IL123404A - Antisecretory factor peptides regulating pathological permeability changes - Google Patents

Antisecretory factor peptides regulating pathological permeability changes

Info

Publication number
IL123404A
IL123404A IL12340496A IL12340496A IL123404A IL 123404 A IL123404 A IL 123404A IL 12340496 A IL12340496 A IL 12340496A IL 12340496 A IL12340496 A IL 12340496A IL 123404 A IL123404 A IL 123404A
Authority
IL
Israel
Prior art keywords
homologues
fragments
antisecretory factor
permeability changes
protein
Prior art date
Application number
IL12340496A
Other languages
English (en)
Other versions
IL123404A0 (en
Original Assignee
Rural Patent Svenska Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rural Patent Svenska Ab filed Critical Rural Patent Svenska Ab
Priority to IL15290996A priority Critical patent/IL152909A0/xx
Publication of IL123404A0 publication Critical patent/IL123404A0/xx
Publication of IL123404A publication Critical patent/IL123404A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/142Amino acids; Derivatives thereof
    • A23K20/147Polymeric derivatives, e.g. peptides or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
IL12340496A 1995-08-24 1996-08-23 Antisecretory factor peptides regulating pathological permeability changes IL123404A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL15290996A IL152909A0 (en) 1995-08-24 1996-08-23 Antisecretory factor peptides regulating pathological permeability changes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9502936A SE508609C2 (sv) 1995-08-24 1995-08-24 Antisekretorisk faktor - dess aminosyrasekvens, nubleinsyrasekvens och användning
PCT/SE1996/001049 WO1997008202A1 (en) 1995-08-24 1996-08-23 Antisecretory factor peptides regulating pathological permeability changes

Publications (2)

Publication Number Publication Date
IL123404A0 IL123404A0 (en) 1998-09-24
IL123404A true IL123404A (en) 2005-07-25

Family

ID=20399269

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12340496A IL123404A (en) 1995-08-24 1996-08-23 Antisecretory factor peptides regulating pathological permeability changes

Country Status (29)

Country Link
US (2) US6344440B1 (pt)
EP (1) EP0851876B1 (pt)
JP (2) JP4040679B2 (pt)
KR (1) KR100552947B1 (pt)
CN (1) CN1171902C (pt)
AT (1) ATE270305T1 (pt)
AU (1) AU702589B2 (pt)
BG (1) BG63209B1 (pt)
BR (1) BR9610308A (pt)
CA (1) CA2230111C (pt)
CZ (1) CZ295444B6 (pt)
DE (2) DE69632828T2 (pt)
DK (1) DK0851876T3 (pt)
EA (1) EA001201B1 (pt)
EE (1) EE04501B1 (pt)
ES (1) ES2118683T3 (pt)
HK (1) HK1018468A1 (pt)
HU (1) HU224971B1 (pt)
IL (1) IL123404A (pt)
NO (1) NO320560B1 (pt)
NZ (2) NZ316647A (pt)
PL (1) PL188530B1 (pt)
PT (1) PT851876E (pt)
RO (1) RO120197B1 (pt)
SE (1) SE508609C2 (pt)
SI (1) SI0851876T1 (pt)
SK (1) SK23698A3 (pt)
TR (1) TR199800304T1 (pt)
WO (1) WO1997008202A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE508609C2 (sv) * 1995-08-24 1998-10-19 Rural Patent Svenska Ab Antisekretorisk faktor - dess aminosyrasekvens, nubleinsyrasekvens och användning
SE506486C2 (sv) * 1996-11-20 1997-12-22 Svenska Lantmaennen Riksfoerbu Födoämne som vid förtäring inducerar antisekretoriska proteiner
SE513496C2 (sv) 1998-12-17 2000-09-18 Rural Patent Svenska Ab NASP-berikad äggula samt dess användning
CA2340721A1 (en) * 1999-06-21 2001-01-25 George Tuszynski Angiocidin: a cys-ser-val-thr-cys-gly specific tumor cell adhesion receptor
GB0322645D0 (en) * 2003-09-26 2003-10-29 Melacure Therapeutics Ab Use of antisecretory factor peptides
EP2040734B1 (en) * 2006-04-27 2011-09-28 Lantmännen AS-Faktor AB Antisecretory protein for use in the treatment of compartment syndrome
PL2037950T3 (pl) 2006-04-27 2014-09-30 Lantmaennen As Faktor Ab Dodatkowe zastosowania medyczne białka antysekrecyjnego
PL2468292T3 (pl) 2006-04-27 2020-08-24 Lantmännen Medical Ab Nowe peptydy wykazujące działanie przeciwwydzielnicze
WO2010065342A1 (en) 2008-11-25 2010-06-10 Temple University Angiocidin inhibition of tumor cell growth
JP5820277B2 (ja) 2009-02-11 2015-11-24 ラントメネン・アーエス−ファクトール・アーベー 細胞取込を最適化するための抗分泌性因子(af)の使用
BR112018000522A2 (pt) * 2015-07-10 2018-09-18 Lantmännen As-Faktor Ab processo para produzir gema de ovo com alto teor de af-16
CA3030316C (en) * 2016-07-18 2023-10-10 Lantmannen As-Faktor Ab Antisecretory factor 17
CN112368014A (zh) 2018-06-28 2021-02-12 兰特门内医疗公司 抗分泌因子在治疗和/或预防急性呼吸衰竭中的用途
WO2020065091A1 (en) 2018-09-28 2020-04-02 Lantmännen Functional Foods Ab A consumable product comprising malted wheat
CN112770643A (zh) * 2018-09-28 2021-05-07 兰特门内保健食品公司 包含麦芽化脱壳燕麦的可消耗产品
US20230096303A1 (en) 2020-03-26 2023-03-30 Lantmännen Functional Foods Ab A Consumable Product Comprising Malted Cereals for Promoting Recovery at Physical Activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE508609C2 (sv) * 1995-08-24 1998-10-19 Rural Patent Svenska Ab Antisekretorisk faktor - dess aminosyrasekvens, nubleinsyrasekvens och användning

Also Published As

Publication number Publication date
HU224971B1 (en) 2006-04-28
NO320560B1 (no) 2005-12-19
EE9800055A (et) 1998-08-17
BR9610308A (pt) 1999-12-21
AU702589B2 (en) 1999-02-25
HUP9900137A2 (hu) 1999-04-28
ES2118683T3 (es) 2004-12-01
CN1171902C (zh) 2004-10-20
NZ337380A (en) 2001-02-23
KR100552947B1 (ko) 2006-04-21
DE851876T1 (de) 1998-11-12
NZ316647A (en) 1999-10-28
KR19990044110A (ko) 1999-06-25
DE69632828T2 (de) 2005-07-14
JP2008043331A (ja) 2008-02-28
WO1997008202A1 (en) 1997-03-06
PL325114A1 (en) 1998-07-06
EP0851876A1 (en) 1998-07-08
PT851876E (pt) 2004-10-29
EA199800221A1 (ru) 1998-10-29
SE9502936L (sv) 1997-02-25
EE04501B1 (et) 2005-06-15
SK23698A3 (en) 1998-12-02
RO120197B1 (ro) 2005-10-28
NO980743D0 (no) 1998-02-23
HUP9900137A3 (en) 1999-11-29
EP0851876B1 (en) 2004-06-30
JPH11511972A (ja) 1999-10-19
BG102280A (en) 1999-04-30
TR199800304T1 (xx) 1998-05-21
AU6893296A (en) 1997-03-19
IL123404A0 (en) 1998-09-24
ATE270305T1 (de) 2004-07-15
HK1018468A1 (en) 1999-12-24
US20020099016A1 (en) 2002-07-25
CZ52098A3 (cs) 1998-09-16
CA2230111A1 (en) 1997-03-06
EA001201B1 (ru) 2000-12-25
DK0851876T3 (da) 2004-10-25
ES2118683T1 (es) 1998-10-01
SE9502936D0 (sv) 1995-08-24
NO980743L (no) 1998-04-16
JP4040679B2 (ja) 2008-01-30
SI0851876T1 (en) 2004-10-31
CZ295444B6 (cs) 2005-08-17
SE508609C2 (sv) 1998-10-19
CN1208420A (zh) 1999-02-17
US6344440B1 (en) 2002-02-05
CA2230111C (en) 2012-10-30
PL188530B1 (pl) 2005-02-28
DE69632828D1 (de) 2004-08-05
BG63209B1 (bg) 2001-06-29

Similar Documents

Publication Publication Date Title
IL123404A (en) Antisecretory factor peptides regulating pathological permeability changes
NZ504548A (en) Polypeptides and nucleic acids encoding human chordin
PT101297A (pt) Factores mitogenicos gliais, sua preparacao e utilizacao
BG104149A (en) Interleukin-18-binding proteins, methods for their preparation and administration
ATE389666T1 (de) Hohe expressionsrate von proteinen
ATE335078T1 (de) Überexpression von säugetier- und virusproteinen
NO990086L (no) Avkortete, l°selige tumornekrosefaktorreseptorer av type I og type II
DK564989D0 (da) Bindingsproteiner
ATA168590A (de) Für das baumpollenallergen p14 codierende rekombinante dna-moleküle, daraus hergestellte und abgeleitete polypeptide und deren verwendung
ATE202570T1 (de) Gene, die für macif proteine kodieren, expressionsvektoren mit diesem genen, und transformantenzellen mit diesem proteinen
DE69028783D1 (de) Künstliche peptide, die die zellbindung steigern
DE59109235D1 (de) Peptide des HIV-gag Proteins, ihre Herstellung und Verwendung
WO1999031229A3 (en) Peptides and nucleic acids derived from eisenia foetida and the use thereof
NO974713L (no) Gener som koder for lymfocyttinterferon-regulatorisk faktor (LSIRF) polypeptider
ATE315646T1 (de) Leukocyten-aktivierender faktor
ATE512162T1 (de) Antikörper gegen das p51 protein
CA2199843A1 (en) Novel PKA-Binding Proteins and Uses Thereof
TW342413B (en) Novel toxins isolated from Bracon Hebetor
AU5990100A (en) ICBP90 polypeptide and its fragments and polynucleotides coding for said polypeptides and applications for diagnosing and treating cancer
Terletskaya et al. BINDING OF PROTEIN SCP WITH MYELIN, ITS IDENTITY WITH PROTEIN P2. A SIMPLE METHOD OF PROTEIN P2 ISOLATION
MX9701904A (es) Proteinas de enlace de pka novedosas y usos de las mismas.
MX24651A (es) Compuestos de adn recombinante, vectores de expresion de mutantes de glicosilacion de la proteina c humana, celulas huesped transformadas y metodo para la produccion recombinante de formas zimogenas de proteina c humana.
WO2002096355A3 (en) Compositions and methods for adipose abundant protein

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired