DK0873332T3 - Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi - Google Patents

Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi

Info

Publication number
DK0873332T3
DK0873332T3 DK96943591T DK96943591T DK0873332T3 DK 0873332 T3 DK0873332 T3 DK 0873332T3 DK 96943591 T DK96943591 T DK 96943591T DK 96943591 T DK96943591 T DK 96943591T DK 0873332 T3 DK0873332 T3 DK 0873332T3
Authority
DK
Denmark
Prior art keywords
well
pharmaceutical compositions
compositions containing
cancer therapy
compounds
Prior art date
Application number
DK96943591T
Other languages
English (en)
Inventor
Ross E Longley
Sarath P Gunasekera
Shirley Pomponi
Original Assignee
Harbor Branch Oceanographic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Branch Oceanographic filed Critical Harbor Branch Oceanographic
Application granted granted Critical
Publication of DK0873332T3 publication Critical patent/DK0873332T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
DK96943591T 1995-12-05 1996-12-05 Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi DK0873332T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/567,442 US5681847A (en) 1995-12-05 1995-12-05 Methods of using discodermolide compounds
PCT/US1996/019344 WO1997020835A1 (en) 1995-12-05 1996-12-05 Discodermolide compounds and pharmaceutical compositions containing them for cancer therapy

Publications (1)

Publication Number Publication Date
DK0873332T3 true DK0873332T3 (da) 2004-07-26

Family

ID=24267168

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96943591T DK0873332T3 (da) 1995-12-05 1996-12-05 Discodermolidforbindelser samt farmaceutiske sammensætninger indeholdende dem til cancerterapi

Country Status (10)

Country Link
US (2) US5681847A (da)
EP (1) EP0873332B1 (da)
JP (1) JP3293833B2 (da)
AT (1) ATE262515T1 (da)
CA (1) CA2233716C (da)
DE (1) DE69631975T2 (da)
DK (1) DK0873332T3 (da)
ES (1) ES2218608T3 (da)
PT (1) PT873332E (da)
WO (1) WO1997020835A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050065353A1 (en) * 1996-12-03 2005-03-24 Smith Amos B. Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US6870058B2 (en) * 1996-12-03 2005-03-22 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
US6242616B1 (en) * 1996-12-03 2001-06-05 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) * 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6127406A (en) * 1998-10-09 2000-10-03 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds and methods of use
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6384187B1 (en) 1999-05-15 2002-05-07 Harbor Branch Oceanographic Institution, Inc. Antiproliferative activity of microsclerodermins
US6414015B1 (en) 2000-01-28 2002-07-02 Utah State University Laulimalide microtubule stabilizing agents
WO2001064663A2 (en) * 2000-03-01 2001-09-07 Harbor Branch Oceanographic Institution, Inc. Biologically active analogs of discodermolide
US6774143B1 (en) 2000-04-04 2004-08-10 Novartis Ag Method for treating cells resistant to antineoplastic agents
JP2004505890A (ja) * 2000-04-04 2004-02-26 ノバルティス　アクチエンゲゼルシャフト 抗新生物剤に耐性の細胞を処置する方法
KR20040032898A (ko) * 2001-08-07 2004-04-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 디스코데르몰리드의 화학적 및 생물학적 성질을 모사하는화합물
US6833367B2 (en) * 2001-11-16 2004-12-21 Novartis Ac Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
US7342124B2 (en) * 2003-04-02 2008-03-11 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
WO2005084349A2 (en) * 2004-03-02 2005-09-15 Kosan Biosciences, Inc. Compounds useful for the synthesis of (+)-discodermolide and methods therefor
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
JP4954983B2 (ja) 2005-05-18 2012-06-20 ファーマサイエンス・インコーポレイテッド Ｂｉｒドメイン結合化合物
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
US9187445B2 (en) 2007-12-20 2015-11-17 Pharma Mar, S.A. Antitumoral compounds
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine
LT2719708T (lt) 2009-11-13 2018-02-12 Daiichi Sankyo Europe Gmbh Medžiaga ir būdai, skirti su her-3 susijusių ligų gydymui arba prevencijai
SG182724A1 (en) 2010-02-12 2012-08-30 Pharmascience Inc Iap bir domain binding compounds
US20120156130A1 (en) 2010-08-06 2012-06-21 Thore Hettmann Use of her3 binding agents in prostate treatment
CA3046358A1 (en) * 2016-12-09 2018-06-14 Akanocure Pharmaceuticals, Inc. Scalable polypropionate lactone stereotetrads
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206221A (en) * 1979-01-03 1980-06-03 The United States Of America As Represented By The Secretary Of Agriculture Cephalomannine and its use in treating leukemic tumors
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US4939168A (en) * 1989-08-11 1990-07-03 Harbor Branch Oceanographics Institution, Inc. Discodermolide compounds, compositions containing same and methods of preparation and use
US5010099A (en) * 1989-08-11 1991-04-23 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and method of preparation and use

Also Published As

Publication number Publication date
JP3293833B2 (ja) 2002-06-17
CA2233716C (en) 2006-05-09
DE69631975T2 (de) 2005-01-20
CA2233716A1 (en) 1997-06-12
DE69631975D1 (de) 2004-04-29
ES2218608T3 (es) 2004-11-16
US5840750A (en) 1998-11-24
US5681847A (en) 1997-10-28
EP0873332B1 (en) 2004-03-24
JP2000501710A (ja) 2000-02-15
EP0873332A1 (en) 1998-10-28
PT873332E (pt) 2004-08-31
WO1997020835A1 (en) 1997-06-12
ATE262515T1 (de) 2004-04-15

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