IL133959A0 - Triazolo [4,5-d] pyrimidine compounds, their use anovel compounds s medicaments, compositions containing them and processes for their preparation - Google Patents

Triazolo [4,5-d] pyrimidine compounds, their use anovel compounds s medicaments, compositions containing them and processes for their preparation

Info

Publication number
IL133959A0
IL133959A0 IL13395998A IL13395998A IL133959A0 IL 133959 A0 IL133959 A0 IL 133959A0 IL 13395998 A IL13395998 A IL 13395998A IL 13395998 A IL13395998 A IL 13395998A IL 133959 A0 IL133959 A0 IL 133959A0
Authority
IL
Israel
Prior art keywords
compounds
anovel
triazolo
medicaments
processes
Prior art date
Application number
IL13395998A
Other languages
English (en)
Original Assignee
Astra Pharmaceuticals Ltd Astr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26663042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL133959(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9702775A external-priority patent/SE9702775D0/xx
Priority claimed from SE9702773A external-priority patent/SE9702773D0/xx
Application filed by Astra Pharmaceuticals Ltd Astr filed Critical Astra Pharmaceuticals Ltd Astr
Publication of IL133959A0 publication Critical patent/IL133959A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
IL13395998A 1997-07-22 1998-07-15 Triazolo [4,5-d] pyrimidine compounds, their use anovel compounds s medicaments, compositions containing them and processes for their preparation IL133959A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9702775A SE9702775D0 (sv) 1997-07-22 1997-07-22 Novel compounds
SE9702773A SE9702773D0 (sv) 1997-07-22 1997-07-22 Novel compounds
PCT/SE1998/001393 WO1999005143A1 (en) 1997-07-22 1998-07-15 Novel compounds

Publications (1)

Publication Number Publication Date
IL133959A0 true IL133959A0 (en) 2001-04-30

Family

ID=26663042

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13395998A IL133959A0 (en) 1997-07-22 1998-07-15 Triazolo [4,5-d] pyrimidine compounds, their use anovel compounds s medicaments, compositions containing them and processes for their preparation
IL133959A IL133959A (en) 1997-07-22 2000-01-09 History 3 - (Cyclopentyl Polymethar) - 5 - Transformed - 3H - 3,2,1 - Triazolo [5,4 – D] Pyrimidine - 7 - Amine, pharmaceutical preparations containing them and processes for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL133959A IL133959A (en) 1997-07-22 2000-01-09 History 3 - (Cyclopentyl Polymethar) - 5 - Transformed - 3H - 3,2,1 - Triazolo [5,4 – D] Pyrimidine - 7 - Amine, pharmaceutical preparations containing them and processes for their preparation

Country Status (31)

Country Link
EP (1) EP0996621B1 (ja)
JP (1) JP4187406B2 (ja)
KR (2) KR20050084540A (ja)
CN (1) CN1154650C (ja)
AR (2) AR017014A1 (ja)
AT (1) ATE251161T1 (ja)
AU (1) AU745381B2 (ja)
BR (1) BR9810802B1 (ja)
CA (1) CA2296665C (ja)
CZ (1) CZ302629B6 (ja)
DE (1) DE69818668T2 (ja)
DK (1) DK0996621T3 (ja)
EE (1) EE04193B1 (ja)
EG (1) EG24412A (ja)
ES (1) ES2207846T3 (ja)
HK (1) HK1026421A1 (ja)
HU (1) HU230074B1 (ja)
IL (2) IL133959A0 (ja)
IS (1) IS2236B (ja)
MY (1) MY123196A (ja)
NO (1) NO315854B1 (ja)
NZ (1) NZ502381A (ja)
PL (1) PL200325B1 (ja)
PT (1) PT996621E (ja)
RU (1) RU2225407C2 (ja)
SA (1) SA98190487B1 (ja)
SK (1) SK284199B6 (ja)
TR (1) TR200000197T2 (ja)
TW (1) TW530058B (ja)
UA (1) UA66801C2 (ja)
WO (1) WO1999005143A1 (ja)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
SE9903290D0 (sv) * 1999-09-15 1999-09-15 Astra Pharma Prod Novel compounds
SE9904129D0 (sv) 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
SE9904128D0 (sv) * 1999-11-15 1999-11-15 Astra Pharma Prod Novel compounds
GB0013487D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Novel process
GB0013488D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
GB0013407D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Forms of a chemical compound
TWI290549B (en) 2000-06-02 2007-12-01 Astrazeneca Ab Process for the preparation of cyclopropyl carboxylic acid ester and derivatives
IT1317049B1 (it) 2000-06-23 2003-05-26 Sigma Tau Ind Farmaceuti Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv.
SE0004098D0 (sv) 2000-11-09 2000-11-09 Astrazeneca Ab Novel compounds
SE0004099D0 (sv) * 2000-11-09 2000-11-09 Astrazeneca Ab Novel compounds
GB0219746D0 (en) 2002-08-23 2002-10-02 Inst Of Ex Botany Ascr Azapurine derivatives
ATE469157T1 (de) 2003-10-21 2010-06-15 Inspire Pharmaceuticals Inc Tetrahydrofuroä3,4-düdioxolverbindungen und zusammensetzungen und verfahren zur inhibierung der trombozytenaggregation
US7335648B2 (en) 2003-10-21 2008-02-26 Inspire Pharmaceuticals, Inc. Non-nucleotide composition and method for inhibiting platelet aggregation
US7749981B2 (en) 2003-10-21 2010-07-06 Inspire Pharmaceuticals, Inc. Drug-eluting stents coated with non-nucleotide P2Y12 receptor antagonist compound
US7504497B2 (en) 2003-10-21 2009-03-17 Inspire Pharmaceuticals, Inc. Orally bioavailable compounds and methods for inhibiting platelet aggregation
SE0401001D0 (sv) 2004-03-31 2004-03-31 Astrazeneca Ab Chemical process
US7932376B2 (en) 2005-05-05 2011-04-26 Inspire Pharmaceuticals, Inc. Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation
GB0615620D0 (en) 2006-08-05 2006-09-13 Astrazeneca Ab A process for the preparation of optically active intermediates
JP2010508350A (ja) 2006-10-31 2010-03-18 ヤンセン ファーマシューティカ エヌ．ベー． Ａｄｐｐ２ｙ１２レセプターアンタゴニストとしてのトリアゾロピリミジン誘導体
UA100864C2 (uk) * 2007-12-03 2013-02-11 Астразенека Аб Спосіб лікування або запобігання аневризмі черевної аорти
US8563755B2 (en) 2008-09-09 2013-10-22 Astrazeneca Ab Process for preparing [1S-[1-α, 2-α, 3-β(1S*,2R*) 5-β]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl]-5-(2-hydroxyethoxy) cyclopentane-1,2-diol and to its intermediates
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
EP2389362B1 (en) 2009-01-21 2019-12-11 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
US8389580B2 (en) 2009-06-02 2013-03-05 Duke University Arylcyclopropylamines and methods of use
EP2305376A1 (en) 2009-09-23 2011-04-06 Lonza Ltd. Process and catalyst for the catalytic hydrogenation of aromatic and heteroaromatic nitro compounds
KR101736218B1 (ko) 2009-09-25 2017-05-16 오리존 지노믹스 에스.에이. 라이신 특이적 디메틸라아제-1 억제제 및 이의 용도
EP2486002B1 (en) 2009-10-09 2019-03-27 Oryzon Genomics, S.A. Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use
WO2011067571A1 (en) 2009-12-03 2011-06-09 Astrazeneca Ab Co - crystals of a triazolo [4,5 - d] pyrimidine platelet aggregation inhibitor
ES2550033T3 (es) 2009-12-23 2015-11-04 Ratiopharm Gmbh Forma de dosificación farmacéutica sólida de ticagrelor
US8859769B2 (en) 2010-02-16 2014-10-14 Actavis Group Ptc Ehf Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine
WO2011106105A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Inhibitors for antiviral use
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
ES2607081T3 (es) 2010-04-19 2017-03-29 Oryzon Genomics, S.A. Inhibidores de desmetilasa específica de lisina-1 y su uso
US20130150577A1 (en) 2010-04-20 2013-06-13 Actavis Group Ptc Ehf Novel process for preparing phenylcyclopropylamine derivatives using novel intermediates
CN103003231A (zh) 2010-06-30 2013-03-27 阿特维斯集团公司 制备苯基环丙基胺衍生物的新方法及其用于制备替卡格雷的用途
HUE037937T2 (hu) 2010-07-29 2021-11-29 Oryzon Genomics Sa Arilciklopropilamin-alapú LSD1-demetiláz inhibitorok és gyógyászati alkalmazásuk
US9006449B2 (en) * 2010-07-29 2015-04-14 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as LSD1 inhibitors
US9061966B2 (en) 2010-10-08 2015-06-23 Oryzon Genomics S.A. Cyclopropylamine inhibitors of oxidases
WO2012063126A2 (en) 2010-11-09 2012-05-18 Actavis Group Ptc Ehf Improved processes for preparing pure (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahdro-3ah-cyclopenta[d] [1,3]-dioxol-4-ol and its key starting material
WO2012072713A2 (en) 2010-11-30 2012-06-07 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae
RU2013133879A (ru) 2010-12-20 2015-01-27 Актавис Груп Птс Ехф НОВЫЕ СПОСОБЫ ПОЛУЧЕНИЯ ТРИАЗОЛО[4, 5-d]ПИРИМИДИНА, ЕГО ПРОИЗВОДНЫЕ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ
WO2012107498A1 (en) 2011-02-08 2012-08-16 Oryzon Genomics S.A. Lysine demethylase inhibitors for myeloproliferative disorders
CN102731510B (zh) * 2011-04-07 2015-12-16 博瑞生物医药（苏州）股份有限公司 替卡格雷的衍生物、制备方法及其药物用途
CA2836394A1 (en) 2011-06-01 2012-12-06 Astrazeneca Ab Novel ticagrelor co - crystal
CA2839057A1 (en) 2011-06-15 2012-12-20 Actavis Group Ptc Ehf Improved process for preparing cyclopentylamine derivatives and intermediates thereof
CN102924457A (zh) * 2011-08-12 2013-02-13 上海恒瑞医药有限公司 三唑并嘧啶类衍生物、其制备方法及其用途
PE20141692A1 (es) 2011-10-20 2014-11-08 Oryzon Genomics Sa Compuestos de (hetero) aril ciclopropilamina como inhibidores de lsd1
EP2768805B1 (en) 2011-10-20 2020-03-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
CA2852652A1 (en) * 2011-10-27 2013-05-02 Lek Pharmaceuticals D.D. Synthesis of triazolopyrimidine compounds
EP2589587A1 (en) 2011-11-04 2013-05-08 Chemo Ibérica, S.A. Synthesis of nitrogen substituted cyclopropanes
MX2014006190A (es) 2011-11-30 2014-07-10 Actavis Group Ptc Ehf Nueva forma cristalina de ticagrelor y proceso para la preparacion de la misma.
US20130178520A1 (en) 2011-12-23 2013-07-11 Duke University Methods of treatment using arylcyclopropylamine compounds
EP2834247A4 (en) 2012-04-05 2016-03-30 Reddys Lab Ltd Dr PREPARATION OF TICAGRELOR
CN102675321B (zh) * 2012-05-11 2014-12-10 上海皓元化学科技有限公司 一种替卡格雷的制备方法
CN103626743B (zh) * 2012-08-23 2018-06-08 广东东阳光药业有限公司 替卡格雷的新型中间体及其制备方法
CZ2012705A3 (cs) 2012-10-16 2014-04-23 Zentiva, K.S. Pevná orální farmaceutická formulace obsahující ticagrelor
WO2014083139A1 (en) 2012-11-29 2014-06-05 Actavis Group Ptc Ehf Novel amorphous form of ticagrelor
CN103965198A (zh) * 2013-02-05 2014-08-06 郝聪梅 替卡格雷的中间体及其制备方法以及利用该中间体制备替卡格雷的方法
CN103183679A (zh) * 2013-03-20 2013-07-03 西藏海思科药业集团股份有限公司 抗凝血化合物及其应用
CN107573333B (zh) * 2013-04-10 2019-10-18 江苏恒瑞医药股份有限公司 替格瑞洛的中间体及其制备方法和替格瑞洛的制备方法
US20160120869A1 (en) 2013-05-29 2016-05-05 Ratiopharm Gmbh Solid pharmaceutical dosage form
WO2014206187A1 (zh) 2013-06-24 2014-12-31 苏州明锐医药科技有限公司 替卡格雷及其中间体的制备方法
CN103588751B (zh) * 2013-11-07 2014-12-17 苏州明锐医药科技有限公司 替格瑞洛中间体的制备方法
WO2015162630A1 (en) 2014-04-25 2015-10-29 Anlon Chemical Research Organization Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
EP3157907B1 (en) 2014-06-18 2018-08-29 Flamma S.P.A. Process for the preparation of triazolo[4,5-d]pyrimidine cyclopentane compounds
CN105272985B (zh) * 2014-06-24 2017-11-21 珠海联邦制药股份有限公司 三唑并[4,5‑d]嘧啶化合物及其合成方法、用途、组合物
US9982061B2 (en) 2014-10-01 2018-05-29 Medimmune Limited Antibodies to ticagrelor and methods of use
WO2016116942A1 (en) 2015-01-20 2016-07-28 Anlon Chemical Research Organization Novel pharmaceutical compounds comprising ticagrelor with salts of aspirin
CN105985346B (zh) * 2015-03-06 2019-10-18 苏州朗科生物技术股份有限公司 一种新的替格瑞洛化合物制备方法及其中间体化合物
TR201601835A2 (tr) 2016-02-12 2017-08-21 Ali Raif Ilac Sanayi Ve Ticaret Anonim Sirketi Ti̇kagrelor i̇çeren formülasyonlar i̇çi̇n üreti̇m yöntemi̇
TN2018000322A1 (en) 2016-03-22 2020-01-16 Merck Sharp & Dohme Allosteric modulators of nicotinic acetylcholine receptors
WO2018167447A1 (en) 2017-03-14 2018-09-20 University Of Sheffield Low dose aspirin (1-50 mg) together with antiplatelets such as ticagrelor of anticoagulants
CN107141298A (zh) * 2017-07-24 2017-09-08 苏州信恩医药科技有限公司 一种替格瑞洛的合成方法
TWI641327B (zh) * 2017-09-30 2018-11-21 双邦實業股份有限公司 Socks that are comfortable and comfortable to wear
EP3527571A1 (en) * 2018-02-14 2019-08-21 Université de Liège Pyrimidine derivatives for prevention and treatment of bacterial infection
WO2023213198A1 (zh) * 2022-05-04 2023-11-09 华东师范大学 芳香稠环化合物作为trek-1激活剂的用途、包含其的药物组合物、镇痛剂
CN114805367B (zh) * 2022-05-24 2023-04-07 郑州大学 一种三氮唑并嘧啶类衍生物及其制备方法和应用
CN115710275B (zh) * 2022-11-21 2024-02-02 河南中医药大学 一种嘧啶-tcp类化合物、制备方法和医药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742064A (en) * 1985-09-10 1988-05-03 Regents Of The University Of Minnesota Antiviral carbocyclic analogs of xylofuranosylpurines
GB8826205D0 (en) * 1988-11-09 1988-12-14 Wellcome Found Heterocyclic compounds
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
JP4084415B2 (ja) * 1995-07-11 2008-04-30 アストラゼネカ・アクチエボラーグ 新しい血小板凝集抑制剤
ATE213245T1 (de) * 1996-12-20 2002-02-15 Triazolo(4,5-d)pyrimidinyl-derivate und ihre verwendung als medikamente

Also Published As

Publication number Publication date
RU2225407C2 (ru) 2004-03-10
BR9810802B1 (pt) 2010-10-19
NZ502381A (en) 2001-12-21
CN1270590A (zh) 2000-10-18
IS5354A (is) 2000-01-20
EP0996621A1 (en) 2000-05-03
JP4187406B2 (ja) 2008-11-26
NO20000312L (no) 2000-03-21
HU230074B1 (hu) 2015-06-29
AR017014A1 (es) 2001-08-22
PL200325B1 (pl) 2008-12-31
MY123196A (en) 2006-05-31
ATE251161T1 (de) 2003-10-15
DK0996621T3 (da) 2004-02-02
KR100535837B1 (ko) 2006-01-12
DE69818668D1 (de) 2003-11-06
DE69818668T2 (de) 2004-08-12
NO315854B1 (no) 2003-11-03
CN1154650C (zh) 2004-06-23
AR077553A2 (es) 2011-09-07
BR9810802A (pt) 2000-09-12
KR20010022083A (ko) 2001-03-15
SK284199B6 (sk) 2004-10-05
ES2207846T3 (es) 2004-06-01
CA2296665C (en) 2008-06-10
NO20000312D0 (no) 2000-01-21
HUP0004333A2 (hu) 2001-04-28
TR200000197T2 (tr) 2000-06-21
PL338516A1 (en) 2000-11-06
JP2001510842A (ja) 2001-08-07
AU745381B2 (en) 2002-03-21
EE200000044A (et) 2000-10-16
UA66801C2 (uk) 2004-06-15
EE04193B1 (et) 2003-12-15
HUP0004333A3 (en) 2001-11-28
EG24412A (en) 2009-05-25
PT996621E (pt) 2004-02-27
IS2236B (is) 2007-05-15
CA2296665A1 (en) 1999-02-04
EP0996621B1 (en) 2003-10-01
KR20050084540A (ko) 2005-08-26
IL133959A (en) 2007-10-31
WO1999005143A1 (en) 1999-02-04
CZ2000233A3 (cs) 2000-07-12
HK1026421A1 (en) 2000-12-15
TW530058B (en) 2003-05-01
SK188199A3 (en) 2000-10-09
CZ302629B6 (cs) 2011-08-10
AU8370698A (en) 1999-02-16
SA98190487B1 (ar) 2006-08-20

Similar Documents

Publication Publication Date Title
IL133959A0 (en) Triazolo [4,5-d] pyrimidine compounds, their use anovel compounds s medicaments, compositions containing them and processes for their preparation
HUP0100202A3 (en) Novel triazolo[4,5-d]pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
HUP0105081A3 (en) Triazolo[4,5-d]pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
IL125342A0 (en) Pyrimido [5,4-d] pyrimidines their preparation and pharmaceutical compositions containing them
HUP0001507A3 (en) Pyrrolo [2,3-d] pyrimidine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
IL128869A (en) ARYSULFONYL-SUBSTITUTED-PYRAZOLO [1,5-a]-PYRIMIDINE AND PYRAZOLO [1,5-a] [1, 3, 5]-TRIAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUP0002104A3 (en) Pyrazolo[3,4-d]pyrimidinedione derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0204246A3 (en) Novel thiazolo[4,5-d]pyrimidine compounds, process for their preparation, pharmaceutical compositions containing them and their use
HUP0203503A3 (en) Pyrrolo[2,3-d]pirimidine compounds, pharmaceutical compositions containing them and their use
HUT76435A (en) N-aryl-1,2,4-triazolo[1,5-a]pyridine-2-sulfonamide-derivatives, intermediates, preparation and use thereof, herbicide compositions containing these compounds as active ingredients
IL125341A0 (en) Pyrimido [5,4-d] pyrimidines their preparation and pharmaceutical compositions containing them
HUP9801336A3 (en) 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones and pharmaceutical compositions containing them
HUP0204431A3 (en) 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use, process for their preparation and pharmaceutical compositions containing them
HUP0203450A3 (en) Pyrazolo '4,3-d! pyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them and their use
HK1036801A1 (en) Pyrrolo(2,3-d)pyrimidine compounds, composition and use there of
HUP9801587A3 (en) 5h-thiazolo[3,2-a]pyrimidine derivatives, process for their preparation, intermediates, use of the compounds and pharmaceutical compositions containing them
HUP0002480A3 (en) Pyrrolo[2,1-c][1,4]benzodiazepine derivatives, their use, process for their preparation and pharmaceutical compositions containing them
IL134688A (en) CYCLOOXYGENASE 2 INHIBITING 2, 3-DIARYL-PYRAZOLO [1, 5-b] PYRIDAZINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUP0103472A3 (en) Pyrrolo[2,3-d]pyrimidine derivatives and pharmaceutical compositions containing the same
IL134081A0 (en) 1,2,4-triazolo [4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
HUP0003826A3 (en) Novel triazolo [4,5-b] pyrimidine derivatives, process for their preparation and pharmaceutical compositions thereof
HUP0002839A3 (en) Pyrrolo[3,4-d]pyrimidinone derivatives, their use, pharmaceutical compositions containing them, process for their preparation
HUP0100328A3 (en) Novel triazolo(4,5-d)pyrimidine compounds, and pharmaceutical compositions containing the compounds
HUP0202624A3 (en) Pyrazolo[4,3-d]pyrimidine-derivatives, process for their preparation, pharmaceutical compositions containing them and their use
HUP0102981A3 (en) Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof

Legal Events

Date Code Title Description
ERR Corrigendum

Free format text: IN JOURNAL 8/2007 P. 3102 PATENT APPLICATION NO. 133959 CORRECT DATE OF APPLICATION TO- 15.7.1998

FF Patent granted
KB Patent renewed
KB Patent renewed