MXPA03009553A - Uso de acido biliar o conjugados de acidos grasos de sales biliares. - Google Patents
Uso de acido biliar o conjugados de acidos grasos de sales biliares.Info
- Publication number
- MXPA03009553A MXPA03009553A MXPA03009553A MXPA03009553A MXPA03009553A MX PA03009553 A MXPA03009553 A MX PA03009553A MX PA03009553 A MXPA03009553 A MX PA03009553A MX PA03009553 A MXPA03009553 A MX PA03009553A MX PA03009553 A MXPA03009553 A MX PA03009553A
- Authority
- MX
- Mexico
- Prior art keywords
- bile
- acid
- fatty acid
- bile salt
- salt fatty
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invencion se refiere al uso de un acido biliar o conjugado de acido graso de la sal biliar de la formula general II, W-X-G, en la cual G es un acido biliar o el radical de la sal biliar, el cual si se desea, es conjugado en la posicion 24 con un aminoacido adecuado, W representa uno o dos radicales de acidos grasos que tienen 14-22 atomos de carbono, y X representa un elemento de enlace adecuado o un enlace C=C directo entre el acido biliar o el radical de la sal biliar, y el (los) acido(s) graso(s), o una composicion farmaceutica que comprende los mismos para la reduccion del colesterol en la sangre, para la reduccion del colesterol en la sangre, para el tratamiento de Esteatosis Hepatica, Hiperglicemia y Diabetes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL142650A IL142650A (en) | 1998-04-08 | 2001-04-17 | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
PCT/IL2002/000303 WO2002083147A1 (en) | 2001-04-17 | 2002-04-15 | Use of bile acid or bile salt fatty acid conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03009553A true MXPA03009553A (es) | 2004-05-24 |
Family
ID=11075322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03009553A MXPA03009553A (es) | 2001-04-17 | 2002-04-15 | Uso de acido biliar o conjugados de acidos grasos de sales biliares. |
Country Status (24)
Country | Link |
---|---|
US (2) | US7501403B2 (es) |
EP (2) | EP1379254B1 (es) |
JP (1) | JP4324706B2 (es) |
KR (1) | KR100883080B1 (es) |
CN (1) | CN1259918C (es) |
AT (2) | ATE365044T1 (es) |
AU (2) | AU2002307771B2 (es) |
BR (1) | BR0208924A (es) |
CA (2) | CA2444266C (es) |
CY (1) | CY1106853T1 (es) |
CZ (2) | CZ300489B6 (es) |
DE (2) | DE60232559D1 (es) |
DK (2) | DK1790346T3 (es) |
EA (1) | EA007565B1 (es) |
ES (2) | ES2328966T3 (es) |
HU (1) | HU230548B1 (es) |
IL (1) | IL142650A (es) |
MX (1) | MXPA03009553A (es) |
NO (2) | NO333910B1 (es) |
NZ (1) | NZ528868A (es) |
PL (2) | PL205057B1 (es) |
PT (2) | PT1790346E (es) |
UA (1) | UA78699C2 (es) |
WO (1) | WO2002083147A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL142650A (en) | 1998-04-08 | 2007-06-03 | Galmed Int Ltd | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
US8975246B2 (en) * | 2001-04-17 | 2015-03-10 | Galmed Research And Development Ltd. | Bile acid or bile salt fatty acid conjugates |
WO2009013334A1 (en) * | 2007-07-25 | 2009-01-29 | Medizinische Universität Graz | Use of nor-bile acids in the treatment of arteriosclerosis |
US9006288B2 (en) | 2009-01-12 | 2015-04-14 | Biokier, Inc. | Composition and method for treatment of diabetes |
US9314444B2 (en) | 2009-01-12 | 2016-04-19 | Biokier, Inc. | Composition and method for treatment of NASH |
EA022631B1 (ru) * | 2009-01-12 | 2016-02-29 | Байокир Инк. | Лекарственная форма, содержащая масляную кислоту или глутамин, и способ лечения состояния с повышенным уровнем глюкозы у субъекта |
WO2010086864A1 (en) | 2009-02-02 | 2010-08-05 | Galmed International Ltd. | Methods and compositions for treating alzheimer's disease |
US20120202890A1 (en) | 2011-02-08 | 2012-08-09 | Nian Wu | Polymer-carbohydrate-lipid conjugates |
MX2014013150A (es) | 2012-05-01 | 2015-05-11 | Catabasis Pharmaceuticals Inc | Conjugados de acidos grasos de estatina y agonistas fxr, composiciones y metodos de uso. |
CN103571617A (zh) * | 2012-07-26 | 2014-02-12 | 丰益(上海)生物技术研发中心有限公司 | 改进的动物油脂加工工艺 |
US10702546B2 (en) | 2012-11-29 | 2020-07-07 | St Pharm Co., Ltd. | Bile acid oligomer conjugate for novel vesicular transport and use thereof |
IL227890A0 (en) * | 2013-08-08 | 2014-01-30 | Galderm Therapeutics Ltd | Antiaging compounds containing bile acid and fatty acid conjugates |
WO2015083164A1 (en) * | 2013-12-04 | 2015-06-11 | Galmed Research & Development Ltd. | Aramchol salts |
US11571431B2 (en) | 2013-12-04 | 2023-02-07 | Galmed Research And Development Ltd | Aramchol salts |
AU2015270099A1 (en) * | 2014-06-01 | 2016-12-15 | Galmed Research And Development Ltd. | Fatty acid bile acid conjugates for treatment of lipodystrophy |
US10849911B2 (en) | 2015-06-10 | 2020-12-01 | Galmed Research And Development Ltd. | Low dose compositions of Aramachol salts |
IL243707A0 (en) | 2016-01-20 | 2016-05-01 | Galmed Res And Dev Ltd | Treatment to regulate the microbiota in the intestine |
US11197870B2 (en) | 2016-11-10 | 2021-12-14 | Galmed Research And Development Ltd | Treatment for hepatic fibrosis |
CN116687850A (zh) | 2022-02-24 | 2023-09-05 | 甘莱制药有限公司 | 包含环状膦酸酯化合物的药物组合物及其制备方法与用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3859437A (en) * | 1972-06-02 | 1975-01-07 | Intellectual Property Dev Corp | Reducing cholesterol levels |
US3856953A (en) * | 1973-05-15 | 1974-12-24 | Intellectual Property Dev Corp | Method of treating fatty liver |
IT1167479B (it) * | 1981-07-24 | 1987-05-13 | Carlo Scolastico | Derivati dell'acido chenodesossicolico |
IT1167478B (it) * | 1981-07-24 | 1987-05-13 | Carlo Scolastico | Derivati dell'acido ursodesossicolico |
JPS6164701A (ja) * | 1984-09-06 | 1986-04-03 | Meito Sangyo Kk | カチオン化デキストラン誘導体とポリウロン酸の高分子電解質錯体及びその利用 |
DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
US5278320A (en) * | 1992-09-11 | 1994-01-11 | Merck & Co., Inc. | Cholesterol lowering compounds produced by directed biosynthesis |
DE4432708A1 (de) * | 1994-09-14 | 1996-03-21 | Hoechst Ag | Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
US20030153541A1 (en) * | 1997-10-31 | 2003-08-14 | Robert Dudley | Novel anticholesterol compositions and method for using same |
WO1999022728A1 (en) * | 1997-10-31 | 1999-05-14 | Arch Development Corporation | Methods and compositions for regulation of 5-alpha reductase activity |
IL123998A (en) * | 1998-04-08 | 2004-09-27 | Galmed Int Ltd | Conjugates of bile salts and pharmaceutical preparations containing them |
IL142650A (en) * | 1998-04-08 | 2007-06-03 | Galmed Int Ltd | Use of bile acid conjugates or bile salts and fatty acids or fatty acids in the preparation of pharmaceuticals for lowering cholesterol, for the treatment of fatty liver and for the treatment of hyperglycemia and diabetes |
US6620821B2 (en) * | 2000-06-15 | 2003-09-16 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
JP2006306800A (ja) * | 2005-04-28 | 2006-11-09 | Kirin Brewery Co Ltd | ファルネソイドx受容体活性化剤 |
-
2001
- 2001-04-17 IL IL142650A patent/IL142650A/en active IP Right Grant
-
2002
- 2002-04-15 WO PCT/IL2002/000303 patent/WO2002083147A1/en active IP Right Grant
- 2002-04-15 AT AT02761957T patent/ATE365044T1/de active
- 2002-04-15 CN CNB028081870A patent/CN1259918C/zh not_active Expired - Lifetime
- 2002-04-15 DE DE60232559T patent/DE60232559D1/de not_active Expired - Lifetime
- 2002-04-15 DK DK07002485T patent/DK1790346T3/da active
- 2002-04-15 AT AT07002485T patent/ATE432705T1/de not_active IP Right Cessation
- 2002-04-15 HU HU0400801A patent/HU230548B1/hu unknown
- 2002-04-15 CZ CZ20032710A patent/CZ300489B6/cs not_active IP Right Cessation
- 2002-04-15 JP JP2002580951A patent/JP4324706B2/ja not_active Expired - Lifetime
- 2002-04-15 PT PT07002485T patent/PT1790346E/pt unknown
- 2002-04-15 UA UA2003109404A patent/UA78699C2/uk unknown
- 2002-04-15 CZ CZ2008296A patent/CZ309042B6/cs not_active IP Right Cessation
- 2002-04-15 PL PL366585A patent/PL205057B1/pl unknown
- 2002-04-15 CA CA2444266A patent/CA2444266C/en not_active Expired - Lifetime
- 2002-04-15 PL PL387458A patent/PL211438B1/pl unknown
- 2002-04-15 US US10/474,032 patent/US7501403B2/en not_active Expired - Lifetime
- 2002-04-15 ES ES07002485T patent/ES2328966T3/es not_active Expired - Lifetime
- 2002-04-15 NZ NZ528868A patent/NZ528868A/en not_active IP Right Cessation
- 2002-04-15 BR BR0208924-6A patent/BR0208924A/pt not_active Application Discontinuation
- 2002-04-15 EA EA200301017A patent/EA007565B1/ru not_active IP Right Cessation
- 2002-04-15 AU AU2002307771A patent/AU2002307771B2/en not_active Expired
- 2002-04-15 DE DE60220775T patent/DE60220775T2/de not_active Expired - Lifetime
- 2002-04-15 PT PT02761957T patent/PT1379254E/pt unknown
- 2002-04-15 EP EP02761957A patent/EP1379254B1/en not_active Expired - Lifetime
- 2002-04-15 EP EP07002485A patent/EP1790346B1/en not_active Expired - Lifetime
- 2002-04-15 DK DK02761957T patent/DK1379254T3/da active
- 2002-04-15 ES ES02761957T patent/ES2289137T3/es not_active Expired - Lifetime
- 2002-04-15 MX MXPA03009553A patent/MXPA03009553A/es active IP Right Grant
- 2002-04-15 KR KR1020037013339A patent/KR100883080B1/ko active IP Right Grant
- 2002-04-15 CA CA2703688A patent/CA2703688C/en not_active Expired - Lifetime
-
2003
- 2003-10-15 NO NO20034609A patent/NO333910B1/no not_active IP Right Cessation
-
2007
- 2007-01-19 AU AU2007200191A patent/AU2007200191B2/en not_active Expired
- 2007-09-07 CY CY20071101160T patent/CY1106853T1/el unknown
-
2009
- 2009-01-28 US US12/361,291 patent/US8110564B2/en not_active Expired - Lifetime
-
2013
- 2013-09-10 NO NO20131219A patent/NO335087B1/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA03009553A (es) | Uso de acido biliar o conjugados de acidos grasos de sales biliares. | |
CA2325933A1 (en) | Fatty acid derivatives of bile acids and bile acid derivatives | |
WO2003022208A3 (en) | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith | |
UA103758C2 (ru) | Конъюгаты олигомеров инсулина, их композиции и применение | |
EP1196444B8 (en) | Exendin-4 conjugates and their medical use | |
BRPI0207700B8 (pt) | mistura de conjugados monodispersa, composição farmacêutica, e, uso de uma mistura substancialmente monodispersa de um conjugado de polipeptídeo de insulina-oligômero | |
LT2003002A (en) | A soluble ctla4 molecule for use in the treatment rheumatic diseases | |
BR0010750A (pt) | Peptìdeos insulinotrópicos de longa duração | |
MXPA04004837A (es) | Inhibidores de 11-??-hidroxiesteroide deshidrogenasa de tipo 1. | |
MXPA04004842A (es) | Inhibidores de 11-(-hidroxiesteroide deshidrogenasa de tipo 1. | |
AU2002351593A1 (en) | Pharmaceutical compositions comprising unacylated ghrelin and therapeutical uses thereof | |
JP2004525962A5 (es) | ||
RS44204A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
WO2005041881A8 (en) | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof | |
WO2002038566A3 (en) | Carbene porphyrins and carbene porphyrinoids for use in medical diagnosis and treatment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |