IL143104A - Method and apparatus for liposome production - Google Patents
Method and apparatus for liposome productionInfo
- Publication number
- IL143104A IL143104A IL14310499A IL14310499A IL143104A IL 143104 A IL143104 A IL 143104A IL 14310499 A IL14310499 A IL 14310499A IL 14310499 A IL14310499 A IL 14310499A IL 143104 A IL143104 A IL 143104A
- Authority
- IL
- Israel
- Prior art keywords
- liposome production
- liposomes
- therapeutic applications
- mixing system
- liposome
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/411—Emulsifying using electrical or magnetic fields, heat or vibrations
- B01F23/4111—Emulsifying using electrical or magnetic fields, heat or vibrations using vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/82—Combinations of dissimilar mixers
- B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/213—Measuring of the properties of the mixtures, e.g. temperature, density or colour
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/22—Control or regulation
- B01F35/221—Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
- B01F35/2215—Temperature
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
- B01F35/83—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices
- B01F35/831—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows
- B01F35/8311—Forming a predetermined ratio of the substances to be mixed by controlling the ratio of two or more flows, e.g. using flow sensing or flow controlling devices using one or more pump or other dispensing mechanisms for feeding the flows in predetermined proportion, e.g. one of the pumps being driven by one of the flows with means for controlling the motor driving the pumps or the other dispensing mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0468—Numerical pressure values
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2215/00—Auxiliary or complementary information in relation with mixing
- B01F2215/04—Technical information in relation with mixing
- B01F2215/0413—Numerical information
- B01F2215/0436—Operational information
- B01F2215/0472—Numerical temperature values
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10835598P | 1998-11-13 | 1998-11-13 | |
PCT/US1999/026738 WO2000029103A1 (en) | 1998-11-13 | 1999-11-12 | Method and apparatus for liposome production |
Publications (2)
Publication Number | Publication Date |
---|---|
IL143104A0 IL143104A0 (en) | 2002-04-21 |
IL143104A true IL143104A (en) | 2005-09-25 |
Family
ID=22321729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14310499A IL143104A (en) | 1998-11-13 | 1999-11-12 | Method and apparatus for liposome production |
Country Status (9)
Country | Link |
---|---|
US (3) | US6534018B1 (id) |
EP (1) | EP1146959B1 (id) |
JP (1) | JP2002529240A (id) |
AT (1) | ATE397488T1 (id) |
AU (1) | AU756196B2 (id) |
CA (1) | CA2350430C (id) |
DE (1) | DE69938875D1 (id) |
IL (1) | IL143104A (id) |
WO (1) | WO2000029103A1 (id) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0943242A1 (en) * | 1998-02-26 | 1999-09-22 | Puratos N.V. | Granulated bread improver for the preparation of bakery products |
US6855296B1 (en) * | 1998-11-13 | 2005-02-15 | Optime Therapeutics, Inc. | Method and apparatus for liposome production |
IL144561A0 (en) * | 1999-01-25 | 2002-05-23 | Optime Therapeutics Inc | Liposome compositions and methods for treating pests utilizing the same |
CN1228041C (zh) * | 1999-07-15 | 2005-11-23 | 英耐克斯药品股份有限公司 | 脂质包埋的治疗剂的制备方法 |
US20020119188A1 (en) * | 2000-02-08 | 2002-08-29 | Susan Niemiec | Method of manufacturing liposomes |
DE60138934D1 (de) * | 2000-02-25 | 2009-07-23 | Hitachi Ltd | Mischvorrichtung für Analysenautomat |
EP1203614A1 (de) * | 2000-11-03 | 2002-05-08 | Polymun Scientific Immunbiologische Forschung GmbH | Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln |
DK1519714T3 (da) * | 2002-06-28 | 2011-01-31 | Protiva Biotherapeutics Inc | Fremgangsmåde og apparat til fremstilling af liposomer |
US7879351B2 (en) | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
KR101424980B1 (ko) | 2002-10-29 | 2014-08-01 | 인스메드 인코포레이티드 | 항감염제의 지속적인 방출 |
FR2854072B1 (fr) * | 2003-04-23 | 2006-08-04 | Centre Nat Rech Scient | Vecteur pour administration par voie orale |
PL1749598T3 (pl) * | 2004-03-23 | 2011-04-29 | Sintokogio Ltd | Urządzenie do wytwarzania formy odlewniczej i jednostka formy metalowej do zastosowania w nim |
TW201204410A (en) * | 2004-04-01 | 2012-02-01 | Oncothyreon Inc | Mucinous glycoprotein (MUC-1) vaccine |
DE102004018283A1 (de) * | 2004-04-15 | 2005-11-03 | Wacker-Chemie Gmbh | Verfahren zur kontinuierlichen Herstellung von Silicon Emulsionen |
WO2006095798A1 (ja) * | 2005-03-09 | 2006-09-14 | Sunstar Inc. | フィトステロールを含んだリポソームを含有する抗癌用経口組成物、該リポソームによる癌の予防又は治療 |
US9005654B2 (en) | 2005-07-27 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Systems and methods for manufacturing liposomes |
ES2594368T3 (es) | 2005-12-08 | 2016-12-19 | Insmed Incorporated | Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares |
US10631558B2 (en) | 2006-03-06 | 2020-04-28 | The Coca-Cola Company | Methods and apparatuses for making compositions comprising an acid and an acid degradable component and/or compositions comprising a plurality of selectable components |
US11214476B2 (en) | 2006-03-06 | 2022-01-04 | Deka Products Limited Partnership | System and method for generating a drive signal |
US11906988B2 (en) | 2006-03-06 | 2024-02-20 | Deka Products Limited Partnership | Product dispensing system |
US9146564B2 (en) | 2006-03-06 | 2015-09-29 | Deka Products Limited Partnership | Product dispensing system |
US7740152B2 (en) | 2006-03-06 | 2010-06-22 | The Coca-Cola Company | Pump system with calibration curve |
WO2008016691A2 (en) * | 2006-08-01 | 2008-02-07 | Covaris, Inc. | Methods and apparatus for treating samples with acoustic energy |
US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
US8071127B2 (en) * | 2006-10-24 | 2011-12-06 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
US8119156B2 (en) | 2006-10-24 | 2012-02-21 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
US7985058B2 (en) * | 2007-01-12 | 2011-07-26 | Mark Gray | Method and apparatus for making uniformly sized particles |
US20100196455A1 (en) | 2007-05-04 | 2010-08-05 | Transave, Inc. | Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
CA2710983A1 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
WO2010041727A1 (ja) * | 2008-10-10 | 2010-04-15 | 株式会社リポソーム工学研究所 | リポソーム製造装置 |
JPWO2010044399A1 (ja) * | 2008-10-14 | 2012-03-15 | 株式会社リポソーム工学研究所 | 多機能リポソーム自動製造装置 |
EP3243504A1 (en) | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Improved lipid formulation |
AU2010223967B2 (en) | 2009-03-12 | 2015-07-30 | Alnylam Pharmaceuticals, Inc. | Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes |
SG10201402054UA (en) | 2009-05-05 | 2014-09-26 | Muthiah Manoharan | Lipid compositions |
CA2760706C (en) | 2009-05-05 | 2019-08-06 | Alnylam Pharmaceuticals, Inc. | Methods of delivering oligonucleotides to immune cells |
HUE056773T2 (hu) | 2009-06-10 | 2022-03-28 | Arbutus Biopharma Corp | Továbbfejlesztett lipid készítmény |
AP2015008874A0 (en) | 2009-08-14 | 2015-11-30 | Alnylam Pharmaceuticals Inc | Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus |
US20130156845A1 (en) | 2010-04-29 | 2013-06-20 | Alnylam Pharmaceuticals, Inc. | Lipid formulated single stranded rna |
CN110123830A (zh) | 2010-11-09 | 2019-08-16 | 阿尔尼拉姆医药品有限公司 | 用于抑制Eg5和VEGF基因的表达的脂质配制的组合物和方法 |
CN103906503B (zh) | 2011-11-04 | 2016-12-14 | 日东电工株式会社 | 用于无菌制备脂质-核酸颗粒的单次使用系统 |
HRP20220158T1 (hr) | 2012-05-21 | 2022-04-15 | Insmed Incorporated | Sustavi za liječenje plućnih infekcija |
WO2014008334A1 (en) | 2012-07-06 | 2014-01-09 | Alnylam Pharmaceuticals, Inc. | Stable non-aggregating nucleic acid lipid particle formulations |
CN104884047A (zh) | 2012-11-29 | 2015-09-02 | 英斯梅德股份有限公司 | 稳定的万古霉素制剂 |
AU2013355258A1 (en) | 2012-12-07 | 2015-06-11 | Alnylam Pharmaceuticals, Inc. | Improved nucleic acid lipid particle formulations |
CA2906732C (en) | 2013-03-15 | 2023-08-08 | The University Of British Columbia | Lipid nanoparticles for transfection and related methods |
US9987227B2 (en) | 2013-10-22 | 2018-06-05 | Aradigm Corporation | Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile |
KR101713886B1 (ko) | 2013-12-19 | 2017-03-10 | 연세대학교 산학협력단 | PRK2를 표적으로 하는 C형 간염 바이러스 치료제 siRNA |
CA2949078C (en) | 2014-05-15 | 2022-09-20 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
WO2016004318A1 (en) * | 2014-07-02 | 2016-01-07 | Shire Human Genetic Therapies, Inc. | Encapsulation of messenger rna |
US10987048B2 (en) | 2014-08-13 | 2021-04-27 | Elwha Llc | Systems, methods, and devices to incentivize inhaler use |
US10765817B2 (en) | 2014-08-13 | 2020-09-08 | Elwha, Llc | Methods, systems, and devices related to delivery of alcohol with an inhaler |
US10245393B2 (en) | 2014-08-13 | 2019-04-02 | Elwha Llc | Methods, systems, and devices related to a supplemental inhaler |
JP6373749B2 (ja) | 2014-12-19 | 2018-08-15 | 富士フイルム株式会社 | リポソームの製造方法及びリポソーム製造装置 |
US10632072B2 (en) * | 2015-03-19 | 2020-04-28 | University Of Connecticut | Systems and methods for continuous manufacturing of liposomal drug formulations |
EP3773505A4 (en) | 2018-03-30 | 2021-12-22 | Insmed Incorporated | PROCESS FOR THE CONTINUOUS MANUFACTURING OF LIPOSOMAL MEDICINAL PRODUCTS |
EP3852911A2 (en) * | 2018-09-21 | 2021-07-28 | Acuitas Therapeutics, Inc. | Systems and methods for manufacturing lipid nanoparticles and liposomes |
CN112955252B (zh) * | 2018-10-26 | 2023-11-21 | 康涅狄格大学 | 用于对纳米粒子进行内部和外部修饰的连续处理系统和方法 |
US11154502B2 (en) * | 2019-01-24 | 2021-10-26 | CannaClear Inc. | Lecithin vesicles for oral delivery |
EP4359528A1 (en) | 2021-06-25 | 2024-05-01 | Alpine Antiviral GmbH | Sirna combinations targeting sars-cov-2 and/or host factor transcripts |
EP4247529A1 (en) | 2021-11-03 | 2023-09-27 | Leon-Nanodrugs GmbH | Apparatus and method for mixing small liquid volumes, and use of the apparatus |
WO2024069014A1 (en) | 2022-09-30 | 2024-04-04 | Leon-Nanodrugs Gmbh | Apparatus and method for operating a static mixing device |
WO2024069012A1 (en) | 2022-09-30 | 2024-04-04 | Leon-Nanodrugs Gmbh | Cassette system for aseptic mixing process |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1298194A (en) | 1968-11-20 | 1972-11-29 | Agfa Gevaert | Improved method for encapsulating aqueous or hydrophilic material, the capsules obtained therewith and their application |
JPS4945224B1 (id) | 1970-12-14 | 1974-12-03 | ||
DE2357212A1 (de) * | 1973-11-16 | 1975-05-22 | Henkel & Cie Gmbh | Verfahren und vorrichtung zur kontinuierlichen herstellung von kolloidalen loesungen und emulsionen |
US4108115A (en) * | 1974-06-07 | 1978-08-22 | Lucas Electrical Company, Limited | Fuel injection systems for compression ignition engines |
CH588887A5 (id) | 1974-07-19 | 1977-06-15 | Battelle Memorial Institute | |
JPS5186117A (en) | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
AU499635B2 (en) * | 1976-02-20 | 1979-04-26 | Thapa Chemical Industry Co Ltd | Material mixing apparatus |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
ATE8584T1 (de) | 1980-01-16 | 1984-08-15 | Hans Georg Prof. Dr. Weder | Verfahren und dialysiereinrichtung zur herstellung von bilayer-vesikeln und verwendung der bilayer-vesikel. |
US4452747A (en) * | 1982-03-22 | 1984-06-05 | Klaus Gersonde | Method of and arrangement for producing lipid vesicles |
DE3230289A1 (de) * | 1982-08-14 | 1984-02-16 | Bayer Ag, 5090 Leverkusen | Herstellung von pharmazeutischen oder kosmetischen dispersionen |
US4551288A (en) * | 1982-08-16 | 1985-11-05 | Sandoz, Inc. | Processes for the preparation of liposome drug delivery systems |
US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
JPS607932A (ja) | 1983-06-29 | 1985-01-16 | Dai Ichi Seiyaku Co Ltd | リポソーム懸濁液およびその製法 |
US4532089A (en) | 1984-01-14 | 1985-07-30 | Northwestern University | Method of preparing giant size liposomes |
US4761288A (en) | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
US4737276A (en) * | 1984-12-21 | 1988-04-12 | E. I. Du Pont De Nemours And Company | Apparatus for manufacturing liposomes |
US4781871A (en) * | 1986-09-18 | 1988-11-01 | Liposome Technology, Inc. | High-concentration liposome processing method |
US4752425A (en) | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
US5628936A (en) | 1987-03-13 | 1997-05-13 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
US5474848A (en) | 1987-03-13 | 1995-12-12 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US4855090A (en) | 1987-03-13 | 1989-08-08 | Micro-Pak, Inc. | Method of producing high aqueous volume multilamellar vesicles |
US4853228A (en) | 1987-07-28 | 1989-08-01 | Micro-Pak, Inc. | Method of manufacturing unilamellar lipid vesicles |
US5271881A (en) * | 1987-09-28 | 1993-12-21 | Redding Bruce K | Apparatus and method for making microcapsules |
US4895452A (en) * | 1988-03-03 | 1990-01-23 | Micro-Pak, Inc. | Method and apparatus for producing lipid vesicles |
US5013497A (en) * | 1988-03-03 | 1991-05-07 | Micro-Pak, Inc. | Method and apparatus for producing lipid vesicles |
US4935171A (en) | 1989-01-27 | 1990-06-19 | Vestar, Inc. | Method for vesicle formation |
DE3916465A1 (de) * | 1989-05-20 | 1990-11-22 | Bayer Ag | Herstellung kugelfoermiger dispersionen durch kristallisation von emulsionen |
DE4031094A1 (de) | 1990-10-02 | 1992-04-09 | Basf Ag | Verfahren zur herstellung von stabilen injizierbaren (beta)-carotin-solubilisaten |
JP2729538B2 (ja) * | 1991-02-13 | 1998-03-18 | 富士写真フイルム株式会社 | マイクロカプセルの製造方法 |
US5474846A (en) * | 1993-01-26 | 1995-12-12 | Haldenby; George A. | Uniform polymeric coated interior cylinder surface |
ATE166573T1 (de) * | 1993-03-24 | 1998-06-15 | Ciba Geigy Ag | Verfahren zur herstellung einer liposomendispersion im hochdruckbereich |
US5554382A (en) * | 1993-05-28 | 1996-09-10 | Aphios Corporation | Methods and apparatus for making liposomes |
EP0706374B1 (en) * | 1993-06-30 | 1997-12-10 | Genentech, Inc. | Method for preparing liposomes |
DE4432378A1 (de) * | 1994-09-12 | 1996-03-14 | Bayer Ag | Injizierbare liposomale Arzneizubereitungen |
JP3430787B2 (ja) * | 1996-04-02 | 2003-07-28 | ミノルタ株式会社 | 現像装置 |
EP1334765B1 (en) * | 2000-10-13 | 2010-06-30 | National Institute of Advanced Industrial Science and Technology | Process for producing liposome |
EP1203614A1 (de) * | 2000-11-03 | 2002-05-08 | Polymun Scientific Immunbiologische Forschung GmbH | Verfahren und Vorrichtung zur Herstellung von Lipidvesikeln |
-
1999
- 1999-11-12 CA CA002350430A patent/CA2350430C/en not_active Expired - Lifetime
- 1999-11-12 EP EP99972124A patent/EP1146959B1/en not_active Expired - Lifetime
- 1999-11-12 US US09/439,619 patent/US6534018B1/en not_active Expired - Lifetime
- 1999-11-12 AT AT99972124T patent/ATE397488T1/de not_active IP Right Cessation
- 1999-11-12 WO PCT/US1999/026738 patent/WO2000029103A1/en active IP Right Grant
- 1999-11-12 AU AU14768/00A patent/AU756196B2/en not_active Expired
- 1999-11-12 DE DE69938875T patent/DE69938875D1/de not_active Expired - Lifetime
- 1999-11-12 JP JP2000582143A patent/JP2002529240A/ja not_active Withdrawn
- 1999-11-12 IL IL14310499A patent/IL143104A/xx not_active IP Right Cessation
-
2002
- 2002-11-15 US US10/298,143 patent/US6855277B2/en not_active Expired - Lifetime
-
2005
- 2005-01-05 US US11/030,583 patent/US20050196435A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU756196B2 (en) | 2003-01-09 |
EP1146959A4 (en) | 2004-12-29 |
EP1146959B1 (en) | 2008-06-04 |
WO2000029103A1 (en) | 2000-05-25 |
JP2002529240A (ja) | 2002-09-10 |
DE69938875D1 (id) | 2008-07-17 |
EP1146959A1 (en) | 2001-10-24 |
US20050196435A1 (en) | 2005-09-08 |
US6855277B2 (en) | 2005-02-15 |
CA2350430A1 (en) | 2000-05-25 |
AU1476800A (en) | 2000-06-05 |
US6534018B1 (en) | 2003-03-18 |
ATE397488T1 (de) | 2008-06-15 |
IL143104A0 (en) | 2002-04-21 |
CA2350430C (en) | 2008-06-03 |
US20030124033A1 (en) | 2003-07-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL143104A (en) | Method and apparatus for liposome production | |
GB2326974B (en) | Plasma producing method and apparatus including an inductively-coupled plasma source | |
ZA964665B (en) | Method of producing l-lysine | |
PL332072A1 (en) | L-glutamic acid producing micro-organism and method of obtaining l-glutamic acid | |
PL332071A1 (en) | L-glutamic acid producing micro-organism and method of obtaining l-glutamic acid | |
AU4160996A (en) | Process for production of mushroom inoculum | |
IL144756A0 (en) | Method for controlling liposome size | |
AU6421698A (en) | Method of production of low pollution fuel and production apparatus therefor | |
EP0990755A4 (en) | KEY PANNER AND MANUFACTURING METHOD | |
AU3355595A (en) | Photocatalyst, method for preparing the same, and production of hydrogen using the same | |
AU7030496A (en) | Process and plant for the production of hydrogen and of energy | |
PL312350A1 (en) | Method of obtaining flavanolignane preparations of enhanced liberation and resorption power, flavanolignane preparations of enhanced liberation and resorption power, and their application in production of pharmaceutic agents | |
AU4410697A (en) | Production of moulded articles and apparatus for producing moulded articles | |
AU4166099A (en) | Mixing-agitating machine and method of producing gypsum board using mixing-agitating machine | |
AU2278899A (en) | Method of producing aerogels and apparatus for carrying out the method | |
ATE116646T1 (de) | Verfahren zur herstellung von hochreinem propylencarbonat und zur gleichzeitigen herstellung von passivierten elektroden. | |
AU1721899A (en) | Industrial precursor for use in construction material production and method of producing same | |
GB8917138D0 (en) | Process for the production of stable dispersions,the dispersions so produced,and the use thereof in the manufacture of polyurethanes | |
AU2756699A (en) | Method of producing dinitramide salts | |
AU695168B2 (en) | Process for producing iron carbide and equipment therefor | |
AU4716496A (en) | Method of producing l-aspartyl-d-alanine-n-(thiethane-3-yl)-amides | |
EP0816328A3 (en) | Process for the manufacture of acetonylbenzamides | |
AU5722890A (en) | Method of producing lightweight foamed concrete | |
PL322700A1 (en) | Method of and apparatus for making cheeses in an intermittent and continuous production process | |
HU9602959D0 (en) | Spider neurotoxins and method of producing the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |