IL127771A0 - Non-aqueous polar aprotic peptide formualtions - Google Patents

Non-aqueous polar aprotic peptide formualtions

Info

Publication number
IL127771A0
IL127771A0 IL12777197A IL12777197A IL127771A0 IL 127771 A0 IL127771 A0 IL 127771A0 IL 12777197 A IL12777197 A IL 12777197A IL 12777197 A IL12777197 A IL 12777197A IL 127771 A0 IL127771 A0 IL 127771A0
Authority
IL
Israel
Prior art keywords
formualtions
polar aprotic
aqueous polar
peptide
aprotic peptide
Prior art date
Application number
IL12777197A
Other languages
English (en)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21810971&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL127771(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Publication of IL127771A0 publication Critical patent/IL127771A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/23Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
IL12777197A 1996-07-03 1997-07-01 Non-aqueous polar aprotic peptide formualtions IL127771A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2269996P 1996-07-03 1996-07-03
PCT/US1997/011450 WO1998000158A1 (en) 1996-07-03 1997-07-01 Non-aqueous polar aprotic peptide formulations

Publications (1)

Publication Number Publication Date
IL127771A0 true IL127771A0 (en) 1999-10-28

Family

ID=21810971

Family Applications (3)

Application Number Title Priority Date Filing Date
IL12777197A IL127771A0 (en) 1996-07-03 1997-07-01 Non-aqueous polar aprotic peptide formualtions
IL170958A IL170958A (en) 1996-07-03 2005-09-19 Stable non-proteinaceous polar aphrotic preparations of peptides
IL178824A IL178824A (en) 1996-07-03 2006-10-23 Stable peptide non-aqueous polar erotic preparation

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL170958A IL170958A (en) 1996-07-03 2005-09-19 Stable non-proteinaceous polar aphrotic preparations of peptides
IL178824A IL178824A (en) 1996-07-03 2006-10-23 Stable peptide non-aqueous polar erotic preparation

Country Status (29)

Country Link
US (3) US5932547A (hu)
EP (2) EP0921808B1 (hu)
JP (2) JP2000515131A (hu)
CN (4) CN102512658A (hu)
AR (1) AR007714A1 (hu)
AT (2) ATE224199T1 (hu)
AU (1) AU739169B2 (hu)
BR (1) BR9710132A (hu)
CA (1) CA2259557A1 (hu)
CO (1) CO4870762A1 (hu)
CY (1) CY2486B1 (hu)
CZ (2) CZ300378B6 (hu)
DE (2) DE69715639T2 (hu)
DK (2) DK0921808T3 (hu)
ES (2) ES2215967T3 (hu)
HU (1) HUP9904270A3 (hu)
ID (2) ID28822A (hu)
IL (3) IL127771A0 (hu)
MY (1) MY128850A (hu)
NO (2) NO322514B1 (hu)
NZ (1) NZ333294A (hu)
PL (1) PL189015B1 (hu)
PT (2) PT921808E (hu)
RO (1) RO119863B1 (hu)
RU (1) RU2203084C2 (hu)
SK (1) SK283926B6 (hu)
TW (1) TW584562B (hu)
WO (1) WO1998000158A1 (hu)
ZA (1) ZA975941B (hu)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) * 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
WO2001078683A2 (en) 2000-04-19 2001-10-25 Genentech, Inc. Sustained release formulations comprising growth hormone
US8470359B2 (en) 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
AU2002242231B2 (en) * 2001-02-23 2007-09-06 Genentech, Inc. Erodible polymers for injection
PT1397155E (pt) * 2001-06-21 2015-12-07 Genentech Inc Formulação de libertação sustentada
ES2545090T3 (es) 2001-12-21 2015-09-08 Human Genome Sciences, Inc. Proteínas de fusión de albúmina y GCSF
CA2472956A1 (en) * 2002-02-14 2003-08-21 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
CA2489325C (en) * 2002-06-17 2010-08-10 Alza Corporation Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle
EP1578398A2 (en) * 2002-12-19 2005-09-28 ALZA Corporation Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
US8110209B2 (en) 2002-12-20 2012-02-07 Xeris Pharmaceuticals Inc. Intracutaneous injection
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CL2004000697A1 (es) * 2003-03-31 2005-05-20 Alza Corp Dispositivo de administracion osmotica que comprende: un reservorio, una composicion osmotica, la formulacion de la droga, y una membrana precargada que comprende un material semipermeable y un material liquido de relleno seleccionado de un polietile
CL2004000696A1 (es) * 2003-03-31 2005-05-20 Alza Corp Bomba osmotica, esta formada por una cubierta cilindrica con una camara que recibe al agente osmotico, un extremo abierto que recibe un tapon semipermeable y un orificio de ventilacion en la pared lateral ubicado proximo al extremo abierto, para disi
CA2523432C (en) * 2003-04-25 2014-10-28 Microchips, Inc. Solid drug formulation and device for storage and controlled delivery thereof
WO2005000222A2 (en) * 2003-05-30 2005-01-06 Amylin Pharmaceuticals, Inc. Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins
JP2007509703A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン 自己保持性、迅速スタート膜プラグを有する浸透式ポンプ
MXPA06003065A (es) * 2003-11-06 2006-05-31 Alza Corp Reductor de velocidad de imbibicion modular para uso con bomba osmotica implantable.
FI116942B (fi) * 2004-05-10 2006-04-13 Biohit Oyj Proteiini- ja peptidistabilointi
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US20060039949A1 (en) * 2004-08-20 2006-02-23 Nycz Jeffrey H Acetabular cup with controlled release of an osteoinductive formulation
US20060045902A1 (en) * 2004-09-01 2006-03-02 Serbousek Jon C Polymeric wrap for in vivo delivery of osteoinductive formulations
US20060057184A1 (en) * 2004-09-16 2006-03-16 Nycz Jeffrey H Process to treat avascular necrosis (AVN) with osteoinductive materials
US8137664B2 (en) * 2005-02-02 2012-03-20 Sdgi Holdings, Inc. Method and kit for repairing a defect in bone
CA2596966A1 (en) * 2005-02-03 2006-08-10 Intarcia Therapeutics, Inc. Implantable osmotic device for continuous delivery of suspension formulations
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) * 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
CN101193652B (zh) * 2005-04-08 2011-11-02 安米林药品公司 包含肠降血糖素肽和非质子极性溶剂的药物制剂
US20070015689A1 (en) * 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
CN101511170B (zh) * 2005-12-22 2014-03-26 奥克伍德药业有限公司 可升华持续释放传递系统和其制造方法
EP2007397B1 (en) * 2006-04-07 2013-07-24 Merrion Research III Limited Solid oral dosage form containing an enhancer
AU2007266475B2 (en) 2006-05-30 2009-12-03 Intarcia Therapeutics, Inc. Two-piece, internal-channel osmotic delivery system flow modulator
WO2007146234A2 (en) * 2006-06-09 2007-12-21 Merrion Research Ii Limited Solid oral dosage form containing an enhancer
DK2049081T3 (da) * 2006-08-09 2013-02-25 Intarcia Therapeutics Inc Osmotiske leveringssystemer og stempelarrangementer
PT2157967E (pt) * 2007-04-23 2013-04-03 Intarcia Therapeutics Inc Formulações de suspensões de péptidos insulinotrópicos e suas utilizações
CA2691531C (en) 2007-06-22 2016-11-01 Board Of Regents,The University Of Texas System Formation of stable submicron peptide or protein particles by thin film freezing
WO2009046846A2 (en) * 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Use of il-1 receptor peptide, alone or in combination with peptide ll-37, as a therapeutic agent
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
TW200950799A (en) * 2008-05-07 2009-12-16 Merrion Res Iii Ltd Compositions of GnRH related compounds and processes of preparation
WO2010009291A1 (en) * 2008-07-16 2010-01-21 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles containing bioactive peptides
PE20151205A1 (es) 2008-08-15 2015-08-31 Ironwood Pharmaceuticals Inc Formulaciones que contienen linaclotida para administracion oral
EP2161030A1 (en) * 2008-09-09 2010-03-10 Rijksuniversiteit te Groningen Oxytocin formulations and uses thereof
CN106880596A (zh) * 2008-10-15 2017-06-23 精达制药公司 高浓缩药物颗粒、制剂、混悬剂及其应用
WO2010056657A2 (en) 2008-11-16 2010-05-20 Board Of Regents, The Univesity Of Texas System Low viscosity highly concentrated suspensions
US20100215743A1 (en) * 2009-02-25 2010-08-26 Leonard Thomas W Composition and drug delivery of bisphosphonates
WO2011017502A2 (en) 2009-08-06 2011-02-10 Ironwood Pharmaceuticals, Inc. Linaclotide-containing formulations for oral administration
KR102148624B1 (ko) 2009-09-28 2020-08-26 인타르시아 세라퓨틱스 인코포레이티드 실질 항정상태 약물 전달의 신속 확립 및/또는 종결
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
UA108636C2 (xx) 2010-02-17 2015-05-25 Пептид
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
US20120046225A1 (en) 2010-07-19 2012-02-23 The Regents Of The University Of Colorado, A Body Corporate Stable glucagon formulations for the treatment of hypoglycemia
EP3626253B8 (en) 2010-08-11 2022-04-20 Ironwood Pharmaceuticals, Inc. Stable formulations of linaclotide
CA2819234A1 (en) 2011-01-07 2012-07-12 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CA2829400C (en) * 2011-03-10 2022-02-15 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of peptide drugs
PL2776055T3 (pl) 2011-08-17 2017-06-30 Ironwood Pharmaceuticals, Inc. Sposoby leczenia zaburzeń żołądkowo-jelitowych
JP6117811B2 (ja) 2011-10-31 2017-04-19 ゼリス ファーマシューティカルズ インコーポレイテッド 糖尿病を処置するための製剤
US9207513B2 (en) 2012-04-10 2015-12-08 The Regents Of The University Of California Nanocrystal-polymer nanocomposite electrochromic device
US9125805B2 (en) 2012-06-27 2015-09-08 Xeris Pharmaceuticals, Inc. Stable formulations for parenteral injection of small molecule drugs
US9018162B2 (en) 2013-02-06 2015-04-28 Xeris Pharmaceuticals, Inc. Methods for rapidly treating severe hypoglycemia
DK3102184T3 (da) * 2014-02-06 2019-05-06 Xeris Pharmaceuticals Inc Stabile formuleringer af peptider og fremgangsmåder til fremstilling
EP3871709A1 (en) 2014-08-06 2021-09-01 Xeris Pharmaceuticals, Inc. Syringes, kits, and methods for intracutaneous and/or subcutaneous injection of pastes
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
KR20240042548A (ko) 2015-06-03 2024-04-02 인타르시아 세라퓨틱스 인코포레이티드 임플란트 배치 및 제거 시스템들
US9649364B2 (en) 2015-09-25 2017-05-16 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic formulations in aprotic polar solvents
US11590205B2 (en) 2015-09-25 2023-02-28 Xeris Pharmaceuticals, Inc. Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents
CN109310743A (zh) 2016-05-16 2019-02-05 因塔西亚制药公司 胰高血糖素受体选择性多肽及其使用方法
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
KR20190104039A (ko) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법
AU2018275686B2 (en) 2017-06-02 2024-02-01 Xeris Pharmaceuticals, Inc. Precipitation resistant small molecule drug formulations
TWI762706B (zh) 2017-08-24 2022-05-01 丹麥商諾佛 儂迪克股份有限公司 Glp-1組成物及其用途
BR112022013795A2 (pt) 2020-02-18 2022-09-13 Novo Nordisk As Composição farmacêutica líquida, e, kit

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL22493A (en) * 1963-12-09 1968-10-24 Crown Zellerbach Corp Membrane penetrant composition containing a dialkyl sulfoxide
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
GB2008403B (en) * 1977-11-04 1982-07-28 Christie R B Parsons J A Pharmaceutical compositions
GB2119248A (en) * 1982-04-28 1983-11-16 John Kenneth Mcmullen Insulin formulations and method of producing them
US4547370A (en) * 1983-11-29 1985-10-15 The Salk Institute For Biological Studies GnRH Antagonists
US4661472A (en) * 1985-05-09 1987-04-28 The Salk Institute For Biological Studies GnRH antagonists IX
US4897256A (en) * 1986-11-25 1990-01-30 Abbott Laboratories LHRH analog formulations
US4851385A (en) * 1987-07-15 1989-07-25 Indiana University Foundation LHRH antagonist analogs having low histamine-release activity
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
EP0312052B1 (en) * 1987-10-15 1994-01-05 Syntex (U.S.A.) Inc. Intranasal administration of polypeptides in powdered form
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5110596A (en) * 1988-12-13 1992-05-05 Alza Corporation Delivery system comprising means for delivering agent to livestock
DE4117507A1 (de) * 1991-05-24 1992-11-26 Schering Ag Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
DK0661989T3 (da) * 1992-09-21 1998-03-02 Upjohn Co Proteinsammensætninger med vedvarende frigivelse
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
ATE197550T1 (de) * 1993-02-23 2000-12-15 Genentech Inc Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff
DE4320201A1 (de) * 1993-06-18 1995-01-12 Asta Medica Ag Verwendung von Cetrorelix und weiteren Nona- und Dekapeptiden zur Herstellung eines Arzneimittels zur Bekämpfung von Aids und zur Wachstumsstimulation
US5413990A (en) * 1993-08-06 1995-05-09 Tap Pharmaceuticals Inc. N-terminus modified analogs of LHRH
PT1238660E (pt) * 1996-02-02 2005-10-31 Alza Corp Distribuicao sustentada de um agente activo utilizando um sistema implantavel
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations

Also Published As

Publication number Publication date
ATE224199T1 (de) 2002-10-15
AR007714A1 (es) 1999-11-10
CN1636589A (zh) 2005-07-13
NO322514B1 (no) 2006-10-16
CY2486B1 (en) 2005-06-03
US6124261A (en) 2000-09-26
DE69728582D1 (de) 2004-05-13
HUP9904270A2 (hu) 2000-05-28
CN102512658A (zh) 2012-06-27
EP1208846A3 (en) 2003-04-16
DE69715639D1 (de) 2002-10-24
BR9710132A (pt) 1999-08-10
AU739169B2 (en) 2001-10-04
PT1208846E (pt) 2004-06-30
WO1998000158A1 (en) 1998-01-08
NO986207L (no) 1999-03-03
ES2181010T3 (es) 2003-02-16
JP2009073852A (ja) 2009-04-09
ATE263570T1 (de) 2004-04-15
ES2215967T3 (es) 2004-10-16
HUP9904270A3 (en) 2001-08-28
JP2000515131A (ja) 2000-11-14
CZ300378B6 (cs) 2009-05-06
CZ434098A3 (cs) 1999-04-14
CO4870762A1 (es) 1999-12-27
CN101239179A (zh) 2008-08-13
RO119863B1 (ro) 2005-05-30
TW584562B (en) 2004-04-21
ID19718A (id) 1998-07-30
NZ333294A (en) 2000-05-26
CA2259557A1 (en) 1998-01-08
CN101116742A (zh) 2008-02-06
DE69715639T2 (de) 2003-02-06
CZ299464B6 (cs) 2008-08-06
PL330927A1 (en) 1999-06-07
ID28822A (id) 1998-01-08
EP0921808B1 (en) 2002-09-18
US6235712B1 (en) 2001-05-22
AU3587997A (en) 1998-01-21
DE69728582T2 (de) 2004-08-19
DK0921808T3 (da) 2003-01-27
EP1208846A2 (en) 2002-05-29
DK1208846T3 (da) 2004-08-02
RU2203084C2 (ru) 2003-04-27
EP1208846B1 (en) 2004-04-07
SK283926B6 (sk) 2004-05-04
MY128850A (en) 2007-02-28
NO20063870L (no) 1999-03-03
SK179798A3 (en) 1999-05-07
PL189015B1 (pl) 2005-06-30
IL178824A0 (en) 2007-03-08
IL170958A (en) 2009-11-18
IL178824A (en) 2011-08-31
US5932547A (en) 1999-08-03
PT921808E (pt) 2003-01-31
EP0921808A1 (en) 1999-06-16
ZA975941B (en) 1998-04-16
NO986207D0 (no) 1998-12-30

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