IL144299A - N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists - Google Patents

N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists

Info

Publication number
IL144299A
IL144299A IL14429901A IL14429901A IL144299A IL 144299 A IL144299 A IL 144299A IL 14429901 A IL14429901 A IL 14429901A IL 14429901 A IL14429901 A IL 14429901A IL 144299 A IL144299 A IL 144299A
Authority
IL
Israel
Prior art keywords
lower alkyl
alkyl
hetero
phenyl
twice
Prior art date
Application number
IL14429901A
Other languages
English (en)
Hebrew (he)
Other versions
IL144299A0 (en
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of IL144299A0 publication Critical patent/IL144299A0/xx
Publication of IL144299A publication Critical patent/IL144299A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL14429901A 2000-07-28 2001-07-12 N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists IL144299A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10036818A DE10036818A1 (de) 2000-07-28 2000-07-28 Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten

Publications (2)

Publication Number Publication Date
IL144299A0 IL144299A0 (en) 2002-05-23
IL144299A true IL144299A (en) 2004-08-31

Family

ID=7650544

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14429901A IL144299A (en) 2000-07-28 2001-07-12 N-triazolylmethyl-piperazine derivatives as neurokinin receptor antagonists

Country Status (28)

Country Link
US (1) US6407106B1 (zh)
EP (1) EP1176144B1 (zh)
JP (1) JP2002053577A (zh)
KR (1) KR100924405B1 (zh)
CN (1) CN1167698C (zh)
AR (1) AR028743A1 (zh)
AT (1) ATE244716T1 (zh)
AU (1) AU779318B2 (zh)
BR (1) BR0103048A (zh)
CA (1) CA2354213C (zh)
CZ (1) CZ301695B6 (zh)
DE (2) DE10036818A1 (zh)
DK (1) DK1176144T3 (zh)
DZ (1) DZ3119A1 (zh)
ES (1) ES2201007T3 (zh)
HK (1) HK1042699A1 (zh)
HU (1) HU226687B1 (zh)
IL (1) IL144299A (zh)
IN (1) IN191021B (zh)
NO (1) NO323233B1 (zh)
NZ (1) NZ513041A (zh)
PL (1) PL210436B1 (zh)
PT (1) PT1176144E (zh)
RU (1) RU2288918C2 (zh)
SK (1) SK284802B6 (zh)
TW (1) TWI304403B (zh)
UA (1) UA73728C2 (zh)
ZA (1) ZA200105737B (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77515C2 (en) * 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
PT1501808E (pt) * 2002-04-26 2008-09-26 Lilly Co Eli Antagonistas de receptores taquiquininas
NZ535886A (en) * 2002-04-26 2007-07-27 Lilly Co Eli Triazole derivatives as tachykinin receptor antagonists
WO2005000821A1 (en) * 2003-06-12 2005-01-06 Eli Lilly And Company Tachykinin receptor antagonists
US20070082905A1 (en) * 2005-05-27 2007-04-12 De Vries Michiel H Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same
ES2353724T3 (es) * 2005-07-25 2011-03-04 F. Hoffmann-La Roche Ag Derivados de triazol substitutidos y su uso como antagonistas del receptor neuroquinina 3.
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
WO2008090117A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
WO2011020874A1 (en) 2009-08-20 2011-02-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
EP4371613A3 (en) 2018-02-26 2024-07-24 Ospedale San Raffaele S.r.l. Compounds for use in the treatment of ocular pain
WO2021180885A1 (en) 2020-03-11 2021-09-16 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency
CN115184498B (zh) * 2022-07-15 2023-02-21 山东京卫制药有限公司 N-Boc-哌嗪中有关物质哌嗪的检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5883098A (en) 1993-11-29 1999-03-16 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
IL111730A (en) 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them
CA2222041A1 (en) * 1995-05-25 1996-11-28 Fujisawa Pharmaceutical Co., Ltd. 1-benzoyl-2-(indolyl-3-alkyl)-piperazine derivatives as neurokinin receptor antagonists
GB9513118D0 (en) * 1995-06-28 1995-08-30 Merck Sharp & Dohme Therapeutic agents
JP2000502100A (ja) * 1995-12-18 2000-02-22 藤沢薬品工業株式会社 タキキニン拮抗薬としてのピペラジン誘導体
KR100458346B1 (ko) * 1996-03-29 2005-06-21 듀파 인터내셔날 리서치 베 파우 피페라진및피페리딘화합물
AUPO735997A0 (en) * 1997-06-17 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Piperazine derivatives
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
ATE396187T1 (de) * 1997-08-27 2008-06-15 Solvay Pharm Gmbh Indolmethyl-n,n'-bisacylpiperazine als neurokininrezeptorantagonisten
ES2162731B1 (es) * 1999-06-04 2003-02-16 Faes Fabrica Espanola De Produ Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.

Also Published As

Publication number Publication date
AR028743A1 (es) 2003-05-21
ZA200105737B (en) 2002-01-22
CZ301695B6 (cs) 2010-05-26
TWI304403B (en) 2008-12-21
CN1335316A (zh) 2002-02-13
US20020065276A1 (en) 2002-05-30
KR20020010482A (ko) 2002-02-04
DE50100358D1 (de) 2003-08-14
SK284802B6 (sk) 2005-11-03
AU779318B2 (en) 2005-01-13
PT1176144E (pt) 2003-11-28
HK1042699A1 (en) 2002-08-23
ES2201007T3 (es) 2004-03-16
BR0103048A (pt) 2002-04-02
CZ20011813A3 (cs) 2002-03-13
HU0102931D0 (en) 2001-09-28
ATE244716T1 (de) 2003-07-15
HUP0102931A3 (en) 2003-07-28
IL144299A0 (en) 2002-05-23
UA73728C2 (en) 2005-09-15
NO20013709D0 (no) 2001-07-27
NO323233B1 (no) 2007-02-05
DK1176144T3 (da) 2003-10-27
NZ513041A (en) 2002-12-20
HUP0102931A2 (hu) 2002-11-28
EP1176144B1 (de) 2003-07-09
RU2288918C2 (ru) 2006-12-10
PL210436B1 (pl) 2012-01-31
DE10036818A1 (de) 2002-02-07
CN1167698C (zh) 2004-09-22
CA2354213A1 (en) 2002-01-28
EP1176144A1 (de) 2002-01-30
AU5767501A (en) 2002-01-31
KR100924405B1 (ko) 2009-10-29
US6407106B1 (en) 2002-06-18
NO20013709L (no) 2002-01-29
JP2002053577A (ja) 2002-02-19
PL348946A1 (en) 2002-02-11
CA2354213C (en) 2010-04-27
IN191021B (zh) 2003-09-13
SK7572001A3 (en) 2002-02-05
DZ3119A1 (fr) 2004-09-19
HU226687B1 (en) 2009-06-29

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Legal Events

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