BR9900009A - Dispositivo de transferência de pelo menos um produto ativo no interior do globo ocular humano por meio de iontoforese - Google Patents
Dispositivo de transferência de pelo menos um produto ativo no interior do globo ocular humano por meio de iontoforeseInfo
- Publication number
- BR9900009A BR9900009A BR9900009-1A BR9900009A BR9900009A BR 9900009 A BR9900009 A BR 9900009A BR 9900009 A BR9900009 A BR 9900009A BR 9900009 A BR9900009 A BR 9900009A
- Authority
- BR
- Brazil
- Prior art keywords
- iontophoresis
- transferring
- reservoir
- active product
- product inside
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
"DISPOSITIVO DE TRANSFERêNCIA DE PELO MENOS UM PRODUTO ATIVO NO INTERIOR DO GLOBO OCULAR HUMANO POR MEIO DE IONTOFORESE". A invenção é relativa a um dispositivo de transferência de pelo menos um produto ativo, especificamente um medicamento, para o interior do globo ocular por meio de iontoforese, que compreende um reservatório (15) de produto ativo, e suscetível de ser aplicado sobre o olho de um paciente. O reservatório (15) apresenta, pelo menos, um eletrodo ativo de superfície (11), colocado frente a frente com um tecido ocular situado na periferia da córnea (C), um eletrodo de retorno (12) e um gerador de corrente. O eletrodo de retorno (12) está, de preferencia, em contato com as pálpebras (22, 24) parcialmente fechadas do paciente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9800009A FR2773320B1 (fr) | 1998-01-05 | 1998-01-05 | Dispositif pour le transfert intraoculaire de produits actifs par iontophorese |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9900009A true BR9900009A (pt) | 2001-03-20 |
Family
ID=9521510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9900009-1A BR9900009A (pt) | 1998-01-05 | 1999-01-04 | Dispositivo de transferência de pelo menos um produto ativo no interior do globo ocular humano por meio de iontoforese |
Country Status (13)
Country | Link |
---|---|
US (1) | US6154671A (pt) |
EP (2) | EP1452203B1 (pt) |
JP (1) | JP4308353B2 (pt) |
KR (1) | KR100551706B1 (pt) |
AT (2) | ATE292493T1 (pt) |
BR (1) | BR9900009A (pt) |
CA (1) | CA2257749C (pt) |
DE (2) | DE69829637T2 (pt) |
DK (1) | DK0927560T3 (pt) |
ES (2) | ES2236880T3 (pt) |
FR (1) | FR2773320B1 (pt) |
IL (1) | IL127711A (pt) |
PT (1) | PT927560E (pt) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6101411A (en) * | 1998-09-24 | 2000-08-08 | Newsome; David A. | Dilation enhancer |
US7346389B1 (en) * | 1998-09-24 | 2008-03-18 | Newsome David A | Dilation enhancer with pre-medicated contact lenses |
US6319240B1 (en) * | 1999-05-25 | 2001-11-20 | Iomed, Inc. | Methods and apparatus for ocular iontophoresis |
US7252655B2 (en) | 1999-05-25 | 2007-08-07 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US6539251B2 (en) | 1999-05-25 | 2003-03-25 | Iomed, Inc. | Ocular iontophoretic apparatus |
US6728573B1 (en) * | 2000-02-23 | 2004-04-27 | Iomed, Inc. | Ocular iontophoretic apparatus handle |
US6546283B1 (en) | 2000-10-18 | 2003-04-08 | Iomed, Inc. | High current density iontophoretic device and method of use thereof |
US20030045830A1 (en) * | 2001-04-17 | 2003-03-06 | De Bizemont Therese | Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis |
US20040106965A1 (en) * | 2001-06-29 | 2004-06-03 | Chow Alan Y. | Methods and apparatus for treatment of degenerative retinal disease via indirect electrical stimulation |
US20050004625A1 (en) * | 2001-06-29 | 2005-01-06 | Chow Alan Y. | Treatment of degenerative retinal disease via electrical stimulation of surface structures |
US20050033202A1 (en) | 2001-06-29 | 2005-02-10 | Chow Alan Y. | Mechanically activated objects for treatment of degenerative retinal disease |
US7031776B2 (en) * | 2001-06-29 | 2006-04-18 | Optobionics | Methods for improving damaged retinal cell function |
DE60219189T2 (de) * | 2001-07-20 | 2008-01-03 | Iomed, Inc., Salt Lake City | Iontophoretische okularvorrichtung zur abgabe von medikamenten auf methotrexat-basis und deren verwendung zur behandlung von neoplastischen, angiogenen, fibroplastischen und/oder immunsuppressiven augenunregelmässigkeiten |
JP2004535462A (ja) * | 2001-07-20 | 2004-11-25 | イオメド インコーポレイテッド | 眼、眼球結膜、眼瞼結膜、瞼、眼窩周囲の軟組織及び皮膚の細胞増殖阻害剤として、イオン導入によって送達する5−フルオロウラシルの使用方法。 |
FR2830766B1 (fr) | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese transpalpebrale |
FR2830767B1 (fr) * | 2001-10-12 | 2004-03-12 | Optis France Sa | Dispositif de delivrance de medicaments par iontophorese ou electroporation introculaire |
FR2836832B1 (fr) | 2002-03-08 | 2005-02-04 | Optis France Sa | Ensemble de connexion a usage medical pour le transfert de fluides |
EP1507826A4 (en) | 2002-05-17 | 2007-11-07 | Othera Pharmaceuticals Inc | IMPROVING THE EVOLUTION OF CATARACTS AND OTHER OPHTHALMIC DISEASES |
FR2851912B1 (fr) | 2003-03-03 | 2005-05-13 | Optis France Sa | Connecteur d'alimentation uniforme pour des dispositifs de delivrance de principes actifs |
US7589107B2 (en) | 2003-05-19 | 2009-09-15 | Othera Holding, Inc. | Amelioration of vitrectomy-induced cataracts |
US7825134B2 (en) * | 2003-05-19 | 2010-11-02 | Othera Holding, Inc. | Amelioration of cataracts, macular degeneration and other ophthalmic diseases |
FR2855761B1 (fr) * | 2003-06-03 | 2006-02-24 | Optis France Sa | Dispositif oculaire de delivrance variable de principes actifs par iontophorese |
AU2004293105B2 (en) * | 2003-11-20 | 2010-09-09 | Othera Holding, Inc. | Amelioration of macular degeneration and other ophthalmic diseases |
JP2007521124A (ja) * | 2004-02-06 | 2007-08-02 | シフィックス リミテッド ライアビリティ カンパニー | 電気エネルギー、光エネルギー、および音響エネルギーのうち少なくともいずれか1つを用いる視覚障害の治療 |
FR2869531B1 (fr) | 2004-04-30 | 2006-07-14 | Optis France Sa Sa | Dispositif de iontophorese oculaire diminuant les irritations |
CA2591267C (fr) | 2004-04-30 | 2012-04-10 | Eyegate Pharma S.A. | Dispositif de iontophorese oculaire diminuant les irritations |
NZ551379A (en) * | 2004-05-25 | 2010-11-26 | Othera Holding Inc | Oculoselective drugs and prodrugs |
US8246949B2 (en) * | 2004-10-27 | 2012-08-21 | Aciont, Inc. | Methods and devices for sustained in-vivo release of an active agent |
CN100553588C (zh) * | 2004-11-23 | 2009-10-28 | 小爱德华·K·王 | 控制眼和眼周围组织温度以及治疗眼疾病的医疗装置 |
US20070282282A1 (en) * | 2004-11-23 | 2007-12-06 | Wong Edward K Jr | Medical device and method for temperature control and treatment of the eye and surrounding tissues |
US8262715B2 (en) * | 2004-11-23 | 2012-09-11 | Eye Delivery System, Llc | Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy |
WO2006072887A1 (en) * | 2005-01-05 | 2006-07-13 | Eyegate Pharma Sa | Ocular iontophoresis device for delivering sirna and aptamers |
EP2266656B1 (en) * | 2005-04-18 | 2020-10-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Devices for delivering a biologically active agent to the ocular sphere of a subject |
US20080312283A1 (en) * | 2005-05-26 | 2008-12-18 | Othera Pharmaceuticals, Inc. | Use of Hydroxylamine Derivates for Inhibiting Vitrectomy-Induced Cataracts |
US8755880B2 (en) * | 2005-10-24 | 2014-06-17 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
US20070260171A1 (en) * | 2005-09-27 | 2007-11-08 | Higuchi John W | Intraocular iontophoretic device and associated methods |
WO2007050645A2 (en) * | 2005-10-24 | 2007-05-03 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
US8634907B2 (en) | 2005-10-24 | 2014-01-21 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
US8099162B2 (en) * | 2005-11-29 | 2012-01-17 | Eyegate Pharma, S.A.S. | Ocular iontophoresis device |
FR2893852B1 (fr) * | 2005-11-29 | 2010-09-03 | Eyegate Pharma Sa | Dispositif d'iontophorese oculaire |
US20070203190A1 (en) * | 2006-02-22 | 2007-08-30 | Ghanshyam Patil | Hydroxylamines and derivatives for the inhibition of complement activation |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
WO2007123142A1 (ja) * | 2006-04-20 | 2007-11-01 | Tti Ellebeau, Inc. | イオントフォレーシス装置 |
US20070299386A1 (en) * | 2006-06-23 | 2007-12-27 | Minu, L.L.C. | Delivery of an ocular agent using iontophoresis |
US20080027371A1 (en) * | 2006-07-26 | 2008-01-31 | Higuchi John W | Method and device for minimally invasive site specific ocular drug delivery |
US8923961B2 (en) | 2006-10-18 | 2014-12-30 | The Cleveland Clinic Foundation | Electrode assembly for delivering a therapeutic agent into ocular tissue |
CA2679066A1 (en) | 2007-02-22 | 2008-08-28 | Othera Holding, Inc. | Hydroxylamine compounds and methods of their use |
US9125807B2 (en) | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
US8480638B2 (en) * | 2007-10-04 | 2013-07-09 | Aciont, Inc. | Intraocular iontophoretic device and associated methods |
CA2707964A1 (en) * | 2007-12-05 | 2009-06-18 | Eyegate Pharma S.A.S. | Methods for delivering sirna via iontophoresis |
BRPI0908229A8 (pt) | 2008-02-25 | 2017-10-10 | Eyegate Pharma S A S | Uso de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste, kit e dispositivo para dispensar iontoforeticamente um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente para tratar um distúrbio ocular mediado por inflamação no referido paciente, e, formulação apropriada para dispensação iontoforética ocular de um corticosteróide, derivado de corticosteróide, pró-fármaco ou sal deste no olho de um paciente |
FR2928536B1 (fr) | 2008-03-14 | 2012-04-27 | Inst Nat Sante Rech Med | Dispositif d'injection dans l'oeil |
CN102341146B (zh) * | 2008-12-31 | 2015-09-23 | 艾盖茨药品公司 | 具有缓冲的眼用离子电渗用体系和方法 |
WO2010093873A2 (en) | 2009-02-12 | 2010-08-19 | Incept, Llc | Drug delivery through hydrogel plugs |
EP2555751B8 (en) | 2010-04-03 | 2018-02-14 | Praful Doshi | Methods of coating a contact lens |
US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
EP2585057B1 (en) | 2010-06-25 | 2017-08-23 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Methods of treatment using sterculic acid |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
BR112013010050B8 (pt) * | 2011-01-12 | 2021-06-22 | Sooft Italia Spa | dispositivo de iontoforese ocular para administrar qualquer solução medicamentosa ionizada |
WO2012162459A1 (en) * | 2011-05-26 | 2012-11-29 | Pepose Jay | Device and method for administering eye medications |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
EP3613413A1 (en) | 2011-12-05 | 2020-02-26 | Incept, LLC | Medical organogel processes and compositions |
EP2968613B1 (en) | 2013-03-11 | 2019-09-11 | University of Florida Research Foundation, Inc. | Delivery of card protein as therapy for occular inflammation |
CN105246529B (zh) | 2013-05-03 | 2019-06-14 | 科尼尔赛德生物医学公司 | 用于眼部注射的设备和方法 |
ITVE20130043A1 (it) * | 2013-07-31 | 2015-02-01 | I A C E R S R L | Dispositivo perfezionato oftalmologico per il trattamento di malattie corneali quali il cheratocono. |
ES2672327T3 (es) * | 2014-01-27 | 2018-06-13 | Opia Technologies | Dispositivo de iontoforesis ocular |
JP5828535B1 (ja) | 2014-10-10 | 2015-12-09 | 石根 三井 | 矯正角膜クロスリンキング用コンタクトレンズ |
CN104353183B (zh) * | 2014-10-31 | 2016-12-07 | 厦门微科格瑞生物科技有限公司 | 电解液位置固定的可佩戴智能药物导入结构 |
MX2017009193A (es) | 2015-01-22 | 2017-12-12 | Eyegate Pharmaceuticals Inc | Lente de contacto iontoforetica. |
US10206814B2 (en) * | 2016-01-06 | 2019-02-19 | David R. Hardten | System and method for the delivery of medications or fluids to the eye |
WO2017192565A1 (en) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
EP3599987A4 (en) | 2017-03-23 | 2020-12-16 | Doheny Eye Institute | SYSTEMS, METHODS AND DEVICES FOR OPTICAL COHERENCE TOMOGRAPHY WITH MULTI-ENFACE ANGIOGRAPHY MEANS |
AU2019352954B2 (en) | 2018-10-01 | 2022-03-10 | Biovisics Medical, Inc. | System and methods for controlled electrical modulation for vision therapy |
EP3886974A2 (en) | 2018-11-30 | 2021-10-06 | Biovisics Medical, Inc. | Head worn apparatuses for vision therapy |
JP7465271B2 (ja) | 2019-01-09 | 2024-04-10 | トゥウェンティ トゥウェンティ セラピューティクス エルエルシー | 治療剤放出のための眼球装着装置 |
KR102593449B1 (ko) | 2019-01-09 | 2023-10-23 | 트웬티 트웬티 테라퓨틱스 엘엘씨 | 눈 장착형 장치로부터의 프로그래밍 가능한 치료제 전달 |
US11471680B2 (en) | 2019-04-10 | 2022-10-18 | Biovisics, Inc. | Systems and interfaces for ocular therapy |
US11511112B2 (en) | 2019-06-14 | 2022-11-29 | Biovisics Medical, Inc. | Wearable medical device |
CN110547907A (zh) * | 2019-08-15 | 2019-12-10 | 中南大学湘雅二医院 | 一种用于眼内手术的双环虹膜扩张器 |
WO2024009535A1 (ja) * | 2022-07-08 | 2024-01-11 | テルモ株式会社 | 眼内薬物投与装置、薬剤リザーバ及び眼内薬物投与装置の動作方法 |
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US551880A (en) * | 1895-12-24 | Theodore b | ||
US2525381A (en) * | 1947-09-25 | 1950-10-10 | Tower Paul | Contact-type electrode holder |
US3122137A (en) * | 1961-10-30 | 1964-02-25 | Erlanger Gustav | Device for facilitating iontophoresis treatment of eyes |
SU995783A1 (ru) | 1980-07-21 | 1983-02-15 | Омский Государственный Ордена Трудового Красного Знамени Медицинский Институт Им.М.И.Калинина | Устройство дл электрофореза лекарственных веществ в ткани глаза |
US4678466A (en) * | 1981-06-25 | 1987-07-07 | Rosenwald Peter L | Internal medication delivery method and vehicle |
US4564016A (en) | 1982-05-24 | 1986-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus for introducing ionized drugs into the posterior segment of the eye and method |
US5053000A (en) * | 1985-11-13 | 1991-10-01 | Imperial Chemical Industries Plc | Ocular treatment |
IL86076A (en) * | 1988-04-14 | 1992-12-01 | Inventor S Funding Corp Ltd | Transdermal drug delivery device |
US4955378A (en) * | 1988-05-02 | 1990-09-11 | University Of South Florida | Apparatus and methods for performing electrofusion at specific anatomical sites |
WO1990011054A1 (en) * | 1989-03-17 | 1990-10-04 | Candela Laser Corporation | Non-invasive sclerostomy laser apparatus and method |
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US5472436A (en) * | 1994-07-26 | 1995-12-05 | Fremstad; Daria A. | Ocular appliance for delivering medication |
US5522864A (en) * | 1994-10-25 | 1996-06-04 | Wallace; Larry B. | Apparatus and method for ocular treatment |
AUPM982694A0 (en) * | 1994-12-02 | 1995-01-05 | University Of Queensland, The | Iontophoresis method and apparatus |
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-
1998
- 1998-01-05 FR FR9800009A patent/FR2773320B1/fr not_active Expired - Lifetime
- 1998-12-17 AT AT98403189T patent/ATE292493T1/de not_active IP Right Cessation
- 1998-12-17 DK DK98403189T patent/DK0927560T3/da active
- 1998-12-17 ES ES98403189T patent/ES2236880T3/es not_active Expired - Lifetime
- 1998-12-17 PT PT98403189T patent/PT927560E/pt unknown
- 1998-12-17 EP EP04011635A patent/EP1452203B1/fr not_active Expired - Lifetime
- 1998-12-17 DE DE69829637T patent/DE69829637T2/de not_active Expired - Lifetime
- 1998-12-17 ES ES04011635T patent/ES2327636T3/es not_active Expired - Lifetime
- 1998-12-17 AT AT04011635T patent/ATE437672T1/de not_active IP Right Cessation
- 1998-12-17 EP EP98403189A patent/EP0927560B1/fr not_active Expired - Lifetime
- 1998-12-17 DE DE69841028T patent/DE69841028D1/de not_active Expired - Lifetime
- 1998-12-23 IL IL12771198A patent/IL127711A/en not_active IP Right Cessation
- 1998-12-28 KR KR1019980059369A patent/KR100551706B1/ko active IP Right Grant
- 1998-12-28 JP JP37384898A patent/JP4308353B2/ja not_active Expired - Lifetime
-
1999
- 1999-01-04 BR BR9900009-1A patent/BR9900009A/pt not_active IP Right Cessation
- 1999-01-04 US US09/225,206 patent/US6154671A/en not_active Expired - Lifetime
- 1999-01-04 CA CA002257749A patent/CA2257749C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR19990066875A (ko) | 1999-08-16 |
IL127711A (en) | 2004-06-20 |
EP0927560B1 (fr) | 2005-04-06 |
US6154671A (en) | 2000-11-28 |
EP1452203A3 (fr) | 2004-09-08 |
DE69829637D1 (de) | 2005-05-12 |
IL127711A0 (en) | 1999-10-28 |
JP4308353B2 (ja) | 2009-08-05 |
DK0927560T3 (da) | 2005-08-15 |
DE69829637T2 (de) | 2006-03-09 |
JPH11244323A (ja) | 1999-09-14 |
DE69841028D1 (de) | 2009-09-10 |
EP1452203A2 (fr) | 2004-09-01 |
KR100551706B1 (ko) | 2006-07-06 |
CA2257749A1 (en) | 1999-07-05 |
FR2773320B1 (fr) | 2000-03-03 |
EP1452203B1 (fr) | 2009-07-29 |
ATE292493T1 (de) | 2005-04-15 |
PT927560E (pt) | 2005-07-29 |
CA2257749C (en) | 2009-03-24 |
ES2327636T3 (es) | 2009-11-02 |
EP0927560A1 (fr) | 1999-07-07 |
ES2236880T3 (es) | 2005-07-16 |
FR2773320A1 (fr) | 1999-07-09 |
ATE437672T1 (de) | 2009-08-15 |
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