IL136063A - Nanoelectrode arrays - Google Patents

Nanoelectrode arrays

Info

Publication number
IL136063A
IL136063A IL13606398A IL13606398A IL136063A IL 136063 A IL136063 A IL 136063A IL 13606398 A IL13606398 A IL 13606398A IL 13606398 A IL13606398 A IL 13606398A IL 136063 A IL136063 A IL 136063A
Authority
IL
Israel
Prior art keywords
chip
nanoelectrodes
molecules
built
arrays
Prior art date
Application number
IL13606398A
Other languages
English (en)
Other versions
IL136063A0 (en
Inventor
John P Peeters
Original Assignee
Protiveris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protiveris Inc filed Critical Protiveris Inc
Publication of IL136063A0 publication Critical patent/IL136063A0/xx
Publication of IL136063A publication Critical patent/IL136063A/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6825Nucleic acid detection involving sensors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60Detection means characterised by use of a special device
    • C12Q2565/607Detection means characterised by use of a special device being a sensor, e.g. electrode
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/788Of specified organic or carbon-based composition
    • Y10S977/789Of specified organic or carbon-based composition in array format
    • Y10S977/79Of specified organic or carbon-based composition in array format with heterogeneous nanostructures
    • Y10S977/791Molecular array
    • Y10S977/792Nucleic acid array, e.g. human genome array
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/788Of specified organic or carbon-based composition
    • Y10S977/789Of specified organic or carbon-based composition in array format
    • Y10S977/79Of specified organic or carbon-based composition in array format with heterogeneous nanostructures
    • Y10S977/791Molecular array
    • Y10S977/793Protein array
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/84Manufacture, treatment, or detection of nanostructure
    • Y10S977/849Manufacture, treatment, or detection of nanostructure with scanning probe
    • Y10S977/852Manufacture, treatment, or detection of nanostructure with scanning probe for detection of specific nanostructure sample or nanostructure-related property
    • Y10S977/853Biological sample
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/84Manufacture, treatment, or detection of nanostructure
    • Y10S977/849Manufacture, treatment, or detection of nanostructure with scanning probe
    • Y10S977/86Scanning probe structure
    • Y10S977/874Probe tip array

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Inert Electrodes (AREA)
  • Electrodes Of Semiconductors (AREA)
  • Cold Cathode And The Manufacture (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
IL13606398A 1997-11-12 1998-11-04 Nanoelectrode arrays IL136063A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6537397P 1997-11-12 1997-11-12
US09/044,350 US6123819A (en) 1997-11-12 1998-03-19 Nanoelectrode arrays
PCT/US1998/023547 WO1999024823A1 (en) 1997-11-12 1998-11-04 Nanoelectrode arrays

Publications (2)

Publication Number Publication Date
IL136063A0 IL136063A0 (en) 2001-05-20
IL136063A true IL136063A (en) 2003-07-31

Family

ID=26721443

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13606398A IL136063A (en) 1997-11-12 1998-11-04 Nanoelectrode arrays

Country Status (13)

Country Link
US (2) US6123819A (de)
EP (1) EP1038171B8 (de)
JP (1) JP3693572B2 (de)
KR (2) KR20010032068A (de)
CN (1) CN1278917A (de)
AT (1) ATE318409T1 (de)
AU (1) AU746886B2 (de)
BR (1) BR9815581A (de)
CA (1) CA2309450C (de)
DE (1) DE69833562T2 (de)
EA (1) EA200000404A1 (de)
IL (1) IL136063A (de)
WO (1) WO1999024823A1 (de)

Families Citing this family (228)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120160687A1 (en) 1995-03-17 2012-06-28 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US7775368B2 (en) * 1995-04-03 2010-08-17 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
US8142708B2 (en) * 1995-04-03 2012-03-27 Wisconsin Alumni Research Foundation Micro fluidic system for single molecule imaging
US6511803B1 (en) * 1997-10-10 2003-01-28 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
DE69817329T2 (de) * 1998-06-02 2004-06-09 International Business Machines Corp. Vorrichtung und Verfahren zur Identifikation einer Substanz durch Oberflächenwechselwirkungen
KR100277881B1 (ko) * 1998-06-16 2001-02-01 김영환 트랜지스터
DE19860547C1 (de) * 1998-12-23 2000-10-12 Genetrix B V I O Affinitätssensor für den Nachweis spezifischer molekularer Bindungsereignisse und dessen Verwendung
US20030087277A1 (en) * 1998-12-23 2003-05-08 Wolfgang Fritzsche Means and methods for detection of binding of members of specific binding pairs
ATE309042T1 (de) * 1999-05-03 2005-11-15 Cantion As Sensor für ein mikrofluidisches bearbeitungssystem
US6575020B1 (en) * 1999-05-03 2003-06-10 Cantion A/S Transducer for microfluid handling system
US20020042081A1 (en) * 2000-10-10 2002-04-11 Eric Henderson Evaluating binding affinities by force stratification and force panning
US6573369B2 (en) * 1999-05-21 2003-06-03 Bioforce Nanosciences, Inc. Method and apparatus for solid state molecular analysis
US20030186311A1 (en) * 1999-05-21 2003-10-02 Bioforce Nanosciences, Inc. Parallel analysis of molecular interactions
US20030073250A1 (en) * 1999-05-21 2003-04-17 Eric Henderson Method and apparatus for solid state molecular analysis
WO2000079257A1 (en) * 1999-06-22 2000-12-28 President And Fellows Of Harvard College Molecular and atomic scale evaluation of biopolymers
US6286226B1 (en) * 1999-09-24 2001-09-11 Agere Systems Guardian Corp. Tactile sensor comprising nanowires and method for making the same
US6649343B1 (en) * 1999-10-22 2003-11-18 Ngk Insulators, Ltd. DNA chip and method for producing the same
US6248674B1 (en) * 2000-02-02 2001-06-19 Hewlett-Packard Company Method of aligning nanowires
US6897015B2 (en) * 2000-03-07 2005-05-24 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of pathogens and biological materials
DE10015818A1 (de) 2000-03-30 2001-10-18 Infineon Technologies Ag Biosensor und Verfahren zum Ermitteln makromolekularer Biopolymere mit einem Biosensor
DE60135150D1 (de) * 2000-08-15 2008-09-11 Bioforce Nanosciences Inc Vorrichtung zur bildung von nanomolekularen netzwerken
EP2298968A3 (de) 2000-08-22 2011-10-05 President and Fellows of Harvard College Verfahren zur Züchtung von Nanodrähten
US7301199B2 (en) * 2000-08-22 2007-11-27 President And Fellows Of Harvard College Nanoscale wires and related devices
KR20030059187A (ko) * 2000-10-10 2003-07-07 바이오포스 나노사이언스, 인크. 나노미터 크기 검측용 감지기
US7216660B2 (en) * 2000-11-02 2007-05-15 Princeton University Method and device for controlling liquid flow on the surface of a microfluidic chip
EP1736760A3 (de) * 2000-12-11 2008-06-18 President And Fellows Of Harvard College Nanosensoren
JP4583710B2 (ja) 2000-12-11 2010-11-17 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ ナノセンサ
WO2002072789A2 (en) * 2001-03-12 2002-09-19 Irm, Llc. Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters
US6593666B1 (en) * 2001-06-20 2003-07-15 Ambient Systems, Inc. Energy conversion systems using nanometer scale assemblies and methods for using same
US20030134273A1 (en) * 2001-07-17 2003-07-17 Eric Henderson Combined molecular binding detection through force microscopy and mass spectrometry
US20030148314A1 (en) * 2001-08-01 2003-08-07 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer
US20040248125A1 (en) * 2001-08-13 2004-12-09 Stremler Mark A Distribution of solutions across a surface
KR100455284B1 (ko) * 2001-08-14 2004-11-12 삼성전자주식회사 탄소나노튜브를 이용한 고용량의 바이오분자 검출센서
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
US7042488B2 (en) 2001-09-27 2006-05-09 Fujinon Corporation Electronic endoscope for highlighting blood vessel
EP1461605A4 (de) * 2001-10-02 2009-10-21 Univ Northwestern Protein- und peptid-nanoarrays
US7318908B1 (en) * 2001-11-01 2008-01-15 The Board Of Trustees Of The Leland Stanford Junior University Integrated nanotube sensor
US6926864B2 (en) * 2001-11-09 2005-08-09 Protiveris Inc Microfluidics apparatus and methods for use thereof
US20060121502A1 (en) * 2001-11-09 2006-06-08 Robert Cain Microfluidics apparatus for cantilevers and methods of use therefor
JP2005516940A (ja) * 2001-12-20 2005-06-09 ブリストル−マイヤーズ スクイブ カンパニー 高血圧患者に対する血管ペプチダーゼ阻害剤投与による脈圧と血管硬化度の低下
US6882767B2 (en) * 2001-12-27 2005-04-19 The Regents Of The University Of California Nanowire optoelectric switching device and method
WO2003061470A1 (en) * 2002-01-18 2003-07-31 California Institute Of Technology Method and apparatus for nanomagnetic manipulation and sensing
US20060078961A1 (en) * 2002-02-12 2006-04-13 Daniel Chiu Systems and methods for rapidly changing the solution environment around sensors
GB0205794D0 (en) * 2002-03-12 2002-04-24 Montelius Lars G Mems devices on a nanometer scale
US20030233197A1 (en) * 2002-03-19 2003-12-18 Padilla Carlos E. Discrete bayesian analysis of data
US7288404B2 (en) * 2002-04-29 2007-10-30 Regents Of The University Of California Microcantilevers for biological and chemical assays and methods of making and using thereof
US6801041B2 (en) * 2002-05-14 2004-10-05 Abbott Laboratories Sensor having electrode for determining the rate of flow of a fluid
US20030215816A1 (en) * 2002-05-20 2003-11-20 Narayan Sundararajan Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
US20050239193A1 (en) * 2002-05-30 2005-10-27 Bioforce Nanosciences, Inc. Device and method of use for detection and characterization of microorganisms and microparticles
US6798200B2 (en) * 2002-06-03 2004-09-28 Long-Sheng Fan Batch-fabricated gradient and RF coils for submicrometer resolution magnetic resonance imaging and manipulation
AU2003240561A1 (en) * 2002-06-06 2003-12-22 Rutgers, The State University Of New Jersey MULTIFUNCTIONAL BIOSENSOR BASED ON ZnO NANOSTRUCTURES
US6946851B2 (en) * 2002-07-03 2005-09-20 The Regents Of The University Of California Carbon nanotube array based sensor
AU2003261205A1 (en) 2002-07-19 2004-02-09 President And Fellows Of Harvard College Nanoscale coherent optical components
US7199305B2 (en) * 2002-08-08 2007-04-03 Nanoink, Inc. Protosubstrates
US7153687B2 (en) * 2002-08-13 2006-12-26 Hong Kong Dna Chips Limited Apparatus and methods for detecting DNA in biological samples
US7005378B2 (en) * 2002-08-26 2006-02-28 Nanoink, Inc. Processes for fabricating conductive patterns using nanolithography as a patterning tool
US20040054342A1 (en) * 2002-09-18 2004-03-18 Newbill Vincent B. Absorbent articles having a superabsorbent retention web
EP1556506A1 (de) * 2002-09-19 2005-07-27 The Chancellor, Masters And Scholars Of The University Of Oxford Molekulare arrays und einzelmolekülnachweis
AU2003298588A1 (en) * 2002-09-20 2004-04-23 The Ohio State University Research Foundation Detection of biological threat agents
JP4398375B2 (ja) * 2002-09-24 2010-01-13 インテル・コーポレーション フィードバック制御式カンチレバー偏向をモニターすることによる分子結合の検出方法
US7270952B2 (en) * 2002-09-24 2007-09-18 Intel Corporation Detecting molecular binding by monitoring feedback controlled cantilever deflections
US20040069633A1 (en) * 2002-09-30 2004-04-15 The Regents Of The University Of California Electrophoretic devices with nanometer-scale, metallic elements
US6974678B2 (en) * 2002-10-08 2005-12-13 Mississippi State University Micro-fluidic device for measuring osmotic second virial coefficients
AU2003278461A1 (en) * 2002-10-16 2004-05-04 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
EP1561108A1 (de) * 2002-10-18 2005-08-10 Kristinn Johnsen Nanoelektrodenvorrichtung zur chemischen analyse
KR100479263B1 (ko) * 2002-10-18 2005-03-28 한국전자통신연구원 비정질 실리콘 박막 트랜지스터를 이용한 생체 분자 감지를 위한 형광 검출 소자
AU2003301262A1 (en) * 2002-10-18 2004-05-04 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
WO2004044551A2 (en) * 2002-11-08 2004-05-27 Protiveris, Inc. Multiplex illuminator and device reader for microcantilever array
FR2847983B1 (fr) * 2002-11-29 2005-02-25 Centre Nat Rech Scient Dispositif miniature de detection electrique d'interactions de type ligand-recepteur, preparation et utilisations.
US7355216B2 (en) * 2002-12-09 2008-04-08 The Regents Of The University Of California Fluidic nanotubes and devices
US7898005B2 (en) * 2002-12-09 2011-03-01 The Regents Of The University Of California Inorganic nanotubes and electro-fluidic devices fabricated therefrom
US7211143B2 (en) * 2002-12-09 2007-05-01 The Regents Of The University Of California Sacrificial template method of fabricating a nanotube
US7183568B2 (en) * 2002-12-23 2007-02-27 International Business Machines Corporation Piezoelectric array with strain dependant conducting elements and method therefor
EP1583845A4 (de) * 2003-01-02 2006-06-28 Bioforce Nanosciences Inc Verfahren und vorrichtung zur molekularen analyse bei kleinen probenvolumen
WO2004062697A2 (en) 2003-01-07 2004-07-29 Tufts University Silk fibroin materials and use thereof
DE10311315A1 (de) * 2003-03-14 2004-09-30 Apibio Sas Verfahren und Vorrichtung zur Detektion von Biomolekülen
JP4698596B2 (ja) 2003-04-10 2011-06-08 タフツ ユニバーシティー 濃縮された水性シルクフィブロイン溶液およびそれらの使用
US7741033B2 (en) * 2003-05-13 2010-06-22 Trustees Of Boston College Electrocatalytic nucleic acid hybridization detection
US7095645B2 (en) * 2003-06-02 2006-08-22 Ambient Systems, Inc. Nanoelectromechanical memory cells and data storage devices
US7148579B2 (en) 2003-06-02 2006-12-12 Ambient Systems, Inc. Energy conversion systems utilizing parallel array of automatic switches and generators
US7199498B2 (en) * 2003-06-02 2007-04-03 Ambient Systems, Inc. Electrical assemblies using molecular-scale electrically conductive and mechanically flexible beams and methods for application of same
US20040238907A1 (en) * 2003-06-02 2004-12-02 Pinkerton Joseph F. Nanoelectromechanical transistors and switch systems
US7910064B2 (en) * 2003-06-03 2011-03-22 Nanosys, Inc. Nanowire-based sensor configurations
WO2005000483A1 (en) * 2003-06-06 2005-01-06 Tufts University Method for forming inorganic coatings
WO2005031300A2 (en) * 2003-06-27 2005-04-07 Purdue Research Foundation Device for detecting biological and chemical particles
US20050017173A1 (en) * 2003-07-15 2005-01-27 Nalin Kumar Individually addressable nanoelectrode array
WO2005017025A2 (en) 2003-08-15 2005-02-24 The President And Fellows Of Harvard College Study of polymer molecules and conformations with a nanopore
US7241479B2 (en) * 2003-08-22 2007-07-10 Clemson University Thermal CVD synthesis of nanostructures
US7632234B2 (en) * 2003-08-29 2009-12-15 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
US7344753B2 (en) * 2003-09-19 2008-03-18 The Board Of Trustees Of The University Of Illinois Nanostructures including a metal
US8030833B2 (en) * 2003-09-19 2011-10-04 The Board Of Trustees Of The University Of Illinois Electron emission device incorporating free standing monocrystalline nanowires
KR100861522B1 (ko) * 2003-12-26 2008-10-02 후지제롯쿠스 가부시끼가이샤 정류 소자 및 그것을 사용한 전자 회로, 및 정류 소자의제조 방법
US7612370B2 (en) * 2003-12-31 2009-11-03 Intel Corporation Thermal interface
US7048889B2 (en) * 2004-03-23 2006-05-23 Lucent Technologies Inc. Dynamically controllable biological/chemical detectors having nanostructured surfaces
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US8354066B2 (en) * 2004-03-24 2013-01-15 Technion Research & Development Foundation Ltd. Artificial receptors
WO2005090981A2 (en) * 2004-03-24 2005-09-29 Technion Research & Development Foundation Ltd. Electrode
JP2008506548A (ja) 2004-07-19 2008-03-06 アンビエント システムズ, インコーポレイテッド ナノスケール静電および電磁モータおよび発電機
WO2007013872A2 (en) 2004-07-22 2007-02-01 The Board Of Trustees Of The University Of Illinois Sensors employing single-walled carbon nanotubes
JP4742533B2 (ja) * 2004-08-06 2011-08-10 独立行政法人科学技術振興機構 Bi層状化合物ナノプレート及びその配列体並びにその製造方法とそれを用いた装置
US20060032289A1 (en) * 2004-08-11 2006-02-16 Pinnaduwage Lal A Non-optical explosive sensor based on two-track piezoresistive microcantilever
US7713849B2 (en) * 2004-08-20 2010-05-11 Illuminex Corporation Metallic nanowire arrays and methods for making and using same
US7211789B2 (en) * 2004-10-14 2007-05-01 International Business Machines Corporation Programmable molecular manipulating processes
ATE491938T1 (de) * 2004-10-29 2011-01-15 Japan Science & Tech Agency Substrat für maldi-tof-ms und massenspektrometrisches verfahren unter verwendung davon
EP1825560A4 (de) * 2004-11-20 2010-09-15 Kenneth E Salsman Einrichtung zur emission von hochfrequenzsignalen
US7280078B2 (en) * 2004-11-20 2007-10-09 Scenterra, Inc. Sensor for detecting high frequency signals
CN101124638A (zh) 2004-12-06 2008-02-13 哈佛大学 基于纳米尺度线的数据存储
US20060174385A1 (en) * 2005-02-02 2006-08-03 Lewis Gruber Method and apparatus for detecting targets
US20090203547A1 (en) * 2005-02-18 2009-08-13 Albert Banes Gene and Cognate Protein Profiles and Methods to Determine Connective Tissue Markers in Normal and Pathologic Conditions
JP2008534018A (ja) 2005-03-29 2008-08-28 アプレラ コーポレーション 核酸分析ナノワイヤベースシステム
EP1877789A4 (de) * 2005-04-12 2010-02-10 Trustees Boston College Verfahren zur elektrokatalytischen proteindetektion
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US20100227382A1 (en) 2005-05-25 2010-09-09 President And Fellows Of Harvard College Nanoscale sensors
US20060275779A1 (en) * 2005-06-03 2006-12-07 Zhiyong Li Method and apparatus for molecular analysis using nanowires
WO2006132659A2 (en) 2005-06-06 2006-12-14 President And Fellows Of Harvard College Nanowire heterostructures
WO2007012028A2 (en) * 2005-07-19 2007-01-25 Pinkerton Joseph P Heat activated nanometer-scale pump
KR100727393B1 (ko) * 2005-08-10 2007-06-12 학교법인 포항공과대학교 국부 전기화학석출법을 이용한 높은 구조적 집적도를 갖는고 종횡비의 미세구조물을 제조하는 방법
KR100707204B1 (ko) * 2005-08-16 2007-04-13 삼성전자주식회사 저단면비의 저항성 팁을 구비한 반도체 탐침 및 그제조방법
GB0523282D0 (en) 2005-11-15 2005-12-21 Isis Innovation Methods using pores
US20070127164A1 (en) * 2005-11-21 2007-06-07 Physical Logic Ag Nanoscale Sensor
US20080241935A1 (en) 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods for pathogen detection
US8068991B2 (en) 2005-11-30 2011-11-29 The Invention Science Fund I, Llc Systems and methods for transmitting pathogen related information and responding
JP2009540798A (ja) * 2006-03-15 2009-11-26 プレジデント アンド フェロウズ オブ ハーバード カレッジ ナノバイオエレクトロニクス
KR100754399B1 (ko) * 2006-04-05 2007-08-31 삼성전자주식회사 단일 챔버를 이용한 세포 파괴 및 핵산의 정제 방법 및장치
DE602007012248D1 (de) 2006-06-12 2011-03-10 Harvard College Nanosensoren und entsprechende technologien
US20080100279A1 (en) * 2006-06-15 2008-05-01 University Of South Florida Nano-Based Device for Detection of Disease Biomarkers and Other Target Molecules
US8349604B2 (en) * 2006-06-15 2013-01-08 University Of South Florida Nano-based device for detection of disease biomarkers and other target molecules
WO2008033303A2 (en) 2006-09-11 2008-03-20 President And Fellows Of Harvard College Branched nanoscale wires
GB2441784A (en) * 2006-09-13 2008-03-19 Rtc North Ltd Device for obtaining and analysing a biological fluid
US7388200B2 (en) * 2006-10-19 2008-06-17 Hewlett-Packard Development Company, L.P. Sensing method and nanosensing device for performing the same
WO2008060455A2 (en) 2006-11-09 2008-05-22 Nanosys, Inc. Methods for nanowire alignment and deposition
US8575663B2 (en) 2006-11-22 2013-11-05 President And Fellows Of Harvard College High-sensitivity nanoscale wire sensors
US20080280776A1 (en) * 2006-12-04 2008-11-13 Rashid Bashir Method and apparatus for detection of molecules using a sensor array
US20080161887A1 (en) * 2006-12-28 2008-07-03 Cvrx, Inc. Noble metal electrodes with nanostructures
US20080169003A1 (en) * 2007-01-17 2008-07-17 Nasa Headquarters Field reactive amplification controlling total adhesion loading
US8617903B2 (en) 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US20080186801A1 (en) * 2007-02-06 2008-08-07 Qisda Corporation Bubble micro-pump and two-way fluid-driving device, particle-sorting device, fluid-mixing device, ring-shaped fluid-mixing device and compound-type fluid-mixing device using the same
KR100814390B1 (ko) 2007-02-15 2008-03-18 삼성전자주식회사 메모리 소자 및 그 제조 방법.
WO2008106485A2 (en) 2007-02-27 2008-09-04 Trustees Of Tufts College Tissue-engineered silk organs
US8168120B1 (en) 2007-03-06 2012-05-01 The Research Foundation Of State University Of New York Reliable switch that is triggered by the detection of a specific gas or substance
KR100850273B1 (ko) 2007-03-08 2008-08-04 삼성전자주식회사 멀티 비트 전기 기계적 메모리 소자 및 그의 제조방법
US8385113B2 (en) 2007-04-03 2013-02-26 Cjp Ip Holdings, Ltd. Nanoelectromechanical systems and methods for making the same
DE102007019842A1 (de) * 2007-04-25 2008-10-30 Forschungsinstitut Für Die Biologie Landwirtschaftlicher Nutztiere Verfahren und Anordnung zum elektrischen Kontaktieren eines membranumhüllten Objekts mit einer Elektrode
US7892610B2 (en) * 2007-05-07 2011-02-22 Nanosys, Inc. Method and system for printing aligned nanowires and other electrical devices
KR100876948B1 (ko) 2007-05-23 2009-01-09 삼성전자주식회사 멀티 비트 전기 기계적 메모리 소자 및 그의 제조방법
KR100876088B1 (ko) 2007-05-23 2008-12-26 삼성전자주식회사 멀티 비트 전기 기계적 메모리 소자 및 그의 제조방법
AU2008260156B2 (en) 2007-05-29 2013-10-31 Trustees Of Tufts College Method for silk fibroin gelation using sonication
WO2009033056A1 (en) 2007-09-06 2009-03-12 Bioscale, Inc. Reusable detection surfaces and methods of using same
GB2453377A (en) * 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
WO2009050168A1 (en) * 2007-10-15 2009-04-23 Universite Catholique De Louvain Drug-eluting nanowire array
KR100959067B1 (ko) 2008-01-14 2010-05-20 전북대학교산학협력단 산화아연 나노구조물에 기초한 히드라진 검출용 화학 센서
WO2009100280A2 (en) * 2008-02-07 2009-08-13 Trustees Of Tufts College 3-dimensional silk hydroxyapatite compositions
US20100330612A1 (en) * 2008-02-21 2010-12-30 Inxell Bionics Aps Biochip for electrophysiological measurements
CA2721961A1 (en) * 2008-05-15 2009-11-19 Trustees Of Tufts College Silk polymer-based adenosine release: therapeutic potential for epilepsy
WO2010042798A2 (en) * 2008-10-09 2010-04-15 Trustees Of Tufts College Modified silk films containing glycerol
US8093667B2 (en) * 2008-06-30 2012-01-10 Intel Corporation Flexible gate electrode device for bio-sensing
WO2010004265A1 (en) 2008-07-07 2010-01-14 Oxford Nanopore Technologies Limited Enzyme-pore constructs
US10670559B2 (en) * 2008-07-11 2020-06-02 Cornell University Nanofluidic channels with integrated charge sensors and methods based thereon
ES2517919T3 (es) * 2008-09-02 2014-11-04 The Governing Council Of The University Of Toronto Microelectrodos nanoestructurados y dispositivos de biodetección que los incorporan
US8421052B2 (en) * 2008-09-02 2013-04-16 Georgia Tech Research Corporation Transverse force, pressure and vibration sensors using piezoelectric nanostructures
WO2010037085A1 (en) 2008-09-29 2010-04-01 The Board Of Trustees Of The University Of Illinois Dna sequencing and amplification systems using nanoscale field effect sensor arrays
GB0820927D0 (en) 2008-11-14 2008-12-24 Isis Innovation Method
EP2391732B1 (de) 2009-01-30 2015-05-27 Oxford Nanopore Technologies Limited Verfahren die adaptoren zur nukleinsaure constructen für transmembrane sequenzierung benutzen
US9778188B2 (en) * 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
EP2409153B1 (de) * 2009-03-20 2014-05-14 Attana AB Verfahren zur detektion von liganden-bindung unter verwendung eines massesensitiver sensors mit auf dessen oberfläche immobilisierte zellen
GB0905140D0 (en) * 2009-03-25 2009-05-06 Isis Innovation Method
US9304132B2 (en) 2009-04-16 2016-04-05 President And Fellows Of Harvard College Molecular delivery with nanowires
WO2010138506A1 (en) 2009-05-26 2010-12-02 Nanosys, Inc. Methods and systems for electric field deposition of nanowires and other devices
US8728498B2 (en) 2009-07-14 2014-05-20 Trustees Of Tufts College Electrospun silk material systems for wound healing
US9376713B2 (en) * 2009-09-23 2016-06-28 The Board Of Trustees Of The University Of Illinois Label free detection of nucleic acid amplification
US9297796B2 (en) 2009-09-24 2016-03-29 President And Fellows Of Harvard College Bent nanowires and related probing of species
EP2483460B1 (de) 2009-09-28 2015-09-02 Trustees Of Tufts College Verfahren zur herstellung gezogene seiden-egel-fasern
WO2011041395A2 (en) 2009-09-29 2011-04-07 Trustees Of Tufts College Silk nanospheres and microspheres and methods of making same
CN101738417B (zh) * 2009-12-08 2012-09-05 清华大学 基于冷场电子检测生化物质的芯片及检测方法
WO2011109691A2 (en) 2010-03-05 2011-09-09 Trustees Of Tufts College Silk-based ionomeric compositions
US9482615B2 (en) * 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
US9267919B1 (en) * 2010-05-06 2016-02-23 The Florida International University Board Of Trustees Nanotip sensor
US9670243B2 (en) 2010-06-02 2017-06-06 Industrial Technology Research Institute Compositions and methods for sequencing nucleic acids
WO2012005857A1 (en) 2010-06-08 2012-01-12 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
WO2012031144A2 (en) 2010-09-01 2012-03-08 Trustees Of Tufts College Silk fibroin and polyethylene glycol-based biomaterials
JP5947795B2 (ja) * 2010-09-10 2016-07-06 日立化成株式会社 個別にアドレス可能なバンド電極アレイ及びそれを製造する方法
EP2629836B1 (de) 2010-10-19 2018-09-12 Trustees Of Tufts College Mikronadeln auf seidenfibroinbasis und verfahren zu ihrer herstellung
JP5989668B2 (ja) 2011-01-11 2016-09-07 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント タンパク質検出方法
AU2012215135B9 (en) 2011-02-11 2017-03-09 Oxford Nanopore Technologies Limited Mutant pores
EP2683822B1 (de) 2011-03-10 2020-04-22 General Atomics Vorrichtungen und verfahren zur diagnose und probenherstellung
US10335519B2 (en) 2011-04-20 2019-07-02 Trustees Of Tufts College Dynamic silk coatings for implantable devices
WO2012170630A2 (en) 2011-06-10 2012-12-13 President And Fellows Of Harvard College Nanoscale wires, nanoscale wire fet devices, and nanotube-electronic hybrid devices for sensing and other applications
JP6298404B2 (ja) 2011-07-25 2018-03-20 オックスフォード ナノポール テクノロジーズ リミテッド 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法
AU2012321400B2 (en) * 2011-10-14 2016-04-14 Digital Sensing Limited Arrays and methods of manufacture
US10912862B2 (en) 2012-02-06 2021-02-09 Children's Medical Center Corporation Multi-layer biomaterial for tissue regeneration and wound healing
JP6271505B2 (ja) 2012-04-10 2018-01-31 オックスフォード ナノポール テクノロジーズ リミテッド 変異体ライセニンポア
US9810688B2 (en) * 2013-03-15 2017-11-07 Robert Bosch Gmbh Smart glass slide for microarrays
US11155860B2 (en) 2012-07-19 2021-10-26 Oxford Nanopore Technologies Ltd. SSB method
CN102890108B (zh) * 2012-10-11 2014-08-27 中国科学院长春应用化学研究所 一种超微阵列电极的制备方法
BR112015021788B1 (pt) 2013-03-08 2023-02-28 Oxford Nanopore Technologies Plc Métodos para mover uma ou mais helicases imobilizadas, para controlar o movimento de um polinucleotídeo alvo, para caracterizar um polinucleotídeo alvo e para controlar o carregamento de uma ou mais helicases em um polinucleotídeo alvo, uso de um poro de transmembrana e de um potencial aplicado e de um ou mais espaçadores, complexo, e, kit
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
CN107966576B (zh) 2013-03-15 2021-08-03 雅培制药有限公司 具有后面可进入轨道系统的自动化诊断分析仪及相关方法
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
EP3105572B1 (de) 2014-02-13 2019-04-10 Robert Bosch GmbH Kapazitive luftblasenerkennung
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
EP3137490B1 (de) 2014-05-02 2021-01-27 Oxford Nanopore Technologies Limited Mutante poren
CN117164684A (zh) 2014-09-01 2023-12-05 弗拉芒区生物技术研究所 突变csgg孔
US10266885B2 (en) 2014-10-07 2019-04-23 Oxford Nanopore Technologies Ltd. Mutant pores
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
WO2016112315A2 (en) 2015-01-09 2016-07-14 President And Fellows Of Harvard College Nanowire arrays for neurotechnology and other applications
JP7166586B2 (ja) 2015-06-25 2022-11-08 ロズウェル バイオテクノロジーズ,インコーポレイテッド 生体分子センサーおよび方法
CN109328301B (zh) 2016-01-28 2021-03-12 罗斯韦尔生物技术股份有限公司 大规模并行dna测序装置
CN109071212A (zh) 2016-01-28 2018-12-21 罗斯韦尔生物技术股份有限公司 使用大规模分子电子传感器阵列测量分析物的方法和装置
KR20180104159A (ko) 2016-02-09 2018-09-19 로스웰 바이오테크놀로지스 인코포레이티드 전자 비표지 dna 및 게놈 시퀀싱
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
US10782014B2 (en) 2016-11-11 2020-09-22 Habib Technologies LLC Plasmonic energy conversion device for vapor generation
EP3568407A4 (de) 2017-01-10 2020-12-23 Roswell Biotechnologies, Inc Verfahren und system zur speicherung von dna-daten
EP3571286A4 (de) 2017-01-19 2020-10-28 Roswell Biotechnologies, Inc Festkörpersequenziervorrichtungen mit zweidimensionalen schichtmaterialien
AT519716B1 (de) * 2017-03-14 2019-01-15 Mat Center Leoben Forschung Gmbh Partikelsensor und Verfahren zur Messung von Partikelkonzentrationen
US10508296B2 (en) 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
CN110546276A (zh) 2017-04-25 2019-12-06 罗斯威尔生命技术公司 用于分子传感器的酶电路
EP4023764A3 (de) 2017-05-09 2022-09-21 Roswell Biotechnologies, Inc. Bindungssondenschaltungen für molekulare sensoren
KR20200039795A (ko) 2017-08-30 2020-04-16 로스웰 바이오테크놀로지스 인코포레이티드 Dna 데이터 저장을 위한 진행성 효소 분자 전자 센서들
EP3694990A4 (de) 2017-10-10 2022-06-15 Roswell Biotechnologies, Inc. Verfahren, vorrichtung und systeme zur amplikationsfreien dna-datenspeicherung
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452682A (en) * 1980-10-24 1984-06-05 Hitachi, Ltd. Apparatus for measuring clinical emergency check items of blood
US5019238A (en) * 1984-03-28 1991-05-28 Baxter Diagnostics Inc. Means for quantitative determination of analyte in liquids
JPS60231156A (ja) * 1984-04-30 1985-11-16 Kuraray Co Ltd 液絡式の比較電極
DE3513168A1 (de) * 1985-04-12 1986-10-16 Thomas 8000 München Dandekar Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren)
USH201H (en) * 1985-08-23 1987-01-06 United States Of America Biosensors from membrane proteins reconstituted in polymerized lipid bilayers
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
GB8725333D0 (en) * 1987-10-29 1987-12-02 Monsanto Europe Sa Immobilised enzymes
US4981572A (en) * 1988-06-16 1991-01-01 Glastron, Inc. Electrode unit and package for a blood analyzer
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
JP2794763B2 (ja) * 1989-04-18 1998-09-10 エヌオーケー株式会社 水晶振動子たん白質センサ
US5156810A (en) * 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
WO1991005262A1 (en) * 1989-10-02 1991-04-18 University Of Michigan Bioanalytical detection system
US5328847A (en) * 1990-02-20 1994-07-12 Case George D Thin membrane sensor with biochemical switch
US5166100A (en) 1990-12-06 1992-11-24 Gossard Arthur C Methods of making nanometer period optical gratings
DE69212062T2 (de) * 1991-04-30 1996-11-28 Matsushita Electric Industrial Co., Ltd., Kadoma, Osaka Raster-Abtastmikroskop, molekulares Verarbeitungsverfahren unter Verwendung des Mikroskops und Verfahren zum Wahrnehmen der DNA-Basen-Anordnung
JP3118015B2 (ja) * 1991-05-17 2000-12-18 アークレイ株式会社 バイオセンサーおよびそれを用いた分離定量方法
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5202290A (en) * 1991-12-02 1993-04-13 Martin Moskovits Process for manufacture of quantum dot and quantum wire semiconductors
US5310469A (en) * 1991-12-31 1994-05-10 Abbott Laboratories Biosensor with a membrane containing biologically active material
US5607567A (en) * 1992-03-10 1997-03-04 The Board Of Regents Acting For And On Behalf Of University Of Michigan Protamine-responsive polymeric membrane electrode
JP2541081B2 (ja) * 1992-08-28 1996-10-09 日本電気株式会社 バイオセンサ及びバイオセンサの製造・使用方法
JP2760234B2 (ja) * 1992-09-30 1998-05-28 松下電器産業株式会社 基質濃度測定方法
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
DE4318519C2 (de) * 1993-06-03 1996-11-28 Fraunhofer Ges Forschung Elektrochemischer Sensor
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
US8087288B1 (en) 1993-08-17 2012-01-03 Bruker Nano, Inc. Scanning stylus atomic force microscope with cantilever tracking and optical access
US5494831A (en) * 1993-08-30 1996-02-27 Hughes Aircraft Company Electrochemical immunosensor system and methods
US5445008A (en) 1994-03-24 1995-08-29 Martin Marietta Energy Systems, Inc. Microbar sensor
CN1040043C (zh) * 1994-04-29 1998-09-30 武汉大学 纳米级超微传感器及其制作方法
DE4422049C2 (de) * 1994-06-27 1997-12-11 Meinhard Prof Dr Knoll Ultramikroelektroden- oder Nanoden-Array für chemische und biochemische Analysen sowie Verfahren zu dessen Herstellung
US5624537A (en) * 1994-09-20 1997-04-29 The University Of British Columbia - University-Industry Liaison Office Biosensor and interface membrane
US5495109A (en) * 1995-02-10 1996-02-27 Molecular Imaging Corporation Electrochemical identification of molecules in a scanning probe microscope
FR2730810B1 (fr) * 1995-02-21 1997-03-14 Thomson Csf Capteur chimique hautement selectif
US5567301A (en) * 1995-03-01 1996-10-22 Illinois Institute Of Technology Antibody covalently bound film immunobiosensor
US5582697A (en) * 1995-03-17 1996-12-10 Matsushita Electric Industrial Co., Ltd. Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5824470A (en) * 1995-05-30 1998-10-20 California Institute Of Technology Method of preparing probes for sensing and manipulating microscopic environments and structures
US5719324A (en) 1995-06-16 1998-02-17 Lockheed Martin Energy Systems, Inc. Microcantilever sensor
US5786621A (en) 1995-06-23 1998-07-28 Cornell Research Foundation, Inc. Microelectromechanical integrated microloading device
US6000280A (en) 1995-07-20 1999-12-14 Cornell Research Foundation, Inc. Drive electrodes for microfabricated torsional cantilevers
US5807758A (en) 1995-07-21 1998-09-15 Lee; Gil U. Chemical and biological sensor using an ultra-sensitive force transducer
JP3679519B2 (ja) 1995-09-14 2005-08-03 キヤノン株式会社 トンネル電流または微小力または磁気力検出用の微小ティップの製造方法、並びにその微小ティップを有するプローブの製造方法とそのプローブ、該プローブを有するプローブユニットと走査型プローブ顕微鏡及び情報記録再生装置
US5851769A (en) 1995-09-27 1998-12-22 The Regents Of The University Of California Quantitative DNA fiber mapping
DE19601488C1 (de) 1996-01-17 1997-05-28 Itt Ind Gmbh Deutsche Verfahren zum Herstellen einer Meßeinrichtung sowie danach hergestellte Meßeinrichtung
US6118124A (en) 1996-01-18 2000-09-12 Lockheed Martin Energy Research Corporation Electromagnetic and nuclear radiation detector using micromechanical sensors
DE19610115C2 (de) * 1996-03-14 2000-11-23 Fraunhofer Ges Forschung Detektion von Molekülen und Molekülkomplexen
US5908981A (en) 1996-09-05 1999-06-01 Board Of Trustees Of The Leland Stanford, Jr. University Interdigital deflection sensor for microcantilevers
US5825020A (en) 1996-09-06 1998-10-20 The Regents Of The University Of California Atomic force microscope for generating a small incident beam spot
US5763768A (en) 1997-03-17 1998-06-09 Iowa State University Research Foundation, Inc. Analytical method using modified scanning probes
US5923421A (en) 1997-07-24 1999-07-13 Lockheed Martin Energy Research Corporation Chemical detection using calorimetric spectroscopy
JP3497734B2 (ja) 1997-07-24 2004-02-16 オリンパス株式会社 走査型プローブ顕微鏡

Also Published As

Publication number Publication date
AU1308599A (en) 1999-05-31
KR20010032068A (ko) 2001-04-16
EA200000404A1 (ru) 2000-10-30
CN1278917A (zh) 2001-01-03
DE69833562T2 (de) 2006-10-05
EP1038171A4 (de) 2003-01-15
EP1038171B8 (de) 2006-05-17
IL136063A0 (en) 2001-05-20
CA2309450C (en) 2004-01-27
EP1038171A1 (de) 2000-09-27
AU746886B2 (en) 2002-05-02
CA2309450A1 (en) 1999-05-20
KR100599906B1 (ko) 2006-07-20
ATE318409T1 (de) 2006-03-15
JP2001522999A (ja) 2001-11-20
KR20010032064A (ko) 2001-04-16
US6325904B1 (en) 2001-12-04
BR9815581A (pt) 2001-02-13
WO1999024823A1 (en) 1999-05-20
EP1038171B1 (de) 2006-02-22
US6123819A (en) 2000-09-26
DE69833562D1 (de) 2006-04-27
JP3693572B2 (ja) 2005-09-07

Similar Documents

Publication Publication Date Title
IL136063A0 (en) Nanoelectrode arrays
SG151333A1 (en) Addressable chem/bio chip array
ATE53125T1 (de) Hilfsmittel zur mengenbestimmung von zu analysierenden substanzen in fluessigkeiten.
DE69528859D1 (de) Zellpotentialmessvorrichtung mit mehreren Mikroelektroden
ATE346291T1 (de) Mehrschichtige feuchtigkeitsbarriere für eine vorrichtung zum prüfen von elektrochemischen zellen
TW366279B (en) Method for assessing disposable absorbent articles with improved skin dryness performance and with improved skin aeration
EP1032705A4 (de) Sondenanordnungen und deren verwendungen für verfahren zur dns-unterscheidung
NO894085D0 (no) Instrument for maaling av fysikalske proever, f.eks. en urindraapes ledningsevne.
ATE340997T1 (de) Elektroden zur messung von analyten in kleinen probemengen
DE59004587D1 (de) Messzelle für den elektrochemischen Gasnachweis.
ATE19437T1 (de) System zum elektrochemischen nachweis.
ATE257944T1 (de) Testsäule mit mehreren lagen
ATE268904T1 (de) Zellbasiertes festphasentest
ATE239274T1 (de) Proteom-analyse zum charakterisieren von auf- und abgeregelten proteinen in biologischen proben
DE59610015D1 (de) Elektrochemische Messzelle
DE68909959D1 (de) Schaltung zum Abfühlen des Zustandes von Matrixzellen in MOS-EPROM-Speichern.
ATE213064T1 (de) Die verwendung von bmp-protein-rezeptor komplexen für das screening von substanzen aus dem knochenmetabolismus und zellen die mit einem typ i- und typ ii-bmp-rezeptor co-transfiziertsind
DE58903433D1 (de) Einrichtung zum vibrationsfuellen von poroesen elektrodengeruesten fuer galvanische zellen.
DE59403729D1 (de) Testpflaster zur epicutanen hauttestung
DE60111525D1 (de) Peptid-potentiation von säure-sensorischen ionenkanälen bei schmerz
EP1581645A4 (de) Verfahren zur verwendung unterteilungsarretierter zellen in screening-assays
Kramer et al. Chemical speciation and metal toxicity in surface freshwaters
BR9407433A (pt) Reagente e teste de célula
IL147646A0 (en) Sample arrays and high-throughput testing thereof to detect interactions
Isaeva The use of molluscan haemocytes and echinoderm coelomocytes for biotesting.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees