IL121860A0 - Interleukin-18 binding proteins their preparation and use - Google Patents

Interleukin-18 binding proteins their preparation and use

Info

Publication number
IL121860A0
IL121860A0 IL12186097A IL12186097A IL121860A0 IL 121860 A0 IL121860 A0 IL 121860A0 IL 12186097 A IL12186097 A IL 12186097A IL 12186097 A IL12186097 A IL 12186097A IL 121860 A0 IL121860 A0 IL 121860A0
Authority
IL
Israel
Prior art keywords
interleukin
preparation
binding proteins
proteins
binding
Prior art date
Application number
IL12186097A
Other languages
English (en)
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12155497A external-priority patent/IL121554A0/xx
Priority claimed from IL12163997A external-priority patent/IL121639A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Priority to IL12186097A priority Critical patent/IL121860A0/xx
Priority to IL12213497A priority patent/IL122134A0/xx
Publication of IL121860A0 publication Critical patent/IL121860A0/xx
Priority to IL12546398A priority patent/IL125463A0/xx
Priority to HU0003533A priority patent/HU226698B1/hu
Priority to CA2298855A priority patent/CA2298855C/en
Priority to AU87460/98A priority patent/AU755794B2/en
Priority to CZ20000490A priority patent/CZ300818B6/cs
Priority to ES98938877T priority patent/ES2149149T3/es
Priority to NZ502392A priority patent/NZ502392A/xx
Priority to UA2000031437A priority patent/UA75862C2/uk
Priority to SI9830922T priority patent/SI1003781T1/sl
Priority to IL13452398A priority patent/IL134523A0/xx
Priority to DK98938877.2T priority patent/DK1003781T3/da
Priority to EEP200000073A priority patent/EE05538B1/xx
Priority to PCT/IL1998/000379 priority patent/WO1999009063A1/en
Priority to HK00108180.3A priority patent/HK1028773B/xx
Priority to EP98938877A priority patent/EP1003781B1/en
Priority to JP2000509740A priority patent/JP4272348B2/ja
Priority to SK176-2000A priority patent/SK287194B6/sk
Priority to BRPI9811940 priority patent/BRPI9811940B8/pt
Priority to KR1020007001504A priority patent/KR100687388B1/ko
Priority to PL338647A priority patent/PL206070B1/pl
Priority to DE1003781T priority patent/DE1003781T1/de
Priority to PT98938877T priority patent/PT1003781E/pt
Priority to AT98938877T priority patent/ATE443719T1/de
Priority to DE69841175T priority patent/DE69841175D1/de
Priority to CNB988081342A priority patent/CN1243021C/zh
Priority to EA200000216A priority patent/EA003675B1/ru
Priority to US09/485,632 priority patent/US6605280B1/en
Priority to ARP980104054A priority patent/AR013422A1/es
Priority to BG104149A priority patent/BG65519B1/bg
Priority to NO20000700A priority patent/NO327240B1/no
Priority to IL134523A priority patent/IL134523A/en
Priority to US09/790,338 priority patent/US7220717B2/en
Priority to US10/434,583 priority patent/US7101689B2/en
Priority to US11/376,794 priority patent/US7799541B2/en
Priority to US11/505,554 priority patent/US7704944B2/en
Priority to US11/724,737 priority patent/US7696154B2/en
Priority to ARP070104104A priority patent/AR062867A2/es
Priority to US12/511,756 priority patent/US8436148B2/en
Priority to CY20091101232T priority patent/CY1109664T1/el
Priority to US12/715,089 priority patent/US20100254941A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
IL12186097A 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use IL121860A0 (en)

Priority Applications (42)

Application Number Priority Date Filing Date Title
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
CNB988081342A CN1243021C (zh) 1997-08-14 1998-08-13 白细胞介素－18结合蛋白质及其制备和用途
EA200000216A EA003675B1 (ru) 1997-08-14 1998-08-13 Белки, связывающие интерлейкин-18, их получение и применение
US09/485,632 US6605280B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18
SK176-2000A SK287194B6 (sk) 1997-08-14 1998-08-13 Interleukínový-18 väzbový proteín - IL-18BP, DNA, replikovateľný vektor, transformovaná hostiteľská bunka, protilátka k IL-18BP, spôsob výroby IL-18BP, prostriedok s jeho obsahom a jeho použitie
DE1003781T DE1003781T1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
AU87460/98A AU755794B2 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
CZ20000490A CZ300818B6 (cs) 1997-08-14 1998-08-13 Interleukin-18-vazebné proteiny, príprava a použití
ES98938877T ES2149149T3 (es) 1997-08-14 1998-08-13 Proteinas de union a interleuquina-18, su preparacion y uso.
NZ502392A NZ502392A (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins (IL-18BP) their preparation and use in pharmaceuticals
UA2000031437A UA75862C2 (uk) 1997-08-14 1998-08-13 Виділений поліпептид, що зв'язується з il-18 (il-18bp) (варіанти), виділена молекула нуклеїнової кислоти, що його кодує (варіанти), антитіло, що зв'язується з даним поліпептидом, спосіб очищення il-18bp та композиція, що його містить
SI9830922T SI1003781T1 (sl) 1997-08-14 1998-08-13 Interlevkin-18 vezavni proteini, njihova priprava in uporaba
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
DK98938877.2T DK1003781T3 (da) 1997-08-14 1998-08-13 Interleukin-18-bindende proteiner, fremstilling og anvendelse af disse
EEP200000073A EE05538B1 (et) 1997-08-14 1998-08-13 Interleukiin-18 seostuvad valgud, nende valmistamine ja kasutamine
PCT/IL1998/000379 WO1999009063A1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
HK00108180.3A HK1028773B (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
EP98938877A EP1003781B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
JP2000509740A JP4272348B2 (ja) 1997-08-14 1998-08-13 インターロイキン−１８結合タンパク質、それらの調製および用途
HU0003533A HU226698B1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
BRPI9811940 BRPI9811940B8 (pt) 1997-08-14 1998-08-13 vetor de expressão para um polipeptídeo de ligação da interleucina-18 (il-18-bp), célula hospedeira procariótica transformada com o referido vetor, processo para produção de il-18-bp, proteína de fusão compreendendo o referido polipeptídeo, bem como il-18bp modificada.
KR1020007001504A KR100687388B1 (ko) 1997-08-14 1998-08-13 인터루킨-18 결합 단백질, 이들의 제조방법 및 용도
PL338647A PL206070B1 (pl) 1997-08-14 1998-08-13 Izolowane białko wiążące IL-18, sposób jego wytwarzania i izolowania, izolowana cząsteczka DNA, zdolny do replikacji wektor, transformowana komórka gospodarza, przeciwciało, kompozycja farmaceutyczna oraz zastosowanie
CA2298855A CA2298855C (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
PT98938877T PT1003781E (pt) 1997-08-14 1998-08-13 Proteínas de ligação a interleucina-18, sua preparação e utilização
AT98938877T ATE443719T1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
DE69841175T DE69841175D1 (de) 1997-08-14 1998-08-13 Interleukin-18 bindende proteine, deren herstellung und verwendung
ARP980104054A AR013422A1 (es) 1997-08-14 1998-08-14 UN VECTOR DE EXPRESIoN REPLICABLE QUE COMPRENDE UN ÁCIDO NUCLEICO QUE CODIFICA PARA UN POLIPÉPTIDO, UNA CÉLULA HUÉSPED ANIMAL AISLADA INCAPAZ DE CONDUCIR A UN ORGANISMO COMPLETO, UN MICROORGANISMO, UN MÉTODO PARA PRODUCIR UN POLIPEPTIDO DE SEC IN N° 2, UNA PROTEíNA DE FUSIoN, UN ANTICUERPO MONOCLONA
BG104149A BG65519B1 (bg) 1997-08-14 2000-02-10 Белтъци, свързващи интерлевкин-18, тяхното получаване и приложение
NO20000700A NO327240B1 (no) 1997-08-14 2000-02-11 Interleukin-18-bindende protein, DNA som koder for dette, vektor og celle inneholdende slikt DNA, fremgangsmate for fremstilling av proteinet, antistoffer som reagerer mot proteinet samt anvendelse av proteinet for fremstilling av medikamenter.
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use
US09/790,338 US7220717B2 (en) 1997-08-14 2001-02-21 Interleukin-18 binding proteins, their preparation and use
US10/434,583 US7101689B2 (en) 1997-08-14 2003-05-08 Interleukin-18 binding proteins, their preparation and use
US11/376,794 US7799541B2 (en) 1997-08-14 2006-03-15 Interleukin-18 binding proteins, their preparation and use
US11/505,554 US7704944B2 (en) 1997-08-14 2006-08-16 Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
US11/724,737 US7696154B2 (en) 1997-08-14 2007-03-15 Methods for treating interleukin-18 mediated disorders with interleukin-18 binding proteins
ARP070104104A AR062867A2 (es) 1997-08-14 2007-09-17 Proteinas de enlace a interleuquina -18, (il- 18bp), secuencias de adn que codifican para la il -18 bp, secuencias de adnc, un vehiculo de expresion replicable, celula huesped, un proceso para su produccion y aislacion, anticuerpos, composiciones farmaceuticas, el uso de dichas composiciones para la
US12/511,756 US8436148B2 (en) 1997-08-14 2009-07-29 Antibodies against interleukin-18 binding protein, their preparation and use
CY20091101232T CY1109664T1 (el) 1997-08-14 2009-11-25 Πρωτεϊνες δεσμευσεως ιντερλευκινης-18, η παρασκευη και η χρηση τους
US12/715,089 US20100254941A1 (en) 1997-08-14 2010-03-01 Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL12155497A IL121554A0 (en) 1997-08-14 1997-08-14 Interleukin-18 binding proteins their preparation and use
IL12163997A IL121639A0 (en) 1997-08-14 1997-08-27 Interleukin-18 binding proteins their preparation and use
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
PCT/IL1998/000379 WO1999009063A1 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use

Publications (1)

Publication Number Publication Date
IL121860A0 true IL121860A0 (en) 1998-02-22

Family

ID=27517687

Family Applications (5)

Application Number Title Priority Date Filing Date
IL12186097A IL121860A0 (en) 1997-08-14 1997-09-29 Interleukin-18 binding proteins their preparation and use
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL12213497A IL122134A0 (en) 1997-08-14 1997-11-06 Interleukin-18 binding proteins their preparation and use
IL12546398A IL125463A0 (en) 1997-08-14 1998-07-22 Interleukin-18 binding proteins their preparation and use
IL13452398A IL134523A0 (en) 1997-08-14 1998-08-13 Interleukin-18 binding proteins, their preparation and use
IL134523A IL134523A (en) 1997-08-14 2000-02-13 Proteins that bind interleukin-18, their preparation and use

Country Status (28)

Country Link
US (4) US6605280B1 (en:Method)
EP (1) EP1003781B1 (en:Method)
JP (1) JP4272348B2 (en:Method)
KR (1) KR100687388B1 (en:Method)
CN (1) CN1243021C (en:Method)
AR (2) AR013422A1 (en:Method)
AT (1) ATE443719T1 (en:Method)
AU (1) AU755794B2 (en:Method)
BG (1) BG65519B1 (en:Method)
BR (1) BRPI9811940B8 (en:Method)
CA (1) CA2298855C (en:Method)
CY (1) CY1109664T1 (en:Method)
CZ (1) CZ300818B6 (en:Method)
DE (2) DE1003781T1 (en:Method)
DK (1) DK1003781T3 (en:Method)
EA (1) EA003675B1 (en:Method)
EE (1) EE05538B1 (en:Method)
ES (1) ES2149149T3 (en:Method)
HU (1) HU226698B1 (en:Method)
IL (5) IL121860A0 (en:Method)
NO (1) NO327240B1 (en:Method)
NZ (1) NZ502392A (en:Method)
PL (1) PL206070B1 (en:Method)
PT (1) PT1003781E (en:Method)
SI (1) SI1003781T1 (en:Method)
SK (1) SK287194B6 (en:Method)
UA (1) UA75862C2 (en:Method)
WO (1) WO1999009063A1 (en:Method)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7393663B2 (en) * 1997-08-01 2008-07-01 Serono Genetics Institute S.A. Expressed sequence tags and encoded human proteins
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
BR9816013A (pt) * 1998-09-01 2003-01-21 Hayashibara Biochem Lab Proteìna de ligação de interleucina-18
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
IL131047A0 (en) * 1999-07-22 2001-01-28 Yeda Res & Dev Use of il-18 inhibitors
CA2324168A1 (en) * 1999-11-16 2001-05-16 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Antibody specific to interleukin 18 precursor
KR20110032012A (ko) 2000-02-10 2011-03-29 아보트 러보러터리즈 사람 인터류킨-１８에 결합하는 항체 및 이를 제조하고 사용하는 방법
EE05423B1 (et) * 2000-02-21 2011-06-15 Applied Research Systems Ars Holding N.V. IL-18 inhibiitori kasutamine maksakahjustuse ja muude haiguste raviks v?i ennetamiseks sobiva ravimi valmistamiseks, vektori ja raku kasutamine inhibiitori produtseerimisel ning IL-18 inhibiitorit sisaldav farmatseutiline kompositsioon
CN1841066B (zh) * 2000-05-05 2012-08-29 默克雪兰诺有限公司 Il-18抑制剂在治疗和/或预防动脉粥样硬化中的应用
AU2005211606B2 (en) * 2000-05-05 2007-02-22 Inserm - Institut National De La Sante Et De La Recherche Medicale Use of IL-18 inhibitors for the treatment and/or prevention of atherosclerosis
EP1331943A4 (en) * 2000-10-11 2005-01-26 Viron Therapeutics Inc NUCLEIC ACID MOLECULES AND POLYPEPTIDES FOR IMMUNOMODULATION
US7718368B2 (en) * 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
JP4860897B2 (ja) * 2001-01-29 2012-01-25 メルク セロノ ソシエテ アノニム 心疾患の治療および／または予防のためのｉｌ−１８阻害剤の使用
DE60234778D1 (de) * 2001-05-16 2010-01-28 Yeda Res & Dev Verwendung von il-18-hemmern zur behandlung oder prävention von sepsis
AU2002314103B2 (en) * 2001-05-25 2007-07-12 Ares Trading S.A. Use of il-18 inhibitors for treating or preventing cns injuries
DK2270052T3 (en) 2001-06-26 2018-07-02 Amgen Inc Antibodies to OPGL
UA78516C2 (en) * 2001-08-10 2007-04-10 Applied Research Systems Use of inhibitors of il-18 for treatment and/or prevention of hypersensitivity disorders, and in particular of delayed-type hypersensitivity
US9592267B2 (en) 2002-03-22 2017-03-14 Merck Serono Sa Use of IL-18BP for treatment of peripheral vascular diseases
US20040136992A1 (en) 2002-08-28 2004-07-15 Burton Paul B. J. Compositions and method for treating cardiovascular disease
ES2416510T3 (es) * 2002-10-08 2013-08-01 Ares Trading S.A. Uso de una citocina capaz de unirse a IL 18BP y de inhibir la actividad de una segunda citocina
IL152232A0 (en) * 2002-10-10 2003-05-29 Yeda Res & Dev Promoter to il-18bp, its preparation and use
EP1621616A4 (en) * 2003-04-30 2007-07-04 Japan Science & Tech Agency HUMAN ANTI-HUMAN INTERLEUKIN-18 ANTIBODY, FRAGMENT AND METHOD FOR THEIR USE
SI1622939T1 (sl) 2003-05-13 2012-06-29 Merck Serono Sa Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega
US7820800B2 (en) * 2003-11-05 2010-10-26 Ares Trading S.A. Process for the purification of IL-18 binding protein
CN101018808B (zh) * 2003-11-12 2014-07-23 科罗拉多州大学评议会 调节肿瘤坏死因子α的组合物和方法
US20050100965A1 (en) * 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
IL159670A0 (en) * 2003-12-31 2004-06-01 Yeda Res & Dev Use of il-18 binding protein in inflammations
ES2292127T3 (es) * 2004-03-01 2008-03-01 Ares Trading S.A. Uso de un medio de cultivo celular exento de suero para la produccion de il-18bp en celulas de mamiferos.
US7557084B2 (en) * 2004-03-31 2009-07-07 Regeneron Pharmaceuticals, Inc. IL-18 specific polypeptides and therapeutic uses thereof
ES2313367T3 (es) * 2004-06-29 2009-03-01 Ares Trading S.A. Procedimiento para la purificacion de proteina de union al il-18.
PT1885753E (pt) 2005-06-03 2011-10-06 Ares Trading Sa Produção de proteína recombinante de ligação a il-18
PL1888100T3 (pl) * 2005-06-03 2012-03-30 Merck Serono Sa Zastosowanie lizoform IL-18BP do leczenia i/lub zapobiegania neurologicznym chorobom zapalnym
RS52273B (sr) * 2005-06-10 2012-10-31 Ares Trading S.A. Proces za purifikaciju il-18 vezujućeg proteina
CN101003812B (zh) * 2006-01-17 2011-01-05 温州医学院 一种用于制备重组人egf-il18融合蛋白的方法
TWI422387B (zh) 2006-05-25 2014-01-11 Glaxo Group Ltd 免疫球蛋白
WO2010040736A2 (en) * 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
WO2014107530A1 (en) * 2013-01-02 2014-07-10 Wilsa, Inc. Method and apparatus for conditioning fluids
HUE055608T2 (hu) * 2013-09-05 2021-12-28 Ab2 Bio Sa IL-18-kötõ fehérje (IL-18BP) gyulladásos betegségekben
JP7274259B2 (ja) 2015-03-05 2023-05-16 エイビー２ バイオ ソシエテアノニム 炎症性疾患におけるｉｌ－１８結合タンパク質（ｉｌ－１８ｂｐ）および抗体
EP3943097A1 (en) 2020-07-24 2022-01-26 AB2 Bio SA Car-t cell therapy
WO2023143535A1 (zh) * 2022-01-28 2023-08-03 和径医药科技（上海）有限公司 一种靶向il-18bp的抗体及其应用
CR20240379A (es) * 2022-03-15 2024-12-11 Compugen Ltd Anticuerpos antagonistas de il-18bp y su uso en monoterapia y terapia combinada en el tratamiento del cáncer
CN114605521A (zh) * 2022-04-06 2022-06-10 内蒙古农业大学 一种细胞免疫调节蛋白及其应用
CN114891125B (zh) * 2022-06-16 2023-04-11 广东医科大学 一种长效重组白细胞介素-18结合蛋白及其生产方法与应用
WO2024148243A1 (en) 2023-01-06 2024-07-11 Lassen Therapeutics 1, Inc. Anti-il-18bp antibodies
TW202515608A (zh) 2023-06-26 2025-04-16 以色列商坎布根有限公司 Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985863A (en) * 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
GB9214857D0 (en) * 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
US5744451A (en) 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
US5776731A (en) 1996-02-21 1998-07-07 Immunex Corporation DNA encoding type-I interleukin-I receptor-like protein designated 2F1
AU4959997A (en) 1996-11-15 1998-06-10 Kennedy Institute Of Rheumatology, The Suppression of tnf alpha and il-12 in therapy
ATE346085T1 (de) 1996-12-06 2006-12-15 Vertex Pharma Inhibitoren des interleukin-1-beta konvertierenden enzyms
US7141393B2 (en) 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
US6087116A (en) * 1997-03-12 2000-07-11 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18 (IL-18) receptor polypeptides and their uses
SI20110A (sl) 1997-03-18 2000-06-30 Basf Aktiengesellschaft Metode in sestavki za moduliranje odzivnosti na kortikosteroide
ATE495257T1 (de) 1997-08-01 2011-01-15 Merck Serono Biodevelopment 5' ests für sekretierte proteine, die in verschiedenen geweben exprimiert werden
DK1375514T3 (da) 1997-08-01 2007-01-08 Serono Genetics Inst Sa 5' EST'er for secernerede proteiner udtrykt i forskellige væv
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CZ298579B6 (cs) 1998-04-28 2007-11-14 Applied Research Systems Ars Holding N. V. Konjugát polyolu a interferonu-beta
CA2276216A1 (en) 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
BR9816013A (pt) 1998-09-01 2003-01-21 Hayashibara Biochem Lab Proteìna de ligação de interleucina-18
AR022952A1 (es) 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
AU6078500A (en) 1999-07-09 2001-01-30 Amgen, Inc. Combination therapy for conditions leading to bone loss
WO2001019373A2 (en) 1999-09-17 2001-03-22 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids

Also Published As

Publication number Publication date
JP2001514876A (ja) 2001-09-18
HU226698B1 (en) 2009-07-28
WO1999009063A1 (en) 1999-02-25
BG65519B1 (bg) 2008-10-31
SK1762000A3 (en) 2000-09-12
IL134523A0 (en) 2001-04-30
HUP0003533A3 (en) 2003-08-28
US7799541B2 (en) 2010-09-21
ES2149149T1 (es) 2000-11-01
EA003675B1 (ru) 2003-08-28
EP1003781A1 (en) 2000-05-31
US20040037829A1 (en) 2004-02-26
CA2298855C (en) 2014-05-27
PL338647A1 (en) 2000-11-06
PL206070B1 (pl) 2010-06-30
SK287194B6 (sk) 2010-03-08
EA200000216A1 (ru) 2000-08-28
US8436148B2 (en) 2013-05-07
EE200000073A (en:Method) 2000-10-16
BRPI9811940B8 (pt) 2021-07-06
US20060154294A1 (en) 2006-07-13
IL125463A0 (en) 1999-03-12
BRPI9811940B1 (pt) 2011-10-04
DE69841175D1 (de) 2009-11-05
BG104149A (bg) 2000-08-31
PT1003781E (pt) 2009-10-26
CY1109664T1 (el) 2014-08-13
EP1003781B1 (en) 2009-09-23
DE1003781T1 (de) 2001-01-11
HUP0003533A2 (hu) 2001-01-29
SI1003781T1 (sl) 2009-12-31
NO20000700L (no) 2000-04-14
AU755794B2 (en) 2002-12-19
NO20000700D0 (no) 2000-02-11
CZ2000490A3 (cs) 2000-08-16
IL134523A (en) 2011-09-27
JP4272348B2 (ja) 2009-06-03
CA2298855A1 (en) 1999-02-25
US20100010200A1 (en) 2010-01-14
AU8746098A (en) 1999-03-08
US7101689B2 (en) 2006-09-05
KR100687388B1 (ko) 2007-02-26
KR20010022900A (ko) 2001-03-26
ATE443719T1 (de) 2009-10-15
CN1243021C (zh) 2006-02-22
NZ502392A (en) 2002-12-20
IL122134A0 (en) 1998-04-05
EE05538B1 (et) 2012-04-16
DK1003781T3 (da) 2010-01-25
ES2149149T3 (es) 2009-12-01
UA75862C2 (uk) 2006-06-15
CZ300818B6 (cs) 2009-08-19
US6605280B1 (en) 2003-08-12
NO327240B1 (no) 2009-05-18
CN1267307A (zh) 2000-09-20
AR013422A1 (es) 2000-12-27
BRPI9811940A (pt) 2000-09-05
AR062867A2 (es) 2008-12-10
HK1028773A1 (en) 2001-03-02

Similar Documents

Publication Publication Date Title
IL122134A0 (en) Interleukin-18 binding proteins their preparation and use
HUP0001400A3 (en) Osteoprotegerin binding proteins and receptors
ZA983189B (en) Osteoprotegerin binding proteins and receptors
EP1007562A4 (en) TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR
HUT75826A (en) Binding protein function modulator
IL123647A0 (en) Substituted amino compounds their preparation and use
GB9705903D0 (en) VP22 Proteins and uses thereof
IL131929A0 (en) Rap protein its preparation and use
AU8596498A (en) Annexin binding protein
EP1012262A4 (en) HFLP PROTEIN HFLP
AU7410598A (en) Novel human RNA binding protein
IL131247A0 (en) Cash protein its preparation and use
GB9423372D0 (en) Proteins and their uses
ZA984322B (en) Sucrose-binding proteins
AU6035298A (en) Human zinc binding proteins
ZA978220B (en) PTX-sensitive G proteins their preparation and use
IL121554A0 (en) Interleukin-18 binding proteins their preparation and use
IL121639A0 (en) Interleukin-18 binding proteins their preparation and use
AU1320600A (en) Human rna binding proteins
GB9726956D0 (en) Protein binding polypeptides
AU6894398A (en) Human gtp binding protein
AU2003200442A1 (en) Interleukin-18 binding proteins, their preparation and use
IL123477A0 (en) Nik binding proteins their preparation and use
AUPP004197A0 (en) Novel hbv binding protein and portions thereof
GB9424797D0 (en) Binding proteins