IL149582A0 - Substituted oxazoles and thiazoles derivative as hppar alpha activators - Google Patents

Substituted oxazoles and thiazoles derivative as hppar alpha activators

Info

Publication number
IL149582A0
IL149582A0 IL14958200A IL14958200A IL149582A0 IL 149582 A0 IL149582 A0 IL 149582A0 IL 14958200 A IL14958200 A IL 14958200A IL 14958200 A IL14958200 A IL 14958200A IL 149582 A0 IL149582 A0 IL 149582A0
Authority
IL
Israel
Prior art keywords
substituted oxazoles
hppar alpha
alpha activators
thiazoles derivative
thiazoles
Prior art date
Application number
IL14958200A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9928561.1A external-priority patent/GB9928561D0/en
Priority claimed from GB0003500A external-priority patent/GB0003500D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IL149582A0 publication Critical patent/IL149582A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14958200A 1999-12-02 2000-11-30 Substituted oxazoles and thiazoles derivative as hppar alpha activators IL149582A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9928561.1A GB9928561D0 (en) 1999-12-02 1999-12-02 Chemical compounds
GB0003500A GB0003500D0 (en) 2000-02-15 2000-02-15 Chemical compounds
PCT/EP2000/011995 WO2001040207A1 (en) 1999-12-02 2000-11-30 Substituted oxazoles and thiazoles derivatives as hppar alpha activators

Publications (1)

Publication Number Publication Date
IL149582A0 true IL149582A0 (en) 2002-11-10

Family

ID=26243654

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14958200A IL149582A0 (en) 1999-12-02 2000-11-30 Substituted oxazoles and thiazoles derivative as hppar alpha activators
IL149582A IL149582A (en) 1999-12-02 2002-05-09 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF hPPAR ALPHA DISEASE OR CONDITION

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL149582A IL149582A (en) 1999-12-02 2002-05-09 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF hPPAR ALPHA DISEASE OR CONDITION

Country Status (27)

Country Link
US (1) US6518290B1 (ja)
EP (1) EP1244642B1 (ja)
JP (1) JP3884290B2 (ja)
KR (1) KR100706735B1 (ja)
CN (1) CN1184215C (ja)
AR (1) AR035631A1 (ja)
AT (1) ATE265442T1 (ja)
AU (1) AU758758B2 (ja)
BR (1) BR0016067A (ja)
CA (1) CA2393190A1 (ja)
CO (1) CO5251452A1 (ja)
CZ (1) CZ20021903A3 (ja)
DE (1) DE60010333T2 (ja)
DK (1) DK1244642T3 (ja)
ES (1) ES2219423T3 (ja)
GC (1) GC0000215A (ja)
HK (1) HK1047435B (ja)
HU (1) HUP0203532A3 (ja)
IL (2) IL149582A0 (ja)
MX (1) MXPA02005456A (ja)
NO (1) NO323135B1 (ja)
PE (1) PE20011010A1 (ja)
PL (1) PL356772A1 (ja)
PT (1) PT1244642E (ja)
TR (2) TR200201473T2 (ja)
TW (1) TW555753B (ja)
WO (1) WO2001040207A1 (ja)

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UA82048C2 (uk) 2000-11-10 2008-03-11 Эли Лилли Энд Компани Агоністи альфа-рецепторів, активованих проліфератором пероксисом
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GB0031103D0 (en) * 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
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BR0311834A (pt) 2002-06-19 2005-04-12 Lilly Co Eli Composto, composição farmacêutica, métodos para mudular um receptor ativado por proliferador de peroxisoma, para tratar e prevenir diabetes mellitus em um mamìfero e para tratar sìndrome x em um mamìfero, e, uso de um composto ou seu sal farmaceuticamente aceitável
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US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
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CN109810071B (zh) * 2019-03-28 2023-04-21 中国科学院成都生物研究所 一种miRNA生物合成抑制剂
CN110803996B (zh) * 2019-11-13 2022-01-11 台州市创源工业技术有限公司 一种羟基苄胺的合成方法

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Also Published As

Publication number Publication date
NO20022467D0 (no) 2002-05-24
BR0016067A (pt) 2002-08-06
AU758758B2 (en) 2003-03-27
TR200201473T2 (tr) 2002-09-23
AR035631A1 (es) 2004-06-23
CZ20021903A3 (cs) 2003-01-15
EP1244642A1 (en) 2002-10-02
CN1402716A (zh) 2003-03-12
HUP0203532A3 (en) 2005-01-28
MXPA02005456A (es) 2002-11-29
IL149582A (en) 2008-11-26
CA2393190A1 (en) 2001-06-07
KR100706735B1 (ko) 2007-04-13
NO20022467L (no) 2002-07-26
JP3884290B2 (ja) 2007-02-21
HUP0203532A2 (hu) 2003-02-28
KR20020058073A (ko) 2002-07-12
HK1047435B (zh) 2004-11-26
CO5251452A1 (es) 2003-02-28
DE60010333D1 (de) 2004-06-03
WO2001040207A1 (en) 2001-06-07
AU2003001A (en) 2001-06-12
CN1184215C (zh) 2005-01-12
TW555753B (en) 2003-10-01
PL356772A1 (en) 2004-07-12
NO323135B1 (no) 2007-01-08
TR200401772T4 (tr) 2004-09-21
JP2003515597A (ja) 2003-05-07
GC0000215A (en) 2006-03-29
ATE265442T1 (de) 2004-05-15
DE60010333T2 (de) 2005-06-16
ES2219423T3 (es) 2004-12-01
HK1047435A1 (en) 2003-02-21
US6518290B1 (en) 2003-02-11
EP1244642B1 (en) 2004-04-28
PE20011010A1 (es) 2001-10-18
DK1244642T3 (da) 2004-08-16
PT1244642E (pt) 2004-09-30

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