PT873332E - Compostos discodermolida e composicoes farmaceuticas que os contem para terapeutica do cancro - Google Patents

Compostos discodermolida e composicoes farmaceuticas que os contem para terapeutica do cancro

Info

Publication number
PT873332E
PT873332E PT96943591T PT96943591T PT873332E PT 873332 E PT873332 E PT 873332E PT 96943591 T PT96943591 T PT 96943591T PT 96943591 T PT96943591 T PT 96943591T PT 873332 E PT873332 E PT 873332E
Authority
PT
Portugal
Prior art keywords
contain
pharmaceutical compositions
compounds
cancer therapeutics
cancer cells
Prior art date
Application number
PT96943591T
Other languages
English (en)
Inventor
Ross E Longley
Sarath P Gunasekera
Shirley Pomponi
Original Assignee
Harbor Branch Oceanographic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Branch Oceanographic filed Critical Harbor Branch Oceanographic
Publication of PT873332E publication Critical patent/PT873332E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
PT96943591T 1995-12-05 1996-12-05 Compostos discodermolida e composicoes farmaceuticas que os contem para terapeutica do cancro PT873332E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/567,442 US5681847A (en) 1995-12-05 1995-12-05 Methods of using discodermolide compounds

Publications (1)

Publication Number Publication Date
PT873332E true PT873332E (pt) 2004-08-31

Family

ID=24267168

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96943591T PT873332E (pt) 1995-12-05 1996-12-05 Compostos discodermolida e composicoes farmaceuticas que os contem para terapeutica do cancro

Country Status (10)

Country Link
US (2) US5681847A (pt)
EP (1) EP0873332B1 (pt)
JP (1) JP3293833B2 (pt)
AT (1) ATE262515T1 (pt)
CA (1) CA2233716C (pt)
DE (1) DE69631975T2 (pt)
DK (1) DK0873332T3 (pt)
ES (1) ES2218608T3 (pt)
PT (1) PT873332E (pt)
WO (1) WO1997020835A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789605A (en) * 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6242616B1 (en) * 1996-12-03 2001-06-05 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US20050065353A1 (en) * 1996-12-03 2005-03-24 Smith Amos B. Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US6870058B2 (en) * 1996-12-03 2005-03-22 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
US6127406A (en) * 1998-10-09 2000-10-03 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds and methods of use
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6384187B1 (en) 1999-05-15 2002-05-07 Harbor Branch Oceanographic Institution, Inc. Antiproliferative activity of microsclerodermins
US6414015B1 (en) 2000-01-28 2002-07-02 Utah State University Laulimalide microtubule stabilizing agents
EP1259502B1 (en) 2000-03-01 2005-01-12 Harbor Branch Oceanographic Institution, Inc. Biologically active analogs of discodermolide
US6774143B1 (en) 2000-04-04 2004-08-10 Novartis Ag Method for treating cells resistant to antineoplastic agents
EP1274422A1 (en) * 2000-04-04 2003-01-15 Novartis AG Method for treating cells resistant to antineoplastic agents
WO2003013502A1 (en) * 2001-08-07 2003-02-20 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
US6833367B2 (en) * 2001-11-16 2004-12-21 Novartis Ac Certain substituted polyketides, pharmaceutical compositions containing them and their use in treating tumors
TW200408407A (en) * 2001-11-30 2004-06-01 Dana Farber Cancer Inst Inc Methods and compositions for modulating the immune system and uses thereof
WO2004101508A2 (en) * 2003-04-02 2004-11-25 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy dienyl lactones and mimics thereof
US7348436B2 (en) * 2004-03-02 2008-03-25 Kosan Biosciences Incorporated Compounds useful for the synthesis of (+)-discodermolide and methods thereof
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
EP1883627B1 (en) 2005-05-18 2018-04-18 Pharmascience Inc. Bir domain binding compounds
EP2024362A4 (en) 2006-05-16 2012-01-25 Pharmascience Inc IAP BIR DOMAIN BINDING COMPOUNDS
RU2489429C2 (ru) * 2007-12-20 2013-08-10 Фарма Мар, С.А. Противоопухолевые соединения
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine
CN105999263B (zh) 2009-11-13 2021-06-29 第一三共欧洲有限公司 用于治疗或预防人表皮生长因子受体-3(her-3)相关疾病的材料和方法
AU2011214057B2 (en) 2010-02-12 2016-11-17 Pharmascience Inc. IAP BIR domain binding compounds
AU2011286407A1 (en) 2010-08-06 2013-02-21 Amgen Use of HER3 binding agents in prostate treatment
CA3046358A1 (en) * 2016-12-09 2018-06-14 Akanocure Pharmaceuticals, Inc. Scalable polypropionate lactone stereotetrads
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206221A (en) * 1979-01-03 1980-06-03 The United States Of America As Represented By The Secretary Of Agriculture Cephalomannine and its use in treating leukemic tumors
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5010099A (en) * 1989-08-11 1991-04-23 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and method of preparation and use
US4939168A (en) * 1989-08-11 1990-07-03 Harbor Branch Oceanographics Institution, Inc. Discodermolide compounds, compositions containing same and methods of preparation and use

Also Published As

Publication number Publication date
CA2233716A1 (en) 1997-06-12
DK0873332T3 (da) 2004-07-26
JP2000501710A (ja) 2000-02-15
ES2218608T3 (es) 2004-11-16
WO1997020835A1 (en) 1997-06-12
DE69631975D1 (de) 2004-04-29
US5681847A (en) 1997-10-28
ATE262515T1 (de) 2004-04-15
EP0873332B1 (en) 2004-03-24
US5840750A (en) 1998-11-24
CA2233716C (en) 2006-05-09
DE69631975T2 (de) 2005-01-20
EP0873332A1 (en) 1998-10-28
JP3293833B2 (ja) 2002-06-17

Similar Documents

Publication Publication Date Title
PT873332E (pt) Compostos discodermolida e composicoes farmaceuticas que os contem para terapeutica do cancro
BR9710255A (pt) Método para o tratamento de cáncer composto de retinóide de adamantila composição farmacéutica ou cosmética de matéria método de tratamento ou de prevenção e método para controlar
PT674630E (pt) 7-halo- e 7beta,8beta-metano-taxois utilizacao antineoplasica e composicoes farmaceuticas que os contem
BR9711137A (pt) Uso de um gene associado com diferencia-Æo de melanoma (mda 7) para reversÆo de um fenÄtipo canceroso
IT8027029A0 (it) Complessi platino-diamminici e formulazioni farmaceutiche per il trattamento del cancro che licontengono.
GR3005457T3 (pt)
HUP9900905A2 (hu) D4-Vitamin származékok alkalmazása rák kezelésére szolgáló gyógyászati készítmények előállítására
DE69210410D1 (de) Retinoid enthaltende dermatologische und/oder kosmetische zusammensetzungen
BG102250A (en) The use of marigold-extracted glycosides for the treatment of psoriasis
FR2679134B1 (fr) Compositions cosmetiques pour la regulation de la pigmentation cutanee comprenant un extrait d'eclipta alba.
IT8021289V0 (it) Piastrina di condizionamento di strumenti per canali dentari.
GR71207B (pt)
ATE237338T1 (de) Allogene parakrine cytokine tumor impfstoffe
ES2105285T3 (es) Nuevos derivados de la adenosina, sus procedimientos de preparacion, composiciones farmaceuticas que los contienen.
AU611113B2 (en) Basically substituted phenylacetonitriles, their preparation and drugs containing these compounds
TR199801915T2 (xx) Benzotiofenler, bunlar� ihtiva eden form�lasyonlar ve y�ntemler.
ES472284A1 (es) Procedimiento para la preparacion de 6-deoxineamina
FI900646A0 (fi) Foerfarande foer framstaellning av fenylhydrazoner och ur dessa erhaollna laekemedel och kosmetiska aemnen.
ES8609211A1 (es) Un procedimiento para producir un acetileno.
ES473316A1 (es) Procedimiento para la obtencion de 1,4-dihidropiridazinas.
IT8319024A0 (it) Composizione medicinale per il trattamento di certe neurovirosi.
MX9602407A (es) Composiciones farmaceuticas.
ES8506710A1 (es) Procedimiento para la obtencion de teofilin-7-acetato de ambroxol
EP0043976A3 (en) Anti-tumor agent
GB1276097A (en) Improvements in or relating to phloroglucinol derivatives