IL127946A0 - Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents - Google Patents
Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agentsInfo
- Publication number
- IL127946A0 IL127946A0 IL12794697A IL12794697A IL127946A0 IL 127946 A0 IL127946 A0 IL 127946A0 IL 12794697 A IL12794697 A IL 12794697A IL 12794697 A IL12794697 A IL 12794697A IL 127946 A0 IL127946 A0 IL 127946A0
- Authority
- IL
- Israel
- Prior art keywords
- cancer
- adamantyl
- pct
- sec
- useful
- Prior art date
Links
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 title abstract 5
- 230000006907 apoptotic process Effects 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- -1 retinoid compounds Chemical class 0.000 abstract 2
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 206010029260 Neuroblastoma Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 208000000453 Skin Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000019065 cervical carcinoma Diseases 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 230000003780 keratinization Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000849 skin cancer Diseases 0.000 abstract 1
- 208000000587 small cell lung carcinoma Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2128596P | 1996-07-08 | 1996-07-08 | |
| PCT/US1997/011564 WO1998001132A1 (en) | 1996-07-08 | 1997-07-08 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL127946A0 true IL127946A0 (en) | 2000-02-17 |
Family
ID=21803357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL12794697A IL127946A0 (en) | 1996-07-08 | 1997-07-08 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6127415A (cs) |
| EP (1) | EP0920312B1 (cs) |
| JP (1) | JP2000515506A (cs) |
| KR (1) | KR20000023626A (cs) |
| CN (1) | CN1279902C (cs) |
| AT (1) | ATE284213T1 (cs) |
| AU (1) | AU719311B2 (cs) |
| BG (1) | BG103152A (cs) |
| BR (1) | BR9710255A (cs) |
| CA (1) | CA2259936C (cs) |
| CZ (1) | CZ3499A3 (cs) |
| DE (1) | DE69731885T2 (cs) |
| ES (1) | ES2231877T3 (cs) |
| HU (1) | HUP9903834A3 (cs) |
| IL (1) | IL127946A0 (cs) |
| NO (1) | NO990066L (cs) |
| NZ (1) | NZ333800A (cs) |
| PT (1) | PT920312E (cs) |
| RU (1) | RU2209626C2 (cs) |
| TR (1) | TR199900684T2 (cs) |
| WO (1) | WO1998001132A1 (cs) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6462064B1 (en) * | 1996-07-08 | 2002-10-08 | Galderma Research & Development S.N.C. | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias |
| FR2757852B1 (fr) | 1996-12-31 | 1999-02-19 | Cird Galderma | Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations |
| FR2759292B1 (fr) * | 1997-02-10 | 2000-08-11 | Cird Galderma | Utilisation de retinoides en tant qu'agents induisant la pigmentation |
| FR2779723B1 (fr) * | 1998-06-12 | 2000-07-13 | Cird Galderma | Composes biaryles heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| ES2248107T3 (es) | 1999-08-31 | 2006-03-16 | Incyte San Diego Incorporated | Benciliden-tiazolidindionas y analogos y su utilizacion en el tratamiento de la diabetes. |
| AU2002252227A1 (en) | 2001-03-07 | 2002-09-24 | Maxia Pharmaceuticals, Inc. | Heterocyclic derivatives for the treatment of cancer and other proliferative diseases |
| CA2473156A1 (en) * | 2001-03-08 | 2002-09-19 | Incyte San Diego, Inc. | Rxr activating molecules |
| CA2340824A1 (en) * | 2001-03-14 | 2002-09-14 | Ibm Canada Limited-Ibm Canada Limitee | Method and system for application behavior analysis |
| US6613534B2 (en) | 2001-03-20 | 2003-09-02 | Wake Forest University Health Sciences | MAP-2 as a determinant of metastatic potential |
| ITRM20010464A1 (it) * | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica. |
| EP1421061A4 (en) * | 2001-08-17 | 2004-12-22 | Incyte San Diego Inc | OXIME DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA AND HYPERCHOLESTEROLEMIA |
| JP2005513026A (ja) * | 2001-11-15 | 2005-05-12 | インサイト サン ディエゴ インコーポレイテッド | 高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環 |
| CA2468745A1 (en) | 2001-11-30 | 2003-06-12 | The Burnham Institute | Induction of apoptosis in cancer cells |
| US7102000B2 (en) * | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| US7196108B2 (en) * | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| US7019017B2 (en) * | 2002-05-14 | 2006-03-28 | Baylor College Of Medicine | Small molecule inhibitors of HER2 expression |
| US7449480B2 (en) * | 2002-05-14 | 2008-11-11 | Baylor College Of Medicine | Small molecule inhibitors of HER2 expression |
| US20040156799A1 (en) * | 2002-06-04 | 2004-08-12 | Zigang Dong | Cancer treatment method and compositions |
| US6864264B1 (en) * | 2002-08-20 | 2005-03-08 | Gloria L. Anderson | 1-adamantyl chalcones for the treatment of proliferative disorders |
| US20050014767A1 (en) * | 2003-01-29 | 2005-01-20 | Magnus Pfahl | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases |
| MXPA05011242A (es) * | 2003-04-18 | 2006-07-06 | Incyte San Diego Inc | Compuestos isocromanos sustituidos para el tratamiento de trastornos metabolicos, cancer y otras enfermedades. |
| US7645910B2 (en) * | 2005-12-02 | 2010-01-12 | Finorga Sas | Process for the preparation of aromatic derivatives of 1-adamantane |
| ATE468119T1 (de) * | 2006-06-12 | 2010-06-15 | Univ Ramot | Verfahren zur behandlung von krebs |
| JP5826459B2 (ja) | 2007-01-15 | 2015-12-02 | チョンシー ユー | 非常に高い皮膚浸透率を有するレチノイド及びレチノイド様化合物の正に荷電した水溶性プロドラッグ |
| ES2569660T3 (es) | 2007-06-08 | 2016-05-12 | Mannkind Corporation | Inhibidores de la IRE-1alfa |
| CN102241678B (zh) * | 2011-04-26 | 2014-10-29 | 辽宁利锋科技开发有限公司 | 含有脂环结构化合物的抗肿瘤作用与应用 |
| KR101604053B1 (ko) * | 2011-08-05 | 2016-03-16 | (주)아모레퍼시픽 | 신규 벤조산아미드 화합물 |
| CN103936770B (zh) * | 2014-04-11 | 2016-06-01 | 安徽师范大学 | 金刚烷基吡啶酰胺配合物、中间体及其制备方法和应用 |
| CN103923107B (zh) * | 2014-04-11 | 2016-06-01 | 安徽师范大学 | 金刚烷基吡啶配合物、中间体及其制备方法和应用 |
| CN103936771B (zh) * | 2014-04-11 | 2016-06-01 | 安徽师范大学 | 金刚烷基吡啶甲酰胺配合物、中间体及其制备方法和应用 |
| WO2017053778A1 (en) | 2015-09-25 | 2017-03-30 | Fuchs Helen Burgwyn | Antibacterial and antifungal compounds |
| US20170181988A1 (en) * | 2015-12-23 | 2017-06-29 | Cipla Limited | Methods for the treatment of bladder cancer |
| EP3301085A1 (en) * | 2016-09-29 | 2018-04-04 | Biogem S.Ca.R.L. | Retinoid derivatives with antitumor activity |
| US11278025B2 (en) | 2017-05-17 | 2022-03-22 | The General Hospital Corporation | Antibiotic compounds |
| IT201900003343A1 (it) | 2019-03-07 | 2020-09-07 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi |
| AU2020241258A1 (en) * | 2019-03-15 | 2021-10-07 | The General Hospital Corporation | Novel small molecule inhibitors of tead transcription factors |
| CN112341406B (zh) * | 2020-11-18 | 2023-02-10 | 韶远科技（上海)有限公司 | 反式-4-[4-(3-甲氧基-4-硝基苯基)-1-哌嗪基]金刚烷-1-醇合成方法 |
| IT202000029882A1 (it) | 2020-12-04 | 2022-06-04 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi |
| IT202000029906A1 (it) | 2020-12-04 | 2022-06-04 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi. |
| IT202000029912A1 (it) | 2020-12-04 | 2022-06-04 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi |
| WO2022229017A1 (en) | 2021-04-27 | 2022-11-03 | Biogem S.C.A R.L. | Adamantyl retinoid derivative with anticancer activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK155079A (da) * | 1978-04-14 | 1979-10-15 | Sumitomo Chemical Co | Fremgangsmaade til fremstilling af tricycliske broforbindelser |
| DE3026579A1 (de) * | 1980-07-14 | 1982-02-11 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 2,9-dioxatricyclo (4,3,1,o(pfeil hoch)3,7(pfeil hoch)) decane |
| US5098929A (en) * | 1985-07-30 | 1992-03-24 | The Wellcome Foundation Limited | Pesticidal compounds |
| FR2676052B1 (fr) * | 1991-05-02 | 1994-04-29 | Cird Galderma | Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique. |
| US5770382A (en) * | 1994-12-30 | 1998-06-23 | Ligand Pharmaceuticals, Inc. | Tricyclic retinoids, methods for their production and use |
| EP0850067A4 (en) * | 1995-07-17 | 1999-12-15 | Cird Galderma | METHOD FOR CANCER TREATMENT USING 6- (3- (1-ADAMANTYL) -4-HYDROXYPHENYL) 2 NAPHTALINE CARBONIC ACID |
| FR2741876B1 (fr) * | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| US5888432A (en) * | 1996-12-23 | 1999-03-30 | Corning Incorporated | 2-Adamantyl benzopyrans the compositions and (co)polymer matrices containing them |
| US5919970A (en) * | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
-
1997
- 1997-07-08 IL IL12794697A patent/IL127946A0/xx unknown
- 1997-07-08 CZ CZ9934A patent/CZ3499A3/cs unknown
- 1997-07-08 HU HU9903834A patent/HUP9903834A3/hu unknown
- 1997-07-08 BR BR9710255A patent/BR9710255A/pt not_active Application Discontinuation
- 1997-07-08 AU AU36485/97A patent/AU719311B2/en not_active Ceased
- 1997-07-08 EP EP97933256A patent/EP0920312B1/en not_active Expired - Lifetime
- 1997-07-08 NZ NZ333800A patent/NZ333800A/xx unknown
- 1997-07-08 JP JP10505270A patent/JP2000515506A/ja not_active Ceased
- 1997-07-08 RU RU99102174/14A patent/RU2209626C2/ru not_active IP Right Cessation
- 1997-07-08 CN CNB971977437A patent/CN1279902C/zh not_active Expired - Fee Related
- 1997-07-08 PT PT97933256T patent/PT920312E/pt unknown
- 1997-07-08 AT AT97933256T patent/ATE284213T1/de active
- 1997-07-08 ES ES97933256T patent/ES2231877T3/es not_active Expired - Lifetime
- 1997-07-08 DE DE69731885T patent/DE69731885T2/de not_active Expired - Lifetime
- 1997-07-08 WO PCT/US1997/011564 patent/WO1998001132A1/en not_active Application Discontinuation
- 1997-07-08 US US09/214,422 patent/US6127415A/en not_active Expired - Fee Related
- 1997-07-08 TR TR1999/00684T patent/TR199900684T2/xx unknown
- 1997-07-08 CA CA002259936A patent/CA2259936C/en not_active Expired - Fee Related
-
1999
- 1999-01-07 NO NO990066A patent/NO990066L/no unknown
- 1999-01-08 KR KR1019997000075A patent/KR20000023626A/ko not_active Application Discontinuation
- 1999-02-05 BG BG103152A patent/BG103152A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0920312A1 (en) | 1999-06-09 |
| WO1998001132A1 (en) | 1998-01-15 |
| DE69731885T2 (de) | 2005-12-22 |
| BG103152A (en) | 1999-09-30 |
| AU3648597A (en) | 1998-02-02 |
| RU2209626C2 (ru) | 2003-08-10 |
| HUP9903834A2 (hu) | 2000-05-28 |
| ES2231877T3 (es) | 2005-05-16 |
| KR20000023626A (ko) | 2000-04-25 |
| EP0920312B1 (en) | 2004-12-08 |
| BR9710255A (pt) | 1999-08-10 |
| DE69731885D1 (de) | 2005-01-13 |
| TR199900684T2 (xx) | 1999-07-21 |
| ATE284213T1 (de) | 2004-12-15 |
| CN1230111A (zh) | 1999-09-29 |
| AU719311B2 (en) | 2000-05-04 |
| NO990066L (no) | 1999-03-08 |
| CN1279902C (zh) | 2006-10-18 |
| CZ3499A3 (cs) | 1999-11-17 |
| HUP9903834A3 (en) | 2001-02-28 |
| JP2000515506A (ja) | 2000-11-21 |
| US6127415A (en) | 2000-10-03 |
| CA2259936A1 (en) | 1998-01-15 |
| EP0920312A4 (en) | 2000-11-02 |
| PT920312E (pt) | 2005-04-29 |
| NO990066D0 (no) | 1999-01-07 |
| CA2259936C (en) | 2009-02-03 |
| NZ333800A (en) | 2000-08-25 |
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