IL143866A0 - Insulin-like growth factor (igf) i mutant variants - Google Patents
Insulin-like growth factor (igf) i mutant variantsInfo
- Publication number
- IL143866A0 IL143866A0 IL14386600A IL14386600A IL143866A0 IL 143866 A0 IL143866 A0 IL 143866A0 IL 14386600 A IL14386600 A IL 14386600A IL 14386600 A IL14386600 A IL 14386600A IL 143866 A0 IL143866 A0 IL 143866A0
- Authority
- IL
- Israel
- Prior art keywords
- igf
- insulin
- growth factor
- mutant variants
- variants
- Prior art date
Links
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 3
- 102000013275 Somatomedins Human genes 0.000 title 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000008482 dysregulation Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11501099P | 1999-01-06 | 1999-01-06 | |
US17026199P | 1999-12-09 | 1999-12-09 | |
PCT/US2000/000199 WO2000040613A1 (fr) | 1999-01-06 | 2000-01-05 | Variants mutants du facteur de croissance insulinomimetique (igf) de type i |
Publications (1)
Publication Number | Publication Date |
---|---|
IL143866A0 true IL143866A0 (en) | 2002-04-21 |
Family
ID=26812755
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14386600A IL143866A0 (en) | 1999-01-06 | 2000-01-05 | Insulin-like growth factor (igf) i mutant variants |
IL143866A IL143866A (en) | 1999-01-06 | 2001-06-20 | Insulin-like growth factor (igf)1 variant with an amino acid replacement at position 49 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL143866A IL143866A (en) | 1999-01-06 | 2001-06-20 | Insulin-like growth factor (igf)1 variant with an amino acid replacement at position 49 |
Country Status (12)
Country | Link |
---|---|
US (3) | US6403764B1 (fr) |
EP (1) | EP1141014B1 (fr) |
JP (2) | JP3971108B2 (fr) |
AT (1) | ATE284415T1 (fr) |
AU (1) | AU762351B2 (fr) |
CA (1) | CA2356109C (fr) |
DE (1) | DE60016560T2 (fr) |
DK (1) | DK1141014T3 (fr) |
ES (1) | ES2234560T3 (fr) |
IL (2) | IL143866A0 (fr) |
PT (1) | PT1141014E (fr) |
WO (1) | WO2000040613A1 (fr) |
Families Citing this family (45)
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US6875741B2 (en) * | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
JP3971108B2 (ja) * | 1999-01-06 | 2007-09-05 | ジェネンテック・インコーポレーテッド | インシュリン様成長因子(igf)i突然変異体 |
US7250950B2 (en) * | 2001-01-29 | 2007-07-31 | Symyx Technologies, Inc. | Systems, methods and computer program products for determining parameters for chemical synthesis |
US20020143725A1 (en) * | 2001-01-29 | 2002-10-03 | Smith Robin Young | Systems, methods and computer program products for determining parameters for chemical synthesis and for supplying the reagents, equipment and/or chemicals synthesized thereby |
US6849718B2 (en) * | 2001-03-20 | 2005-02-01 | Dana Farber Cancer Institute, Inc. | Muteins of hypoxia inducible factor alpha and methods of use thereof |
US20040048925A1 (en) * | 2002-09-09 | 2004-03-11 | Wiley David B. | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
WO2005047327A2 (fr) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Variants de polypeptide se liant au recepteur fc neonatal (fcrn), proteines de liaison fc dimeres et techniques associees |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
EP1674113A1 (fr) * | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Conjugués de l'IGF-1 et du poly(éthylène glycol) |
MY146381A (en) * | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
DK1838736T3 (da) | 2005-01-05 | 2013-06-03 | Biogen Idec Inc | Cripto-bindende molekyler |
HUE027645T2 (en) | 2005-01-07 | 2016-10-28 | Regeneron Pharma | IGF-1 fusion proteins and therapeutic applications |
TWI406870B (zh) * | 2005-02-21 | 2013-09-01 | Chugai Pharmaceutical Co Ltd | A method of making a protein using hamster IGF-1 |
MY147856A (en) * | 2006-06-09 | 2013-01-31 | Novartis Ag | Stabilized insulin-like growth factor polypeptides |
CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
JP4958975B2 (ja) * | 2006-08-31 | 2012-06-20 | エフ.ホフマン−ラ ロシュ アーゲー | インスリン様増殖因子iの製造方法 |
EP2115477B1 (fr) | 2007-01-25 | 2015-06-24 | Roche Diagnostics GmbH | Utilisation de igfbp-7 dans l'evaluation d'une insuffisance cardiaque |
CA2679548C (fr) * | 2007-03-02 | 2015-01-27 | Amgen Inc. | Procedes et compositions permettant de traiter des maladies tumorales |
US7994127B2 (en) * | 2007-06-08 | 2011-08-09 | Massachusetts Institute Of Technology | Treatment of rett syndrome |
ES2388827T3 (es) * | 2008-04-03 | 2012-10-19 | F. Hoffmann-La Roche Ag | Uso de variantes de IGF-I PEGiladas para el tratamiento de trastornos neuromusculares |
JP5031923B2 (ja) * | 2008-04-03 | 2012-09-26 | エフ.ホフマン−ラ ロシュ アーゲー | ペグ化インシュリン様成長因子アッセイ |
PL219335B1 (pl) * | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
US8759299B2 (en) * | 2009-07-22 | 2014-06-24 | Ipsen Pharma S.A.S. | Analogues of insulin-like growth factor-1 (IGF-1) having amino acid substitution at position 59 |
NZ598381A (en) | 2009-09-10 | 2013-10-25 | Lonza Biologics Plc | Method and system for polypeptide purification |
US20110152188A1 (en) * | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
PT2591006T (pt) | 2010-07-09 | 2019-07-29 | Bioverativ Therapeutics Inc | Moléculas de cadeia simples processáveis e polipéptidos preparados utilizando as mesmas |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
TR201809743T4 (tr) | 2012-01-10 | 2018-07-23 | Biogen Ma Inc | Kan beyin bariyerinden terapötik moleküllerin taşınmasının arttırılması. |
DK2935320T3 (da) | 2012-12-18 | 2019-11-18 | Novartis Ag | Stabiliserede insulinlignende vækstfaktorpolypeptider |
TWI745671B (zh) | 2013-03-15 | 2021-11-11 | 美商百歐維拉提夫治療公司 | 因子ix多肽調配物 |
CN104293766A (zh) * | 2013-07-15 | 2015-01-21 | 四川农业大学 | 山羊IGFBP3基因cDNA编码序列克隆的方法 |
CA2926173A1 (fr) | 2013-10-02 | 2015-04-09 | Novartis Ag | Mimetique du facteur de croissance semblable a l'insuline destine a etre utilise en therapie |
UY35874A (es) | 2013-12-12 | 2015-07-31 | Novartis Ag | Un proceso para la preparación de una composición de proteínas pegiladas |
JP2017505141A (ja) | 2014-01-20 | 2017-02-16 | ハンミ ファーマシューティカル カンパニー リミテッド | 長時間作用型インスリンおよびその使用 |
US20170248609A1 (en) | 2014-01-27 | 2017-08-31 | Novartis Ag | Biomarkers predictive of muscle atrophy, method and use |
AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及glp-1/昇糖素雙重促效劑之治療糖尿病之組成物 |
EP3954993A1 (fr) | 2015-02-04 | 2022-02-16 | Bristol-Myers Squibb Company | Procédés de sélection de molécules thérapeutiques |
SG11201706293XA (en) | 2015-02-04 | 2017-09-28 | Hoffmann La Roche | Tau antisense oligomers and uses thereof |
UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
US11396534B2 (en) | 2016-09-23 | 2022-07-26 | Hanmi Pharm. Co., Ltd. | Insulin analogs with reduced affinity to insulin receptor and use thereof |
TWI798209B (zh) | 2017-03-23 | 2023-04-11 | 南韓商韓美藥品股份有限公司 | 對胰島素受體有降低親和性之胰島素類似物之接合物及其用途 |
CN117384275B (zh) * | 2023-12-13 | 2024-03-15 | 北京科为博生物科技有限公司 | 胰岛素样生长因子突变体igf1m及其应用 |
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-
2000
- 2000-01-05 JP JP2000592321A patent/JP3971108B2/ja not_active Expired - Lifetime
- 2000-01-05 US US09/477,924 patent/US6403764B1/en not_active Expired - Lifetime
- 2000-01-05 DK DK00901397T patent/DK1141014T3/da active
- 2000-01-05 CA CA002356109A patent/CA2356109C/fr not_active Expired - Lifetime
- 2000-01-05 EP EP00901397A patent/EP1141014B1/fr not_active Expired - Lifetime
- 2000-01-05 AT AT00901397T patent/ATE284415T1/de active
- 2000-01-05 IL IL14386600A patent/IL143866A0/xx unknown
- 2000-01-05 ES ES00901397T patent/ES2234560T3/es not_active Expired - Lifetime
- 2000-01-05 AU AU22245/00A patent/AU762351B2/en not_active Expired
- 2000-01-05 PT PT00901397T patent/PT1141014E/pt unknown
- 2000-01-05 DE DE60016560T patent/DE60016560T2/de not_active Expired - Lifetime
- 2000-01-05 WO PCT/US2000/000199 patent/WO2000040613A1/fr active IP Right Grant
-
2001
- 2001-06-20 IL IL143866A patent/IL143866A/en not_active IP Right Cessation
- 2001-12-19 US US10/028,410 patent/US7105167B2/en not_active Expired - Lifetime
-
2006
- 2006-06-21 JP JP2006171517A patent/JP2006328074A/ja active Pending
- 2006-08-28 US US11/512,046 patent/US8097587B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20110003746A1 (en) | 2011-01-06 |
US8097587B2 (en) | 2012-01-17 |
ES2234560T3 (es) | 2005-07-01 |
PT1141014E (pt) | 2005-04-29 |
EP1141014A1 (fr) | 2001-10-10 |
DE60016560D1 (de) | 2005-01-13 |
WO2000040613A9 (fr) | 2001-05-17 |
US20020160955A1 (en) | 2002-10-31 |
AU762351B2 (en) | 2003-06-26 |
DK1141014T3 (da) | 2005-04-11 |
CA2356109C (fr) | 2008-04-22 |
JP3971108B2 (ja) | 2007-09-05 |
IL143866A (en) | 2009-11-18 |
WO2000040613A1 (fr) | 2000-07-13 |
EP1141014B1 (fr) | 2004-12-08 |
DE60016560T2 (de) | 2005-12-15 |
ATE284415T1 (de) | 2004-12-15 |
JP2002535968A (ja) | 2002-10-29 |
JP2006328074A (ja) | 2006-12-07 |
CA2356109A1 (fr) | 2000-07-13 |
US6403764B1 (en) | 2002-06-11 |
AU2224500A (en) | 2000-07-24 |
US7105167B2 (en) | 2006-09-12 |
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