WO2002064172A3 - Fhit gene therapy prevents tumor development in fhit-deficient mice - Google Patents

Fhit gene therapy prevents tumor development in fhit-deficient mice Download PDF

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Publication number
WO2002064172A3
WO2002064172A3 PCT/US2002/004155 US0204155W WO02064172A3 WO 2002064172 A3 WO2002064172 A3 WO 2002064172A3 US 0204155 W US0204155 W US 0204155W WO 02064172 A3 WO02064172 A3 WO 02064172A3
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WIPO (PCT)
Prior art keywords
fhit
gene therapy
tumor development
deficient mice
prevents tumor
Prior art date
Application number
PCT/US2002/004155
Other languages
French (fr)
Other versions
WO2002064172A2 (en
Inventor
Carlo M Croce
Frances Kay Huebner
Kristoffel R Dumon
Hideshi Ishii
Original Assignee
Univ Jefferson
Carlo M Croce
Frances Kay Huebner
Kristoffel R Dumon
Hideshi Ishii
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Publication date
Application filed by Univ Jefferson, Carlo M Croce, Frances Kay Huebner, Kristoffel R Dumon, Hideshi Ishii filed Critical Univ Jefferson
Publication of WO2002064172A2 publication Critical patent/WO2002064172A2/en
Publication of WO2002064172A3 publication Critical patent/WO2002064172A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01029—Bis(5'-adenosyl)-triphosphatase (3.6.1.29)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Inactivation of FHIT, a tumor suppressor gene, is found in a large fraction of cells that are either premalignant or malignant. The present invention relates to gene therapy wherein the FHIT gene is administered, either in vivo or ex vivo, to a patient to inhibit tumor development. The gene therapy methods of the present invention will be used in the treatment of disorders involving an overproliferation of cells. Further, the gene therapy methods of the present invention are useful in protecting a patient that is predisposed to developing a cancer.
PCT/US2002/004155 2001-02-12 2002-02-12 Fhit gene therapy prevents tumor development in fhit-deficient mice WO2002064172A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26809001P 2001-02-12 2001-02-12
US60/268,090 2001-02-12

Publications (2)

Publication Number Publication Date
WO2002064172A2 WO2002064172A2 (en) 2002-08-22
WO2002064172A3 true WO2002064172A3 (en) 2003-02-27

Family

ID=23021427

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/004155 WO2002064172A2 (en) 2001-02-12 2002-02-12 Fhit gene therapy prevents tumor development in fhit-deficient mice

Country Status (1)

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WO (1) WO2002064172A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911998B2 (en) 2007-10-26 2014-12-16 The Ohio State University Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof
US9125923B2 (en) 2008-06-11 2015-09-08 The Ohio State University Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy

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EP2719773A3 (en) 2007-06-15 2014-07-30 The Ohio State University Research Foundation miRNA as marker for acute lamphomic leucemia
CN103866008B (en) 2007-08-03 2016-06-29 俄亥俄州立大学研究基金会 The super conservative region of coding NCRNA
CN102803511A (en) 2009-11-23 2012-11-28 俄亥俄州立大学 Materials and methods useful for affecting tumor cell growth, migration and invasion
AU2011326032B2 (en) 2010-11-12 2016-10-06 The Ohio State University Research Foundation Materials and methods related to microRNA-21, mismatch repair, and colorectal cancer
BR112013011942A2 (en) 2010-11-15 2016-11-01 Univ Michigan formulation, drug dosage form for oral transmucosal administration, transmucosal drug delivery system, method of treatment and prophylaxis of a disease or disorder, method of treatment, formulation, method for treatment or prevention of head and neck squamous cell carcinoma (hnscc), method for chemoprevention of an oral cancer or precancerous condition, method for increasing the concentration of a retinide composition, method of treatment and prophylaxis of a disease or condition, ratification method of a subject presenting a symptomatic medical condition , method of treating an oral cancer or precancerous condition in a patient, method for making an oral drug delivery system, method for increasing the release and permeation of a retinide composition.
JP2014509852A (en) 2011-03-07 2014-04-24 ジ・オハイオ・ステート・ユニバーシティ Mutagenic activity induced by microRNA-155 (miR-155) links inflammation and cancer
AU2012323924A1 (en) 2011-10-14 2014-05-29 The Ohio State University Methods and materials related to ovarian cancer
CN104619353A (en) 2011-12-13 2015-05-13 俄亥俄州国家创新基金会 Methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis
AU2013209477B2 (en) 2012-01-20 2016-12-08 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
CN108715860A (en) * 2018-04-20 2018-10-30 郑州大学 A kind of construction method of epithelium of esophagus tissue p53 specific knockdowns mouse esophageal precancerous lesion model
EP4205799B1 (en) 2021-12-29 2024-02-14 Cairdac Implantable medical device with non-traumatic helical anchoring screw

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997029119A1 (en) * 1996-02-09 1997-08-14 Thomas Jefferson University Fhit proteins and nucleic acids and methods based thereon

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997029119A1 (en) * 1996-02-09 1997-08-14 Thomas Jefferson University Fhit proteins and nucleic acids and methods based thereon

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CROCE CARLO M ET AL: "Role of FHIT in human cancer.", JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 5, May 1999 (1999-05-01), pages 1618 - 1624, XP001095626, ISSN: 0732-183X *
DUMON KRISTOFFEL R ET AL: "FHIT gene therapy prevents tumor development in Fhit-deficient mice.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 98, no. 6, 13 March 2001 (2001-03-13), March 13, 2001, pages 3346 - 3351, XP002209368, ISSN: 0027-8424 *
DUMON KRISTOFFEL R ET AL: "Inhibition of tumor growth and induction of apoptosis by adeno associated virus mediated fragile histidine triade (FHIT) gene overexpression in pancreatic cancer cell lines.", GASTROENTEROLOGY, vol. 118, no. 4 Suppl. 2 Part 1, April 2000 (2000-04-01), 101st Annual Meeting of the American Gastroenterological Association and the Digestive Disease Week.;San Diego, California, USA; May 21-24, 2000, pages AGA A643, XP001095640, ISSN: 0016-5085 *
FONG LOUISE Y Y ET AL: "Muir-Torre-like syndrome in Fhit-deficient mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 9, 25 April 2000 (2000-04-25), pages 4742 - 4747, XP002204095, ISSN: 0027-8424 *
ISHII HIDESHI ET AL: "Potential cancer therapy with the fragile histidine triad gene: Review of the preclinical studies.", JAMA (JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION), vol. 286, no. 19, 21 November 2001 (2001-11-21), pages 2441 - 2449, XP001098544, ISSN: 0098-7484 *
JI LIN ET AL: "Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 14, 15 July 1999 (1999-07-15), pages 3333 - 3339, XP002204093, ISSN: 0008-5472 *
ROZ L ET AL: "Adenoviral transfer of the FHIT gene in cancer cell lines results in apoptosis and activation of the caspase-8 pathway", AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS, CHICAGO, IL, US, vol. 67, no. 4 Supplement 2, October 2000 (2000-10-01), pages 102, XP002204092, ISSN: 0002-9297 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911998B2 (en) 2007-10-26 2014-12-16 The Ohio State University Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof
US9125923B2 (en) 2008-06-11 2015-09-08 The Ohio State University Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy

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Publication number Publication date
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