IL129089A0 - New derivatives from piperidine-keto acid their preparation and use - Google Patents
New derivatives from piperidine-keto acid their preparation and useInfo
- Publication number
- IL129089A0 IL129089A0 IL12908997A IL12908997A IL129089A0 IL 129089 A0 IL129089 A0 IL 129089A0 IL 12908997 A IL12908997 A IL 12908997A IL 12908997 A IL12908997 A IL 12908997A IL 129089 A0 IL129089 A0 IL 129089A0
- Authority
- IL
- Israel
- Prior art keywords
- piperidine
- preparation
- keto acid
- new derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19642591A DE19642591A1 (de) | 1996-10-15 | 1996-10-15 | Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung |
| PCT/EP1997/005202 WO1998016512A1 (de) | 1996-10-15 | 1997-09-23 | Neue piperidin-ketocarbonsäure-derivate, deren herstellung und anwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL129089A0 true IL129089A0 (en) | 2000-02-17 |
Family
ID=7808858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12908997A IL129089A0 (en) | 1996-10-15 | 1997-09-23 | New derivatives from piperidine-keto acid their preparation and use |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6380220B1 (tr) |
| EP (1) | EP0934273A1 (tr) |
| JP (1) | JP2001501955A (tr) |
| KR (1) | KR20000049130A (tr) |
| CN (1) | CN1239950A (tr) |
| AR (1) | AR009379A1 (tr) |
| AU (1) | AU736754B2 (tr) |
| BG (1) | BG103338A (tr) |
| BR (1) | BR9711908A (tr) |
| CA (1) | CA2268917A1 (tr) |
| CO (1) | CO4930264A1 (tr) |
| CZ (1) | CZ126899A3 (tr) |
| DE (1) | DE19642591A1 (tr) |
| HR (1) | HRP970549A2 (tr) |
| HU (1) | HUP9904104A3 (tr) |
| IL (1) | IL129089A0 (tr) |
| NO (1) | NO991761L (tr) |
| NZ (1) | NZ334979A (tr) |
| PL (1) | PL332720A1 (tr) |
| RU (1) | RU2189974C2 (tr) |
| SK (1) | SK38599A3 (tr) |
| TR (1) | TR199900819T2 (tr) |
| WO (1) | WO1998016512A1 (tr) |
| ZA (1) | ZA979175B (tr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19817459A1 (de) | 1998-04-20 | 1999-10-21 | Basf Ag | Neue heterozyklische substituierte Amide, Herstellung und Anwendung |
| BR9909774A (pt) | 1998-04-20 | 2000-12-19 | Basf Ag | Amida, uso de amidas, e, preparação farmacêutica para uso oral, parenteral ou intraperitoneal |
| EP1082308B1 (de) | 1998-04-20 | 2009-04-01 | Abbott GmbH & Co. KG | Heterocyclisch substituierte amide als calpainhemmer |
| HRP20000788A2 (en) * | 1998-04-20 | 2001-06-30 | Basf Ag | Novel heterocyclically substituted amides with cysteine protease-inhibiting effect |
| US6117870A (en) * | 1998-11-12 | 2000-09-12 | Fujirebio Kabushiki Kaisha | Cyclic amide derivatives |
| WO2001014331A2 (en) * | 1999-08-24 | 2001-03-01 | Regents Of The University Of California | Non-quinoline inhibitors of malaria parasites |
| NZ511997A (en) | 1999-09-29 | 2004-12-24 | Ortho Mcneil Pharm Inc | Isonipecotamides for the treatment of integrin-mediated disorders |
| WO2002002546A1 (en) | 2000-06-30 | 2002-01-10 | Seikagaku Corporation | EPOXYCARBOXYLIC ACID AMIDES, AZIDES AND AMINO ALCOHOLS AND PROCESSES FOR PREPARATION OF α-KETO AMIDES BY USING THEM |
| DE10114762A1 (de) * | 2001-03-26 | 2002-10-02 | Knoll Gmbh | Verwendung von Cysteinprotease-Inhibitoren |
| JP2004529918A (ja) | 2001-04-09 | 2004-09-30 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | インテグリンに由来する疾患の治療のためのキナゾリンおよびキナゾリン類似化合物 |
| KR101011373B1 (ko) | 2002-07-11 | 2011-01-28 | 비큐론 파마슈티컬스 인코포레이티드 | 항균작용을 갖는 ｎ-히드록시아미드 유도체 |
| WO2005016883A2 (en) * | 2003-08-14 | 2005-02-24 | Icos Corporation | Acrylamide derivatives as vla-1 integrin antagonists and uses thereof |
| JP4769192B2 (ja) * | 2003-10-24 | 2011-09-07 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | カテプシン阻害剤としての新規な化合物及び組成物 |
| CN101616908B (zh) | 2006-12-29 | 2014-09-10 | Abbvie德国有限责任两合公司 | 羧酰胺化合物及它们作为钙蛋白酶抑制剂的用途 |
| TWI453019B (zh) * | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
| TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| US8236798B2 (en) | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| US8598211B2 (en) | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
| US9051304B2 (en) | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
| WO2012076639A1 (en) | 2010-12-09 | 2012-06-14 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors v |
| RU2014144285A (ru) | 2012-04-03 | 2016-05-27 | Эббви Дойчланд Гмбх Унд Ко. Кг | Карбоксамидные соединения и их применение в качестве ингибиторов кальпаина v |
| US10590084B2 (en) | 2016-03-09 | 2020-03-17 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
| WO2018009417A1 (en) | 2016-07-05 | 2018-01-11 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| CA3038331A1 (en) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| WO2018221546A1 (en) | 2017-06-01 | 2018-12-06 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition comprising pde9 inhibitor |
| US11311530B2 (en) | 2017-06-01 | 2022-04-26 | Eisai R&D Management Co., Ltd. | Lewy body disease therapeutic agent containing pyrazoloquinoline derivative |
| RU2020130022A (ru) * | 2018-03-28 | 2022-05-04 | Блэйд Терапьютикс, Инк. | Модуляторы кальпаина и их терапевтическое применение |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8904298D0 (sv) * | 1989-12-21 | 1989-12-21 | Astra Ab | New compounds |
| CA2098702A1 (en) * | 1990-12-28 | 1992-06-29 | James C. Powers | Peptide ketoamides, ketoacids, and ketoesters |
| CA2098609A1 (en) | 1990-12-28 | 1992-06-29 | Raymond T. Bartus | Use of calpain inhibitors in the inhibition and treatment of neurodegeneration |
| CA2071621C (en) | 1991-06-19 | 1996-08-06 | Ahihiko Hosoda | Aldehyde derivatives |
| EP0650368A1 (en) | 1992-06-24 | 1995-05-03 | Cortex Pharmaceuticals, Inc. | Use of calpain inhibitors in the inhibition and treatment of medical conditions associated with increased calpain activity |
| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
-
1996
- 1996-10-15 DE DE19642591A patent/DE19642591A1/de not_active Withdrawn
-
1997
- 1997-09-23 CA CA002268917A patent/CA2268917A1/en not_active Abandoned
- 1997-09-23 CZ CZ991268A patent/CZ126899A3/cs unknown
- 1997-09-23 BR BR9711908A patent/BR9711908A/pt unknown
- 1997-09-23 NZ NZ334979A patent/NZ334979A/en unknown
- 1997-09-23 SK SK385-99A patent/SK38599A3/sk unknown
- 1997-09-23 JP JP10517955A patent/JP2001501955A/ja active Pending
- 1997-09-23 KR KR1019990703216A patent/KR20000049130A/ko not_active Withdrawn
- 1997-09-23 WO PCT/EP1997/005202 patent/WO1998016512A1/de not_active Ceased
- 1997-09-23 RU RU99109969/04A patent/RU2189974C2/ru active
- 1997-09-23 CN CN97180507A patent/CN1239950A/zh active Pending
- 1997-09-23 US US09/284,543 patent/US6380220B1/en not_active Expired - Fee Related
- 1997-09-23 PL PL97332720A patent/PL332720A1/xx unknown
- 1997-09-23 IL IL12908997A patent/IL129089A0/xx unknown
- 1997-09-23 AU AU47770/97A patent/AU736754B2/en not_active Ceased
- 1997-09-23 EP EP97910332A patent/EP0934273A1/de not_active Withdrawn
- 1997-09-23 TR TR1999/00819T patent/TR199900819T2/tr unknown
- 1997-09-23 HU HU9904104A patent/HUP9904104A3/hu unknown
- 1997-10-14 ZA ZA979175A patent/ZA979175B/xx unknown
- 1997-10-14 HR HR19642591,3A patent/HRP970549A2/hr not_active Application Discontinuation
- 1997-10-14 AR ARP970104718A patent/AR009379A1/es not_active Application Discontinuation
- 1997-10-14 CO CO97060053A patent/CO4930264A1/es unknown
-
1999
- 1999-04-14 NO NO991761A patent/NO991761L/no not_active Application Discontinuation
- 1999-04-15 BG BG103338A patent/BG103338A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR009379A1 (es) | 2000-04-12 |
| CN1239950A (zh) | 1999-12-29 |
| US6380220B1 (en) | 2002-04-30 |
| DE19642591A1 (de) | 1998-04-16 |
| TR199900819T2 (tr) | 1999-06-21 |
| PL332720A1 (en) | 1999-10-11 |
| CZ126899A3 (cs) | 1999-07-14 |
| BG103338A (bg) | 2000-01-31 |
| WO1998016512A1 (de) | 1998-04-23 |
| HUP9904104A2 (hu) | 2000-05-28 |
| CO4930264A1 (es) | 2000-06-27 |
| BR9711908A (pt) | 1999-08-24 |
| HUP9904104A3 (en) | 2001-01-29 |
| SK38599A3 (en) | 2000-04-10 |
| KR20000049130A (ko) | 2000-07-25 |
| EP0934273A1 (de) | 1999-08-11 |
| NZ334979A (en) | 2001-02-23 |
| NO991761D0 (no) | 1999-04-14 |
| NO991761L (no) | 1999-04-14 |
| JP2001501955A (ja) | 2001-02-13 |
| ZA979175B (en) | 1999-04-14 |
| CA2268917A1 (en) | 1998-04-23 |
| HRP970549A2 (en) | 1998-08-31 |
| RU2189974C2 (ru) | 2002-09-27 |
| AU736754B2 (en) | 2001-08-02 |
| AU4777097A (en) | 1998-05-11 |
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