WO2000006733A3 - T cell receptor proteins, nucleic acid molecules, and uses thereof - Google Patents

T cell receptor proteins, nucleic acid molecules, and uses thereof Download PDF

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Publication number
WO2000006733A3
WO2000006733A3 PCT/US1999/017309 US9917309W WO0006733A3 WO 2000006733 A3 WO2000006733 A3 WO 2000006733A3 US 9917309 W US9917309 W US 9917309W WO 0006733 A3 WO0006733 A3 WO 0006733A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
proteins
tcr
antibodies
Prior art date
Application number
PCT/US1999/017309
Other languages
French (fr)
Other versions
WO2000006733A2 (en
Inventor
Gek-Kee Sim
Matthew J Dreitz
Original Assignee
Heska Corp
Sim Gek Kee
Matthew J Dreitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heska Corp, Sim Gek Kee, Matthew J Dreitz filed Critical Heska Corp
Priority to AU52453/99A priority Critical patent/AU5245399A/en
Publication of WO2000006733A2 publication Critical patent/WO2000006733A2/en
Publication of WO2000006733A3 publication Critical patent/WO2000006733A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The present invention relates to TCR Vβ proteins; to TCR Vβ nucleic acid molecules, including those that encode such TCR Vβ proteins; to antibodies raised against such TCR Vβ proteins; and to therapeutic compounds that regulate TCR Vβ function. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal. Also included in the present invention are methods to detect T cell expansion in an animal using reagents including, or derived from such proteins, nucleic acid molecules or antibodies.
PCT/US1999/017309 1998-07-29 1999-07-29 T cell receptor proteins, nucleic acid molecules, and uses thereof WO2000006733A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU52453/99A AU5245399A (en) 1998-07-29 1999-07-29 T cell receptor proteins, nucleic acid molecules, and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9450698P 1998-07-29 1998-07-29
US60/094,506 1998-07-29

Publications (2)

Publication Number Publication Date
WO2000006733A2 WO2000006733A2 (en) 2000-02-10
WO2000006733A3 true WO2000006733A3 (en) 2000-05-04

Family

ID=22245558

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/017309 WO2000006733A2 (en) 1998-07-29 1999-07-29 T cell receptor proteins, nucleic acid molecules, and uses thereof

Country Status (2)

Country Link
AU (1) AU5245399A (en)
WO (1) WO2000006733A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6911204B2 (en) 2000-08-11 2005-06-28 Favrille, Inc. Method and composition for altering a B cell mediated pathology
CN106279404A (en) * 2015-05-20 2017-01-04 广州市香雪制药股份有限公司 A kind of solvable and stable heterogeneous dimerization TCR

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012996A2 (en) * 1991-01-22 1992-08-06 The Immune Response Corporation Vaccination and methods against diseases resulting from pathogenic responses by specific t cell populations
US5635354A (en) * 1991-01-09 1997-06-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635354A (en) * 1991-01-09 1997-06-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for describing the repertoires of antibodies (Ab) and of T-cell receptors (TcR) of an individual's immune system
WO1992012996A2 (en) * 1991-01-22 1992-08-06 The Immune Response Corporation Vaccination and methods against diseases resulting from pathogenic responses by specific t cell populations

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK 17 January 1995 (1995-01-17), WEDDERBURN: "T-cell antigen receptor beta chain", XP002122471 *
DATABASE GENBANK 6 January 1999 (1999-01-06), DREITZ M.J. & SIM G.K.: "T cell receptor beta chain hcvb3 (Canis familiaris)", XP002122470 *
ITO K. ET AL.: "Isolation and sequence analysis of cDNA for the dog T-cell receptor Tcr-alpha and Tcr-beta chains", IMMUNOGENETICS, vol. 38, 1993, pages 60 - 63, XP002122469 *
TAKANO M. ET AL.: "Identification of dog T-cell receptor beta chain genes", IMMUNOGENETICS, vol. 40, 1994, pages 246, XP002122468 *
WEDDERBURN L.R. ET AL.: "In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens", PROC. NATL. ACAD. SCI. USA, vol. 90, September 1993 (1993-09-01), pages 8214 - 8218, XP002122467 *

Also Published As

Publication number Publication date
WO2000006733A2 (en) 2000-02-10
AU5245399A (en) 2000-02-21

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