ATE437672T1 - Vorrichtung zur okularen iontophorese zur verabreichung mehrerer wirkstoffe - Google Patents
Vorrichtung zur okularen iontophorese zur verabreichung mehrerer wirkstoffeInfo
- Publication number
- ATE437672T1 ATE437672T1 AT04011635T AT04011635T ATE437672T1 AT E437672 T1 ATE437672 T1 AT E437672T1 AT 04011635 T AT04011635 T AT 04011635T AT 04011635 T AT04011635 T AT 04011635T AT E437672 T1 ATE437672 T1 AT E437672T1
- Authority
- AT
- Austria
- Prior art keywords
- occular
- administration
- active ingredients
- reservoir
- iontophoresis device
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmacology & Pharmacy (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9800009A FR2773320B1 (fr) | 1998-01-05 | 1998-01-05 | Dispositif pour le transfert intraoculaire de produits actifs par iontophorese |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE437672T1 true ATE437672T1 (de) | 2009-08-15 |
Family
ID=9521510
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98403189T ATE292493T1 (de) | 1998-01-05 | 1998-12-17 | Vorrichtung zur intraokularen übertragung von aktiven wirkstoffen durch iontophorese |
AT04011635T ATE437672T1 (de) | 1998-01-05 | 1998-12-17 | Vorrichtung zur okularen iontophorese zur verabreichung mehrerer wirkstoffe |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98403189T ATE292493T1 (de) | 1998-01-05 | 1998-12-17 | Vorrichtung zur intraokularen übertragung von aktiven wirkstoffen durch iontophorese |
Country Status (13)
Country | Link |
---|---|
US (1) | US6154671A (de) |
EP (2) | EP0927560B1 (de) |
JP (1) | JP4308353B2 (de) |
KR (1) | KR100551706B1 (de) |
AT (2) | ATE292493T1 (de) |
BR (1) | BR9900009A (de) |
CA (1) | CA2257749C (de) |
DE (2) | DE69841028D1 (de) |
DK (1) | DK0927560T3 (de) |
ES (2) | ES2327636T3 (de) |
FR (1) | FR2773320B1 (de) |
IL (1) | IL127711A (de) |
PT (1) | PT927560E (de) |
Families Citing this family (82)
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---|---|---|---|---|
US6101411A (en) * | 1998-09-24 | 2000-08-08 | Newsome; David A. | Dilation enhancer |
US7346389B1 (en) * | 1998-09-24 | 2008-03-18 | Newsome David A | Dilation enhancer with pre-medicated contact lenses |
US7252655B2 (en) * | 1999-05-25 | 2007-08-07 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US6728573B1 (en) | 2000-02-23 | 2004-04-27 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US6319240B1 (en) * | 1999-05-25 | 2001-11-20 | Iomed, Inc. | Methods and apparatus for ocular iontophoresis |
US6539251B2 (en) | 1999-05-25 | 2003-03-25 | Iomed, Inc. | Ocular iontophoretic apparatus |
US6546283B1 (en) * | 2000-10-18 | 2003-04-08 | Iomed, Inc. | High current density iontophoretic device and method of use thereof |
US20030045830A1 (en) * | 2001-04-17 | 2003-03-06 | De Bizemont Therese | Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis |
US20050004625A1 (en) * | 2001-06-29 | 2005-01-06 | Chow Alan Y. | Treatment of degenerative retinal disease via electrical stimulation of surface structures |
US7031776B2 (en) * | 2001-06-29 | 2006-04-18 | Optobionics | Methods for improving damaged retinal cell function |
US20050033202A1 (en) * | 2001-06-29 | 2005-02-10 | Chow Alan Y. | Mechanically activated objects for treatment of degenerative retinal disease |
US20040106965A1 (en) * | 2001-06-29 | 2004-06-03 | Chow Alan Y. | Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation |
WO2003007961A1 (en) * | 2001-07-20 | 2003-01-30 | Iomed, Inc. | Methods for treating neoplastic, angiogenic, fibroplastic, and/or immunosuppresive ocular irregularities via administration of methotrexate based medicaments, and ocular iontophoretic devices for delivering methotrexate based medicaments |
EP1418919A4 (de) * | 2001-07-20 | 2007-06-13 | Iomed Inc | Verwendung von 5-fluorouracil, verabreicht durch inotophorese, als hemmer der zellproliferation im auge, der bulbären und palpebralen konjunktiva, dem augenlid, dem periorbitalen geweben und der haut |
FR2830766B1 (fr) * | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
FR2830767B1 (fr) * | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire |
FR2836832B1 (fr) | 2002-03-08 | 2005-02-04 | Optis France Sa | Ensemble de connexion a usage medical pour le transfert de fluides |
EP1507826A4 (de) | 2002-05-17 | 2007-11-07 | Othera Pharmaceuticals Inc | Verbesserung der entwicklung von katarakten und anderen augenerkrankungen |
FR2851912B1 (fr) * | 2003-03-03 | 2005-05-13 | Optis France Sa | Connecteur d'alimentation uniforme pour des dispositifs de delivrance de principes actifs |
US7825134B2 (en) * | 2003-05-19 | 2010-11-02 | Othera Holding, Inc. | Amelioration of cataracts, macular degeneration and other ophthalmic diseases |
US7589107B2 (en) | 2003-05-19 | 2009-09-15 | Othera Holding, Inc. | Amelioration of vitrectomy-induced cataracts |
FR2855761B1 (fr) * | 2003-06-03 | 2006-02-24 | Optis France Sa | Dispositif oculaire de delivrance variable de principes actifs par iontophorese |
US20050130906A1 (en) * | 2003-11-20 | 2005-06-16 | Matier William L. | Amelioration of macular degeneration and other ophthalmic diseases |
WO2005077452A1 (en) * | 2004-02-06 | 2005-08-25 | Scyfix Llc | Treatment of vision disorders using electrical, light, and/or sound energy |
EP1758598B1 (de) | 2004-04-30 | 2016-04-13 | Eyegate Pharma SAS | Irritationsvermindernde iontophoresevorrichtung für das auge |
FR2869531B1 (fr) * | 2004-04-30 | 2006-07-14 | Optis France Sa Sa | Dispositif de iontophorese oculaire diminuant les irritations |
US20070254950A1 (en) * | 2004-05-25 | 2007-11-01 | Othera Pharmaceuticals, Inc. | Oculoselective Drugs and Prodrugs |
US8246949B2 (en) * | 2004-10-27 | 2012-08-21 | Aciont, Inc. | Methods and devices for sustained in-vivo release of an active agent |
US20070282282A1 (en) * | 2004-11-23 | 2007-12-06 | Wong Edward K Jr | Medical device and method for temperature control and treatment of the eye and surrounding tissues |
JP2008520397A (ja) * | 2004-11-23 | 2008-06-19 | エドワード・ケイ・ジュニアー・ウォング | 眼及び眼の周囲組織の温度制御及び治療のための医療装置 |
US8262715B2 (en) * | 2004-11-23 | 2012-09-11 | Eye Delivery System, Llc | Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy |
WO2006072887A1 (en) * | 2005-01-05 | 2006-07-13 | Eyegate Pharma Sa | Ocular iontophoresis device for delivering sirna and aptamers |
JP5000638B2 (ja) * | 2005-04-18 | 2012-08-15 | アンスティテュー・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシェルシュ・メディカル・(イ・エヌ・エス・ウ・エール・エム) | 対象の眼球に対して治療用生成物を送達するための改良型方法及び装置 |
US20080312283A1 (en) * | 2005-05-26 | 2008-12-18 | Othera Pharmaceuticals, Inc. | Use of Hydroxylamine Derivates for Inhibiting Vitrectomy-Induced Cataracts |
US8755880B2 (en) * | 2005-10-24 | 2014-06-17 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
US20070260171A1 (en) * | 2005-09-27 | 2007-11-08 | Higuchi John W | Intraocular iontophoretic device and associated methods |
EP1940507A4 (de) * | 2005-10-24 | 2011-04-20 | Aciont Inc | Intraokulare iontophoretische vorrichtung und relevante verfahren |
US8634907B2 (en) | 2005-10-24 | 2014-01-21 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
FR2893852B1 (fr) * | 2005-11-29 | 2010-09-03 | Eyegate Pharma Sa | Dispositif d'iontophorese oculaire |
US8099162B2 (en) * | 2005-11-29 | 2012-01-17 | Eyegate Pharma, S.A.S. | Ocular iontophoresis device |
US20070203190A1 (en) * | 2006-02-22 | 2007-08-30 | Ghanshyam Patil | Hydroxylamines and derivatives for the inhibition of complement activation |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
WO2007123142A1 (ja) * | 2006-04-20 | 2007-11-01 | Tti Ellebeau, Inc. | イオントフォレーシス装置 |
US20070299386A1 (en) * | 2006-06-23 | 2007-12-27 | Minu, L.L.C. | Delivery of an ocular agent using iontophoresis |
US20080027371A1 (en) * | 2006-07-26 | 2008-01-31 | Higuchi John W | Method and device for minimally invasive site specific ocular drug delivery |
US8923961B2 (en) | 2006-10-18 | 2014-12-30 | The Cleveland Clinic Foundation | Electrode assembly for delivering a therapeutic agent into ocular tissue |
EP2125716A2 (de) | 2007-02-22 | 2009-12-02 | Othera Holding, Inc. | Hydroxylaminverbindungen und verfahren zu ihrer verwendung |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
US8480638B2 (en) * | 2007-10-04 | 2013-07-09 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
US20110038937A1 (en) * | 2007-12-05 | 2011-02-17 | Eyegate Pharma S.A.S. | Methods for delivering siRNA via Ionthophoresis |
EP2249921B1 (de) | 2008-02-25 | 2020-06-17 | Eyegate Pharmaceuticals, Inc. | Verbesserte freisetzung von dexamethason-phosphat im augengewebe durch iontophorese |
FR2928536B1 (fr) | 2008-03-14 | 2012-04-27 | Inst Nat Sante Rech Med | Dispositif d'injection dans l'oeil |
AU2009332951B2 (en) | 2008-12-31 | 2015-06-11 | Eyegate Pharmaceuticals, Inc. | System and method for ocular iontophoresis with buffering |
CA2750242C (en) | 2009-02-12 | 2018-05-22 | Incept, Llc | Drug delivery through hydrogel plugs |
JP2013524275A (ja) | 2010-04-03 | 2013-06-17 | ドシ,プラフル | 薬剤を含む医療機器、その製造方法とその使用方法 |
US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
WO2011163560A1 (en) | 2010-06-25 | 2011-12-29 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Methods of treatment using sterculic acid |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
EP2627292B1 (de) | 2010-10-15 | 2018-10-10 | Clearside Biomedical, Inc. | Vorrichtung für okularen zugang |
MX347934B (es) * | 2011-01-12 | 2017-05-18 | Sooft Italia Spa | Dispositivo y método para el suministro de riboflavina en la córnea, mediante iontoforesis, para el tratamiento de queratocono. |
WO2012162459A1 (en) * | 2011-05-26 | 2012-11-29 | Pepose Jay | Device and method for administering eye medications |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
EP3613413A1 (de) | 2011-12-05 | 2020-02-26 | Incept, LLC | Medizinische organogelprozesse und -zusammensetzungen |
WO2014164703A1 (en) | 2013-03-11 | 2014-10-09 | University Of Florida Research Foundation, Inc. | Delivery of card protein as therapy for occular inflammation |
CN105246529B (zh) | 2013-05-03 | 2019-06-14 | 科尼尔赛德生物医学公司 | 用于眼部注射的设备和方法 |
ITVE20130043A1 (it) * | 2013-07-31 | 2015-02-01 | I A C E R S R L | Dispositivo perfezionato oftalmologico per il trattamento di malattie corneali quali il cheratocono. |
ES2672327T3 (es) | 2014-01-27 | 2018-06-13 | Opia Technologies | Dispositivo de iontoforesis ocular |
JP5828535B1 (ja) | 2014-10-10 | 2015-12-09 | 石根 三井 | 矯正角膜クロスリンキング用コンタクトレンズ |
CN104353183B (zh) * | 2014-10-31 | 2016-12-07 | 厦门微科格瑞生物科技有限公司 | 电解液位置固定的可佩戴智能药物导入结构 |
WO2016118933A1 (en) * | 2015-01-22 | 2016-07-28 | Eyegate Pharmaceuticals, Inc. | Iontophoretic contact lens |
US10206814B2 (en) * | 2016-01-06 | 2019-02-19 | David R. Hardten | System and method for the delivery of medications or fluids to the eye |
WO2017192565A1 (en) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
JP2020513983A (ja) | 2017-03-23 | 2020-05-21 | ドヘニー アイ インスティテュート | 光干渉断層撮影の多重en−face血管造影平均化システム、方法および装置 |
AU2019352954B2 (en) | 2018-10-01 | 2022-03-10 | Biovisics Medical, Inc. | System and methods for controlled electrical modulation for vision therapy |
WO2020112980A2 (en) | 2018-11-30 | 2020-06-04 | Biovisics Medical, Llc | Head worn apparatuses for vision therapy |
EP3908238A1 (de) | 2019-01-09 | 2021-11-17 | Twenty Twenty Therapeutics LLC | Augenmontierte vorrichtung zur freigabe von therapeutischem mittel |
JP7531496B2 (ja) | 2019-01-09 | 2024-08-09 | トゥウェンティ トゥウェンティ セラピューティクス エルエルシー | 眼球装着装置からのプログラム可能な治療剤送達 |
EP3952979A1 (de) | 2019-04-10 | 2022-02-16 | Biovisics Medical, Inc. | Systeme und schnittstellen zur augentherapie |
US11511112B2 (en) | 2019-06-14 | 2022-11-29 | Biovisics Medical, Inc. | Wearable medical device |
WO2021011255A1 (en) | 2019-07-12 | 2021-01-21 | Biovisics Medical, Inc. | Ocular therapy modes and systems |
CN110547907A (zh) * | 2019-08-15 | 2019-12-10 | 中南大学湘雅二医院 | 一种用于眼内手术的双环虹膜扩张器 |
WO2024009535A1 (ja) * | 2022-07-08 | 2024-01-11 | テルモ株式会社 | 眼内薬物投与装置、薬剤リザーバ及び眼内薬物投与装置の動作方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US551880A (en) * | 1895-12-24 | Theodore b | ||
US2525381A (en) * | 1947-09-25 | 1950-10-10 | Tower Paul | Contact-type electrode holder |
US3122137A (en) * | 1961-10-30 | 1964-02-25 | Erlanger Gustav | Device for facilitating iontophoresis treatment of eyes |
SU995783T (en) | 1980-07-21 | 1983-02-15 | Omskij G Med I | A device for drug electrophoresis in ocular tissue |
US4678466A (en) * | 1981-06-25 | 1987-07-07 | Rosenwald Peter L | Internal medication delivery method and vehicle |
US4564016A (en) | 1982-05-24 | 1986-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus for introducing ionized drugs into the posterior segment of the eye and method |
US5053000A (en) * | 1985-11-13 | 1991-10-01 | Imperial Chemical Industries Plc | Ocular treatment |
IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
US4955378A (en) * | 1988-05-02 | 1990-09-11 | University Of South Florida | Apparatus and methods for performing electrofusion at specific anatomical sites |
WO1990011054A1 (en) * | 1989-03-17 | 1990-10-04 | Candela Laser Corporation | Non-invasive sclerostomy laser apparatus and method |
US5174304A (en) * | 1990-02-16 | 1992-12-29 | Latina Mark A | Electrocycloablation apparatus and method |
US5472436A (en) * | 1994-07-26 | 1995-12-05 | Fremstad; Daria A. | Ocular appliance for delivering medication |
US5522864A (en) * | 1994-10-25 | 1996-06-04 | Wallace; Larry B. | Apparatus and method for ocular treatment |
AUPM982694A0 (en) * | 1994-12-02 | 1995-01-05 | University Of Queensland, The | Iontophoresis method and apparatus |
US5676648A (en) * | 1996-05-08 | 1997-10-14 | The Aps Organization, Llp | Iontophoretic drug delivery apparatus and method for use |
-
1998
- 1998-01-05 FR FR9800009A patent/FR2773320B1/fr not_active Expired - Lifetime
- 1998-12-17 AT AT98403189T patent/ATE292493T1/de not_active IP Right Cessation
- 1998-12-17 AT AT04011635T patent/ATE437672T1/de not_active IP Right Cessation
- 1998-12-17 DE DE69841028T patent/DE69841028D1/de not_active Expired - Lifetime
- 1998-12-17 ES ES04011635T patent/ES2327636T3/es not_active Expired - Lifetime
- 1998-12-17 EP EP98403189A patent/EP0927560B1/de not_active Expired - Lifetime
- 1998-12-17 PT PT98403189T patent/PT927560E/pt unknown
- 1998-12-17 DE DE69829637T patent/DE69829637T2/de not_active Expired - Lifetime
- 1998-12-17 ES ES98403189T patent/ES2236880T3/es not_active Expired - Lifetime
- 1998-12-17 EP EP04011635A patent/EP1452203B1/de not_active Expired - Lifetime
- 1998-12-17 DK DK98403189T patent/DK0927560T3/da active
- 1998-12-23 IL IL12771198A patent/IL127711A/en not_active IP Right Cessation
- 1998-12-28 JP JP37384898A patent/JP4308353B2/ja not_active Expired - Lifetime
- 1998-12-28 KR KR1019980059369A patent/KR100551706B1/ko active IP Right Grant
-
1999
- 1999-01-04 CA CA002257749A patent/CA2257749C/en not_active Expired - Lifetime
- 1999-01-04 US US09/225,206 patent/US6154671A/en not_active Expired - Lifetime
- 1999-01-04 BR BR9900009-1A patent/BR9900009A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2327636T3 (es) | 2009-11-02 |
DE69829637T2 (de) | 2006-03-09 |
JPH11244323A (ja) | 1999-09-14 |
ES2236880T3 (es) | 2005-07-16 |
PT927560E (pt) | 2005-07-29 |
IL127711A (en) | 2004-06-20 |
BR9900009A (pt) | 2001-03-20 |
CA2257749C (en) | 2009-03-24 |
DK0927560T3 (da) | 2005-08-15 |
US6154671A (en) | 2000-11-28 |
DE69829637D1 (de) | 2005-05-12 |
CA2257749A1 (en) | 1999-07-05 |
JP4308353B2 (ja) | 2009-08-05 |
IL127711A0 (en) | 1999-10-28 |
ATE292493T1 (de) | 2005-04-15 |
DE69841028D1 (de) | 2009-09-10 |
EP1452203A3 (de) | 2004-09-08 |
EP0927560B1 (de) | 2005-04-06 |
EP1452203A2 (de) | 2004-09-01 |
EP0927560A1 (de) | 1999-07-07 |
KR19990066875A (ko) | 1999-08-16 |
KR100551706B1 (ko) | 2006-07-06 |
EP1452203B1 (de) | 2009-07-29 |
FR2773320A1 (fr) | 1999-07-09 |
FR2773320B1 (fr) | 2000-03-03 |
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