BG103152A - Appoptosis-inducing adamantyl derivatives and their application as anticarcerogenic forms - Google Patents
Appoptosis-inducing adamantyl derivatives and their application as anticarcerogenic formsInfo
- Publication number
- BG103152A BG103152A BG103152A BG10315299A BG103152A BG 103152 A BG103152 A BG 103152A BG 103152 A BG103152 A BG 103152A BG 10315299 A BG10315299 A BG 10315299A BG 103152 A BG103152 A BG 103152A
- Authority
- BG
- Bulgaria
- Prior art keywords
- cancer
- adamantyl
- compounds
- anticarcerogenic
- appoptosis
- Prior art date
Links
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 title abstract 4
- 230000001939 inductive effect Effects 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010008342 Cervix carcinoma Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 206010073069 Hepatic cancer Diseases 0.000 abstract 1
- 206010029260 Neuroblastoma Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000453 Skin Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract 1
- 201000010881 cervical cancer Diseases 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000021045 exocrine pancreatic carcinoma Diseases 0.000 abstract 1
- 208000005017 glioblastoma Diseases 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000849 skin cancer Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2128596P | 1996-07-08 | 1996-07-08 | |
| PCT/US1997/011564 WO1998001132A1 (en) | 1996-07-08 | 1997-07-08 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG103152A true BG103152A (en) | 1999-09-30 |
Family
ID=21803357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103152A BG103152A (en) | 1996-07-08 | 1999-02-05 | Appoptosis-inducing adamantyl derivatives and their application as anticarcerogenic forms |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6127415A (xx) |
| EP (1) | EP0920312B1 (xx) |
| JP (1) | JP2000515506A (xx) |
| KR (1) | KR20000023626A (xx) |
| CN (1) | CN1279902C (xx) |
| AT (1) | ATE284213T1 (xx) |
| AU (1) | AU719311B2 (xx) |
| BG (1) | BG103152A (xx) |
| BR (1) | BR9710255A (xx) |
| CA (1) | CA2259936C (xx) |
| CZ (1) | CZ3499A3 (xx) |
| DE (1) | DE69731885T2 (xx) |
| ES (1) | ES2231877T3 (xx) |
| HU (1) | HUP9903834A3 (xx) |
| IL (1) | IL127946A0 (xx) |
| NO (1) | NO990066L (xx) |
| NZ (1) | NZ333800A (xx) |
| PT (1) | PT920312E (xx) |
| RU (1) | RU2209626C2 (xx) |
| TR (1) | TR199900684T2 (xx) |
| WO (1) | WO1998001132A1 (xx) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6462064B1 (en) * | 1996-07-08 | 2002-10-08 | Galderma Research & Development S.N.C. | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias |
| FR2757852B1 (fr) | 1996-12-31 | 1999-02-19 | Cird Galderma | Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations |
| FR2759292B1 (fr) * | 1997-02-10 | 2000-08-11 | Cird Galderma | Utilisation de retinoides en tant qu'agents induisant la pigmentation |
| FR2779723B1 (fr) * | 1998-06-12 | 2000-07-13 | Cird Galderma | Composes biaryles heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| US6515003B1 (en) * | 1999-08-31 | 2003-02-04 | Maxia Pharmaceuticals, Inc. | Heterocyclic derivatives for the treatment of diabetes and other diseases |
| WO2002072009A2 (en) | 2001-03-07 | 2002-09-19 | Maxia Pharmaceuticals, Inc. | Heterocyclic derivatives for the treatment of cancer and other proliferative diseases |
| WO2002072543A2 (en) * | 2001-03-08 | 2002-09-19 | Maxia Pharmaceuticals, Inc. | Rxr activating molecules |
| CA2340824A1 (en) * | 2001-03-14 | 2002-09-14 | Ibm Canada Limited-Ibm Canada Limitee | Method and system for application behavior analysis |
| US6613534B2 (en) | 2001-03-20 | 2003-09-02 | Wake Forest University Health Sciences | MAP-2 as a determinant of metastatic potential |
| ITRM20010464A1 (it) * | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica. |
| WO2003016267A1 (en) * | 2001-08-17 | 2003-02-27 | Incyte San Diego Incorporated | Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia |
| WO2003043998A1 (en) * | 2001-11-15 | 2003-05-30 | Incyte San Diego Incorporated | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
| AU2002346620A1 (en) | 2001-11-30 | 2003-06-17 | Department Of Veteran Affairs | Induction of apoptosis in cancer cells |
| US7102000B2 (en) * | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| US7196108B2 (en) * | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| US7449480B2 (en) * | 2002-05-14 | 2008-11-11 | Baylor College Of Medicine | Small molecule inhibitors of HER2 expression |
| US7019017B2 (en) * | 2002-05-14 | 2006-03-28 | Baylor College Of Medicine | Small molecule inhibitors of HER2 expression |
| US20040156799A1 (en) * | 2002-06-04 | 2004-08-12 | Zigang Dong | Cancer treatment method and compositions |
| US6864264B1 (en) * | 2002-08-20 | 2005-03-08 | Gloria L. Anderson | 1-adamantyl chalcones for the treatment of proliferative disorders |
| US20050014767A1 (en) * | 2003-01-29 | 2005-01-20 | Magnus Pfahl | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases |
| CA2522759A1 (en) * | 2003-04-18 | 2004-11-04 | Incyte San Diego Incorporated | Substituted isochroman compounds for the treatment of metabolic disorders, cancer and other diseases |
| DE602006015535D1 (de) * | 2005-12-02 | 2010-08-26 | Finorga Sas | Verfahren zur herstellung aromatischer derivate von 1-adamantan |
| ATE468119T1 (de) * | 2006-06-12 | 2010-06-15 | Univ Ramot | Verfahren zur behandlung von krebs |
| EP3181132A1 (en) * | 2007-01-15 | 2017-06-21 | Chongxi Yu | Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates |
| WO2008154484A1 (en) | 2007-06-08 | 2008-12-18 | Mannkind Corporation | Ire-1a inhibitors |
| CN102241678B (zh) * | 2011-04-26 | 2014-10-29 | 辽宁利锋科技开发有限公司 | 含有脂环结构化合物的抗肿瘤作用与应用 |
| KR101604053B1 (ko) * | 2011-08-05 | 2016-03-16 | (주)아모레퍼시픽 | 신규 벤조산아미드 화합물 |
| CN103936771B (zh) * | 2014-04-11 | 2016-06-01 | 安徽师范大学 | 金刚烷基吡啶甲酰胺配合物、中间体及其制备方法和应用 |
| CN103923107B (zh) * | 2014-04-11 | 2016-06-01 | 安徽师范大学 | 金刚烷基吡啶配合物、中间体及其制备方法和应用 |
| CN103936770B (zh) * | 2014-04-11 | 2016-06-01 | 安徽师范大学 | 金刚烷基吡啶酰胺配合物、中间体及其制备方法和应用 |
| WO2017053778A1 (en) | 2015-09-25 | 2017-03-30 | Fuchs Helen Burgwyn | Antibacterial and antifungal compounds |
| US20170181988A1 (en) * | 2015-12-23 | 2017-06-29 | Cipla Limited | Methods for the treatment of bladder cancer |
| EP3301085A1 (en) | 2016-09-29 | 2018-04-04 | Biogem S.Ca.R.L. | Retinoid derivatives with antitumor activity |
| WO2018213609A1 (en) * | 2017-05-17 | 2018-11-22 | Ausubel Frederick M | Antibiotic compounds |
| IT201900003343A1 (it) | 2019-03-07 | 2020-09-07 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi |
| WO2020190774A1 (en) * | 2019-03-15 | 2020-09-24 | The General Hospital Corporation | Novel small molecule inhibitors of tead transcription factors |
| CN112341406B (zh) * | 2020-11-18 | 2023-02-10 | 韶远科技（上海)有限公司 | 反式-4-[4-(3-甲氧基-4-硝基苯基)-1-哌嗪基]金刚烷-1-醇合成方法 |
| IT202000029882A1 (it) | 2020-12-04 | 2022-06-04 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi |
| IT202000029906A1 (it) | 2020-12-04 | 2022-06-04 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi. |
| IT202000029912A1 (it) | 2020-12-04 | 2022-06-04 | Special Product’S Line S P A | Derivati fenolici per uso come antimicrobici, antibatterici, battericidi |
| WO2022229017A1 (en) | 2021-04-27 | 2022-11-03 | Biogem S.C.A R.L. | Adamantyl retinoid derivative with anticancer activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU182048B (en) * | 1978-04-14 | 1983-12-28 | Sumitomo Chemical Co | Process for preparing brendane derivatives and brendane analogues |
| DE3026579A1 (de) * | 1980-07-14 | 1982-02-11 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 2,9-dioxatricyclo (4,3,1,o(pfeil hoch)3,7(pfeil hoch)) decane |
| US5098929A (en) * | 1985-07-30 | 1992-03-24 | The Wellcome Foundation Limited | Pesticidal compounds |
| FR2676052B1 (fr) * | 1991-05-02 | 1994-04-29 | Cird Galderma | Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique. |
| US5770382A (en) * | 1994-12-30 | 1998-06-23 | Ligand Pharmaceuticals, Inc. | Tricyclic retinoids, methods for their production and use |
| EP0850067A4 (en) * | 1995-07-17 | 1999-12-15 | Cird Galderma | METHOD FOR CANCER TREATMENT USING 6- (3- (1-ADAMANTYL) -4-HYDROXYPHENYL) 2 NAPHTALINE CARBONIC ACID |
| FR2741876B1 (fr) * | 1995-12-01 | 1998-01-09 | Cird Galderma | Composes biaromatiques portant un groupement adamantyl en para, compositions pharmaceutiques et cosmetiques les contenant et utilisations |
| US5888432A (en) * | 1996-12-23 | 1999-03-30 | Corning Incorporated | 2-Adamantyl benzopyrans the compositions and (co)polymer matrices containing them |
| US5919970A (en) * | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
-
1997
- 1997-07-08 CN CNB971977437A patent/CN1279902C/zh not_active Expired - Fee Related
- 1997-07-08 RU RU99102174/14A patent/RU2209626C2/ru not_active IP Right Cessation
- 1997-07-08 AT AT97933256T patent/ATE284213T1/de active
- 1997-07-08 HU HU9903834A patent/HUP9903834A3/hu unknown
- 1997-07-08 EP EP97933256A patent/EP0920312B1/en not_active Expired - Lifetime
- 1997-07-08 WO PCT/US1997/011564 patent/WO1998001132A1/en not_active Application Discontinuation
- 1997-07-08 IL IL12794697A patent/IL127946A0/xx unknown
- 1997-07-08 PT PT97933256T patent/PT920312E/pt unknown
- 1997-07-08 TR TR1999/00684T patent/TR199900684T2/xx unknown
- 1997-07-08 ES ES97933256T patent/ES2231877T3/es not_active Expired - Lifetime
- 1997-07-08 CZ CZ9934A patent/CZ3499A3/cs unknown
- 1997-07-08 CA CA002259936A patent/CA2259936C/en not_active Expired - Fee Related
- 1997-07-08 NZ NZ333800A patent/NZ333800A/xx unknown
- 1997-07-08 US US09/214,422 patent/US6127415A/en not_active Expired - Fee Related
- 1997-07-08 AU AU36485/97A patent/AU719311B2/en not_active Ceased
- 1997-07-08 JP JP10505270A patent/JP2000515506A/ja not_active Ceased
- 1997-07-08 BR BR9710255A patent/BR9710255A/pt not_active Application Discontinuation
- 1997-07-08 DE DE69731885T patent/DE69731885T2/de not_active Expired - Lifetime
-
1999
- 1999-01-07 NO NO990066A patent/NO990066L/no unknown
- 1999-01-08 KR KR1019997000075A patent/KR20000023626A/ko not_active Application Discontinuation
- 1999-02-05 BG BG103152A patent/BG103152A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6127415A (en) | 2000-10-03 |
| CA2259936A1 (en) | 1998-01-15 |
| ES2231877T3 (es) | 2005-05-16 |
| CN1230111A (zh) | 1999-09-29 |
| AU3648597A (en) | 1998-02-02 |
| IL127946A0 (en) | 2000-02-17 |
| AU719311B2 (en) | 2000-05-04 |
| JP2000515506A (ja) | 2000-11-21 |
| EP0920312A1 (en) | 1999-06-09 |
| KR20000023626A (ko) | 2000-04-25 |
| EP0920312A4 (en) | 2000-11-02 |
| NO990066L (no) | 1999-03-08 |
| RU2209626C2 (ru) | 2003-08-10 |
| WO1998001132A1 (en) | 1998-01-15 |
| PT920312E (pt) | 2005-04-29 |
| DE69731885D1 (de) | 2005-01-13 |
| CN1279902C (zh) | 2006-10-18 |
| DE69731885T2 (de) | 2005-12-22 |
| TR199900684T2 (xx) | 1999-07-21 |
| CA2259936C (en) | 2009-02-03 |
| EP0920312B1 (en) | 2004-12-08 |
| CZ3499A3 (cs) | 1999-11-17 |
| NO990066D0 (no) | 1999-01-07 |
| HUP9903834A3 (en) | 2001-02-28 |
| NZ333800A (en) | 2000-08-25 |
| BR9710255A (pt) | 1999-08-10 |
| ATE284213T1 (de) | 2004-12-15 |
| HUP9903834A2 (hu) | 2000-05-28 |
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