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL149995(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xcyte Therapies Inc filed Critical Xcyte Therapies Inc
Publication of IL149995A0 publication Critical patent/IL149995A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14999500A 1999-12-08 2000-12-06 Depsipeptides and pharmaceutical compositions containing the same IL149995A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16973199P 1999-12-08 1999-12-08
US19358200P 2000-03-30 2000-03-30
PCT/US2000/033169 WO2001042282A1 (fr) 1999-12-08 2000-12-06 Depsipeptide et ses congeneres destines a etre utilises en tant qu'immunodepresseurs

Publications (1)

Publication Number Publication Date
IL149995A0 true IL149995A0 (en) 2002-12-01

Family

ID=26865325

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14999500A IL149995A0 (en) 1999-12-08 2000-12-06 Depsipeptides and pharmaceutical compositions containing the same
IL149995A IL149995A (en) 1999-12-08 2002-06-03 Depsipeptides and pharmaceutical compositions containing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL149995A IL149995A (en) 1999-12-08 2002-06-03 Depsipeptides and pharmaceutical compositions containing the same

Country Status (16)

Country Link
US (2) US6403555B1 (fr)
EP (3) EP1246839B1 (fr)
JP (4) JP4824890B2 (fr)
KR (1) KR20020062956A (fr)
CN (1) CN1414971A (fr)
AT (3) ATE353663T1 (fr)
AU (1) AU762525B2 (fr)
BR (1) BR0016154A (fr)
CA (1) CA2393682C (fr)
DE (3) DE60044542D1 (fr)
DK (1) DK1438966T3 (fr)
ES (3) ES2347284T3 (fr)
HK (2) HK1049849B (fr)
IL (2) IL149995A0 (fr)
PT (1) PT1438966E (fr)
WO (1) WO2001042282A1 (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
US8119159B2 (en) 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
EP1313872A1 (fr) * 2000-09-01 2003-05-28 Fujisawa Pharmaceutical Co., Ltd. Procede de preparation de fr901228
WO2002055017A2 (fr) * 2000-11-21 2002-07-18 Wake Forest University Methode de traitement de maladies auto-immunes
US6632553B2 (en) * 2001-03-27 2003-10-14 Mti Microfuel Cells, Inc. Methods and apparatuses for managing effluent products in a fuel cell system
PT1426054E (pt) 2001-08-21 2011-12-06 Astellas Pharma Inc Utilização medicinal de inibidor da histona desacetilase e método de avaliação do seu efeito antitumoral
US8163764B2 (en) * 2002-04-26 2012-04-24 Asan Laboratories Company (Cayman) Limited Skincare methods
US20060275370A1 (en) * 2002-07-25 2006-12-07 Yih-Lin Chung Method and compositions for treatment of epithelial damage
US8846039B2 (en) * 2002-04-26 2014-09-30 Asan Laboratories Company (Cayman), Limited Method for ameliorating pruritus
US8883148B2 (en) * 2002-04-26 2014-11-11 Asan Laboratories Company (Cayman), Limited Prevention of joint destruction
US6809118B2 (en) * 2002-07-25 2004-10-26 Yih-Lin Chung Methods for therapy of radiation cutaneous syndrome
US8946295B2 (en) * 2002-07-25 2015-02-03 Sunny Pharmtech Inc. Histone hyperacetylating agents for promoting wound healing and preventing scar formation
EP1547617B1 (fr) * 2002-08-20 2010-04-28 Astellas Pharma Inc. Inhibiteur de degradation de la matrice extracellulaire du cartilage arthrodial
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7381825B2 (en) 2003-03-17 2008-06-03 Takeda San Diego, Inc. Histone deacetylase inhibitors
CA2529840A1 (fr) * 2003-06-27 2005-01-06 Astellas Pharma Inc. Agent therapeutique contre le sarcome des tissus mous
US20090285783A1 (en) * 2003-07-09 2009-11-19 Henry Ford Health System Methods and compositions for cancer therapy using a novel adenovirus
ES2344899T3 (es) * 2003-09-25 2010-09-09 Astellas Pharma Inc. Agente antitumoral que comprende un inhibidor de histona desacetilasa y un inhibidor de topoisomerasa ii.
WO2005066151A2 (fr) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
WO2005065681A1 (fr) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. Derives de n-hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide et composes associes en tant qu'inhibiteurs d'histone deacetylase pour le traitement du cancer
US20050187148A1 (en) * 2004-02-25 2005-08-25 Yoshinori Naoe Antitumor agent
US7951780B2 (en) * 2004-02-25 2011-05-31 Astellas Pharma Inc. Antitumor agent
EP1812036A2 (fr) * 2004-11-17 2007-08-01 The University Of Chicago Inhibiteurs de l'histone desacetylase et leurs methodes d'utilisation
EP1824831A2 (fr) 2004-12-16 2007-08-29 Takeda San Diego, Inc. Inhibiteurs d'histone desacetylase
WO2006122319A2 (fr) 2005-05-11 2006-11-16 Takeda San Diego, Inc. Inhibiteurs d'histone deacetylase
GB0511266D0 (en) * 2005-06-02 2005-07-13 Trust Chemical compounds
US7732475B2 (en) 2005-07-14 2010-06-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
CA2621560A1 (fr) * 2005-09-07 2007-03-15 Braincells, Inc. Modulation de la neurogenese par inhibition de la hdac
CA2630216A1 (fr) * 2005-11-18 2007-05-31 Gloucester Pharmaceuticals, Inc. Derives de metabolites de l'inhibiteur de hdac fk228
JP2009525955A (ja) * 2006-01-13 2009-07-16 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
EP2007397B1 (fr) 2006-04-07 2013-07-24 Merrion Research III Limited Forme pharmaceutique solide par voie orale contenant un activateur
CA2650520A1 (fr) * 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Traitement de tumeurs exprimant ras
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
WO2007146234A2 (fr) * 2006-06-09 2007-12-21 Merrion Research Ii Limited Forme posologique solide à administrer par voie orale contenant un activateur
US7883855B2 (en) 2006-07-21 2011-02-08 Abbott Laboratories Immunosuppressant drug extraction reagent for immunoassays
EP2063905B1 (fr) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Traitement des troubles hépatiques par l'administration de conjugués de protéine associée au récepteur (rap)
AU2007323215B2 (en) * 2006-11-22 2012-07-19 Karus Therapeutics Limited Depsipeptides and their therapeutic use
GB0623388D0 (en) * 2006-11-23 2007-01-03 Univ Southampton Chemical compounds
BRPI0720734A2 (pt) * 2006-12-29 2014-01-07 Gloucester Pharmaceuticals Inc Preparação da romidepsina
JP2010514801A (ja) * 2006-12-29 2010-05-06 グラスター ファーマシューティカルズ， インコーポレイテッド ロミデプシンの精製
US7914999B2 (en) 2006-12-29 2011-03-29 Abbott Laboratories Non-denaturing lysis reagent
WO2008151306A1 (fr) * 2007-06-05 2008-12-11 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Synthèse de composés cyclodepsipeptide ayant une activité antinéoplasique et/ou antimicrobienne
GB0715750D0 (en) * 2007-08-13 2007-09-19 Karus Therapeutics Ltd Chemical compounds
ES2559311T3 (es) * 2007-12-19 2016-02-11 Abbott Laboratories Reactivo de extracción de fármacos inmunosupresores para inmunoanálisis
TW200950799A (en) 2008-05-07 2009-12-16 Merrion Res Iii Ltd Compositions of GnRH related compounds and processes of preparation
EP2293845A1 (fr) * 2008-05-22 2011-03-16 Karus Therapeutics Limited Depsipeptides et leur utilisation thérapeutique
DK2293846T3 (da) * 2008-05-22 2013-10-14 Karus Therapeutics Ltd Depsipeptider og deres terapeutiske anvendelse
CA2763299C (fr) * 2009-06-26 2015-11-24 Asan Laboratories Co., Ltd. Methode traitement ou d'amelioration de toxicites mucocutanees ou oculaires
TWI412359B (zh) * 2009-07-07 2013-10-21 Asan Lab Co Ltd 組織蛋白去乙醯酵素抑制劑在製備治療或減緩黏膜／皮膚或眼睛毒性或副作用之藥物的用途
WO2011120033A1 (fr) 2010-03-26 2011-09-29 Merrion Research Iii Limited Compositions pharmaceutiques d'inhibiteurs de facteur xa sélectifs destinées à une administration orale
CA2804795A1 (fr) 2010-07-12 2012-01-19 Nicholas Vrolijk Formes solides de la romidepsine et leurs utilisations
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CA2819234A1 (fr) 2011-01-07 2012-07-12 Merrion Research Iii Limited Compositions pharmaceutiques de fer pour administration orale
WO2013047509A1 (fr) * 2011-09-30 2013-04-04 国立大学法人東北大学 Nouvel inhibiteur de phosphatidylinositol-3-kinase et composition pharmaceutique
AU2013203395A1 (en) 2012-03-30 2013-10-17 Isis Pharmaceuticals, Inc. Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
TW202246503A (zh) * 2013-07-19 2022-12-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
KR20150140177A (ko) * 2014-06-05 2015-12-15 한미약품 주식회사 단백질 및 펩타이드의 면역원성을 감소시키는 방법
WO2016120378A1 (fr) 2015-01-29 2016-08-04 Novo Nordisk A/S Comprimés contenant un agoniste de glp-1 et revêtement gastro-résistant
CN110760564A (zh) * 2019-10-16 2020-02-07 菲诺克生物科技(上海)有限公司 细胞周期检测方法及其所用试剂与试剂盒

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268516A (en) 1978-10-11 1981-05-19 Pfizer Inc. [1]Benzothiopyrano[4,3-c]pyrazoles as immunoregulatory agents
US4950649A (en) * 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
GB8817743D0 (en) * 1988-07-26 1988-09-01 Fujisawa Pharmaceutical Co Fr901228 substance & preparation thereof
WO1993019778A1 (fr) 1992-04-07 1993-10-14 The Scripps Research Institute Procede servant a provoquer la tolerance a un antigene au moyen de butyrate
ZA946765B (en) 1993-09-02 1996-02-15 Dartmouth College Methods of prolonged suppression of humoral immunity
US5591717A (en) 1994-04-06 1997-01-07 Rojko; Jennifer L. Branched apogenic peptide for inducing apoptosis
WO1995033823A1 (fr) 1994-06-03 1995-12-14 The United States Of America, Represented By The Secretary Of The Navy Procedes de stimulation selective de la proliferation des cellules t
US5843943A (en) 1994-12-29 1998-12-01 The Regents Of The University Of California Compounds for inhibition of ceramide-mediated signal transduction
US5962019A (en) 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5891653A (en) 1995-12-29 1999-04-06 Attfield; Derrick Cecil Method of suppressing graft rejection by means of stress proteins
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
WO1998039412A1 (fr) 1997-03-03 1998-09-11 Duke University Immunodepression
DE19713626A1 (de) * 1997-04-02 1998-10-08 Bayer Ag Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung
WO1998046640A2 (fr) 1997-04-15 1998-10-22 Coulter International Corp. Procedes et compositions permettant d'induire l'immunosuppression
JP3494624B2 (ja) 1997-09-02 2004-02-09 住友製薬株式会社 新規な環状テトラペプチド誘導体とその医薬用途
AU9395998A (en) 1997-09-17 1999-04-05 Genentech Inc. Compositions and methods for the treatment of immune related diseases
WO1999015174A1 (fr) 1997-09-22 1999-04-01 Sloan-Kettering Institute For Cancer Research Composes de prenyle inverse utiles comme immunodepresseurs
AU1399199A (en) 1997-11-14 1999-06-07 Merck & Co., Inc. Immunosuppressant tetracyclic triterpenes
AU1864999A (en) 1997-12-15 1999-07-05 Universite Laval Methods and compositions for improving the success of cell transplantation in a host
JPH11180873A (ja) 1997-12-22 1999-07-06 Kaken Shoyaku Kk ＮＦ−κＢ活性阻害剤
US6211145B1 (en) * 1997-12-25 2001-04-03 Nisshin Flour Milling Co., Ltd. Bicyclic depsipeptides
US6001815A (en) * 1997-12-25 1999-12-14 Nisshin Flour Milling Co., Ltd. Depsipeptides containing N-substituted glycine residue
EP0931792B1 (fr) * 1998-01-27 2004-01-07 Nisshin Seifun Group Inc. Depsipeptides comportant des acides aminés non naturelles
US6287843B1 (en) 1998-04-03 2001-09-11 Pioneer Hi-Bred International, Inc. Maize histone deacetylases and their use
ATE331730T1 (de) * 1999-01-13 2006-07-15 Astellas Pharma Inc Neue depsipeptid-verbindung

Also Published As

Publication number Publication date
EP1246839B1 (fr) 2004-06-16
ATE353663T1 (de) 2007-03-15
US20020045575A1 (en) 2002-04-18
ES2347284T3 (es) 2010-10-27
EP1438966A3 (fr) 2004-08-04
DE60033453D1 (de) 2007-03-29
BR0016154A (pt) 2003-02-25
JP2013107902A (ja) 2013-06-06
AU762525B2 (en) 2003-06-26
EP1779859A3 (fr) 2007-05-16
US6548479B1 (en) 2003-04-15
DE60011678D1 (de) 2004-07-22
HK1070268A1 (en) 2005-06-17
WO2001042282A9 (fr) 2002-05-30
IL149995A (en) 2009-09-01
AU2068001A (en) 2001-06-18
DE60044542D1 (de) 2010-07-22
DK1438966T3 (da) 2007-06-11
EP1438966B1 (fr) 2007-02-14
DE60033453T2 (de) 2007-11-29
EP1246839A1 (fr) 2002-10-09
HK1049849B (zh) 2004-12-03
PT1438966E (pt) 2007-05-31
EP1779859B1 (fr) 2010-06-09
CA2393682C (fr) 2012-01-31
WO2001042282A1 (fr) 2001-06-14
JP2014205714A (ja) 2014-10-30
CN1414971A (zh) 2003-04-30
KR20020062956A (ko) 2002-07-31
JP2011084585A (ja) 2011-04-28
EP1438966A2 (fr) 2004-07-21
US6403555B1 (en) 2002-06-11
ATE470447T1 (de) 2010-06-15
HK1049849A1 (en) 2003-05-30
ES2225282T3 (es) 2005-03-16
JP2003516418A (ja) 2003-05-13
ES2282751T3 (es) 2007-10-16
EP1779859A2 (fr) 2007-05-02
CA2393682A1 (fr) 2001-06-14
JP4824890B2 (ja) 2011-11-30
DE60011678T2 (de) 2005-07-14
ATE269354T1 (de) 2004-07-15

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