IL142650A - Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes - Google Patents

Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes

Info

Publication number
IL142650A
IL142650A IL142650A IL14265001A IL142650A IL 142650 A IL142650 A IL 142650A IL 142650 A IL142650 A IL 142650A IL 14265001 A IL14265001 A IL 14265001A IL 142650 A IL142650 A IL 142650A
Authority
IL
Israel
Prior art keywords
acid
bile
bond
fatty acid
bile salt
Prior art date
Application number
IL142650A
Other languages
English (en)
Hebrew (he)
Other versions
IL142650A0 (en
Original Assignee
Galmed Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12399898A external-priority patent/IL123998A/en
Application filed by Galmed Int Ltd filed Critical Galmed Int Ltd
Priority to IL142650A priority Critical patent/IL142650A/en
Publication of IL142650A0 publication Critical patent/IL142650A0/xx
Priority to EA200301017A priority patent/EA007565B1/ru
Priority to BR0208924-6A priority patent/BR0208924A/pt
Priority to PT02761957T priority patent/PT1379254E/pt
Priority to DE60232559T priority patent/DE60232559D1/de
Priority to KR1020037013339A priority patent/KR100883080B1/ko
Priority to JP2002580951A priority patent/JP4324706B2/ja
Priority to HU0400801A priority patent/HU230548B1/hu
Priority to MXPA03009553A priority patent/MXPA03009553A/es
Priority to EP07002485A priority patent/EP1790346B1/en
Priority to UA2003109404A priority patent/UA78699C2/uk
Priority to DK07002485T priority patent/DK1790346T3/da
Priority to AU2002307771A priority patent/AU2002307771B2/en
Priority to PCT/IL2002/000303 priority patent/WO2002083147A1/en
Priority to DE60220775T priority patent/DE60220775T2/de
Priority to PL387458A priority patent/PL211438B1/pl
Priority to PL366585A priority patent/PL205057B1/pl
Priority to CA2444266A priority patent/CA2444266C/en
Priority to AT02761957T priority patent/ATE365044T1/de
Priority to ES02761957T priority patent/ES2289137T3/es
Priority to NZ528868A priority patent/NZ528868A/en
Priority to EP02761957A priority patent/EP1379254B1/en
Priority to AT07002485T priority patent/ATE432705T1/de
Priority to CZ2008296A priority patent/CZ309042B6/cs
Priority to ES07002485T priority patent/ES2328966T3/es
Priority to CZ20032710A priority patent/CZ300489B6/cs
Priority to CNB028081870A priority patent/CN1259918C/zh
Priority to US10/474,032 priority patent/US7501403B2/en
Priority to CA2703688A priority patent/CA2703688C/en
Priority to PT07002485T priority patent/PT1790346E/pt
Priority to DK02761957T priority patent/DK1379254T3/da
Priority to NO20034609A priority patent/NO333910B1/no
Priority to AU2007200191A priority patent/AU2007200191B2/en
Publication of IL142650A publication Critical patent/IL142650A/en
Priority to CY20071101160T priority patent/CY1106853T1/el
Priority to US12/361,291 priority patent/US8110564B2/en
Priority to US13/366,796 priority patent/US8975246B2/en
Priority to NO20131219A priority patent/NO335087B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL142650A 1998-04-08 2001-04-17 Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes IL142650A (en)

Priority Applications (37)

Application Number Priority Date Filing Date Title
IL142650A IL142650A (en) 1998-04-08 2001-04-17 Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
PT07002485T PT1790346E (pt) 2001-04-17 2002-04-15 Utilização do ácido biliar e de conjugados de ácidos gordos e sais biliares
DK02761957T DK1379254T3 (da) 2001-04-17 2002-04-15 Anvendelse af galdesyre- eller galdesalt-fedtsyre-konjugater
CA2444266A CA2444266C (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates
ES02761957T ES2289137T3 (es) 2001-04-17 2002-04-15 Utilizacion de conjugados de acido o acidos grasos con un acido biliar o una sal biliar.
PT02761957T PT1379254E (pt) 2001-04-17 2002-04-15 Utilização de conjugados de ácido biliar ou de sal biliar de ácido gordo
DE60232559T DE60232559D1 (de) 2001-04-17 2002-04-15 Verwendung von Gallensäure- oder Gallensalz-Fettsäurekonjugaten
KR1020037013339A KR100883080B1 (ko) 2001-04-17 2002-04-15 담즙산 또는 담즙산염 지방산 컨쥬게이트의 용도
EP02761957A EP1379254B1 (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates
HU0400801A HU230548B1 (hu) 2001-04-17 2002-04-15 Epesavak vagy epesavas só-zsírsav konjugátumok alkalmazása
MXPA03009553A MXPA03009553A (es) 2001-04-17 2002-04-15 Uso de acido biliar o conjugados de acidos grasos de sales biliares.
EP07002485A EP1790346B1 (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates
UA2003109404A UA78699C2 (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates for decreasing cholesterol blood content, treating fatty liver, hyperglycemia, and diabetes
DK07002485T DK1790346T3 (da) 2001-04-17 2002-04-15 Anvendelse af galdesyre eller galdesalt-fedtsyre-konjugater
AU2002307771A AU2002307771B2 (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates
PCT/IL2002/000303 WO2002083147A1 (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates
DE60220775T DE60220775T2 (de) 2001-04-17 2002-04-15 Verwendung eines gallensaeure-fettsaeure-konjugats oder eines gallensaeuresalz-fettsaeure-konjugats
PL387458A PL211438B1 (pl) 2001-04-17 2002-04-15 Zastosowanie koniugatu kwasu żółciowego albo soli kwasu żółciowego z kwasem tłuszczowym oraz zastosowanie kompozycji farmaceutycznej zawierającej taki koniugat do obniżania poziomu cholesterolu we krwi
PL366585A PL205057B1 (pl) 2001-04-17 2002-04-15 Zastosowanie koniugatu kwasu żółciowego albo soli kwasu żółciowego z kwasem tłuszczowym oraz zastosowanie kompozycji farmaceutycznej zawierającej taki koniugat
EA200301017A EA007565B1 (ru) 2001-04-17 2002-04-15 Применение конъюгатов желчной кислоты или соли желчной кислоты с жирными кислотами для лечения жировой инфильтрации печени
AT02761957T ATE365044T1 (de) 2001-04-17 2002-04-15 Verwendung eines gallensaeure-fettsaeure- konjugats oder eines gallensaeuresalz-fettsaeure- konjugats
NZ528868A NZ528868A (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates
BR0208924-6A BR0208924A (pt) 2001-04-17 2002-04-15 Uso de conjugados de ácido graxo de sal biliar ou de ácido biliar
JP2002580951A JP4324706B2 (ja) 2001-04-17 2002-04-15 胆汁酸または胆汁酸塩脂肪酸結合体の使用
AT07002485T ATE432705T1 (de) 2001-04-17 2002-04-15 Verwendung von gallensäure- oder gallensalz- fettsäurekonjugaten
CZ2008296A CZ309042B6 (cs) 2001-04-17 2002-04-15 Použití konjugátu žlučové kyseliny nebo soli žlučové kyseliny s mastnou kyselinou nebo farmaceutického prostředku jej obsahujícího pro snížení cholesterolu a léčbu hyperglykémie a diabetu
ES07002485T ES2328966T3 (es) 2001-04-17 2002-04-15 Uso de conjugados de acido biliar o sal biliar con acido graso.
CZ20032710A CZ300489B6 (cs) 2001-04-17 2002-04-15 Farmaceutický prostredek obsahující konjugát žlucové kyseliny nebo soli žlucové kyseliny s mastnou kyselinou pro lécbu syndromu ztucnelých jater
CNB028081870A CN1259918C (zh) 2001-04-17 2002-04-15 胆酸或胆盐脂肪酸共轭物的用途
US10/474,032 US7501403B2 (en) 2001-04-17 2002-04-15 Bile acid or bile salt fatty acid conjugates
CA2703688A CA2703688C (en) 2001-04-17 2002-04-15 Use of bile acid or bile salt fatty acid conjugates
NO20034609A NO333910B1 (no) 2001-04-17 2003-10-15 Anvendelse av gallesyre eller gallesaltfettsyrekonjugater
AU2007200191A AU2007200191B2 (en) 2001-04-17 2007-01-19 Use of bile acid or bile salt fatty acid conjugates
CY20071101160T CY1106853T1 (el) 2001-04-17 2007-09-07 Χρηση συζευγματων χολικου οξεος ή λιπαρου οξεος χολικου αλατος
US12/361,291 US8110564B2 (en) 2001-04-17 2009-01-28 Bile acid or bile salt fatty acid conjugates
US13/366,796 US8975246B2 (en) 2001-04-17 2012-02-06 Bile acid or bile salt fatty acid conjugates
NO20131219A NO335087B1 (no) 2001-04-17 2013-09-10 Anvendelse av gallesyre eller gallesaltfettsyrekonjugater ved behandling av hyperglykemi og diabetes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12399898A IL123998A (en) 1998-04-08 1998-04-08 Conjugates of bile salts and pharmaceutical preparations containing them
IL142650A IL142650A (en) 1998-04-08 2001-04-17 Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes

Publications (2)

Publication Number Publication Date
IL142650A0 IL142650A0 (en) 2002-03-10
IL142650A true IL142650A (en) 2007-06-03

Family

ID=11075322

Family Applications (1)

Application Number Title Priority Date Filing Date
IL142650A IL142650A (en) 1998-04-08 2001-04-17 Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes

Country Status (24)

Country Link
US (2) US7501403B2 (https=)
EP (2) EP1379254B1 (https=)
JP (1) JP4324706B2 (https=)
KR (1) KR100883080B1 (https=)
CN (1) CN1259918C (https=)
AT (2) ATE432705T1 (https=)
AU (2) AU2002307771B2 (https=)
BR (1) BR0208924A (https=)
CA (2) CA2703688C (https=)
CY (1) CY1106853T1 (https=)
CZ (2) CZ309042B6 (https=)
DE (2) DE60232559D1 (https=)
DK (2) DK1790346T3 (https=)
EA (1) EA007565B1 (https=)
ES (2) ES2289137T3 (https=)
HU (1) HU230548B1 (https=)
IL (1) IL142650A (https=)
MX (1) MXPA03009553A (https=)
NO (2) NO333910B1 (https=)
NZ (1) NZ528868A (https=)
PL (2) PL211438B1 (https=)
PT (2) PT1379254E (https=)
UA (1) UA78699C2 (https=)
WO (1) WO2002083147A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142650A (en) 1998-04-08 2007-06-03 Galmed Int Ltd Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
US8975246B2 (en) * 2001-04-17 2015-03-10 Galmed Research And Development Ltd. Bile acid or bile salt fatty acid conjugates
SI2182954T1 (sl) * 2007-07-25 2019-04-30 Medizinische Universitat Graz Uporaba nor-žolčnih kislin pri zdravljenju arterioskleroze
RS56054B1 (sr) * 2009-01-12 2017-09-29 Biokier Inc Smeša i metod za lečenje dijabetesa
US9006288B2 (en) 2009-01-12 2015-04-14 Biokier, Inc. Composition and method for treatment of diabetes
US9314444B2 (en) 2009-01-12 2016-04-19 Biokier, Inc. Composition and method for treatment of NASH
US20120157419A1 (en) 2009-02-02 2012-06-21 Tuvia Gilat Methods and compositions for treating alzheimer's disease
US20120202890A1 (en) 2011-02-08 2012-08-09 Nian Wu Polymer-carbohydrate-lipid conjugates
BR112014027204A2 (pt) 2012-05-01 2017-06-27 Catabasis Pharmaceuticals Inc conjugados d ácido graxo de estatina e agonistas fxr; composições e método de usos
CN103571617A (zh) * 2012-07-26 2014-02-12 丰益(上海)生物技术研发中心有限公司 改进的动物油脂加工工艺
WO2014084421A1 (en) * 2012-11-29 2014-06-05 Mediplex Corp. Bile acid oligomer conjugate for novel vesicular transport and use thereof
IL227890A0 (en) * 2013-08-08 2014-01-30 Galderm Therapeutics Ltd Antiaging compounds containing bile acid and fatty acid conjugates
US11571431B2 (en) 2013-12-04 2023-02-07 Galmed Research And Development Ltd Aramchol salts
SI3077047T1 (sl) * 2013-12-04 2019-09-30 Galmed Research & Development Ltd. Soli aramchola
JP2017519726A (ja) * 2014-06-01 2017-07-20 ガルメッド リサーチ アンド ディベロップメント リミテッド． リポジストロフィー治療用脂肪酸胆汁酸複合体
US10849911B2 (en) 2015-06-10 2020-12-01 Galmed Research And Development Ltd. Low dose compositions of Aramachol salts
IL243707A0 (en) 2016-01-20 2016-05-01 Galmed Res And Dev Ltd Treatment to regulate the microbiota in the intestine
US11197870B2 (en) 2016-11-10 2021-12-14 Galmed Research And Development Ltd Treatment for hepatic fibrosis
CN116687850A (zh) 2022-02-24 2023-09-05 甘莱制药有限公司 包含环状膦酸酯化合物的药物组合物及其制备方法与用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3859437A (en) * 1972-06-02 1975-01-07 Intellectual Property Dev Corp Reducing cholesterol levels
US3856953A (en) * 1973-05-15 1974-12-24 Intellectual Property Dev Corp Method of treating fatty liver
IT1167479B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido chenodesossicolico
IT1167478B (it) * 1981-07-24 1987-05-13 Carlo Scolastico Derivati dell'acido ursodesossicolico
JPS6164701A (ja) * 1984-09-06 1986-04-03 Meito Sangyo Kk カチオン化デキストラン誘導体とポリウロン酸の高分子電解質錯体及びその利用
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
US5278320A (en) 1992-09-11 1994-01-11 Merck & Co., Inc. Cholesterol lowering compounds produced by directed biosynthesis
DE4432708A1 (de) * 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
US20030153541A1 (en) * 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
US6576660B1 (en) * 1997-10-31 2003-06-10 Arch Development Corporation Methods and compositions for regulation of 5-α-reductase activity
IL123998A (en) * 1998-04-08 2004-09-27 Galmed Int Ltd Conjugates of bile salts and pharmaceutical preparations containing them
IL142650A (en) * 1998-04-08 2007-06-03 Galmed Int Ltd Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes
US6620821B2 (en) * 2000-06-15 2003-09-16 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
JP2006306800A (ja) * 2005-04-28 2006-11-09 Kirin Brewery Co Ltd ファルネソイドｘ受容体活性化剤

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