IL145777A0 - Macrolide antiinfective agents - Google Patents

Macrolide antiinfective agents

Info

Publication number
IL145777A0
IL145777A0 IL14577700A IL14577700A IL145777A0 IL 145777 A0 IL145777 A0 IL 145777A0 IL 14577700 A IL14577700 A IL 14577700A IL 14577700 A IL14577700 A IL 14577700A IL 145777 A0 IL145777 A0 IL 145777A0
Authority
IL
Israel
Prior art keywords
sub
substituted
unsubstituted
alkyl
amino
Prior art date
Application number
IL14577700A
Other languages
English (en)
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of IL145777A0 publication Critical patent/IL145777A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
    • A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14577700A 1999-04-16 2000-04-14 Macrolide antiinfective agents IL145777A0 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US12972999P 1999-04-16 1999-04-16
US14017599P 1999-06-18 1999-06-18
US17215499P 1999-12-17 1999-12-17
US17215999P 1999-12-17 1999-12-17
US17380499P 1999-12-30 1999-12-30
US17380599P 1999-12-30 1999-12-30
PCT/US2000/009914 WO2000063224A2 (fr) 1999-04-16 2000-04-14 ipcNTS ANTI-INFECTIEUX MACROLIDES
US09/550,045 US6395710B1 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents

Publications (1)

Publication Number Publication Date
IL145777A0 true IL145777A0 (en) 2002-07-25

Family

ID=27568857

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14577700A IL145777A0 (en) 1999-04-16 2000-04-14 Macrolide antiinfective agents
IL145777A IL145777A (en) 1999-04-16 2001-10-04 History 3 - Descladinosil - 3 - Oxo - Erythromycin A 12,11 - Cyclic cyclamate and anti-inflammatory drugs containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL145777A IL145777A (en) 1999-04-16 2001-10-04 History 3 - Descladinosil - 3 - Oxo - Erythromycin A 12,11 - Cyclic cyclamate and anti-inflammatory drugs containing them

Country Status (16)

Country Link
US (3) US6395710B1 (fr)
EP (1) EP1171446B1 (fr)
JP (1) JP2003523938A (fr)
KR (2) KR100710605B1 (fr)
CN (1) CN1241931C (fr)
AT (1) ATE340183T1 (fr)
AU (2) AU773678B2 (fr)
BR (1) BR0010680A (fr)
CA (1) CA2369816A1 (fr)
DE (1) DE60030847T2 (fr)
ES (1) ES2272273T3 (fr)
ID (1) ID30547A (fr)
IL (2) IL145777A0 (fr)
MX (1) MXPA01010524A (fr)
NZ (1) NZ515027A (fr)
WO (2) WO2000063224A2 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
DK1147121T3 (da) 1999-01-27 2004-04-13 Pfizer Prod Inc Ketolidantibiotika
US6590083B1 (en) * 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
DE60104240T2 (de) 2000-06-30 2005-08-04 Pfizer Products Inc., Groton Makrolid-Antibiotika
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
EP1373290B1 (fr) * 2001-03-21 2014-08-20 Dow AgroSciences LLC Derives de spinosyne pesticides
US6713455B2 (en) 2001-09-17 2004-03-30 Ortho-Mcneil Pharmaceutical, Inc. 6-O-carbamate-11,12-lacto-ketolide antimicrobials
CA2469304A1 (fr) 2001-12-05 2003-06-19 Ortho-Mcneil Pharmaceutical, Inc. Agents anti-bacteriens de 6-o-acyl cetolide
US8063021B2 (en) * 2002-01-17 2011-11-22 Kosan Biosciences Incorporated Ketolide anti-infective compounds
DK1483251T3 (da) 2002-03-12 2010-04-12 Bristol Myers Squibb Co C3-cyano-epothilon-derivater
US20040014691A1 (en) * 2002-04-25 2004-01-22 Searle Xenia Beebe 9-Oxime macrolide antibacterials
US20040009932A1 (en) * 2002-04-26 2004-01-15 Kathleen Phelan Antibacterial compounds with activity against penicillin-resistant streptococcus pneumoniae
CA2487918A1 (fr) 2002-05-31 2003-12-11 Janssen Pharmaceutica N.V. Agents antibacteriens macrolides 3-descladinosyl-6-o-carbamyle et 6-o-carbonyle
US7427493B2 (en) 2002-06-28 2008-09-23 Kosan Biosciences Incorporated Recombinant genes for polyketide modifying enzymes
SI1532131T1 (sl) * 2002-08-29 2009-04-30 Pfizer Motilidne spojine
CA2529817C (fr) * 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Nouveaux agents antibacteriens
US7407941B2 (en) * 2003-08-26 2008-08-05 Pfizer, Inc. N-desmethyl-N-substituted-11-deoxyerythromycin compounds
US20050113319A1 (en) * 2003-08-26 2005-05-26 Christopher Carreras 11-Deoxy-6,9-ether erythromycin compounds
WO2005067919A1 (fr) * 2003-12-24 2005-07-28 Enanta Pharmaceuticals, Inc. Derives d'erythromycine 11-c substitues
BRPI0519135A2 (pt) * 2004-12-21 2008-12-23 Pfizer Prod Inc macrolÍdeos
US7595300B2 (en) 2005-12-13 2009-09-29 Kosan Biosciences Incorporated 7-quinolyl ketolide antibacterial agents
JP5698979B2 (ja) * 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド系抗菌剤の調製プロセス
WO2009098320A2 (fr) * 2008-02-08 2009-08-13 Basilea Pharmaceutica Ag Macrolides et utilisation de macrolides
JP5602748B2 (ja) 2008-10-24 2014-10-08 センプラ ファーマシューティカルズ，インコーポレイテッド トリアゾール含有マクロライドを用いた生体防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2608285T3 (es) 2009-09-10 2017-04-07 Cempra Pharmaceuticals, Inc. Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
WO2012117357A2 (fr) * 2011-03-01 2012-09-07 Wockhardt Limited Procédé de préparation d'intermédiaires de cétolides
US10188674B2 (en) 2012-03-27 2019-01-29 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102718816B (zh) * 2012-07-11 2014-11-05 山东大学 4''-O-(反式-β-芳基烯丙酰胺)氨基甲酰基阿奇霉素衍生物
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
US20230174567A1 (en) * 2020-05-22 2023-06-08 Merck Sharp & Dohme Llc Synthesis of fluorinated nucleotides

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141926A (en) * 1990-04-18 1992-08-25 Abbott Laboratories Erythromycin derivatives
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
JP3259429B2 (ja) * 1992-04-22 2002-02-25 大正製薬株式会社 ５−ｏ−デソサミニルエリスロノライドａ誘導体
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US6066721A (en) 1995-07-06 2000-05-23 Stanford University Method to produce novel polyketides
US5672491A (en) 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
IL122859A0 (en) 1995-07-06 1998-08-16 Univ Leland Stanford Junior Cell-free synthesis of polyketides
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
FR2742757B1 (fr) 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AU726075B2 (en) 1996-05-07 2000-10-26 Abbott Laboratories 6-o-substituted erythromycin compounds and method for making same
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
US6271255B1 (en) 1996-07-05 2001-08-07 Biotica Technology Limited Erythromycins and process for their preparation
NZ333861A (en) 1996-07-05 2000-08-25 Pfizer Erythromycins and preparation from unnatural starter units in microorganisms
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
ATE296308T1 (de) * 1996-09-04 2005-06-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
FR2754821B1 (fr) * 1996-10-23 2003-04-04 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
WO1998018808A1 (fr) * 1996-10-31 1998-05-07 Taisho Pharmaceutical Co., Ltd. Derives de l'erythromycine
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
EP0975330A1 (fr) * 1997-02-04 2000-02-02 Abbott Laboratories Formulation analgesique a administration parenterale encapsulee dans un liposome
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
HUP0002252A3 (en) * 1997-06-11 2002-01-28 Pfizer Prod Inc 9-oxime erythromycin derivatives, process for preparing them and pharmaceutical compositions containing them
ES2217579T3 (es) * 1997-09-30 2004-11-01 Abbott Laboratories Derivados de eritromicina cetolidos, modificados en n-3 y sustituidos en o-6, que tiene una actividad antibacteriana.
US6124269A (en) 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
CO4990960A1 (es) 1997-10-29 2000-12-26 Abbott Lab Derivados de cetolidos 2-halo-6-o sustituidos
WO1999021870A1 (fr) * 1997-10-29 1999-05-06 Taisho Pharmaceutical Co., Ltd. Derives de l'erythromycine a 11,12-carbamate
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
PT941998E (pt) 1998-03-03 2004-12-31 Pfizer Prod Inc Antibioticos macrolidos do tipo 3,6-cetal
FR2777282B1 (fr) 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
PT952157E (pt) * 1998-04-24 2003-11-28 Pfizer Prod Inc Derivados 9a, 11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina
FR2781484B1 (fr) * 1998-07-21 2001-08-10 Hoechst Marion Roussel Inc Nouveaux derives de la 6-deoxy erythromycine, leur procede de preparation et leur application comme medicaments
WO2000026349A2 (fr) 1998-10-29 2000-05-11 Kosan Biosciences, Inc. Oleandolide-polyketide-synthase de recombinaison
OA11670A (en) 1998-11-03 2005-01-12 Pfizer Prod Inc Novel macrolide antibiotics.
EP1137654A1 (fr) 1998-12-10 2001-10-04 Pfizer Products Inc. Antibiotiques a base de cetolides de carbamate et de carbazate
DK1147121T3 (da) 1999-01-27 2004-04-13 Pfizer Prod Inc Ketolidantibiotika
SK13162001A3 (sk) * 1999-03-15 2001-12-03 Abbott Laboratories 6-o-substituované makrolidy majúce antibakteriálnu aktivitu
US6458771B1 (en) * 1999-04-16 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
SK15162001A3 (sk) 1999-05-24 2003-02-04 Pfizer Products Inc. Deriváty 13-metylerytromycínu

Also Published As

Publication number Publication date
AU773678B2 (en) 2004-06-03
KR20020007372A (ko) 2002-01-26
US6395710B1 (en) 2002-05-28
AU4457800A (en) 2000-11-02
EP1171446A2 (fr) 2002-01-16
KR20020007374A (ko) 2002-01-26
CA2369816A1 (fr) 2000-10-26
WO2000063225A2 (fr) 2000-10-26
US20020119938A1 (en) 2002-08-29
ES2272273T3 (es) 2007-05-01
JP2003523938A (ja) 2003-08-12
CN1241931C (zh) 2006-02-15
CN1384838A (zh) 2002-12-11
AU4237900A (en) 2000-11-02
NZ515027A (en) 2004-01-30
ID30547A (id) 2001-12-20
USRE39836E1 (en) 2007-09-11
DE60030847T2 (de) 2007-04-19
BR0010680A (pt) 2002-02-19
AU775637B2 (en) 2004-08-12
MXPA01010524A (es) 2002-03-14
US6593302B2 (en) 2003-07-15
EP1171446B1 (fr) 2006-09-20
IL145777A (en) 2007-02-11
WO2000063225A3 (fr) 2001-01-18
WO2000063224A2 (fr) 2000-10-26
DE60030847D1 (de) 2006-11-02
WO2000063224A3 (fr) 2001-01-18
ATE340183T1 (de) 2006-10-15
KR100710605B1 (ko) 2007-04-24

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