IL134031A - Method for preparing the history of alkoxy furanone, compounds produced by this method and use of these compounds - Google Patents

Method for preparing the history of alkoxy furanone, compounds produced by this method and use of these compounds

Info

Publication number
IL134031A
IL134031A IL13403198A IL13403198A IL134031A IL 134031 A IL134031 A IL 134031A IL 13403198 A IL13403198 A IL 13403198A IL 13403198 A IL13403198 A IL 13403198A IL 134031 A IL134031 A IL 134031A
Authority
IL
Israel
Prior art keywords
formula
acid
compound
cis
compounds
Prior art date
Application number
IL13403198A
Other languages
English (en)
Hebrew (he)
Other versions
IL134031A0 (en
Inventor
Raphael Bouchet
Francis Brion
Colette Colladant
Jacques Lagouardat
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of IL134031A0 publication Critical patent/IL134031A0/xx
Publication of IL134031A publication Critical patent/IL134031A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL13403198A 1997-07-15 1998-07-09 Method for preparing the history of alkoxy furanone, compounds produced by this method and use of these compounds IL134031A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9708932A FR2766188B1 (fr) 1997-07-15 1997-07-15 Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
PCT/FR1998/001480 WO1999003852A1 (fr) 1997-07-15 1998-07-09 Procede de preparation de derives amines d'alkyloxyfuranone, composes issus de ce procede et utilisation de ces composes

Publications (2)

Publication Number Publication Date
IL134031A0 IL134031A0 (en) 2001-04-30
IL134031A true IL134031A (en) 2004-06-01

Family

ID=9509210

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13403198A IL134031A (en) 1997-07-15 1998-07-09 Method for preparing the history of alkoxy furanone, compounds produced by this method and use of these compounds

Country Status (34)

Country Link
US (1) US6235899B1 (ko)
EP (1) EP0998470B1 (ko)
JP (1) JP4450987B2 (ko)
KR (1) KR100519691B1 (ko)
CN (1) CN100363355C (ko)
AP (1) AP1071A (ko)
AR (1) AR015924A1 (ko)
AT (1) ATE239713T1 (ko)
AU (1) AU744272B2 (ko)
BG (1) BG64050B1 (ko)
BR (1) BR9810896A (ko)
CA (1) CA2296742C (ko)
CZ (1) CZ295312B6 (ko)
DE (1) DE69814395T2 (ko)
DK (1) DK0998470T3 (ko)
EA (1) EA002883B1 (ko)
EE (1) EE03873B1 (ko)
ES (1) ES2197489T3 (ko)
FR (1) FR2766188B1 (ko)
HR (1) HRP20000027B1 (ko)
HU (1) HU230148B1 (ko)
ID (1) ID23784A (ko)
IL (1) IL134031A (ko)
ME (1) ME01708B (ko)
NO (1) NO324508B1 (ko)
NZ (1) NZ502338A (ko)
PL (1) PL200820B1 (ko)
PT (1) PT998470E (ko)
RS (1) RS49832B (ko)
SK (1) SK284168B6 (ko)
TR (1) TR200000117T2 (ko)
UA (1) UA66364C2 (ko)
WO (1) WO1999003852A1 (ko)
ZA (1) ZA986203B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053056B2 (en) 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
ATE472539T1 (de) 2000-04-24 2010-07-15 Vertex Pharma Verfahren und zwischenprodukte zur herstellung von substituierten asparaginsäure-acetalen
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) * 2000-09-20 2003-11-19 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸誘導体の製造方法
WO2002055478A1 (fr) * 2001-01-16 2002-07-18 Kaneka Corporation Procede de preparation de derives d'aminolactone optiquement actifs et intermediaires de ces derives
AR047981A1 (es) 2004-02-27 2006-03-15 Vertex Pharma Inhibidores de caspasa y sus usos correspondientes
EP1725548B1 (en) 2004-03-12 2015-01-14 Vertex Pharmaceuticals Incorporated Processes and intermediates for the preparation of aspartic acetal caspase inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme

Also Published As

Publication number Publication date
HRP20000027A2 (en) 2000-10-31
US6235899B1 (en) 2001-05-22
CZ200065A3 (cs) 2000-07-12
AR015924A1 (es) 2001-05-30
CA2296742A1 (fr) 1999-01-28
TR200000117T2 (tr) 2000-07-21
HUP0003857A2 (hu) 2001-04-28
AP2000001732A0 (en) 2000-03-31
EP0998470A1 (fr) 2000-05-10
EA200000127A1 (ru) 2000-08-28
ZA986203B (en) 1999-08-18
EA002883B1 (ru) 2002-10-31
JP4450987B2 (ja) 2010-04-14
CN1269795A (zh) 2000-10-11
IL134031A0 (en) 2001-04-30
SK302000A3 (en) 2000-11-07
SK284168B6 (sk) 2004-10-05
KR100519691B1 (ko) 2005-10-13
ATE239713T1 (de) 2003-05-15
BG104073A (en) 2001-05-31
BG64050B1 (bg) 2003-11-28
NO324508B1 (no) 2007-11-05
ID23784A (id) 2000-05-11
NZ502338A (en) 2001-09-28
PT998470E (pt) 2003-09-30
HRP20000027B1 (en) 2006-07-31
FR2766188A1 (fr) 1999-01-22
KR20010021834A (ko) 2001-03-15
DE69814395T2 (de) 2003-12-11
NO20000182D0 (no) 2000-01-14
AP1071A (en) 2002-05-20
CZ295312B6 (cs) 2005-07-13
PL338035A1 (en) 2000-09-25
DE69814395D1 (de) 2003-06-12
YU1500A (sh) 2002-10-18
PL200820B1 (pl) 2009-02-27
DK0998470T3 (da) 2003-09-01
AU8633398A (en) 1999-02-10
EP0998470B1 (fr) 2003-05-07
NO20000182L (no) 2000-03-07
EE03873B1 (et) 2002-10-15
CN100363355C (zh) 2008-01-23
ES2197489T3 (es) 2004-01-01
HUP0003857A3 (en) 2002-08-28
CA2296742C (fr) 2009-12-08
WO1999003852A1 (fr) 1999-01-28
EE200000024A (et) 2000-10-16
UA66364C2 (uk) 2004-05-17
FR2766188B1 (fr) 2000-02-11
AU744272B2 (en) 2002-02-21
JP2001510191A (ja) 2001-07-31
HU230148B1 (hu) 2015-09-28
ME01708B (me) 2008-08-07
BR9810896A (pt) 2000-09-26
RS49832B (sr) 2008-08-07

Similar Documents

Publication Publication Date Title
FI115300B (fi) 4-[4-dimetyyliamino-1-(4'-fluorifenyyli)-1-hydroksibutyyli]-3-hydroksimetyyli-bentsonitriilin di-(p-toloyyli)viinihapon kanssa muodostama diastereomeerinen suola
AU2003256539B2 (en) Modified pictet-spengler reaction and products prepared therefrom
US4562263A (en) Process for producing 3-(3,4-dihydroxyphenyl) serine
IL134031A (en) Method for preparing the history of alkoxy furanone, compounds produced by this method and use of these compounds
Braun et al. Asymmetric synthesis of primary amines from alkenes and chiral chloronitroso sugar derivatives.
AU666626B2 (en) 1-aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharamceutical composition
FI81339C (fi) Foerfarande foer framstaellning av pyrrolidinoderivat, mellanprodukt och dess framstaellningsfoerfarande.
JPH03271269A (ja) カルシウム管遮断剤の製造に用いるキラル中間体の分割法
US4345082A (en) Process for the preparation of hydroxyamino-eburnane derivatives and octahydroindoloquinolizine intermediates
GB1598667A (en) 1,3-dioxolane derivatives and their use in the preparation of 1-amino-3-aryloxy-2-propanols
CN112272665B (zh) 制备立他司特的方法
JP2001521498A (ja) Ｏ−（３−アミノ−２−ヒドロキシ−プロピル）−ヒドロキシミック酸ハロゲン化物の製造方法
JP2006525294A (ja) ４−ヒドロキシイソロイシン及びその誘導体の製造方法
US4831167A (en) Process for diastereoselective reduction of 3-amino-1-benzoxepin-5(2H)-ones
US5322944A (en) Process for the synthesis of enantiomers of 3-aminochroman compounds
US5183922A (en) Process for the optical resolution of threo-2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid
CA1210014A (en) Diastereomers of 1-ethyl-2-aminomethyl pyrrolidine
DE3906460C1 (ko)
US5929242A (en) Manufacture of levobupivacaine and analogues thereof from L-lysine
MXPA00000506A (en) Method for preparing alkyloxy furanone derivatives, compounds obtained by said method and use of said compounds
KR100404965B1 (ko) 조합화학(combinatorial chemistry)에서 특징적으로 고체상과 고리화반응 단계에 트리에틸아민과 ＴＨＦ를 이용하여 신규 히덴토인 유도체의 합성법
JPS63135386A (ja) 新規環状ジペプチド化合物
CN115197115A (zh) 一种手性5-氧代吡咯烷-3-甲酸的制备方法与应用

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired