HUP9900905A2 - D4-Vitamin származékok alkalmazása rák kezelésére szolgáló gyógyászati készítmények előállítására - Google Patents

D4-Vitamin származékok alkalmazása rák kezelésére szolgáló gyógyászati készítmények előállítására

Info

Publication number
HUP9900905A2
HUP9900905A2 HU9900905A HUP9900905A HUP9900905A2 HU P9900905 A2 HUP9900905 A2 HU P9900905A2 HU 9900905 A HU9900905 A HU 9900905A HU P9900905 A HUP9900905 A HU P9900905A HU P9900905 A2 HUP9900905 A2 HU P9900905A2
Authority
HU
Hungary
Prior art keywords
general formula
cancer
vitamin
derivatives
treating cancer
Prior art date
Application number
HU9900905A
Other languages
English (en)
Inventor
Charles W. Bishop
Joyce C. Knutson
Original Assignee
Bone Care International, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bone Care International, Inc. filed Critical Bone Care International, Inc.
Publication of HUP9900905A2 publication Critical patent/HUP9900905A2/hu
Publication of HUP9900905A3 publication Critical patent/HUP9900905A3/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/606Nucleosides; Nucleotides; Nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5929,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/21Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a non-condensed ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A találmány tárgyát az (I) általánős képletű vegyületek alkalmazásaképezi őlyan gyógyászati készítmények előállítására, amelyekalkalmasak hűmán rákős sejtek túlbűrjánzó aktivitásának gátlására. Az(I) általánős képletben R1 jelentése hidrőgénatőm vagyhidrőxilcsőpőrt, és R2 jelentése hidrőgénatőm vagy hidrőxilcsőpőrt. Az(I) általánős képletű vegyületek közül előnyös az 1,24-dihidrőxi-D4-vitamin, különösen előnyös az (S) alaktól lényegében mentes 1a,24(R)-dihidrőxi-D4-vitamin. A találmány tárgyát képezik az (I) általánősképletű gyógyászati készítmények is, amelyek a hűmán rákős sejtektúlbűrjánzását gátőlják, és így elsősőrban a bőrrák, mellrák ésvégbélrák kezelésére alkalmasak. ŕ
HU9900905A 1995-06-07 1996-06-06 Use of vitamin d4 derivatives for treating cancer HUP9900905A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/486,387 US5798345A (en) 1990-09-21 1995-06-07 Method of inhibiting the hyperproliferation of malignant cells

Publications (2)

Publication Number Publication Date
HUP9900905A2 true HUP9900905A2 (hu) 1999-08-30
HUP9900905A3 HUP9900905A3 (en) 2000-03-28

Family

ID=23931691

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900905A HUP9900905A3 (en) 1995-06-07 1996-06-06 Use of vitamin d4 derivatives for treating cancer

Country Status (11)

Country Link
US (1) US5798345A (hu)
EP (1) EP0831839A1 (hu)
JP (1) JPH11506791A (hu)
KR (1) KR19990022320A (hu)
CN (1) CN1186435A (hu)
AU (1) AU718625B2 (hu)
BR (1) BR9608488A (hu)
CA (1) CA2222593A1 (hu)
HU (1) HUP9900905A3 (hu)
PL (1) PL323866A1 (hu)
WO (1) WO1996040153A1 (hu)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
US5763429A (en) * 1993-09-10 1998-06-09 Bone Care International, Inc. Method of treating prostatic diseases using active vitamin D analogues
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) * 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en) * 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US6929797B2 (en) 1997-02-13 2005-08-16 Bone Care International, Inc. Targeted therapeutic delivery of vitamin D compounds
AUPO727097A0 (en) * 1997-06-10 1997-07-03 Unisearch Limited Method of treatment of hepatoma and pharmaceutical compositions for use therein
US6605599B1 (en) * 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
AU762481C (en) * 1998-03-27 2004-08-19 Oregon Health Sciences University Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders
AU765846B2 (en) * 1998-05-04 2003-10-02 Mrc Holdings Pty Limited Pharmaceutical composition
AUPP332898A0 (en) * 1998-05-04 1998-05-28 Unisearch Limited Pharmaceutical composition
US7943182B2 (en) * 2004-05-03 2011-05-17 Timothy Heeg Berry oils and products
US6391345B1 (en) * 2000-05-12 2002-05-21 Tim Heeg Cranberry seed oil, cranberry seed flour and a method for making
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
CN109843378B (zh) 2016-05-26 2022-06-10 匹兹堡大学联邦高等教育系统 用于治疗肺血管疾病的组合物和方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR877356A (fr) * 1940-12-03 1942-12-04 Eberspaecher J Dispositif utilisable à bord des avions pour le chauffage, l'atténuation des flammes et l'utilisation de la réaction
US2383446A (en) * 1941-06-04 1945-08-28 Du Pont Antirachitic materials and processes for their production
US3697559A (en) * 1971-02-25 1972-10-10 Wisconsin Alumni Res Found 1,25-dihydroxycholecalciferol
US3741996A (en) * 1971-12-02 1973-06-26 Wisconsin Alumni Res Found 1{60 -hydroxycholecalciferol
US4202829A (en) * 1978-01-05 1980-05-13 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4260549A (en) * 1979-05-21 1981-04-07 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4362710A (en) * 1980-07-04 1982-12-07 Nissan Gosei Kogyo Co., Ltd. Feeds for baby pigs, process for preparing the same and method of breeding baby pigs
US4689180A (en) * 1984-01-30 1987-08-25 Wisconsin Alumni Research Foundation 1α,25-dihydroxy-22Z-dehydroxyvitamin D compound
US4555364A (en) * 1984-11-01 1985-11-26 Wisconsin Alumni Research Foundation Method for preparing 1-hydroxyvitamin D compounds
US4661294A (en) * 1985-03-18 1987-04-28 The General Hospital Corporation Biologically active 1-thio derivatives of vitamin D
JPH07100685B2 (ja) * 1985-08-02 1995-11-01 レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ/エス(レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ) 新規ビタミンd類似体
JP2550391B2 (ja) * 1988-06-30 1996-11-06 日清製粉株式会社 1β−ヒドロキシビタミンD▲下2▼およびD▲下3▼の製造方法
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
JP2645130B2 (ja) * 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
WO1992005130A1 (en) * 1990-09-21 1992-04-02 Lunar Corporation NOVEL 1α-HYDROXY VITAMIN D4 AND NOVEL INTERMEDIATES AND ANALOGUES
EP0562497A1 (en) * 1992-03-27 1993-09-29 Nisshin Flour Milling Co., Ltd. 1 alpha-hydroxy vitamins D7 and D4' processes for the preparation thereof and pharmaceutical compositions

Also Published As

Publication number Publication date
AU718625B2 (en) 2000-04-20
WO1996040153A1 (en) 1996-12-19
KR19990022320A (ko) 1999-03-25
CN1186435A (zh) 1998-07-01
MX9709683A (es) 1998-06-28
HUP9900905A3 (en) 2000-03-28
AU6379196A (en) 1996-12-30
BR9608488A (pt) 1999-11-30
PL323866A1 (en) 1998-04-27
JPH11506791A (ja) 1999-06-15
US5798345A (en) 1998-08-25
EP0831839A1 (en) 1998-04-01
CA2222593A1 (en) 1996-12-19

Similar Documents

Publication Publication Date Title
HUP9900905A2 (hu) D4-Vitamin származékok alkalmazása rák kezelésére szolgáló gyógyászati készítmények előállítására
IL107109A0 (en) Compounds for modifying drug resistance and pharmaceutical compositions containing the same
MX9703621A (es) Nuevos derivados aminoacidos con actividad mejorada para la resistencia a drogas multiples.
HUP0000558A2 (hu) Aktív D-vitamin analógok alkalmazása prosztatabetegségek kezelésére szolgáló gyógyszerkészítmények előállítására
EP1138673A3 (en) Novel carbamates and ureas as modifiers of multi-drug resistance
MY121548A (en) Compounds and methods for the treatment of cancer
CA2337205A1 (en) Treatment of skin disorders
PL323798A1 (en) Application of derivatives of vitamin d4 in treating skin diseases
NZ308789A (en) Tetralin derivatives and medicaments
ATE358668T1 (de) Drogen zur behandlung maligner tumoren
TR200001147T2 (tr) Kanser ve makular dejenerasyonun tedavisi için makrolidlerin kullanımı
ATE262515T1 (de) Discodermolide verbindungen und deren pharmazeutische zusammensetzungen zur krebstherapie
AU1958195A (en) Hygienic and cosmetic preparations for preventing and treating skin-diseases as well as a process for obtaining same
DK0651636T3 (da) Kemoterapi for cancer
HUP9900186A2 (hu) Lamellarin alkaloidok gyógyászati alkalmazása és az ezeket tartalmazó gyógyszerkészítmények
ES2134778T3 (es) Bistriazenos como agentes quimioterapeuticos.
TR199900662T2 (xx) 1-Hidroksi-2-piridonlar�n seborik dermatit tedavisi amac�yla kullan�m�
MX9805065A (es) Nuevos derivados bi-aromaticos del dibenzofurano y su utilizacion en medicina humana o veterinaria asi como en cosmetica.
NZ331165A (en) Verotoxin pharmaceutical compositions and medical treatments therewith
MX9702671A (es) Derivados metalocenicos de diariletileno, metodos de preparacion y composiciones farmaceuticas que contienen estos derivados.
FI913531A0 (fi) Anvaendning av 1,2-bensopyronderivater till behandling av maligna tumoerer hos maenniskan.
RS20050793A (sr) 8beta-vinil-11beta-(omega- supstituisani)alkil-estra-1,3,5 (10)- trieni
UA31283A (uk) Спосіб вилучення пухлини зорового нерву орбітальної локалізації
ES2106858T3 (es) Nuevos derivados de la citarabina, su procedimiento de preparacion y su uso contra enfermedades cancerosas.