AR037343A1 - Uso de antagonistas del receptor de endotelina para la preparacion de un medicamento destinado al tratamiento de enfermedades tumorales - Google Patents
Uso de antagonistas del receptor de endotelina para la preparacion de un medicamento destinado al tratamiento de enfermedades tumoralesInfo
- Publication number
- AR037343A1 AR037343A1 ARP020104289A ARP020104289A AR037343A1 AR 037343 A1 AR037343 A1 AR 037343A1 AR P020104289 A ARP020104289 A AR P020104289A AR P020104289 A ARP020104289 A AR P020104289A AR 037343 A1 AR037343 A1 AR 037343A1
- Authority
- AR
- Argentina
- Prior art keywords
- treatment
- tumor diseases
- endotheline
- medicinal
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describe el uso de los antagonistas del receptor de endotelina que responden a las formulas (1) cuyos sustituyentes se definen en la memoria descriptiva, para preparar un medicamento destinado al tratamiento de las enfermedades tumorales, entre las cuales se destacan el cáncer de próstata, carcinoma de ovario, cáncer de intestino, carcinoma de cérvix, melanoma y el cáncer de páncreas. Estos compuestos también se usan para preparar un medicamento destinado al tratamiento de las lesiones precancerosas y a la regulación de la apoptosis en células humanas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10155076A DE10155076A1 (de) | 2001-11-09 | 2001-11-09 | Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037343A1 true AR037343A1 (es) | 2004-11-03 |
Family
ID=7705184
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020104289A AR037343A1 (es) | 2001-11-09 | 2002-11-08 | Uso de antagonistas del receptor de endotelina para la preparacion de un medicamento destinado al tratamiento de enfermedades tumorales |
Country Status (15)
Country | Link |
---|---|
US (1) | US20050014769A1 (es) |
EP (1) | EP1441721A2 (es) |
JP (1) | JP2005510511A (es) |
KR (1) | KR20050035181A (es) |
CN (1) | CN1585636A (es) |
AR (1) | AR037343A1 (es) |
BR (1) | BR0213684A (es) |
CA (1) | CA2465744A1 (es) |
DE (1) | DE10155076A1 (es) |
HU (1) | HUP0402281A2 (es) |
MX (1) | MXPA04004306A (es) |
PL (1) | PL369822A1 (es) |
RU (1) | RU2004117596A (es) |
WO (1) | WO2003039539A2 (es) |
ZA (1) | ZA200404544B (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0219660D0 (en) * | 2002-08-23 | 2002-10-02 | Astrazeneca Ab | Therapeutic use |
GB0223367D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Therapeutic treatment |
GB0223854D0 (en) * | 2002-10-12 | 2002-11-20 | Astrazeneca Ab | Therapeutic treatment |
GB0320806D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
GB0403744D0 (en) | 2004-02-20 | 2004-03-24 | Astrazeneca Ab | Chemical process |
WO2005095972A2 (en) * | 2004-03-19 | 2005-10-13 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor etb (etb) |
ITMI20040874A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici ed azaindolici con azione antitumorale |
GB0425854D0 (en) * | 2004-11-25 | 2004-12-29 | Astrazeneca Ab | Therapeutic treatment |
GB0514743D0 (en) * | 2005-07-19 | 2005-08-24 | Astrazeneca Ab | Salt |
US7939545B2 (en) * | 2006-05-16 | 2011-05-10 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
KR100989141B1 (ko) * | 2007-05-14 | 2010-10-20 | 경희대학교 산학협력단 | 시클로옥시게나제-2 저해제 |
WO2008140251A2 (en) * | 2007-05-14 | 2008-11-20 | University-Industry Cooperation Group Of Kyung Hee University | Cyclooxygenase-2 inhibitors |
CA2705318C (en) | 2007-11-15 | 2013-12-31 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
JP5285709B2 (ja) | 2007-11-16 | 2013-09-11 | ギリアード サイエンシス インコーポレーテッド | ヒト免疫不全ウイルスの複製阻害薬 |
MX2012015252A (es) | 2010-06-30 | 2013-05-30 | Ironwood Pharmaceuticals Inc | Estimuladores de sgc. |
CN107266433A (zh) | 2010-11-09 | 2017-10-20 | 铁木医药有限公司 | sGC刺激剂 |
CN104066731B (zh) | 2011-12-27 | 2016-06-15 | 铁木医药有限公司 | 可用作sgc刺激剂的2-苄基、3-(嘧啶-2-基)取代的吡唑类 |
US10183949B2 (en) | 2014-08-29 | 2019-01-22 | The University Of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063911A (en) * | 1993-12-01 | 2000-05-16 | Marine Polymer Technologies, Inc. | Methods and compositions for treatment of cell proliferative disorders |
DE19509950A1 (de) * | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19527568A1 (de) * | 1995-07-28 | 1997-01-30 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
AU717172B2 (en) * | 1995-08-02 | 2000-03-16 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
DE19528418A1 (de) * | 1995-08-02 | 1997-02-06 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19530032A1 (de) * | 1995-08-16 | 1997-02-20 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19537548A1 (de) * | 1995-10-09 | 1997-04-10 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
JPH09124620A (ja) * | 1995-10-11 | 1997-05-13 | Bristol Myers Squibb Co | 置換ビフェニルスルホンアミドエンドセリン拮抗剤 |
DE19543639A1 (de) * | 1995-11-23 | 1997-05-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19606980A1 (de) * | 1996-02-24 | 1997-08-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19607096A1 (de) * | 1996-02-24 | 1997-08-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19609597A1 (de) * | 1996-03-12 | 1997-09-18 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19612101A1 (de) * | 1996-03-27 | 1997-10-02 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19653037A1 (de) * | 1996-12-19 | 1998-06-25 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19653024A1 (de) * | 1996-12-19 | 1998-06-25 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19710831A1 (de) * | 1997-03-15 | 1998-09-17 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19711428A1 (de) * | 1997-03-19 | 1998-09-24 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19711785A1 (de) * | 1997-03-21 | 1998-09-24 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19712141A1 (de) * | 1997-03-22 | 1998-09-24 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
DE19731571A1 (de) * | 1997-07-23 | 1999-01-28 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
-
2001
- 2001-11-09 DE DE10155076A patent/DE10155076A1/de not_active Withdrawn
-
2002
- 2002-10-10 JP JP2003541830A patent/JP2005510511A/ja active Pending
- 2002-10-10 KR KR1020047007032A patent/KR20050035181A/ko not_active Application Discontinuation
- 2002-10-10 PL PL02369822A patent/PL369822A1/xx unknown
- 2002-10-10 RU RU2004117596/15A patent/RU2004117596A/ru not_active Application Discontinuation
- 2002-10-10 HU HU0402281A patent/HUP0402281A2/hu unknown
- 2002-10-10 EP EP02802624A patent/EP1441721A2/de not_active Withdrawn
- 2002-10-10 US US10/495,108 patent/US20050014769A1/en not_active Abandoned
- 2002-10-10 BR BR0213684-8A patent/BR0213684A/pt not_active Application Discontinuation
- 2002-10-10 CA CA002465744A patent/CA2465744A1/en not_active Abandoned
- 2002-10-10 MX MXPA04004306A patent/MXPA04004306A/es not_active Application Discontinuation
- 2002-10-10 WO PCT/EP2002/011350 patent/WO2003039539A2/de not_active Application Discontinuation
- 2002-10-10 CN CNA028222520A patent/CN1585636A/zh active Pending
- 2002-11-08 AR ARP020104289A patent/AR037343A1/es not_active Application Discontinuation
-
2004
- 2004-06-08 ZA ZA200404544A patent/ZA200404544B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200404544B (en) | 2005-02-08 |
US20050014769A1 (en) | 2005-01-20 |
JP2005510511A (ja) | 2005-04-21 |
HUP0402281A2 (hu) | 2005-02-28 |
WO2003039539A2 (de) | 2003-05-15 |
WO2003039539A3 (de) | 2003-11-06 |
BR0213684A (pt) | 2004-10-26 |
EP1441721A2 (de) | 2004-08-04 |
RU2004117596A (ru) | 2005-05-27 |
KR20050035181A (ko) | 2005-04-15 |
PL369822A1 (en) | 2005-05-02 |
CN1585636A (zh) | 2005-02-23 |
CA2465744A1 (en) | 2003-05-15 |
DE10155076A1 (de) | 2003-05-22 |
MXPA04004306A (es) | 2004-08-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR037343A1 (es) | Uso de antagonistas del receptor de endotelina para la preparacion de un medicamento destinado al tratamiento de enfermedades tumorales | |
ES2191187T3 (es) | Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa. | |
GT200300294A (es) | Compuestos de indazol y composiciones farmaceuticas para inhibir proteinquinasas y procedimientos para su uso | |
BR9710255A (pt) | Método para o tratamento de cáncer composto de retinóide de adamantila composição farmacéutica ou cosmética de matéria método de tratamento ou de prevenção e método para controlar | |
ATE380552T1 (de) | Pharmazeutische zusammensetzung enthältend estetrolderivate und anwendung in der krebsbehandlung | |
NO20022065D0 (no) | Terapeutisk anvendelse | |
UY27981A1 (es) | Nuevos compuestos de triazol como inhibidores del factor de crecimiento transformante (tgf) | |
UY28441A1 (es) | Derivados de quinazolina | |
ECSP045410A (es) | Nuevos derivados de piridazin-3(2h)-ona | |
ATE261974T1 (de) | Hoch-lipophile campothecin-derivate | |
PA8582701A1 (es) | Nuevos compuestos de oxazol y tiazol como inhibidores del factor de crecimiento transformador (tgf) | |
AR009849A1 (es) | Compuestos estilbenicos de grupo adamantil, composiciones que los contienen y utilizaciones | |
PA8595001A1 (es) | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf) | |
PA8583101A1 (es) | Nuevos compuestos de isotiazol e isoxazol como inhibidores del factor de crecimiento transformador (tgf) | |
ES2267706T3 (es) | Agentes como la nicotinamida o cardr para el tratamiento de trastornos de la piel. | |
BR0316296A (pt) | Compostos lapacone e seus métodos de uso | |
AU5338401A (en) | Methods and compositions for modulating alpha adrenergic receptor activity | |
BR0010702A (pt) | Novas quinonas como terapias de doenças | |
NO20092339L (no) | Universal tumorcellevaksine for anti-cancer terapeutisk og profylaktisk anvendelse | |
BR9608488A (pt) | Uso de derivados da vitamina d4 no tratamento de câncer | |
SE9802208D0 (sv) | Novel compounds | |
HUP0100170A1 (hu) | N-benzil-3-indenil-acetamid-származékok és alkalmazásuk neoplázia kezelésére alkalmas gyógyszerkészítmények előállítására | |
HUP0300005A2 (hu) | Módosított citokinek a rák kezelésében | |
AR039843A1 (es) | Tratamiento de padecimientos post-menopausicos en pacientes con cancer de mama | |
AR041595A1 (es) | Tratamiento terapeutico |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |