IL142103A0 - Receptor based antagonists and methods of making and using - Google Patents

Receptor based antagonists and methods of making and using

Info

Publication number
IL142103A0
IL142103A0 IL14210399A IL14210399A IL142103A0 IL 142103 A0 IL142103 A0 IL 142103A0 IL 14210399 A IL14210399 A IL 14210399A IL 14210399 A IL14210399 A IL 14210399A IL 142103 A0 IL142103 A0 IL 142103A0
Authority
IL
Israel
Prior art keywords
making
methods
receptor based
based antagonists
fusion polypeptides
Prior art date
Application number
IL14210399A
Other languages
English (en)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of IL142103A0 publication Critical patent/IL142103A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL14210399A 1998-09-25 1999-09-22 Receptor based antagonists and methods of making and using IL142103A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10185898P 1998-09-25 1998-09-25
US09/313,942 US6472179B2 (en) 1998-09-25 1999-05-19 Receptor based antagonists and methods of making and using
PCT/US1999/022045 WO2000018932A2 (en) 1998-09-25 1999-09-22 Receptor based antagonists and methods of making and using

Publications (1)

Publication Number Publication Date
IL142103A0 true IL142103A0 (en) 2002-03-10

Family

ID=26798712

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14210399A IL142103A0 (en) 1998-09-25 1999-09-22 Receptor based antagonists and methods of making and using
IL142103A IL142103A (en) 1998-09-25 2001-03-19 Receptor based antagonists and methods of making and using them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL142103A IL142103A (en) 1998-09-25 2001-03-19 Receptor based antagonists and methods of making and using them

Country Status (19)

Country Link
US (2) US6472179B2 (de)
EP (3) EP1229047B1 (de)
JP (1) JP3902728B2 (de)
CN (1) CN100345970C (de)
AT (2) ATE283365T1 (de)
AU (1) AU758970C (de)
BE (1) BE2010C021I2 (de)
CA (1) CA2345109C (de)
DE (3) DE69932832T2 (de)
DK (1) DK1229047T3 (de)
ES (2) ES2267300T3 (de)
FR (1) FR10C0025I2 (de)
HK (1) HK1045847B (de)
IL (2) IL142103A0 (de)
NO (2) NO329976B1 (de)
NZ (1) NZ510720A (de)
PL (1) PL201246B1 (de)
PT (1) PT1229047E (de)
WO (1) WO2000018932A2 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
ATE272114T1 (de) * 1998-01-23 2004-08-15 Immunex Corp Rezeptoren für il-18
US6927044B2 (en) * 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
US7083950B2 (en) * 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. High affinity fusion proteins and therapeutic and diagnostic methods for use
US7083949B2 (en) 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US20040120891A1 (en) * 1998-12-21 2004-06-24 Craig Hill Compounds for intracellular delivery of therapeutic moieties to nerve cells
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
WO2001092340A2 (en) 2000-05-26 2001-12-06 Immunex Corporation Use of interleukin-4 antagonists and compositions thereof
US7446183B2 (en) 2000-06-16 2008-11-04 Asterion Limited Fusion protein comprising growth hormone and growth hormone receptor
EP2177616B1 (de) * 2000-08-08 2012-02-29 ZymoGenetics, Inc. Lösliche Zcyctor 11 Cytokinrezeptoren
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20050112616A1 (en) * 2001-12-10 2005-05-26 William Lee Functionalized materials and libraries thereof
US7795213B2 (en) * 2001-12-13 2010-09-14 Posco Methods of contacting β amyloid protein with VEGF
US6846520B2 (en) * 2002-01-17 2005-01-25 Canon Kabushiki Kaisha Epoxy resin composition, surface treatment method, liquid-jet recording head and liquid-jet recording apparatus
JP2005525404A (ja) * 2002-05-01 2005-08-25 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Hiv感染およびaidsを処置するためにサイトカインアンタゴニストを使用する方法
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
EP1578397B1 (de) * 2002-11-15 2012-12-26 Genmab A/S Humane monoklonale antikörper gegen cd25
US6919012B1 (en) 2003-03-25 2005-07-19 Olimex Group, Inc. Method of making a composite article comprising a ceramic coating
DK1606318T3 (da) 2003-03-26 2009-11-02 Apogenix Gmbh Forbedrede Fc-fusionsproteiner
WO2004100987A2 (en) * 2003-05-06 2004-11-25 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat neointimal hyperplasia
WO2004098596A1 (en) * 2003-05-12 2004-11-18 Altana Pharma Ag Composition comprising roflumilast and il-1 trap
BRPI0411248A (pt) * 2003-06-11 2006-07-25 Wyeth Corp método para produzir um polipeptìdeo
HUE029951T2 (en) * 2003-07-28 2017-04-28 Genentech Inc Reduction of Protein A Dissolution in Protein A Affinity Chromatography
CA2536936A1 (en) * 2003-09-05 2005-03-17 National Research Council Of Canada E- and k-coiled-coil fusion proteins comprising tgf-b cell receptor domains
NZ547588A (en) 2003-11-07 2009-05-31 Immunex Corp Antibodies that bind interleukin-4 receptor
EP1723173B1 (de) * 2004-02-27 2008-05-14 Regeneron Pharmaceuticals, Inc. Il-4/il-13-spezifische polypetide und deren therapeutische verwendung
AU2005249570B2 (en) 2004-06-04 2011-06-16 Regeneron Pharmaceuticals, Inc. Methods of using IL-1 antagonists to treat autoinflammatory disease
EP3489257A1 (de) 2004-07-23 2019-05-29 Acceleron Pharma Inc. Actrii-rezeptor-polypeptide, verfahren und zusammensetzungen
AU2005277357B2 (en) * 2004-08-17 2011-08-04 Regeneron Pharmaceuticals, Inc. IL-1 antagonist formulations
EP1630232B1 (de) * 2004-08-27 2008-07-02 CONARIS research institute AG Optimierte Nukleotidsequenzen die für sgp130 kodieren
US7786261B2 (en) * 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains
CN101094688B (zh) * 2004-09-13 2013-05-01 建新公司 多聚构建体
MX2007004374A (es) * 2004-10-12 2008-01-29 Amprotein Corp Proteina quimerica.
EA015706B1 (ru) 2004-10-22 2011-10-31 Займоджинетикс, Инк. Моноклональное антитело или его фрагмент, связывающиеся с полипептидом il-22ra, гуманизированное антитело, полученное из указанного антитела, гибридомы, продуцирующие антитело, и применение указанного антитела
JP2008527981A (ja) * 2005-01-25 2008-07-31 アポロ ライフ サイエンシズ リミテッド 治療目的および診断目的のためにパラメーターにより選択されたgm−csf、il−3、il−4、il−5、ならびにそのキメラ
HUE034109T2 (en) * 2005-03-25 2018-01-29 Regeneron Pharma VEGF antagonist formulations
US7732167B2 (en) * 2005-06-17 2010-06-08 Regeneron Pharmaceuticals, Inc. Interferon-α/β binding fusion proteins and therapeutic uses thereof
US7608430B2 (en) * 2005-07-08 2009-10-27 Regeneron Pharmaceuticals, Inc. Interferon-γ antagonists and therapeutic uses thereof
EP2295080A3 (de) 2005-07-25 2011-06-22 Emergent Product Development Seattle, LLC B-Zell-Verringerung mit CD37-spezifischen und CD20-spezifischen Bindungsmolekülen
US7666622B2 (en) * 2005-10-19 2010-02-23 Regeneron Pharmaceuticals, Inc. Monomeric self-associating fusion polypeptides and therapeutic uses thereof
US8067562B2 (en) 2005-11-01 2011-11-29 Amgen Inc. Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
WO2007061981A2 (en) 2005-11-21 2007-05-31 Lumera Corporation Surface plasmon resonance spectrometer with an actuator-driven angle scanning mechanism
CN101370511B (zh) * 2005-11-23 2015-07-01 阿塞勒隆制药公司 Activin-ActRIIa拮抗剂及其促进骨骼生长的应用
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
EP2781222B1 (de) * 2005-11-23 2017-08-02 Acceleron Pharma, Inc. Activin-actriia antagonisten zur verwendung in der förderung von knochenwachstum
US7463358B2 (en) 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
WO2007110205A2 (en) 2006-03-24 2007-10-04 Merck Patent Gmbh Engineered heterodimeric protein domains
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
SI2944306T1 (sl) 2006-06-16 2021-04-30 Regeneron Pharmaceuticals, Inc. Formulacije antagonista VEGF, primerne za intravitrealno dajanje
ES2352561T3 (es) * 2006-06-30 2011-02-21 Conaris Research Institute Ag Dímeros de sgp 130fc mejorados.
US8106004B2 (en) * 2006-07-28 2012-01-31 Children's Memorial Hospital Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
AU2007279205B2 (en) 2006-07-28 2013-09-26 Children's Memorial Hospital Methods of inhibiting tumor cell aggressiveness using the microenvironment of human embryonic stem cells
US7632490B2 (en) * 2006-10-20 2009-12-15 Regeneron Pharmaceuticals, Inc. Use of IL-1 antagonists to treat gout
MX2009004051A (es) * 2006-10-20 2009-05-11 Regeneron Pharma Uso de antagonistas de il-1 para tratar gota y pseudo gota.
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
JP5272735B2 (ja) * 2007-01-30 2013-08-28 国立大学法人 新潟大学 生物学的製剤
CA2677007A1 (en) 2007-02-01 2008-08-07 Acceleron Pharma Inc. Activin-actriia antagonists and uses for treating or preventing breast cancer
TW201803890A (zh) 2007-02-02 2018-02-01 艾瑟勒朗法瑪公司 衍生自ActRIIB的變體與其用途
EP2481415B1 (de) 2007-02-09 2019-09-11 Acceleron Pharma Inc. Zusammensetzungen enhaltend Activin-ActRIIA-Antagonisten
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
US7947646B2 (en) 2007-03-06 2011-05-24 Amgen Inc. Variant activin receptor polypeptides
EP2574671B1 (de) 2007-03-19 2016-02-03 National Research Council Of Canada Antagonisten von Liganden und ihre Verwendung
WO2009010539A2 (de) * 2007-07-19 2009-01-22 Ablynx. N.V. Receptor for interleukin-6 (il-6) form macaca fascicularis
JP2010539236A (ja) 2007-09-18 2010-12-16 アクセルロン ファーマ, インコーポレイテッド アクチビン−ActRIIa拮抗薬およびFSH分泌を低減または阻害するための使用
JP2011502163A (ja) * 2007-10-31 2011-01-20 ザ スクリプス リサーチ インスティテュート 持続性ウイルス感染を治療するための併用療法
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
WO2010031168A1 (en) * 2008-09-17 2010-03-25 National Research Council Of Canada HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFβ SUPERFAMILY
PT2132228E (pt) 2008-04-11 2011-10-11 Emergent Product Dev Seattle Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
TWI626945B (zh) 2008-08-14 2018-06-21 艾瑟勒朗法瑪公司 使用gdf阱以增加紅血球水平
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
NZ627111A (en) 2008-11-26 2015-10-30 Amgen Inc Variants of activin iib receptor polypeptides and uses thereof
JP5912078B2 (ja) 2009-06-08 2016-04-27 アクセルロン ファーマ, インコーポレイテッド 熱発生性脂肪細胞を増加させるための方法
EP3290439B1 (de) 2009-06-12 2020-09-02 Acceleron Pharma Inc. Verkürzte actriib-fc-fusionsproteine
EP3332796A1 (de) 2009-11-17 2018-06-13 Acceleron Pharma Inc. Actriib-proteine und varianten davon sowie verwendungen davon zur utrophin-induktion für therapien gegen muskuläre dystrophie
KR20130132824A (ko) 2010-11-08 2013-12-05 악셀레론 파마 인코포레이티드 Actriia 결합제 및 이의 용도
CN103492416A (zh) 2011-04-15 2014-01-01 默克专利股份公司 用于癌症中使用的抗il-1r1抑制剂
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
BR112014015003A2 (pt) 2011-12-19 2019-09-24 Amgen Inc composição farmacêutica, método para tratar um cancer e método para reduzir o tamanho de uma massa tumoral
US10195249B2 (en) 2012-11-02 2019-02-05 Celgene Corporation Activin-ActRII antagonists and uses for treating bone and other disorders
EP2928916B1 (de) * 2012-12-10 2019-03-13 Vib Vzw Neuartige interleukin-33-hemmer
SG11201505960VA (en) 2013-02-01 2015-08-28 Santa Maria Biotherapeutics Inc Administration of an anti-activin-a compound to a subject
EP4050019A1 (de) 2013-02-15 2022-08-31 R-Pharm International, LLC Il-1beta-inhibitorzusammensetzung und verwendung davon
US12180264B2 (en) 2014-03-24 2024-12-31 R-Pharm Overseas, Inc. IL1-R1 derived inhibitor of IL-1β and use thereof
MA40008A (fr) 2014-06-13 2021-05-05 Acceleron Pharma Inc Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie
WO2016008975A1 (en) 2014-07-18 2016-01-21 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
RS65665B1 (sr) 2014-12-01 2024-07-31 Ferring Bv Selektivne kompozicije inhibitora il-6-trans-signalizacije
EP3226888B1 (de) 2014-12-01 2021-04-21 Ferring B.V. Verabreichung eines selektiven il-6-transsignalisierenden inhibitors
TWI730949B (zh) 2014-12-03 2021-06-21 美商西建公司 活化素-actrii拮抗劑及治療貧血之用途
GB201503453D0 (en) 2015-03-01 2015-04-15 Jain Arjun Endothelin-1"sponge"
WO2016183222A1 (en) * 2015-05-12 2016-11-17 Regeneron Pharmaceuticals, Inc. Multimeric protein purity determination
KR102784293B1 (ko) 2015-09-21 2025-03-20 압테보 리서치 앤드 디벨롭먼트 엘엘씨 Cd3 결합 폴리펩타이드
AU2017336546C1 (en) 2016-09-27 2025-05-29 Epicentrx, Inc. Immunomodulatory fusion proteins
CA3059731A1 (en) * 2017-04-21 2018-10-25 Kindred Biosciences, Inc. Il4/il13 receptor molecule for veterinary use
KR102757384B1 (ko) 2017-09-27 2025-01-20 에피센트알엑스, 인코포레이티드 면역조절 융합 단백질
TWI823906B (zh) 2018-03-09 2023-12-01 美商艾吉納斯公司 抗-cd73 抗體及其使用方法
MX2021000644A (es) 2018-07-18 2021-08-19 Manzanita Pharmaceuticals Inc Conjugados para suministrar un agente contra el cancer a las celulas nerviosas, metodos de uso y metodos para la elaboracion de los mismos.
CN110950965B (zh) * 2018-09-26 2021-10-15 重庆精准生物技术有限公司 抗人cd123的嵌合抗原受体及其应用
TW202607038A (zh) 2020-10-19 2026-02-16 美商碩騰服務公司 犬及貓抑瘤素M受體β之抗體及其用途

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
WO1991018982A1 (en) * 1990-06-05 1991-12-12 Immunex Corporation Type ii interleukin-1 receptors
ATE169030T1 (de) * 1990-06-28 1998-08-15 Hoechst Ag Fusionsproteine mit immunglobulinanteilen, ihre herstellung und verwendung
EP0533006A1 (de) * 1991-09-18 1993-03-24 F.Hoffmann-La Roche & Co. Aktiengesellschaft Chimäre Interleukin 5-Rezeptor/Immunoglobulin-Polypeptide
EP0611302B1 (de) * 1991-10-15 2000-03-29 MULLARKEY, Michael F. Rezeptoren zur Behandlung von Entzündungen vom verzögerten Typ
US5262522A (en) 1991-11-22 1993-11-16 Immunex Corporation Receptor for oncostatin M and leukemia inhibitory factor
DE69321720T2 (de) * 1992-03-09 1999-05-06 Ludwig Institute For Cancer Research, New York, N.Y. Für den interleukin-9-rezeptor kodierende nukleinsäuresequenzen bzw. dafür komplementäre nuleinsäuresequenzen
US8211422B2 (en) * 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
WO1993019163A1 (en) * 1992-03-18 1993-09-30 Yeda Research And Development Co, Ltd. Chimeric receptor genes and cells transformed therewith
EP0670730B1 (de) * 1992-03-30 2003-06-04 Immunex Corporation Fusionsprotein , das zwei rezeptoren des tumornekrose-faktors enthält
JP3255699B2 (ja) 1992-04-23 2002-02-12 味の素株式会社 ヒトIL−2レセプターγ鎖分子
WO1994022914A1 (en) * 1993-04-06 1994-10-13 Fred Hutchinson Cancer Research Center Chimeric cytokine receptors in lymphocytes
EP0716703A1 (de) * 1993-09-03 1996-06-19 PRENDERGAST, Kenneth, Francis Glycophorin bindende proteine (gbp130) fusionszusammensetzungen
AU701623B2 (en) * 1993-10-14 1999-02-04 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
US5470952A (en) 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
IL114825A0 (en) * 1994-08-04 1995-12-08 Regeneron Pharma Rtk/cytokine receptor chimeras
AU3830895A (en) 1994-10-07 1996-05-02 Amgen Boulder Inc. Dimeric il-4 inhibitors
US5837544A (en) * 1995-02-02 1998-11-17 Cell Genesys, Inc. Method of inducing a cell to proliferate using a chimeric receptor comprising janus kinase
US5837816A (en) * 1995-05-10 1998-11-17 Chiron Corporation Interleukin-2 receptor subunit ectodomain fusion protein comprising a leucine zipper domain
GB9526131D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Recombinant chimeric receptors
US5776731A (en) * 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
US5710023A (en) * 1996-03-01 1998-01-20 Genetics Institute, Inc. IL-13 cytokine receptor chain
AU3668897A (en) * 1996-07-17 1998-02-09 University Of Medicine And Dentistry Of New Jersey Chimeric receptors for jak-stat signal transduction
WO1998008969A1 (en) * 1996-08-26 1998-03-05 Human Genome Sciences, Inc. Soluble interleukin-1 receptor accessory molecule
GB9625899D0 (en) 1996-12-13 1997-01-29 Glaxo Group Ltd Substances and their uses
US6087116A (en) * 1997-03-12 2000-07-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18 (IL-18) receptor polypeptides and their uses
ATE272114T1 (de) * 1998-01-23 2004-08-15 Immunex Corp Rezeptoren für il-18

Also Published As

Publication number Publication date
CA2345109A1 (en) 2000-04-06
JP2002525119A (ja) 2002-08-13
NO20011513D0 (no) 2001-03-23
ATE283365T1 (de) 2004-12-15
EP1229047A3 (de) 2002-10-02
IL142103A (en) 2007-07-04
ES2233733T3 (es) 2005-06-16
AU758970B2 (en) 2003-04-03
EP1115876B1 (de) 2006-08-16
FR10C0025I1 (de) 2010-05-21
US20020164690A1 (en) 2002-11-07
DK1229047T3 (da) 2005-02-21
NO20011513L (no) 2001-05-25
ATE336583T1 (de) 2006-09-15
JP3902728B2 (ja) 2007-04-11
US6472179B2 (en) 2002-10-29
FR10C0025I2 (fr) 2011-04-01
NO2011003I1 (no) 2011-05-02
WO2000018932A3 (en) 2000-11-02
EP1115876A2 (de) 2001-07-18
AU758970C (en) 2007-05-03
CA2345109C (en) 2012-12-18
NO2011003I2 (de) 2011-04-11
HK1045847A1 (en) 2002-12-13
AU6499499A (en) 2000-04-17
HK1045847B (en) 2005-03-24
PL201246B1 (pl) 2009-03-31
DE69922269T2 (de) 2005-12-01
EP1405915A1 (de) 2004-04-07
WO2000018932A9 (en) 2000-08-31
DE69922269D1 (de) 2004-12-30
PT1229047E (pt) 2005-03-31
PL348529A1 (en) 2002-06-03
CN1357049A (zh) 2002-07-03
DE122010000023I2 (de) 2012-04-26
DE69932832D1 (de) 2006-09-28
NO329976B1 (no) 2011-01-31
HK1035377A1 (en) 2001-11-23
DE69932832T2 (de) 2007-02-08
ES2267300T3 (es) 2007-03-01
CN100345970C (zh) 2007-10-31
EP1229047A2 (de) 2002-08-07
DE122010000023I1 (de) 2012-04-26
BE2010C021I2 (de) 2018-12-04
WO2000018932A2 (en) 2000-04-06
US20020012962A1 (en) 2002-01-31
NZ510720A (en) 2003-11-28
EP1229047B1 (de) 2004-11-24

Similar Documents

Publication Publication Date Title
PL348529A1 (en) Receptor based antagonists and methods of making and using
SI1572967T1 (sl) Antagonisti il-1 receptorja in postopek za izdelavo in uporabo
IL166659A0 (en) Nogo receptor antagonists
SG149693A1 (en) Peptides acting as both glp-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use
PL341524A1 (en) Novel receptor coupled wih g protein
DE69834852D1 (de) NL3 TIE Rezeptortyrosinekinase Ligandhomologe
IL140622A0 (en) Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
ATE490323T1 (de) Adiponektin-rezeptor und dafür kodierendes gen
UA87106C2 (uk) БІЛОК, ЯКИЙ ЗВ'ЯЗУЄ РЕЦЕПТОР Nogo
BRPI0413426A (pt) antagonistas de receptor novo
WO2004043403A3 (en) Synthetic single domain polypeptides mimicking apolipoprotein e and methods of use
DK1009817T3 (da) RTD-receptor
WO2003018631A3 (en) Nogo receptor homologues and their use
WO2005042717A3 (en) Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods
WO2000006733A3 (en) T cell receptor proteins, nucleic acid molecules, and uses thereof
WO2001068855A3 (en) Gtp-binding protein gamma-12 subunit

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed