IL127711A - Device for intracellular transfer of active components by ion binding - Google Patents
Device for intracellular transfer of active components by ion bindingInfo
- Publication number
- IL127711A IL127711A IL12771198A IL12771198A IL127711A IL 127711 A IL127711 A IL 127711A IL 12771198 A IL12771198 A IL 12771198A IL 12771198 A IL12771198 A IL 12771198A IL 127711 A IL127711 A IL 127711A
- Authority
- IL
- Israel
- Prior art keywords
- reservoir
- active
- electrode
- annular
- active product
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9800009A FR2773320B1 (fr) | 1998-01-05 | 1998-01-05 | Dispositif pour le transfert intraoculaire de produits actifs par iontophorese |
Publications (2)
Publication Number | Publication Date |
---|---|
IL127711A0 IL127711A0 (en) | 1999-10-28 |
IL127711A true IL127711A (en) | 2004-06-20 |
Family
ID=9521510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL12771198A IL127711A (en) | 1998-01-05 | 1998-12-23 | Device for intracellular transfer of active components by ion binding |
Country Status (13)
Country | Link |
---|---|
US (1) | US6154671A (de) |
EP (2) | EP0927560B1 (de) |
JP (1) | JP4308353B2 (de) |
KR (1) | KR100551706B1 (de) |
AT (2) | ATE437672T1 (de) |
BR (1) | BR9900009A (de) |
CA (1) | CA2257749C (de) |
DE (2) | DE69841028D1 (de) |
DK (1) | DK0927560T3 (de) |
ES (2) | ES2327636T3 (de) |
FR (1) | FR2773320B1 (de) |
IL (1) | IL127711A (de) |
PT (1) | PT927560E (de) |
Families Citing this family (80)
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US6101411A (en) * | 1998-09-24 | 2000-08-08 | Newsome; David A. | Dilation enhancer |
US7346389B1 (en) * | 1998-09-24 | 2008-03-18 | Newsome David A | Dilation enhancer with pre-medicated contact lenses |
US6319240B1 (en) * | 1999-05-25 | 2001-11-20 | Iomed, Inc. | Methods and apparatus for ocular iontophoresis |
US6728573B1 (en) | 2000-02-23 | 2004-04-27 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US7252655B2 (en) | 1999-05-25 | 2007-08-07 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US6539251B2 (en) | 1999-05-25 | 2003-03-25 | Iomed, Inc. | Ocular iontophoretic apparatus |
US6546283B1 (en) | 2000-10-18 | 2003-04-08 | Iomed, Inc. | High current density iontophoretic device and method of use thereof |
US20030045830A1 (en) * | 2001-04-17 | 2003-03-06 | De Bizemont Therese | Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis |
US20040106965A1 (en) * | 2001-06-29 | 2004-06-03 | Chow Alan Y. | Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation |
US20050004625A1 (en) * | 2001-06-29 | 2005-01-06 | Chow Alan Y. | Treatment of degenerative retinal disease via electrical stimulation of surface structures |
US7031776B2 (en) * | 2001-06-29 | 2006-04-18 | Optobionics | Methods for improving damaged retinal cell function |
US20050033202A1 (en) * | 2001-06-29 | 2005-02-10 | Chow Alan Y. | Mechanically activated objects for treatment of degenerative retinal disease |
EP1418919A4 (de) * | 2001-07-20 | 2007-06-13 | Iomed Inc | Verwendung von 5-fluorouracil, verabreicht durch inotophorese, als hemmer der zellproliferation im auge, der bulbären und palpebralen konjunktiva, dem augenlid, dem periorbitalen geweben und der haut |
WO2003007961A1 (en) * | 2001-07-20 | 2003-01-30 | Iomed, Inc. | Methods for treating neoplastic, angiogenic, fibroplastic, and/or immunosuppresive ocular irregularities via administration of methotrexate based medicaments, and ocular iontophoretic devices for delivering methotrexate based medicaments |
FR2830766B1 (fr) | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
FR2830767B1 (fr) * | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire |
FR2836832B1 (fr) | 2002-03-08 | 2005-02-04 | Optis France Sa | Ensemble de connexion a usage medical pour le transfert de fluides |
CA2484512C (en) | 2002-05-17 | 2013-04-16 | Othera Pharmaceuticals, Inc. | Treatment of cataracts and other ophthalmic diseases |
FR2851912B1 (fr) | 2003-03-03 | 2005-05-13 | Optis France Sa | Connecteur d'alimentation uniforme pour des dispositifs de delivrance de principes actifs |
US7825134B2 (en) * | 2003-05-19 | 2010-11-02 | Othera Holding, Inc. | Amelioration of cataracts, macular degeneration and other ophthalmic diseases |
US7589107B2 (en) | 2003-05-19 | 2009-09-15 | Othera Holding, Inc. | Amelioration of vitrectomy-induced cataracts |
FR2855761B1 (fr) * | 2003-06-03 | 2006-02-24 | Optis France Sa | Dispositif oculaire de delivrance variable de principes actifs par iontophorese |
ZA200604403B (en) * | 2003-11-20 | 2007-09-26 | Othera Pharmaceuticals Inc | Amelioration of macular degeneration and other ophthalmic diseases |
CA2556222C (en) * | 2004-02-06 | 2014-01-28 | Scyfix Llc | Treatment of vision disorders using electrical, light, and/or sound energy |
AU2005247122C1 (en) | 2004-04-30 | 2012-02-02 | Eyegate Pharma S.A. | Irritation-reducing ocular iontophoretic device |
FR2869531B1 (fr) | 2004-04-30 | 2006-07-14 | Optis France Sa Sa | Dispositif de iontophorese oculaire diminuant les irritations |
BRPI0511462A (pt) * | 2004-05-25 | 2007-12-26 | Othera Pharmaceuticals Inc | medicamentos e pró-medicamentos óculo-seletivos |
US20060089590A1 (en) * | 2004-10-27 | 2006-04-27 | John Higuchi | Methods and devices for sustained in-vivo release of an active agent |
US8262715B2 (en) * | 2004-11-23 | 2012-09-11 | Eye Delivery System, Llc | Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy |
EP1816980B1 (de) * | 2004-11-23 | 2011-03-16 | Edward Wong | Medizinische vorrichtung zur temperaturregelung und behandlung des auges sowie des umgebenden gewebes |
US20070282282A1 (en) * | 2004-11-23 | 2007-12-06 | Wong Edward K Jr | Medical device and method for temperature control and treatment of the eye and surrounding tissues |
WO2006072887A1 (en) * | 2005-01-05 | 2006-07-13 | Eyegate Pharma Sa | Ocular iontophoresis device for delivering sirna and aptamers |
EP1871890B1 (de) * | 2005-04-18 | 2011-06-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren und vorrichtungen zur abgabe eines therapeutischen produkts an den augapfel eines patienten |
US20080312283A1 (en) * | 2005-05-26 | 2008-12-18 | Othera Pharmaceuticals, Inc. | Use of Hydroxylamine Derivates for Inhibiting Vitrectomy-Induced Cataracts |
US20070260171A1 (en) * | 2005-09-27 | 2007-11-08 | Higuchi John W | Intraocular iontophoretic device and associated methods |
US8755880B2 (en) * | 2005-10-24 | 2014-06-17 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
EP1940507A4 (de) * | 2005-10-24 | 2011-04-20 | Aciont Inc | Intraokulare iontophoretische vorrichtung und relevante verfahren |
US8634907B2 (en) | 2005-10-24 | 2014-01-21 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
US8099162B2 (en) | 2005-11-29 | 2012-01-17 | Eyegate Pharma, S.A.S. | Ocular iontophoresis device |
FR2893852B1 (fr) * | 2005-11-29 | 2010-09-03 | Eyegate Pharma Sa | Dispositif d'iontophorese oculaire |
US20070203190A1 (en) * | 2006-02-22 | 2007-08-30 | Ghanshyam Patil | Hydroxylamines and derivatives for the inhibition of complement activation |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
JPWO2007123142A1 (ja) * | 2006-04-20 | 2009-09-03 | Tti・エルビュー株式会社 | イオントフォレーシス装置 |
US20070299386A1 (en) * | 2006-06-23 | 2007-12-27 | Minu, L.L.C. | Delivery of an ocular agent using iontophoresis |
WO2008013913A2 (en) * | 2006-07-26 | 2008-01-31 | Aciont, Inc. | Method and device for minimally invasive site specific ocular drug delivery |
US8923961B2 (en) | 2006-10-18 | 2014-12-30 | The Cleveland Clinic Foundation | Electrode assembly for delivering a therapeutic agent into ocular tissue |
CN105998028A (zh) | 2007-02-22 | 2016-10-12 | 科尔比制药公司 | 羟胺化合物及其用法 |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
US8480638B2 (en) * | 2007-10-04 | 2013-07-09 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
MX2010006019A (es) * | 2007-12-05 | 2010-08-04 | Eyegate Pharma S A S | Metodos para administrar acido ribonucleico pequeño de interferencia (arnsi) mediante iontoforesis. |
BRPI0908229A8 (pt) | 2008-02-25 | 2017-10-10 | Eyegate Pharma S A S | Uso de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste, kit e dispositivo para dispensar iontoforeticamente um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente para tratar um distúrbio ocular mediado por inflamação no referido paciente, e, formulação apropriada para dispensação iontoforética ocular de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente |
FR2928536B1 (fr) | 2008-03-14 | 2012-04-27 | Inst Nat Sante Rech Med | Dispositif d'injection dans l'oeil |
US9180292B2 (en) | 2008-12-31 | 2015-11-10 | Eyegate Pharmaceuticals, Inc. | System and method for ocular iontophoresis with buffering |
WO2010093873A2 (en) | 2009-02-12 | 2010-08-19 | Incept, Llc | Drug delivery through hydrogel plugs |
EP2555751B8 (de) | 2010-04-03 | 2018-02-14 | Praful Doshi | Verfahren zum beschichtigen von einer kontaktlinse |
US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
US8993626B2 (en) | 2010-06-25 | 2015-03-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of treatment using sterculic acid |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
MX347934B (es) | 2011-01-12 | 2017-05-18 | Sooft Italia Spa | Dispositivo y método para el suministro de riboflavina en la córnea, mediante iontoforesis, para el tratamiento de queratocono. |
WO2012162459A1 (en) * | 2011-05-26 | 2012-11-29 | Pepose Jay | Device and method for administering eye medications |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
CA2858161C (en) | 2011-12-05 | 2020-03-10 | Incept, Llc | Medical organogel processes and compositions |
EP2968613B1 (de) | 2013-03-11 | 2019-09-11 | University of Florida Research Foundation, Inc. | Freisetzung von card-protein zur behandlung von augenentzündungen |
CA3121759C (en) | 2013-05-03 | 2024-01-02 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
ITVE20130043A1 (it) * | 2013-07-31 | 2015-02-01 | I A C E R S R L | Dispositivo perfezionato oftalmologico per il trattamento di malattie corneali quali il cheratocono. |
ES2672327T3 (es) * | 2014-01-27 | 2018-06-13 | Opia Technologies | Dispositivo de iontoforesis ocular |
JP5828535B1 (ja) * | 2014-10-10 | 2015-12-09 | 石根 三井 | 矯正角膜クロスリンキング用コンタクトレンズ |
CN104353183B (zh) * | 2014-10-31 | 2016-12-07 | 厦门微科格瑞生物科技有限公司 | 电解液位置固定的可佩戴智能药物导入结构 |
MX2017009193A (es) | 2015-01-22 | 2017-12-12 | Eyegate Pharmaceuticals Inc | Lente de contacto iontoforetica. |
US10206814B2 (en) * | 2016-01-06 | 2019-02-19 | David R. Hardten | System and method for the delivery of medications or fluids to the eye |
WO2017192565A1 (en) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
JP2020513983A (ja) | 2017-03-23 | 2020-05-21 | ドヘニー アイ インスティテュート | 光干渉断層撮影の多重en−face血管造影平均化システム、方法および装置 |
US11338139B2 (en) | 2018-10-01 | 2022-05-24 | Biovisics Medical, Inc. | System and methods for controlled electrical modulation for vision therapy |
EP3886974A2 (de) | 2018-11-30 | 2021-10-06 | Biovisics Medical, Inc. | Kopfgetragene vorrichtungen für die sichttherapie |
JP7465271B2 (ja) | 2019-01-09 | 2024-04-10 | トゥウェンティ トゥウェンティ セラピューティクス エルエルシー | 治療剤放出のための眼球装着装置 |
US11464674B2 (en) | 2019-01-09 | 2022-10-11 | Twenty Twenty Therapeutics Llc | Programmable therapeutic agent delivery from eye mounted device |
WO2020210471A1 (en) | 2019-04-10 | 2020-10-15 | Biovisics Medical, Inc. | Systems and interfaces for ocular therapy |
WO2020252278A1 (en) | 2019-06-14 | 2020-12-17 | Biovisics Medical, Inc. | Wearable medical device |
CN110547907A (zh) * | 2019-08-15 | 2019-12-10 | 中南大学湘雅二医院 | 一种用于眼内手术的双环虹膜扩张器 |
WO2024009535A1 (ja) * | 2022-07-08 | 2024-01-11 | テルモ株式会社 | 眼内薬物投与装置、薬剤リザーバ及び眼内薬物投与装置の動作方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US551880A (en) * | 1895-12-24 | Theodore b | ||
US2525381A (en) * | 1947-09-25 | 1950-10-10 | Tower Paul | Contact-type electrode holder |
US3122137A (en) * | 1961-10-30 | 1964-02-25 | Erlanger Gustav | Device for facilitating iontophoresis treatment of eyes |
SU995783A1 (ru) | 1980-07-21 | 1983-02-15 | Омский Государственный Ордена Трудового Красного Знамени Медицинский Институт Им.М.И.Калинина | Устройство дл электрофореза лекарственных веществ в ткани глаза |
US4678466A (en) * | 1981-06-25 | 1987-07-07 | Rosenwald Peter L | Internal medication delivery method and vehicle |
US4564016A (en) | 1982-05-24 | 1986-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus for introducing ionized drugs into the posterior segment of the eye and method |
US5053000A (en) * | 1985-11-13 | 1991-10-01 | Imperial Chemical Industries Plc | Ocular treatment |
IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
US4955378A (en) * | 1988-05-02 | 1990-09-11 | University Of South Florida | Apparatus and methods for performing electrofusion at specific anatomical sites |
EP0464138A1 (de) * | 1989-03-17 | 1992-01-08 | Candela Laser Corporation | Lasertherapiestrahlgerät für glaukombehandlung |
US5174304A (en) * | 1990-02-16 | 1992-12-29 | Latina Mark A | Electrocycloablation apparatus and method |
US5472436A (en) * | 1994-07-26 | 1995-12-05 | Fremstad; Daria A. | Ocular appliance for delivering medication |
US5522864A (en) * | 1994-10-25 | 1996-06-04 | Wallace; Larry B. | Apparatus and method for ocular treatment |
AUPM982694A0 (en) * | 1994-12-02 | 1995-01-05 | University Of Queensland, The | Iontophoresis method and apparatus |
US5676648A (en) * | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
-
1998
- 1998-01-05 FR FR9800009A patent/FR2773320B1/fr not_active Expired - Lifetime
- 1998-12-17 ES ES04011635T patent/ES2327636T3/es not_active Expired - Lifetime
- 1998-12-17 DE DE69841028T patent/DE69841028D1/de not_active Expired - Lifetime
- 1998-12-17 EP EP98403189A patent/EP0927560B1/de not_active Expired - Lifetime
- 1998-12-17 AT AT04011635T patent/ATE437672T1/de not_active IP Right Cessation
- 1998-12-17 DK DK98403189T patent/DK0927560T3/da active
- 1998-12-17 PT PT98403189T patent/PT927560E/pt unknown
- 1998-12-17 EP EP04011635A patent/EP1452203B1/de not_active Expired - Lifetime
- 1998-12-17 DE DE69829637T patent/DE69829637T2/de not_active Expired - Lifetime
- 1998-12-17 ES ES98403189T patent/ES2236880T3/es not_active Expired - Lifetime
- 1998-12-17 AT AT98403189T patent/ATE292493T1/de not_active IP Right Cessation
- 1998-12-23 IL IL12771198A patent/IL127711A/en not_active IP Right Cessation
- 1998-12-28 KR KR1019980059369A patent/KR100551706B1/ko active IP Right Grant
- 1998-12-28 JP JP37384898A patent/JP4308353B2/ja not_active Expired - Lifetime
-
1999
- 1999-01-04 CA CA002257749A patent/CA2257749C/en not_active Expired - Lifetime
- 1999-01-04 US US09/225,206 patent/US6154671A/en not_active Expired - Lifetime
- 1999-01-04 BR BR9900009-1A patent/BR9900009A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE292493T1 (de) | 2005-04-15 |
BR9900009A (pt) | 2001-03-20 |
CA2257749A1 (en) | 1999-07-05 |
KR19990066875A (ko) | 1999-08-16 |
ATE437672T1 (de) | 2009-08-15 |
CA2257749C (en) | 2009-03-24 |
ES2236880T3 (es) | 2005-07-16 |
IL127711A0 (en) | 1999-10-28 |
JPH11244323A (ja) | 1999-09-14 |
DE69841028D1 (de) | 2009-09-10 |
EP1452203A2 (de) | 2004-09-01 |
DE69829637T2 (de) | 2006-03-09 |
US6154671A (en) | 2000-11-28 |
FR2773320B1 (fr) | 2000-03-03 |
EP0927560B1 (de) | 2005-04-06 |
EP1452203A3 (de) | 2004-09-08 |
ES2327636T3 (es) | 2009-11-02 |
DK0927560T3 (da) | 2005-08-15 |
FR2773320A1 (fr) | 1999-07-09 |
JP4308353B2 (ja) | 2009-08-05 |
EP1452203B1 (de) | 2009-07-29 |
DE69829637D1 (de) | 2005-05-12 |
KR100551706B1 (ko) | 2006-07-06 |
EP0927560A1 (de) | 1999-07-07 |
PT927560E (pt) | 2005-07-29 |
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