IL127342A - A method for detecting nucleic acid that includes methylated GPC, a kit for using the method and a method for detecting a disease related to the methylation of nucleic acid - Google Patents
A method for detecting nucleic acid that includes methylated GPC, a kit for using the method and a method for detecting a disease related to the methylation of nucleic acidInfo
- Publication number
- IL127342A IL127342A IL12734297A IL12734297A IL127342A IL 127342 A IL127342 A IL 127342A IL 12734297 A IL12734297 A IL 12734297A IL 12734297 A IL12734297 A IL 12734297A IL 127342 A IL127342 A IL 127342A
- Authority
- IL
- Israel
- Prior art keywords
- nucleic acid
- methylated
- primers
- dna
- cpg
- Prior art date
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/656,716 US5786146A (en) | 1996-06-03 | 1996-06-03 | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US08/835,728 US6017704A (en) | 1996-06-03 | 1997-04-11 | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| PCT/US1997/009533 WO1997046705A1 (en) | 1996-06-03 | 1997-06-03 | Methylation specific detection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL127342A0 IL127342A0 (en) | 1999-10-28 |
| IL127342A true IL127342A (en) | 2002-07-25 |
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|---|---|---|---|
| IL12734297A IL127342A (en) | 1996-06-03 | 1997-06-03 | A method for detecting nucleic acid that includes methylated GPC, a kit for using the method and a method for detecting a disease related to the methylation of nucleic acid |
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| Country | Link |
|---|---|
| US (2) | US6017704A (OSRAM) |
| EP (2) | EP0954608B1 (OSRAM) |
| JP (2) | JP3612080B2 (OSRAM) |
| AT (1) | ATE326549T1 (OSRAM) |
| CA (1) | CA2257104C (OSRAM) |
| DE (1) | DE69735894T2 (OSRAM) |
| DK (1) | DK0954608T3 (OSRAM) |
| ES (1) | ES2264165T3 (OSRAM) |
| IL (1) | IL127342A (OSRAM) |
| PT (1) | PT954608E (OSRAM) |
| WO (1) | WO1997046705A1 (OSRAM) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6617434B1 (en) | 1996-05-31 | 2003-09-09 | North Shore Long Island Jewish Research Institute | Identificiaton of differentially methylated and mutated nucleic acids |
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| US5786146A (en) * | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
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| ATE326549T1 (de) | 2006-06-15 |
| ES2264165T3 (es) | 2006-12-16 |
| EP0954608A1 (en) | 1999-11-10 |
| WO1997046705A1 (en) | 1997-12-11 |
| CA2257104A1 (en) | 1997-12-11 |
| JP2000511776A (ja) | 2000-09-12 |
| IL127342A0 (en) | 1999-10-28 |
| DE69735894T2 (de) | 2007-04-19 |
| CA2257104C (en) | 2008-01-29 |
| EP1690948A2 (en) | 2006-08-16 |
| JP2004290200A (ja) | 2004-10-21 |
| PT954608E (pt) | 2006-08-31 |
| EP0954608B1 (en) | 2006-05-17 |
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